• Room 0G.005 - H.S.B Block 10 MBC Site

    United Kingdom

Accepting PhD Students

1992 …2019
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Personal profile

Research Statement

My research is centred on using high quality human biosamples to identify and validate molecular targets as biomarkers for disease prediction, prognosis and response to therapy.   I led the development and expansion of Northern Ireland's first cancer focused Biobank; the Northern Ireland Biobank (NIB) (www.nibiobank.org), securing funding greater than £3.5 million to ensure easier access to high quality, clinically annotated samples which are essential for translational cancer research.   The NIB is now a well established regional resource for all researchers in biomedical sciences to gain quicker, regulated access to quality assured collections of tissue and blood samples linked with reliable clinical and pathological data sets.

Research Interests

A major strand of my current research, using Biobank samples, is in the area of immuno-oncology.  In particular, investigating whether expression profiles of immune checkpoints and biomarkers of the tumour microenvironment can reliably predict clinical outcome in a range of cancer types.  This work is supported by a Cancer Research UK Accelerator Programme grant in Molecular Digital Pathology in which I am a lead investigator.  The Accelerator programme funds a collaborative network of academics from across the UK to utilise novel digital pathology approaches to analyse the immune contexture of tumours.  Specifically I have been working with my colleagues in the QUB Molecular Pathology Programme to predict early development of disease and disease recurrence in Squamous Cell Carcinomas (SCCs) of the aero-digestive tract utilising an open source software image analysis tool 'QuPath' https://qupath.github.io/ .  This software was developed at Queen's as part of the Accelerator programme.   My current research interest builds on a previous successful MRC funded collaborative programme centered on Head and Neck cancer and now extends to other sites in the aero-digestive tract including the oesophagus and lung. 

As an academic pathologist working within the CCRCB Molecular Pathology Programme I also make a significant contribution to ongoing national and international molecular pathology initiatives.  I am a member of the National Cancer Research Institute's (NCRI) Head and Neck Cancer Study Group (H&N CSG) and the NCRI Cellular/Molecular Pathology initiative (CM-PATH).  I have led Belfast's involvement in the Stratified Medicines Programme (2) (funded by Cancer Research UK) on behalf of Belfast's Experimental Cancer Medicine Centre and I lead the work package to deliver the Belfast Tissue Collections for the Movember funded FASTMAN study.

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Projects 2010 2019

Research Output 1992 2019

A systematic review of public perception and attitudes toward informed consent in biobanking

McCarter, R., James, J., Fallis, R., Fisher, H., McCarroll, J., McFerran, E., Reid, J. & Lewis, C., 26 Jul 2019, PROSPERO.

Research output: Other contribution

File

Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 23 Oct 2019, (Accepted) In : Cancer Epidemiology, Biomarkers, & Prevention.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access
File
Reflex
Ligands
Immunohistochemistry
RNA
Pathology
1 Citation (Scopus)

Immune Activation by DNA Damage Predicts Response to Chemotherapy and Survival in Oesophageal Adenocarcinoma

Turkington, R., Knight, L., Blayney, J., Secrier, M., Douglas, R., Parkes, E., Sutton, E., Stevenson, L., McManus, D., Halliday, S., McCavigan, A., Logan, G., Walker, S., Steele, C., Perner, J., Bornscein, J., MacRae, S., Miremadi, A., mccarron, E., McQuaid, S. & 10 othersArthur, K., James, J., Eatock, M., O'Neill, R., Noble, F., Underwood, T., Harkin, D., Salto-Tellez, M., Fitzgerald, R. C. & Kennedy, R., 09 Mar 2019, In : Gut. 10 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Damage
Adenocarcinoma
Drug Therapy
Survival
Adjuvant Chemotherapy

MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma

Berggren, K. L., Restrepo Cruz, S., Hixon, M. D., Cowan, A. T., Keysar, S. B., Craig, S., James, J., Barry, M., Ozbun, M. A., Jimeno, A., McCance, D. J., Beswick, E. J. & Gan, G. N., 15 Aug 2019, In : Oncogene. 13 p.

Research output: Contribution to journalArticle

Radiation
Cytokines
Radiotherapy
Growth
Neoplasms

Prizes

Primary Fellowship Medal, Faculty of Dental Surgery

Jacqueline James (Recipient), 1996

Prize: Prize (including medals and awards)

Activities 2012 2016

Invited speaker: BSOMP Annual Meeting, Edinburgh April 2016

Jacqueline James (Speaker)
24 Apr 2016

Activity: Talk or presentation typesInvited talk

Participant in Stakeholder Workshop

Jacqueline James (Member)
24 Mar 2015

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Paul Brennan

Jacqueline James (Host)
05 Jul 2015

Activity: Hosting a visitor typesHosting of external, non-academic visitor

Launch of the NIB PPI Focus Group

Jacqueline James (Interviewee)
27 Feb 2015

Activity: Talk or presentation typesPublic lecture/debate/seminar

Visit of IT lead for UK CRC Tissue Directory and Coordination Centre

Jacqueline James (Host)
22 May 2015

Activity: Other activity typesHosting a delegation or group

Impact

Successful Commercial Exploitation of Digital Pathology for Cancer Education, Biomarker Discovery and Clinical Diagnosis

Peter Hamilton (Participant), James Diamond (Participant), Yinhai Wang (Participant), Ching-Wei Wang (Participant), Paul Kelly (Participant), Jacqueline James (Participant), Dean Fennell (Participant)

Impact: Health Impact, Quality of Life Impact