Projects per year
Personal profile
Research Statement
I am a Clinical Professor / Consultant Pathologist specialising in Molecular Diagnostics. In 2010 I led the development of Northern Ireland's first cancer focused Biobank (www.nibiobank.org) to ensure easier access to high quality, clinically annotated samples for researchers which are essential for translational research. As Director of the Northern Ireland Biobank (NIB) I have secured more than £3.5 million in direct funding to expand the biobank’s infrastructure across Northern Ireland. Currently NIB supports not only cancer research but also research into other diseases such as neurodegenerative disease, respiratory disease, endocrinology and infectious diseases, including COVID-19. NIB has rapidly become an internationally recognised biomedical resource which enables researchers worldwide to gain quicker, regulated access to quality assured collections of tissue, blood and other biological samples linked with reliable clinical and pathological data sets. To date, NIB has helped researchers to leverage more than £20 million in competitive grant funding.
I am a co-Director of the new Precision Medicine Centre of Excellence (PMC), a clinically accredited laboratory established in the Patrick G Johnston Centre for Cancer Research to deliver integrated high-throughput genomics, digital pathology and big data analytics (https://www.qub.ac.uk/research-centres/PMC). I co-lead the tissue hybridisation and digital pathology division. The PMC hosts the NHS Northern Ireland Regional Molecular Diagnostic Service for Solid Tumours in which I have key responsibilities for Breast and Head/Neck molecular testing. Currently, I co-lead Queen’s contribution to the Innovate UK funded PathLAKE consortium (https://www.pathlake.org), a Centre of Excellence in Digital Pathology established to drive forward innovation in cellular and molecular pathology across the UK. Previously I co-led a Cancer Research UK Accelerator Programme in Molecular Digital Pathology which funded a collaborative network of academics from across the UK to implement novel digital pathology solutions to analyse the immune contexture of tumours.
Research Interests
My current research is centred on using high quality human biosamples to identify and validate molecular targets as biomarkers for disease prediction, prognosis and response to therapy. In particular, I use novel approaches in molecular digital pathology, including application of multiplex immunofluorescence, to identify and validate novel biomarkers in the tumour microenvironment. One of my main interests is the development of new strategies to detect early development of disease and disease recurrence particularly for malignant tumours of the upper aero-digestive tract. Many of the projects I’m involved with utilise the open source software image analysis tool 'QuPath' https://qupath.github.io/ , which is a global phenomenon in part developed at Queen's supported by our Cancer Research UK Accelerator programme.
I make significant contributions to ongoing national and international research initiatives. I am a member of the National Cancer Research Institute's (NCRI) Head and Neck Clinical Study Group (H&N CSG), the international EPIC-Oropharyngeal Cancer consortium and formerly the NCRI Cellular/Molecular Pathology initiative (CM-PATH). I lead Northern Ireland's involvement in the UK-wide Cancer UK Stratified Medicines Programme 2 on behalf of Belfast's Experimental Cancer Medicine Centre. I also delivered the work package to establish the Belfast Tissue Collections for the Movember funded FASTMAN study.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R4860CNR: Clinical, genetic and molecular corelations in aggressive pituitary adenomas
James, J. & McArt, D.
02/06/2019 → …
Project: Research
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R3005CNR: Establishing a Precision Medicine Catapult Centre of Excellence in Northern Ireland
Salto-Tellez, M., Gonzalez de Castro, D., James, J., Kennedy, R., McArt, D. & Waugh, D.
01/12/2017 → …
Project: Research
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R1140CNR: Digital Innovation Hub Programme - DATA CAN
Lawler, M., Gavin, A., James, J. & Salto-Tellez, M.
