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Accepting PhD Students

20002019
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Research Output 2000 2019

2019
Open Access
File
Tarsiidae
Skin
Cells
Cell membranes
Microorganisms
Open Access
File
Cystic Fibrosis
Dimyristoylphosphatidylcholine
Derivatives
Peptides
Hydrophobicity

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor

Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280.

Research output: Contribution to journalArticle

Open Access
File
Protease Inhibitors
Peptides
Trypsin
Skin
Lysine
Open Access
File
Structure-Activity Relationship
Hydrophobic and Hydrophilic Interactions
Peptides
Anti-Bacterial Agents
Skin
2018
2 Citations (Scopus)

A novel antimicrobial peptide, Ranatuerin-2PLx (R2PLx), showing therapeutic potential in inhibiting proliferation of cancer cells

Chen, X., Zhang, L., Ma, C., Zhang, Y., Xi, X., Wang, L., Zhou, M., Burrows, J. F. & Chen, T., Dec 2018, In : Bioscience Reports. 38, 6, 11 p., BSR20180710.

Research output: Contribution to journalArticle

Open Access
File
Cells
Cell Proliferation
Peptides
Neoplasms
Ranidae
3 Citations (Scopus)
Open Access
File
Hydrophobicity
Bioactivity
Hydrophobic and Hydrophilic Interactions
Skin
Peptides
2 Citations (Scopus)
Open Access
File
Anura
Skin
Bioactivity
Peptides
Bioassay
2 Citations (Scopus)
Open Access
File
Ranidae
Skin
Peptides
Methicillin-Resistant Staphylococcus aureus
Cells

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Protein-Tyrosine Kinases
Exons
Chemical activation
Apoptosis
2016
7 Citations (Scopus)

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journalArticle

Ubiquitin
Endocytosis
Enzymes
Degradation
Cell membranes
15 Citations (Scopus)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Caspase 1
Macrophages
Biomarkers
Chemical activation
2015
42 Citations (Scopus)

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 othersKissenpfennig, A. & Scott, C. J., 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.

Research output: Contribution to journalArticle

Open Access
File
Sialic Acid Binding Immunoglobulin-like Lectins
N-Acetylneuraminic Acid
Nanoparticles
Inflammation
Sepsis
2014
9 Citations (Scopus)

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Specific Proteases
Cell membranes
Protein Isoforms
Cell Membrane
Enzymes
12 Citations (Scopus)

Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen

Donley, C., McClelland, K., McKeen, H. D., Nelson, L., Yakkundi, A., Jithesh, P. V., Burrows, J., McClements, L., Valentine, A., Prise, K. M., McCarthy, H. O. & Robson, T., 2014, In : Oncogene. 33, p. 3441-3450 10 p.

Research output: Contribution to journalArticle

Tamoxifen
Estrogen Receptors
Growth
Neoplasms
Clone Cells
6 Citations (Scopus)

USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor

Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6964-6975 12 p.

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Endocytosis
Epidermal Growth Factor Receptor
Transferrin
Amino Acid Motifs
2013
19 Citations (Scopus)

A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity

Olwill, S. A., Joffroy, C., Gille, H., Vigna, E., Matschiner, G., Allersdorfer, A., Lunde, B., Jaworski, J., Burrows, J., Chiriaco, C., Christian, H., Hulsmeyer, M., Trentmann, S., Jensen, K., Hohlbaum, A. & Audoly, L., Nov 2013, In : Molecular Cancer Therapeutics. 12, 11, p. 2459-2571 13 p.

Research output: Contribution to journalArticle

Ligands
Hepatocyte Growth Factor
Proteins
Heterografts
Therapeutics
47 Citations (Scopus)

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Growth
Neoplasms
51 Citations (Scopus)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

Thymidine Monophosphate
Photosensitizing Agents
Photosensitizers
Alginate
Chitosan
2012
12 Citations (Scopus)

Regulation of cellular responses by deubiquitinating enzymes: an update

Burrows, J. F. & Johnston, J. A., 2012, In : Frontiers in bioscience : a journal and virtual library. 17, p. 1184-200 17 p.

Research output: Contribution to journalArticle

Ubiquitin
Enzymes
Explosions
Monomers
Deubiquitinating Enzymes
2011
11 Citations (Scopus)

Added complexity in Ras and Rho family GTPase function: Added complexity in Ras and Rho family GTPase function

de la Vega, M., Burrows, J. F. & Johnston, J. A., 2011, In : Small GTPases. 2, 4, p. 192-201 10 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Ubiquitination
GTP Phosphohydrolases
Monomeric GTP-Binding Proteins
Prenylation
36 Citations (Scopus)

The Deubiquitinating Enzyme USP17 is Essential for GTPase Subcellular localization and Cell Motility

de la Vega, M., Kelvin, A. A., Dunican, D. J., McFarlane, C., Burrows, J. F., Jaworski, J., Stevenson, N. J., Dib, K., Rappoport, J. Z., Scott, C. J., Long, A. & Johnston, J. A., Mar 2011, In : Nature Communications. 2, 1, 259.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
protease
locomotion
GTP Phosphohydrolases
Cell Movement
2010
20 Citations (Scopus)

The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected

de la Vega, M., Burrows, J. F., McFarlane, C., Govender, U., Scott, C. J. & Johnston, J. A., 16 Apr 2010, In : Journal of Biological Chemistry. 285, 16, p. 12028-12036 9 p.

