• Room 02.061 - CEM

    United Kingdom

Accepting PhD Students

1990 …2020

Research output per year

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Research Output

2020

Fluorescent arylphosphonic acids: synergic interactions between bone and fluorescent core

Yücesan, G., Zorlu, Y., Brown, C., Keil, C., Ayhan, M. M., Haase, H., Thompson, R. B. & Lengyel, I., 15 Apr 2020, In : Chemistry-a European Journal.

Research output: Contribution to journalArticle

Open Access
Open Access

Imaging hydroxyapatite in sub-retinal pigment epithelial deposits by fluorescence lifetime imaging microscopy with tetracycline staining

Szmacinski, H., Hegde, K., Zeng, H-H., Eslami, K., Puche, A. C., Lengyel, I. & Thompson, R. B., 21 Apr 2020, In : JOURNAL OF BIOMEDICAL OPTICS. 25, 4, p. 1-11

Research output: Contribution to journalArticle

Open Access
File
2019

Assessing Heterogeneity Of Alzheimer`s Disease Through The Eye

Csincsik, L., Quinn, N., MacGillivray, T., Shakespeare, T. J., Crutch, S. J., Peto, T. & Lengyel, I., Jul 2019, In : Alzheimers & dementia. 15, 7, p. P344

Research output: Contribution to journalMeeting abstract

Calcium, Diet, Imaging, and Age-Related Macular Degeneration

Curcio, C. A., Tan, A. C. S. & Lengyel, I., 19 Sep 2019, In : JAMA Ophthalmology.

Research output: Contribution to journalLetter

Correction to: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Harrison, I. F., Whitaker, R., Bertelli, P. M., O'Callaghan, J. M., Csincsik, L., Wells, J. A., Bocchetta, M., Ma, D., Fisher, A., Ahmed, Z., Murray, T. K., O'Neill, M. J., Rohrer, J. D., Lythgoe, M. F. & Lengyel, I., 05 Aug 2019, In : Acta neuropathologica communications. 7, 1, 1 p., 127.

Research output: Contribution to journalArticle

Open Access

Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease

Koychev, I., Lawson, J., Chessell, T., Mackay, C., Gunn, R., Sahakian, B., Rowe, J. B., Thomas, A. J., Rochester, L., Chan, D., Tom, B., Malhotra, P., Ballard, C., Chessell, I., Ritchie, C. W., Raymont, V., Leroi, I., Lengyel, I., Murray, M., Thomas, D. L. & 2 others, Gallacher, J. & Lovestone, S., 23 Mar 2019, In : BMJ Open. 9, 3, 16 p., e024498.

Research output: Contribution to journalArticle

Open Access
File
118 Downloads (Pure)

Determination of Zn, Cu and Fe in human patients' serum using micro-sampling ICP-MS and sample dilution

Abduljabbar, T. N., Sharp, B. L., Reid, H. J., Barzegar-Befroeid, N., Peto, T. & Lengyel, I., 01 Nov 2019, In : Talanta. 204, p. 663-669 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fluorescence Lifetime Imaging of Tetracycline-Stained Retinal Hydroxyapatite: An Early Biomarker for Age-Related Macular Degeneration?

Thompson, R. B., Szmacinski, H., Hegde, K., Puche, A., McGill, T., Neuringer, M. & Lengyel, I., 15 Feb 2019, In : Biophysical Journal. 116, 3, p. 566a 1 p.

Research output: Contribution to journalMeeting abstract

Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia

European Eye Epidemiology Consortium & EYE-RISK consortium, 01 Mar 2019, In : Ophthalmology. 126, 3, p. 393-406

Research output: Contribution to journalArticle

17 Citations (Scopus)

Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

EYE-RISK consortium, Mar 2019, In : Ophthalmology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
125 Downloads (Pure)

Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway

EYE-RISK consortium, 20 Jun 2019, In : PLoS ONE. 14, 6, 12 p., e0218457.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
26 Downloads (Pure)

Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Harrison, I. F., Whitaker, R., Bertelli, P. M., O'Callaghan, J. M., Csincsik, L., Bocchetta, M., Ma, D., Fisher, A., Ahmed, Z., Murray, T. K., O'Neill, M. J., Rohrer, J. D., Lythgoe, M. F. & Lengyel, I., 07 Jan 2019, In : Acta neuropathologica communications. 7, 1, p. 1-14

Research output: Contribution to journalArticle

Open Access
File
25 Downloads (Pure)

Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer's disease

den Haan, J., Csinscik, L., Parker, T., Paterson, R. W., Slattery, C. F., Foulkes, A., Bouwman, F. H., Verbraak, F. D., Scheltens, P., Peto, T., Lengyel, I., Schott, J. M., Crutch, S. J., Shakespeare, T. J. & Yong, K. X. X., 18 Jul 2019, In : Alzheimer's research & therapy. 11, 9 p., 62.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
29 Downloads (Pure)

The clinical relevance of visualising the peripheral retina

Quinn, N., Csincsik, L., Flynn, E., Curcio, C. A., Kiss, S., Sadda, S. R., Hogg, R., Peto, T. & Lengyel, I., Jan 2019, In : Progress in Retinal and Eye Research. 68, p. 83-109 27 p.

Research output: Contribution to journalReview article

Open Access
File
11 Citations (Scopus)
552 Downloads (Pure)

The Placental Growth Factor Pathway and its Potential Role in Macular Degenerative Disease

Cunningham, F., Van Bergen, T., Canning, P., Lengyel, I., Feyen, J. H. M. & Stitt, A. W., 04 May 2019, In : Current eye research. 44, 8, p. 813-822

Research output: Contribution to journalArticle

2 Citations (Scopus)

Zinc Nutrition and Inflammation in the Aging Retina

Gilbert, R., Peto, T., Lengyel, I. & Emri, E., 30 May 2019, In : Molecular Nutrition & Food Research.

Research output: Contribution to journalReview article

Open Access
File
2018

A new perspective on lipid research in age-related macular degeneration

van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., Delcourt, C., Rodrigez-Bocanegra, E., Biarnés, M., Luthert, P. J., Ueffing, M., Klaver, C. C. W., Nogoceke, E., den Hollander, A. I. & Lengyel, I., 03 May 2018, In : Progress in Retinal and Eye Research. p. 1-31

Research output: Contribution to journalReview article

Open Access
File
20 Citations (Scopus)
120 Downloads (Pure)

Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration

Tan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., Li, M., Messinger, J. D., Dolz-Marco, R., Lei, J., Nittala, M. G., Sadda, S. R., Lengyel, I., Freund, K. B. & Curcio, C. A., 07 Nov 2018, In : Science Translational Medicine. 10, 466, 11 p., eaat4544.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
67 Downloads (Pure)

Metabolomics and Age-Related Macular Degeneration

EYE-RISK consortium, 27 Dec 2018, In : Metabolites. 9, 1

Research output: Contribution to journalReview article

Open Access
File
2 Citations (Scopus)
174 Downloads (Pure)

Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, November 28–30, 2016 – Israel

Jenkins, A., Lengyel, I., Rutter, G. A., Lowe, N., Shai, I., Tirosh, A., Petro, T., Khamaisi, M., Andrews, S., Zmora, N., Gross, A., Maret, W., Lewis, E. C. & Moran, A., 01 Sep 2018, In : Journal of Trace Elements in Medicine and Biology. 49, p. 79-85 7 p.

Research output: Contribution to journalEditorial

Open Access
File
2 Citations (Scopus)
138 Downloads (Pure)

On the origin of proteins in human drusen : The meet, greet and stick hypothesis

Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J. & Lengyel, I., 17 Dec 2018, In : Progress in Retinal and Eye Research.

Research output: Contribution to journalReview article

Open Access
File
11 Citations (Scopus)
193 Downloads (Pure)

Peripheral Retinal Imaging Biomarkers for Alzheimer's Disease: A Pilot Study

Csincsik, L., MacGillivray, T. J., Flynn, E., Pellegrini, E., Papanastasiou, G., Barzegar-Befroei, N., Csutak, A., Bird, A. C., Ritchie, C. W., Peto, T. & Lengyel, I., 05 Apr 2018, In : Ophthalmic Research.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
190 Downloads (Pure)

Precision medicine for age-related macular degeneration: current developments and prospects

Biarnés, M., Vassiliev, V., Nogoceke, E., Emri, E., Rodríguez-Bocanegra, E., Ferraro, L., Garcia, M., Fauser, S., Monés, J., Lengyel, I. & Peto, T., 19 Jul 2018, In : Expert Review of Precision Medicine and Drug Development. 3, 4, p. 249-263 15 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
113 Downloads (Pure)

