Projects per year
Personal profile
Research Statement
I have been a lecturer within the School of Pharmacy since June 2010 and my research focuses upon proteases with particular emphasis on their role in immune signalling and disease.
Currently my work focuses upon the DUB/USP17 family of deubiquitinating enzymes where we have shown that USP17 (DUB-3) is induced in response to cytokines, chemokines and growth factors (IL-4, IL-6, IL-8, SCF1, EGF) and that it regulates cell growth and movement. Subsequently, we have demonstrated that USP17 modulates signalling through the Ras/MEK/ERK pathway due to its regulation of Ras processing and localisation. Moreover, we have identified a novel isoform of the protease Ras converting enzyme 1 (RCE1), which is involved in Ras processing, and shown that it is ubiquitinated and that its deubiquitination by USP17 can regulate its localisation and function. We have also shown that USP17 is over-expressed in a range of tumour tissues and we are currently assessing USP17 as a potential cancer therapeutic target.
In addition, we are examining the role of bacterial proteases potentially involved in the subversion of the host immune response to assess their suitability as therapeutic targets.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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A frog‐derived antimicrobial peptide as a potential anti‐biofilm agent in combating Staphylococcus aureus skin infection
Fei, F., Wang, T., Jiang, Y., Chen, X., Ma, C., Zhou, M., Wu, Q., Cao, P., Duan, J., Chen, T., Burrows, J. F. & Wang, L., 20 May 2023, (Early online date) In: Journal of Cellular and Molecular Medicine. 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Downloads (Pure) -
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISb
Liu, S., Lin, Y., Liu, J., Chen, X., Ma, C., Xi, X., Zhou, M., Chen, T., Burrows, J. F. & Wang, L., Aug 2022, In: Antibiotics. 11, 8, e1048.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)42 Downloads (Pure) -
USP17 is required for peripheral trafficking of lysosomes
Lin, J., McCann, A., Sereesongsaeng, N., Burden, J., Alsa'd, A. A. M., Burden, R., Micu, I., Williams, R., Van Schaeybroeck, S., Evergren, E., Mullan, P., Scott, C. & Burrows, J., 26 Jan 2022, In: EMBO Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile170 Downloads (Pure) -
CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation
Stewart, L. M., Gerner, L., Rettel, M., Stein, F., Burrows, J. F., Mills, I. G. & Evergren, E., 01 Nov 2021, In: Cell, Death & Disease. 12, 11, 1040 .Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Downloads (Pure) -
Evaluation of the In Vitro Cytotoxicity and Modulation of the Inflammatory Response by the Bioresorbable Polymers Poly(D,L-lactide-co-glycolide) and Poly(L-lactide-co-glycolide)
Geddes, L., Themistou, E., Burrows, J. F., Buchanan, F. J. & Carson, L., 15 Oct 2021, In: Acta Biomaterialia. 134, p. 261-275Research output: Contribution to journal › Article › peer-review
Open AccessFile119 Downloads (Pure)
Activities
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UCAS Discovery Event
Johanne Barry (Participant), Dan Corbett (Participant), James Burrows (Participant) & Matthew Wylie (Participant)
09 Mar 2023Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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Grant reviewer French National research Agency
James Burrows (Recipient)
Oct 2022Activity: Other activity types › Other
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Computational and Structural Biotechnology Journal (Journal)
James Burrows (Peer reviewer)
Jul 2022Activity: Publication peer-review and editorial work types › Publication peer-review
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School of Pharmacy Pathway opportunity program
James Burrows (Recipient)
28 Jun 2022Activity: Other activity types › Other
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39th WINTER SCHOOL ON PROTEINASES AND INHIBITORS
James Burrows (Participant)
17 Feb 2022 → 19 Feb 2022Activity: Participating in or organising an event types › Participation in conference