Projects per year
Personal profile
Research Interests
Stem cells and regenerative therapies
Orofacial pain
Minimal intervention dentistry
Oral infections and systemic health
Research Statement
The goal of my research is to develop minimally invasive, biologically based therapies for inflammatory dental diseases. I have particular interest in investigating the link between pain, inflammation and regeneration as well as the implications of dental disease on general health. The current research programmes include:
1- Exploring potential strategies for optimal differentiation of dental pulp stem cells with particular focus on inflammation and its impact on regeneration
2- Developing in vitro and in vivo models to study neuronal signalling in inflammatory and neuropathic pain
3- Investigate potential links between dental infections, systemic inflammation and general heath.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R4896CEM: From traditional to minimally invasive endodontics: A pilot trial for managing teeth with irreversible pulpitis in primary care setting - Siobhan Cushley
El Karim, I. (PI), Clarke, M. (CoI), Lundy, F. (CoI) & O'Neill, C. (CoI)
03/07/2020 → …
Project: Research
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R2714CEM: A single centre pilot prospective study to determine the association between oral health and development of ventilator associated pneumonia
Lundy, F. (PI) & El Karim, I. (CoI)
11/03/2020 → 28/02/2021
Project: Research
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R4826CEM: Endodontic infections and CardiOvascular disease risk (ECO): A prospective study of a possible link?
El Karim, I. (PI), Linden, G. (CoI) & Lundy, F. (CoI)
08/06/2018 → 06/03/2023
Project: Research
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R2480CEM: Endodontic infections and cardiovascular disease risk (ECO)
El Karim, I. (PI), Linden, G. (CoI) & Lundy, F. (CoI)
14/05/2018 → 31/05/2019
Project: Research
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R2376CEM: TRPA1 - inflammasome signalling in temporomandibular joint inflammatory pain
El Karim, I. (PI), Dombrowski, Y. (CoI), Lundy, F. (CoI) & Moynagh, P. (CoI)
29/03/2017 → 29/02/2020
Project: Research
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Clinical validation of a proposed diagnostic classification for pulpitis
Karrar, R. N., Craig, S. G., Duncan, H. F., Abushouk, S. A., Elfiel, S. Y., Lundy, F. T., Clarke, M., El-Karim, I. A. & Reliability Assessment Group, Aug 2025, In: International Endodontic Journal. 58, 8, p. 1158-1171 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)19 Downloads (Pure) -
Endodontic S3-level clinical practice guidelines: the European Society of Endodontology process and recommendations
Duncan, H. F. & El-Karim, I., 11 Apr 2025, In: British Dental Journal. 238, 7, p. 580-586 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)137 Downloads (Pure) -
Neuroinflammatory consequences of Rhinovirus infection in human epithelial and neuronal models
Dunne, O. M., Roe, N. A. M., Mousnier, A., Martin, S. L., Sergeant, G. P., About, I., El-Karim, I., Lundy, F. T. & McGarvey, L. P., 07 Sept 2025, In: Lung. 203, 1, 11 p., 93.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Role of Fusobacterium nucleatum in the pathogenesis of oral squamous cell carcinoma: a systematic review of molecular mechanisms and signalling pathways
El-Dwaikat, B., El Karim, I., Longley, D. B., Moynagh, P. N. & Lundy, F. T., Nov 2025, In: Archives of Oral Biology. 179, 18 p., 106369.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)34 Downloads (Pure) -
Dental pulp stem cells in endodontics: Advances, applications, and challenges
Ahmed, H. M. A., Duncan, H. F., El-Karim, I. A. & Cooper, P. R., 25 Mar 2024, Handbook of Stem Cell Applications. Springer Nature, p. 305-344 40 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Citation (Scopus)
Prizes
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Adjunct Faculty Manipal College of Dental Sciences, India
El Karim, I. (Recipient), 16 Dec 2022
Prize: Appointment
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British Endodontic Society Research Poster Prize awarded to Mary McClory (Primary Supervisor Ikhlas El Karim)
El Karim, I. (Recipient), 2019
Prize: Prize (including medals and awards)
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Dental Health Foundation Award awarded to Mary McClory (primary supervisor Ikhlas El karim)
El Karim, I. (Recipient), Jan 2021
Prize: Prize (including medals and awards)
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Elected Fellow of the Royal College of Surgeons Edinburgh
El Karim, I. (Recipient), 2014
Prize: Fellowship awarded competitively
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Fellowship (Ad Eundem) Royal college of Surgeons in Ireland
El Karim, I. (Recipient), 2016
Prize: Honorary degree
Activities
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Identification of Novel Markers and Therapeutics for Pulpitis using Connectivity Mapping
El Karim, I. (Invited speaker)
23 Jun 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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International PhD Scholarship
Hawamdeh, K. M. A. (Recipient), Craig, S. (Supervisor) & El Karim, I. (Supervisor)
2023 → 2026Activity: Other activity types › Other
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Centre for Dentistry EDI Lead and Committee Chair (Event)
El Karim, I. (Chair)
01 Dec 2022Activity: Membership types › Membership of network
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UK Research and Innovation (External organisation)
El Karim, I. (Member)
Dec 2022Activity: Membership types › Membership of peer review panel or committee
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PhD Thesis: microRNA, Dental Pulp Cell Mineralisation and Therapeutic Epigenetic Modification
El Karim, I. (Examiner)
22 Nov 2022Activity: Examination types › PhD external examination
Press/Media
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Major £2.6m trial to tackle children's tooth decay in a new way
01/06/2021
1 item of Media coverage
Press/Media: Research
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Belfast scientists say aspirin could reverse tooth decay.
07/09/2017
1 item of Media coverage
Press/Media: Research
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Thesis
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Neuropeptide Y and vasoactive intestinal polypeptide in human dental pulps from carious and non-carious teeth
El Karim, I. (Author), Lundy, F. (Supervisor), 2003Student thesis: Doctoral Thesis › Doctor of Philosophy