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

Arya, S., Emri, E., Synowsky, S. A., Shirran, S. L., Barzegar-Befroei, N., Peto, T., Botting, C. H., Lengyel, I. & Stewart, A. J., 24 Mar 2018, In : Experimental Eye Research. 172, p. 21-29

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
156 Downloads (Pure)

The effects of zinc supplementation on primary human retinal pigment epithelium

Pao, P-J., Emri, E., Abdirahman, S. B., Soorma, T., Zeng, H-H., Hauck, S. M., Thompson, R. B. & Lengyel, I., 01 Mar 2018, In : Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
166 Downloads (Pure)

Towards early detection of age-related macular degeneration with tetracyclines and FLIM

Szmacinski, H., Hegde, K., Zeng, H-H., Eslami, K., Puche, A., Lakowicz, J. R., Lengyel, I. & Thompson, R. B., 12 Feb 2018, In : Proceedings of SPIE. 10484, 7 p., 1048409.

Research output: Contribution to journalMeeting abstract

Open Access
File
1 Citation (Scopus)
43 Downloads (Pure)
2017

Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS)

Florea, D., Molina-López, J., Hogstrand, C., Lengyel, I., de la Cruz, A. P., Rodríguez-Elvira, M. & Planells, E., 26 Nov 2017, In : Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
111 Downloads (Pure)

Determining the localization of Tubulin Polymerization Promoting Protein TPPP/p25 in the mice and human retina: effect of zinc supplementation

Tripon, R. G., Oláh, J., Nasir, T., Csincsik, L., Li, C. L., Szunyogh, S., Gong, H., Flinn, J. M., Ovádi, J. & Lengyel, I., Jun 2017, In : Investigative Opthalmology and Visual Science. 58, 8, p. 2227 1 p.

Research output: Contribution to journalMeeting abstract

Open Access

Identifying the hydroxyapatite interactome: Involvement of serum proteins in the formation of sub-RPE deposits

Arya, S., Synowsky, S., Shirran, S., Botting, C., Lengyel, I. & Stewart, A., Jun 2017, In : Investigative Opthalmology and Visual Science. 58, 8, p. 5257 1 p.

Research output: Contribution to journalMeeting abstract

Open Access

Imaging Hydoxyapatite in sub-RPE Deposits by Fluorescence Lifetime Imaging Microscopy (FLIM)

Thompson, R., Hegde, K. R., Szmacinski, H., Zeng, H., McGill, T. J., Neuringer, M., Eslami, K., Puche, A. & Lengyel, I., Jun 2017, In : Investigative Opthalmology and Visual Science. 58, 8, p. 32 1 p.

Research output: Contribution to journalMeeting abstract

Open Access

Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye

Tripon, R. G., Oláh, J., Nasir, T., Csincsik, L., Li, C. L., Szunyogh, S., Gong, H., Flinn, J. M., Ovádi, J. & Lengyel, I., 27 Dec 2017, In : Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
200 Downloads (Pure)

Subretinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture model

Pilgrim, M. G., Lengyel, I., Lanzirotti, A., Newville, M., Fearn, S., Emri, E., Knowles, J. C., Messinger, J. D., Read, R. W., Guidry, C. & Curcio, C. A., 01 Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 708-719 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
241 Downloads (Pure)

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

Kersten, E., Paun, C. C., Schellevis, R. L., Hoyng, C. B., Delcourt, C., Lengyel, I., Peto, T., Ueffing, M., Klaver, C. C. W., Dammeier, S., den Hollander, A. I. & de Jong, E. K., 15 May 2017, In : Survey of ophthalmology. 63

Research output: Contribution to journalReview article

Open Access
File
33 Citations (Scopus)
216 Downloads (Pure)
2016

A novel non-Opioid binding site for endomorphin-1

Lengyel, I., Toth, F., Biyashev, D., Szatmari, I., Monory, K., Tomboly, C., Toth, G., Benyhe, S. & Borsodi, A., 01 Aug 2016, In : Journal of Basic and Clinical Physiology and Pharmacology. 67, 4, p. 605-616 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
52 Downloads (Pure)

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Rink, L., Mariani, E., Fulop, T., Dedoussis, G., Herbein, G., Provinciali, M., Jajte, J., Lengyel, I., Mocchegiani, E. & Malavolta, M., 26 Jul 2016, In : European Journal of Nutrition. p. 1-10 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2015