02/01/2020 → 31/08/2022
Project: Research
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R4867CNR: PathLEAD - Pathology Image Data Lake for Education, Analytics and Discovery
18/07/2019 → 02/09/2022
Project: Research
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CACNA1D overexpression and voltage‑gated calcium channels in prostate cancer during androgen deprivation
McKerr, N., Mohd-Sarip, A., Dorrian, H., Breen, C., James, J. A., McQuaid, S., Mills, I. G. & McCloskey, K. D., 22 Mar 2023, In: Nature Scientific Reports. 13, 4683.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
Distinct molecular profiles of sporadic early onset colorectal cancer: a population-based cohort and systematic review
Hamilton, A. C., Bannon, F. J., Dunne, P. D., James, J., McQuaid, S., Gray, R. T., Salto-Tellez, M., Cardwell, C. R., Loughrey, M. B. & Coleman, H. G., 01 Mar 2023, In: Gastro Hep Advances. 2, 3, p. 347-359 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile18 Downloads (Pure) -
Exploring the immune microenvironment in small bowel adenocarcinoma using digital image analysis
Sidi, F. A., Bingham, V., McQuaid, S., Craig, S. G., Turkington, R. C., James, J. A., Humphries, M. P. & Salto-Tellez, M., 01 Aug 2023, In: PLOS ONE. 18, 8, 14 p., e0289355.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Subcellular epithelial HMGB1 expression is associated with colorectal neoplastic progression, male sex, mismatch repair protein expression, lymph node positivity, and an 'immune cold' phenotype associated with poor survival
Porter, R. J., Murray, G. I., Hapca, S., Hay, A., Craig, S. G., Humphries, M. P., James, J. A., Salto-Tellez, M., Brice, D. P., Berry, S. H. & McLean, M. H., 20 Mar 2023, In: Cancers. 15, 6, p. 1865 1 p., 1865.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Technical note on the exploration of COVID-19 in autopsy material
Humphries, M. P., Bingham, V., Abdullah Sidi, F., Craig, S., Lara, B., El-Daly, H., O'Doherty, N., Maxwell, P., Lewis, C., McQuaid, S., Lyness, J., James, J., Snead, D. R. J. & Salto-Tellez, M., 30 Jan 2023, (Early online date) In: Journal of Clinical Pathology.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Irish Endocrine Society Clinical Science Award - €15,000
Loughrey, Ben (Recipient), Hunter, Steven (Recipient) & James, Jacqueline (Recipient), 12 Nov 2022
Prize: Prize (including medals and awards)
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Primary Fellowship Medal, Faculty of Dental Surgery
James, Jacqueline (Recipient), 1996
Prize: Prize (including medals and awards)
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Queen's University Belfast: Excellence in Teaching by a Team Award
James, Jacqueline (Recipient), Craig, Stephanie (Recipient), Gault, Richard (Recipient) & McCombe, Kris (Recipient), 07 Jun 2022
Prize: Prize (including medals and awards)
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Queen's University Belfast: Innovation in Teaching Fund - £1400
Craig, Stephanie (Recipient), James, Jacqueline (Recipient), Lewis, Claire (Recipient), Gault, Richard (Recipient) & Collins, Matthew (Recipient), 19 Oct 2022
Prize: Other distinction
Activities
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Visiting Reseacher: Behnoush Abedi-Ardekani
Stephanie Craig (Host), Jacqueline James (Host), Manuel Salto-Tellez (Host), Kris McCombe (Host), Mohammad Albraikat (Host), Laura Graham (Host), Perry Maxwell (Host), David Gonzalez de Castro (Host) & Claire Lewis (Host)
14 Sep 2023 → 15 Sep 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Queen's University Belfast: EEECS Impact Award 2023
Jinting Pan (Recipient), Stephen Routley (Recipient), James Morgan (Recipient), Zhenghao Chang (Recipient), Stephanie Craig (Supervisor), Jacqueline James (Supervisor), Claire Lewis (Supervisor), Richard Gault (Supervisor) & Matthew Collins (Supervisor)
03 Jul 2023Activity: Other activity types › Other
