Projects per year
Personal profile
Research Statement
I have been a lecturer within the School of Pharmacy since June 2010 and my research focuses upon proteases with particular emphasis on their role in immune signalling and disease.
Currently my work focuses upon the DUB/USP17 family of deubiquitinating enzymes where we have shown that USP17 (DUB-3) is induced in response to cytokines, chemokines and growth factors (IL-4, IL-6, IL-8, SCF1, EGF) and that it regulates cell growth and movement. Subsequently, we have demonstrated that USP17 modulates signalling through the Ras/MEK/ERK pathway due to its regulation of Ras processing and localisation. Moreover, we have identified a novel isoform of the protease Ras converting enzyme 1 (RCE1), which is involved in Ras processing, and shown that it is ubiquitinated and that its deubiquitination by USP17 can regulate its localisation and function. We have also shown that USP17 is over-expressed in a range of tumour tissues and we are currently assessing USP17 as a potential cancer therapeutic target.
In addition, we are examining the role of bacterial proteases potentially involved in the subversion of the host immune response to assess their suitability as therapeutic targets.
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Projects
- 2 Active
Research Output
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Brevinin-2GHk from Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity
Chen, G., Miao, Y., Ma, C., Zhou, M., Shi, Z., Chen, X., Burrows, J., Xi, X., Chen, T. & Wang, L., 14 Feb 2020, In : Antibiotics. 9, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)58 Downloads (Pure) -
Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer
Greene, M. K., Chen, T., Robinson, E., Straubinger, N. L., Minx, C., Chan, D. K. W., Wang, J., Burrows, J. F., Van Schaeybroeck, S., Baker, J. R., Caddick, S., Longley, D. B., Mager, D. E., Straubinger, R. M., Chudasama, V. & Scott, C. J., 11 Sep 2020, In : British Journal of Cancer.Research output: Contribution to journal › Article › peer-review
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Modification and Targeted Design of N-Terminal Truncates Derived from Brevinin with Improved Therapeutic Efficacy
He, H., Chen, Y., Ye, Z., Chen, X., Ma, C., Zhou, M., Xi, X., Burrows, J., Chen, T. & Wang, L., 06 Aug 2020, In : Biology. 9, 14 p., 209.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells
Greene, M., Nogueira, J., Tracey, S., Richards, D., McDaid, W., Burrows, J., Campbell, K., Longley, D., Chudasama, V. & Scott, C., 14 May 2020, In : Nanoscale.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities
Li, M., Xi, X., Ma, C., Chen, X., Zhou, M., Burrows, J. F., Chen, T. & Wang, L., 18 Oct 2019, In : Biomolecules. 9, 10, 13 p., 628.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)76 Downloads (Pure)
Activities
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Deubiquitinases - from structure to physiology
James Burrows (Participant)
26 Jun 2017 → 28 Jun 2017Activity: Participating in or organising an event types › Participation in conference
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Frontiers in immunology (Journal)
James Burrows (Peer reviewer)
01 Jan 2017 → 31 Dec 2017Activity: Publication peer-review and editorial work types › Editorial activity
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KTP/ Causeway Sensors Ltd - S2410CNR
Christopher Scott (Member) & James Burrows (Member)
01 Apr 2017 → 31 Mar 2020Activity: Consultancy types › KTP & Consultancy in kind
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China Medical University – Queen’s University Belfast Joint College
James Burrows (Contributor)
02 Apr 2016 → 16 Apr 2016Activity: Visiting an external institution types › Research and Teaching at External Organisation
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Sentinus Young Innovators Competition
James Burrows (Contributor)
13 Jun 2016Activity: Other activity types › Hosting a school group or open day