Projects per year
Personal profile
Research Statement
My research is centred on using high quality human biosamples to identify and validate molecular targets as biomarkers for disease prediction, prognosis and response to therapy. I led the development and expansion of Northern Ireland's first cancer focused Biobank; the Northern Ireland Biobank (NIB) (www.nibiobank.org), securing funding greater than £3.5 million to ensure easier access to high quality, clinically annotated samples which are essential for translational cancer research. The NIB is now a well established regional resource for all researchers in biomedical sciences to gain quicker, regulated access to quality assured collections of tissue and blood samples linked with reliable clinical and pathological data sets.
Research Interests
A major strand of my current research, using Biobank samples, is in the area of immuno-oncology. In particular, investigating whether expression profiles of immune checkpoints and biomarkers of the tumour microenvironment can reliably predict clinical outcome in a range of cancer types. This work is supported by a Cancer Research UK Accelerator Programme grant in Molecular Digital Pathology in which I am a lead investigator. The Accelerator programme funds a collaborative network of academics from across the UK to utilise novel digital pathology approaches to analyse the immune contexture of tumours. Specifically I have been working with my colleagues in the QUB Molecular Pathology Programme to predict early development of disease and disease recurrence in Squamous Cell Carcinomas (SCCs) of the aero-digestive tract utilising an open source software image analysis tool 'QuPath' https://qupath.github.io/ . This software was developed at Queen's as part of the Accelerator programme. My current research interest builds on a previous successful MRC funded collaborative programme centered on Head and Neck cancer and now extends to other sites in the aero-digestive tract including the oesophagus and lung.
As an academic pathologist working within the CCRCB Molecular Pathology Programme I also make a significant contribution to ongoing national and international molecular pathology initiatives. I am a member of the National Cancer Research Institute's (NCRI) Head and Neck Cancer Study Group (H&N CSG) and the NCRI Cellular/Molecular Pathology initiative (CM-PATH). I have led Belfast's involvement in the Stratified Medicines Programme (2) (funded by Cancer Research UK) on behalf of Belfast's Experimental Cancer Medicine Centre and I lead the work package to deliver the Belfast Tissue Collections for the Movember funded FASTMAN study.
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Projects
R1140CNR: Digital Innovation Hub Programme - DATA CAN
Lawler, M., Gavin, A., James, J. & Salto-Tellez, M.
02/01/2020 → …
Project: Research
R4860CNR: Clinical, genetic and molecular corelations in aggressive pituitary adenomas
02/06/2019 → …
Project: Research
R1310CNR: The role of p63 isoforms in head and neck cancers
McCance, D., James, J. & Patel, D.
01/08/2010 → 31/07/2015
Project: Research
Research Output
Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study
McCain, R. S., McManus, D. T., McQuaid, S., James, J. A., Salto-Tellez, M., Reid, N. B., Craig, S., Chisambo, C., Bingham, V., McCarron, E., Parkes, E., Turkington, R. C. & Coleman, H. G., 01 Jan 2020, In : Cancer Causes and Control. 31, 1, p. 1-11Research output: Contribution to journal › Article
Open Access
File
Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland
Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In : Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38Research output: Contribution to journal › Article
A systematic review of public perception and attitudes toward informed consent in biobanking
McCarter, R., James, J., Fallis, R., Fisher, H., McCarroll, J., McFerran, E., Reid, J. & Lewis, C., 26 Jul 2019, PROSPERO.Research output: Other contribution
File
Critical Appraisal of Programmed Death Ligand 1 Reflex Diagnostic Testing: Current Standards and Future Opportunities
Humphries, M. P., McQuaid, S., Craig, S. G., Bingham, V., Maxwell, P., Maurya, M., McLean, F., Sampson, J., Higgins, P., Greene, C., James, J. & Salto-Tellez, M., 01 Jan 2019, In : Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.Research output: Contribution to journal › Article
Open Access
File
4
Citations
(Scopus)
94
Downloads
(Pure)
Immune Activation by DNA Damage Predicts Response to Chemotherapy and Survival in Oesophageal Adenocarcinoma
Turkington, R., Knight, L., Blayney, J., Secrier, M., Douglas, R., Parkes, E., Sutton, E., Stevenson, L., McManus, D., Halliday, S., McCavigan, A., Logan, G., Walker, S., Steele, C., Perner, J., Bornscein, J., MacRae, S., Miremadi, A., mccarron, E., McQuaid, S. & 10 others, , 09 Mar 2019, In : Gut. 10 p.Research output: Contribution to journal › Article
Open Access
File
2
Citations
(Scopus)
149
Downloads
(Pure)
Prizes
Primary Fellowship Medal, Faculty of Dental Surgery
Jacqueline James (Recipient), 1996
Prize: Prize (including medals and awards)
Activities
Invited speaker: BSOMP Annual Meeting, Edinburgh April 2016
Jacqueline James (Speaker)24 Apr 2016
Activity: Talk or presentation types › Invited talk
Participant in Stakeholder Workshop
Jacqueline James (Member)24 Mar 2015
Activity: Consultancy types › Contribution to the work of national or international committees and working groups
Julie Harrington
Jacqueline James (Host)17 Apr 2015
Activity: Hosting a visitor types › Hosting of external, non-academic visitor
Launch of the NIB PPI Focus Group
Jacqueline James (Interviewee)27 Feb 2015
Activity: Talk or presentation types › Public lecture/debate/seminar
CRUK Campaign Ambassadors
Jacqueline James (Interviewee)03 Mar 2015
Activity: Talk or presentation types › Public lecture/debate/seminar
Impact
Successful Commercial Exploitation of Digital Pathology for Cancer Education, Biomarker Discovery and Clinical Diagnosis
Peter Hamilton (Participant), James Diamond (Participant), Yinhai Wang (Participant), Ching-Wei Wang (Participant), Paul Kelly (Participant), Jacqueline James (Participant), Dean Fennell (Participant)
Impact: Health Impact, Quality of Life Impact