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Summer Student: Haris Hussain Qurashi
Stephanie Craig (Host), Jacqueline James (Host) & Mohammad Albraikat (Host)
05 Jun 2023 → 28 Jul 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Visiting Researcher: Guillermo Garcia Porrero
Stephanie Craig (Host), Jacqueline James (Host) & Manuel Salto-Tellez (Host)
05 Jun 2023 → 18 Aug 2023Activity: Hosting a visitor types › Hosting an academic visitor
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DfE PhD Scholarship
Hannah Mallon (Recipient), Stephanie Craig (Supervisor) & Jacqueline James (Supervisor)
2023 → 2026Activity: Other activity types › Other
Press/Media
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PGJCCR Cancer Digest: Digital Pathology
Cristina Branco, Maurice Loughrey, Natalie Fisher, Stephanie Craig, Kiera McGill, Philip Dunne, Emma Allott, Lanshan Huang, Gerard Walls, Donna Small, Roisin Morelli, Manuel Salto-Tellez, Jacqueline James, Perry Maxwell & Yasmine Makhlouf
20/07/2022
1 Media contribution
Press/Media: Public Engagement Activities
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Cancers, Volume 13 Issue 1, Cover Story
Fatima Abdullahi Sidi, Victoria Bingham, Stephanie Craig, Stephen McQuaid, Jacqueline James, Matt Humphries & Manuel Salto-Tellez
01/01/2021
1 item of Media coverage
Press/Media: Other
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Molecular Oncology Research Article Highlights 2020, Featured Article
Amelie Viratham Pulsawatdi, Stephanie Craig, Victoria Bingham, Kris McCombe, Matt Humphries, Seedevi Senevirathne, Susan Richman, Phil Quirke, Leticia Campo, Enric Domingo, Timothy Maughan, Jacqueline James & Manuel Salto-Tellez
01/12/2020
1 item of Media coverage
Press/Media: Other
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Molecular Oncology, Volume 14 Number 10, Cover Art
Amelie Viratham Pulsawatdi, Stephanie Craig, Victoria Bingham, Kris McCombe, Matt Humphries, Seedevi Senevirathne, Susan Richman, Phil Quirke, Leticia Campo, Enric Domingo, Timothy Maughan, Jacqueline James & Manuel Salto-Tellez
02/10/2020
1 item of Media coverage
Press/Media: Other
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Medscape News UK: Immune Status is Prognostic for Poor Survival in Colorectal Cancer
Stephanie Craig, Matthew Humphries, Matthew Alderdice, Victoria Bingham, Susan Richman, Maurice Loughrey, Helen Coleman, Amélie Viratham Pulsawatdi, Kris McCombe, Murray Graeme, Andrew Blake, Enric Domingo, James Robineau, Louise Brown, David Fisher, Matt Seymour, Phil Quirke, Peter Bankhead, Stephen McQuaid, Mark Lawler, Darragh McArt, Tim Maughan, Jacqueline James & Manuel Salto-Tellez
24/07/2020
1 item of Media coverage
Press/Media: Research
Impact
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Implementation of HPV-specific testing in addition to assessment of p16 expression in oropharyngeal squamous cell carcinoma
Stephanie Craig (Participant), Lesley Anderson (Participant), Andrew Schache (Participant), Michael Moran (Participant), Laura Graham (Participant), Keith Currie (Participant), Keith Rooney (Participant), Max Robinson (Participant), Navdeep Upile (Participant), Rachel Brooker (Participant), Mina Mesri (Participant), Victoria Bingham (Participant), Kate Cuschieri (Participant), Stephen McQuaid (Participant), Terry Jones (Participant), Dennis McCance (Participant), Manuel Salto-Tellez (Participant), Simon McDade (Participant) & Jacqueline James (Participant)
Impact: Health Impact, Quality of Life Impact
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Successful Commercial Exploitation of Digital Pathology for Cancer Education, Biomarker Discovery and Clinical Diagnosis
Peter Hamilton (Participant), James Diamond (Participant), Yinhai Wang (Participant), Ching-Wei Wang (Participant), Paul Kelly (Participant), Jacqueline James (Participant) & Dean Fennell (Participant)
Impact: Health Impact, Quality of Life Impact