Projects per year
Personal profile
Research Statement
I have been a lecturer within the School of Pharmacy since June 2010 and my research focuses upon proteases with particular emphasis on their role in immune signalling and disease.
Currently my work focuses upon the DUB/USP17 family of deubiquitinating enzymes where we have shown that USP17 (DUB-3) is induced in response to cytokines, chemokines and growth factors (IL-4, IL-6, IL-8, SCF1, EGF) and that it regulates cell growth and movement. Subsequently, we have demonstrated that USP17 modulates signalling through the Ras/MEK/ERK pathway due to its regulation of Ras processing and localisation. Moreover, we have identified a novel isoform of the protease Ras converting enzyme 1 (RCE1), which is involved in Ras processing, and shown that it is ubiquitinated and that its deubiquitination by USP17 can regulate its localisation and function. We have also shown that USP17 is over-expressed in a range of tumour tissues and we are currently assessing USP17 as a potential cancer therapeutic target.
In addition, we are examining the role of bacterial proteases potentially involved in the subversion of the host immune response to assess their suitability as therapeutic targets.
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Projects
- 2 Active
R1253PMY: Can the Disarming of Protease Activated Receptors by Secreted Bacterial Proteases Contribute to their Evasion of the Innate Immune System
01/08/2012 → 17/12/2019
Project: Research
Research Output
Brevinin-2GHk from Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity
Chen, G., Miao, Y., Ma, C., Zhou, M., Shi, Z., Chen, X., Burrows, J., Xi, X., Chen, T. & Wang, L., 14 Feb 2020, In : Antibiotics. 9, 2Research output: Contribution to journal › Article
Open Access
File
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities
Li, M., Xi, X., Ma, C., Chen, X., Zhou, M., Burrows, J. F., Chen, T. & Wang, L., 18 Oct 2019, In : Biomolecules. 9, 10, 13 p., 628.Research output: Contribution to journal › Article
Open Access
File
Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients
Ying, Y., Wang, H., Xi, X., Ma, C., Liu, Y., Zhou, M., Du, Q., Burrows, J. F., Wei, M., Chen, T. & Wang, L., 24 Oct 2019, In : Biomolecules. 9, 11, 14 p., 646.Research output: Contribution to journal › Article
Open Access
File
Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor
Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280.Research output: Contribution to journal › Article
Open Access
File
Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Liu, Y., Du, Q., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J. F., Chen, T. & Wang, H., 23 Jan 2019, In : Drug Design, Development and Therapy. 13, p. 447-458 12 p.Research output: Contribution to journal › Article
Open Access
File
Activities
Frontiers in immunology (Journal)
James Burrows (Peer reviewer)01 Jan 2017 → 31 Dec 2017
Activity: Publication peer-review and editorial work types › Editorial activity
KTP/ Causeway Sensors Ltd - S2410CNR
Christopher Scott (Member), James Burrows (Member)01 Apr 2017 → 31 Mar 2020
Activity: Consultancy types › KTP & Consultancy in kind
Deubiquitinases - from structure to physiology
James Burrows (Participant)26 Jun 2017 → 28 Jun 2017
Activity: Participating in or organising an event types › Participation in conference
33rd Winter School on Proteinases and their inhibitors
James Burrows (Session chair)24 Feb 2016 → 28 Feb 2016
Activity: Participating in or organising an event types › Participation in conference
Sentinus Young Innovators Competition
James Burrows (Contributor)13 Jun 2016
Activity: Other activity types › Hosting a school group or open day
Thesis
Bioactivity evaluation and structural modification of Bowman-Birk type protease inhibitory peptides from amphibian skin secretions
Author: Miao, Y., Dec 2019Supervisor: Chen, T. (Supervisor), Zhou, M. (Supervisor), Burrows, J. (Supervisor) & Burden, R. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy