Projects per year
I have been a lecturer within the School of Pharmacy since June 2010 and my research focuses upon proteases with particular emphasis on their role in immune signalling and disease.
Currently my work focuses upon the DUB/USP17 family of deubiquitinating enzymes where we have shown that USP17 (DUB-3) is induced in response to cytokines, chemokines and growth factors (IL-4, IL-6, IL-8, SCF1, EGF) and that it regulates cell growth and movement. Subsequently, we have demonstrated that USP17 modulates signalling through the Ras/MEK/ERK pathway due to its regulation of Ras processing and localisation. Moreover, we have identified a novel isoform of the protease Ras converting enzyme 1 (RCE1), which is involved in Ras processing, and shown that it is ubiquitinated and that its deubiquitination by USP17 can regulate its localisation and function. We have also shown that USP17 is over-expressed in a range of tumour tissues and we are currently assessing USP17 as a potential cancer therapeutic target.
In addition, we are examining the role of bacterial proteases potentially involved in the subversion of the host immune response to assess their suitability as therapeutic targets.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
- 1 Similar Profiles
Dive into details
Select a country/territory to view shared publications and projects
Targeted Modification and Structure-Activity Study of GL-29, an Analogue of the Antimicrobial Peptide Palustrin-2ISbLiu, S., Lin, Y., Liu, J., Chen, X., Ma, C., Xi, X., Zhou, M., Chen, T., Burrows, J. F. & Wang, L., Aug 2022, In: Antibiotics. 11, 8, e1048.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Lin, J., McCann, A., Sereesongsaeng, N., Burden, J., Alsa'd, A. A. M., Burden, R., Micu, I., Williams, R., Van Schaeybroeck, S., Evergren, E., Mullan, P., Scott, C. & Burrows, J., 26 Jan 2022, In: EMBO Reports.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile122 Downloads (Pure)
Stewart, L. M., Gerner, L., Rettel, M., Stein, F., Burrows, J. F., Mills, I. G. & Evergren, E., 01 Nov 2021, In: Cell, Death & Disease. 12, 11, 1040 .
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile30 Downloads (Pure)
Evaluation of the In Vitro Cytotoxicity and Modulation of the Inflammatory Response by the Bioresorbable Polymers Poly(D,L-lactide-co-glycolide) and Poly(L-lactide-co-glycolide)Geddes, L., Themistou, E., Burrows, J. F., Buchanan, F. J. & Carson, L., 15 Oct 2021, In: Acta Biomaterialia. 134, p. 261-275
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile47 Downloads (Pure)
Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiformeJena, L. N., Bennie, L. A., McErlean, E. M., Pentlavalli, S., Glass, K., Burrows, J. F., Kett, V. L., Buckley, N. E., Coulter, J. A., Dunne, N. J. & McCarthy, H. O., 04 May 2021, In: Journal of nanobiotechnology. 19, 1, p. 127
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile77 Downloads (Pure)
James Burrows (Peer reviewer)Jul 2022
Activity: Publication peer-review and editorial work types › Publication peer-review