Research output: Contribution to journalArticle

Cell membranes
Chemical activation
Cell Membrane
Membranes
Epidermal Growth Factor
44 Citations (Scopus)

The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression

McFarlane, C., Kelvin, A. A., de la Vega, M., Govender, U., Scott, C. J., Burrows, J. F. & Johnston, J. A., 15 Apr 2010, In : Cancer Research. 70, null, p. 3329-3339 11 p.

Research output: Contribution to journalArticle

Cell Cycle
Biopsy
ras Proteins
Neoplasms
rho GTP-Binding Proteins
15 Citations (Scopus)
Open Access
File
beta-Defensins
Genes
Chromosomes
Cytokines
Tandem Repeat Sequences
2009
53 Citations (Scopus)

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.

Research output: Contribution to journalArticle

Cell proliferation
Chemical activation
Cell Proliferation
Enzymes
Membranes
2007
56 Citations (Scopus)

CD33 reponses are blocked by SOCS3 through accelerated proteasomal-mediated turnover

Scott, C., Orr, S. J., Johnston, J., Morgan, N. M., Elliott, J., Burrows, J. & McVickar, D. W., 01 Feb 2007, In : Blood. 109(3), 3, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

Cytokines
Tyrosine
Sialic Acid Binding Immunoglobulin-like Lectins
Degradation
Cytokine Receptors
111 Citations (Scopus)

Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase

Elliott, J., Lynch, O., Suessmuth, Y., Qian, P., Boyd, C., Burrows, J., Buick, L., Stevenson, N., Touzelet, O., Gadina, M., Power, U. & Johnston, J., Apr 2007, In : Journal of Virology. 81, 7, p. 3428-3436 9 p.

Research output: Contribution to journalArticle

STAT2 Transcription Factor
Cullin Proteins
Ubiquitin-Protein Ligases
Respiratory Syncytial Viruses
ligases
43 Citations (Scopus)

SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses

Orr, S. J., Johnston, J., Elliott, J., Morgan, N. M., Buick, R. J., Boyd, C. R., Burrows, J., Jefferies, C. A. & Crocker, P. R., 09 Feb 2007, In : Journal of Biological Chemistry. 282(6), 6, p. 3418-3422 5 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Ig-like Lectin 3
Sialic Acid Binding Immunoglobulin-like Lectins
Cytokines
Degradation
Tyrosine
2006
4 Citations (Scopus)

De-ubiquitinating enzymes: intracellular signalling and disease.

Johnston, J. & Burrows, J., Nov 2006, In : Biochemical society transactions. 34(Pt 5), 5, p. 764-769 6 p.

Research output: Contribution to journalArticle

2005
31 Citations (Scopus)

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence

Burrows, J., McGrattan, M. J. & Johnston, J., Apr 2005, In : Genomics. 85(4), 4, p. 524-529 6 p.

Research output: Contribution to journalArticle

Multigene Family
Genes
Forensic Anthropology
Conserved Sequence
Open Reading Frames
2004
60 Citations (Scopus)

DUB-3, a Cytokine inducible Deubiquitinating Enzyme That Blocks Profileration

Burrows, J., McGrattan, M. J., Johnston, J., Rascle, A., Humbert, M. & Baek, K. H., 02 Apr 2004, In : Journal of Biological Chemistry. 279(14), 14, p. 13993-14000 8 p.

Research output: Contribution to journalArticle

Cells
Cytokines
Cell Line
Burkitt Lymphoma
Interleukin-3
2003
69 Citations (Scopus)

Altered expression of the septin gene, SEPT9, in ovarian neoplasia.

Burrows, J., Chanduloy, S., Godwin, A. K., McIlhatton, M. A., Nagar, H., Yeates, K., Donaghy, P., Price, J., Johnston, P. & Russell, H., Nov 2003, In : Journal of Pathology. 201(4), 4, p. 581-588 8 p.

Research output: Contribution to journalArticle

Septins
Tumor Cell Line
Gene Expression
Genes
Azacitidine
2001
62 Citations (Scopus)

Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3

McIlhatton, M. A., Burrows, J., Donaghy, P., Chanduloy, S., Johnston, P. & Russell, H., 13 Sep 2001, In : Oncogene. 20(41), 41, p. 5930-5939 10 p.

Research output: Contribution to journalArticle

Septins
Chromosomes
Protein Isoforms
3' Untranslated Regions
Genes
2000
88 Citations (Scopus)

Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.

Russell, H., McIlhatton, M. A., Burrows, J., Donaghy, P. G., Chanduloy, S., Petty, E. M., Kalikin, L. M., Church, S., McIlroy, S., Harkin, P., Keilty, G. W., Cranston, A. N., Weissenbach, J., Hickey, I. & Johnston, P., 01 Sep 2000, In : Cancer Research. 60(17), 17, p. 4729-4734 6 p.

Research output: Contribution to journalArticle