A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina

Lengyel, I., Csutak, A., Florea, D., Leung, I., Bird, A. C., Jonasson, F. & Peto, T., 01 Jul 2015, In : Ophthalmology. 122, 7, p. 1340-1347 8 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
238 Downloads (Pure)

Correction for Thompson et al., Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye (Proceedings of the National Academy of Sciences of the United States of America (2015) 112, 5, (1565-1570) DOI: 10.1073/pnas.1413347112)

Thompson, R. B., Reffatto, V., Bundy, J. G., Kortvely, E., Flinn, J. M., Lanzirotti, A., Jones, E. A., McPhail, D. S., Fearn, S., Boldt, K., Ueffing, M., Ratu, S. G. S., Pauleikhoff, L., Bird, A. C. & Lengyel, I., 21 Jul 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. E3971

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

Thompson, R. B., Reffatto, V., Bundy, J. G., Kortvely, E., Flinn, J. M., Lanzirotti, A., Jones, E. A., McPhail, D. S., Fearn, S., Boldt, K., Ueffing, M., Ratu, S. G. S., Pauleikhoff, L., Bird, A. C. & Lengyel, I., 03 Feb 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1565-1570 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2014

Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration

Flinn, J. M., Kakalec, P., Tappero, R., Jones, B. & Lengyel, I., 2014, In : Metallomics. 6, 7, p. 1223-1228 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2010

Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study

Csutak, A., Lengyel, I., Jonasson, F., Leung, I., Geirsdottir, A., Xing, W. & Peto, T., Oct 2010, In : Eye. 24, 10, p. 1568-1575 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2008

Reply to "Comment on: "High concentration of zinc in sub-retinal pigment epithelial deposits" (Lengyel et al.) (Exp. Eye Res. 772-780, 84/4, 2007)"

Lengyel, I., Peto, T., Bird, A. C. & van Kuijk, F. J. G. M., May 2008, In : Experimental Eye Research. 86, 5, p. 862-863 2 p.

Research output: Contribution to journalArticle

Uncontrolled Zinc- and Copper-Induced Oligomerisation of the Human Complement Regulator Factor H and Its Possible Implications for Function and Disease

Nan, R., Gor, J., Lengyel, I. & Perkins, S. J., 31 Dec 2008, In : Journal of Molecular Biology. 384, 5, p. 1341-1352 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2007

High concentration of zinc in sub-retinal pigment epithelial deposits

Lengyel, I., Flinn, J. M., Peto, T., Linkous, D. H., Cano, K., Bird, A. C., Lanzirotti, A., Frederickson, C. J. & van Kuijk, F. J. G. M., Apr 2007, In : Experimental Eye Research. 84, 4, p. 772-780 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
2006

Partial and full agonism in endomorphin derivatives: Comparison by null and operational model

Rónai, A. Z., Al-Khrasani, M., Benyhe, S., Lengyel, I., Kocsis, L., Orosz, G., Tóth, G., Kató, E. & Tóthfalusi, L., Jun 2006, In : Peptides. 27, 6, p. 1507-1513 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2004

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye

Lengyel, I., Tufail, A., Al Hosaini, H., Luthert, P., Bird, A. C. & Jeffery, G., Sep 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2886-2892 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus

Lengyel, I., Voss, K., Cammarota, M., Bradshaw, K., Brent, V., Murphy, K. P. S. J., Giese, K. P., Rostas, J. A. P. & Bliss, T. V. P., Dec 2004, In : European Journal of Neuroscience. 20, 11, p. 3063-3072 10 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Enhanced G-protein activation by a mixture of Aβ(25-35), Aβ(1-40/42) and zinc

Molnár, Z., Kovács, P., Laczkó, I., Soós, K., Fülöp, L., Penket, B. & Lengyel, I., Jun 2004, In : Journal of Neurochemistry. 89, 5, p. 1215-1223 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Enhancement of NMDA responses by β-amyloid peptides in the hippocampus in vivo

Molnár, Z., Soós, K., Lengyel, I., Penke, B., Szegedi, V. & Budai, D., 19 Jul 2004, In : Neuroreport. 15, 10, p. 1649-1652 4 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

S100B-Mediated Inhibition of the Phosphorylation of GFAP Is Prevented by TRTK-12

Frizzo, J. K., Tramontina, F., Bortoli, E., Gottfried, C., Leal, R. B., Lengyel, I., Donato, R., Dunkley, P. R. & Gonçalves, C. A., Apr 2004, In : Neurochemical Research. 29, 4, p. 735-740 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)