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Accepting PhD Students

PhD projects

Open to PhD applications in the field of the biology, characterisation and therapeutic targeting of mammalian and microbial proteases. - USP17 as a therapeutic target in cancer - Targeting bacterial proteases as an antimicrobial strategy

20002020

Research output per year

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Research Output

2020
Open Access
File
19 Downloads (Pure)
2019
Open Access
File
46 Downloads (Pure)
Open Access
File
46 Downloads (Pure)

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor

Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280.

Research output: Contribution to journalArticle

Open Access
File
88 Downloads (Pure)
Open Access
File
144 Downloads (Pure)
2018

A novel antimicrobial peptide, Ranatuerin-2PLx (R2PLx), showing therapeutic potential in inhibiting proliferation of cancer cells

Chen, X., Zhang, L., Ma, C., Zhang, Y., Xi, X., Wang, L., Zhou, M., Burrows, J. F. & Chen, T., Dec 2018, In : Bioscience Reports. 38, 6, 11 p., BSR20180710.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
161 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
175 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
168 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
139 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
128 Downloads (Pure)
2016

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
250 Downloads (Pure)
2015

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, Kissenpfennig, A. & Scott, C. J., 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
698 Downloads (Pure)
2014

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
219 Downloads (Pure)

Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen

Donley, C., McClelland, K., McKeen, H. D., Nelson, L., Yakkundi, A., Jithesh, P. V., Burrows, J., McClements, L., Valentine, A., Prise, K. M., McCarthy, H. O. & Robson, T., 2014, In : Oncogene. 33, p. 3441-3450 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor

Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6964-6975 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
304 Downloads (Pure)
2013

A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity

Olwill, S. A., Joffroy, C., Gille, H., Vigna, E., Matschiner, G., Allersdorfer, A., Lunde, B., Jaworski, J., Burrows, J., Chiriaco, C., Christian, H., Hulsmeyer, M., Trentmann, S., Jensen, K., Hohlbaum, A. & Audoly, L., Nov 2013, In : Molecular Cancer Therapeutics. 12, 11, p. 2459-2571 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
286 Downloads (Pure)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

53 Citations (Scopus)
2012

Regulation of cellular responses by deubiquitinating enzymes: an update

Burrows, J. F. & Johnston, J. A., 2012, In : Frontiers in bioscience : a journal and virtual library. 17, p. 1184-200 17 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2011

Added complexity in Ras and Rho family GTPase function: Added complexity in Ras and Rho family GTPase function

de la Vega, M., Burrows, J. F. & Johnston, J. A., 2011, In : Small GTPases. 2, 4, p. 192-201 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The Deubiquitinating Enzyme USP17 is Essential for GTPase Subcellular localization and Cell Motility

de la Vega, M., Kelvin, A. A., Dunican, D. J., McFarlane, C., Burrows, J. F., Jaworski, J., Stevenson, N. J., Dib, K., Rappoport, J. Z., Scott, C. J., Long, A. & Johnston, J. A., Mar 2011, In : Nature Communications. 2, 1, 259.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2010

The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected

de la Vega, M., Burrows, J. F., McFarlane, C., Govender, U., Scott, C. J. & Johnston, J. A., 16 Apr 2010, In : Journal of Biological Chemistry. 285, 16, p. 12028-12036 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression

McFarlane, C., Kelvin, A. A., de la Vega, M., Govender, U., Scott, C. J., Burrows, J. F. & Johnston, J. A., 15 Apr 2010, In : Cancer Research. 70, null, p. 3329-3339 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
Open Access
File
15 Citations (Scopus)
130 Downloads (Pure)
2009

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2007

CD33 reponses are blocked by SOCS3 through accelerated proteasomal-mediated turnover

Scott, C., Orr, S. J., Johnston, J., Morgan, N. M., Elliott, J., Burrows, J. & McVickar, D. W., 01 Feb 2007, In : Blood. 109(3), 3, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase

Elliott, J., Lynch, O., Suessmuth, Y., Qian, P., Boyd, C., Burrows, J., Buick, L., Stevenson, N., Touzelet, O., Gadina, M., Power, U. & Johnston, J., Apr 2007, In : Journal of Virology. 81, 7, p. 3428-3436 9 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses

Orr, S. J., Johnston, J., Elliott, J., Morgan, N. M., Buick, R. J., Boyd, C. R., Burrows, J., Jefferies, C. A. & Crocker, P. R., 09 Feb 2007, In : Journal of Biological Chemistry. 282(6), 6, p. 3418-3422 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2006

De-ubiquitinating enzymes: intracellular signalling and disease.

Johnston, J. & Burrows, J., Nov 2006, In : Biochemical society transactions. 34(Pt 5), 5, p. 764-769 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2005

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence

Burrows, J., McGrattan, M. J. & Johnston, J., Apr 2005, In : Genomics. 85(4), 4, p. 524-529 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2004

DUB-3, a Cytokine inducible Deubiquitinating Enzyme That Blocks Profileration

Burrows, J., McGrattan, M. J., Johnston, J., Rascle, A., Humbert, M. & Baek, K. H., 02 Apr 2004, In : Journal of Biological Chemistry. 279(14), 14, p. 13993-14000 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2003

Altered expression of the septin gene, SEPT9, in ovarian neoplasia.

Burrows, J., Chanduloy, S., Godwin, A. K., McIlhatton, M. A., Nagar, H., Yeates, K., Donaghy, P., Price, J., Johnston, P. & Russell, H., Nov 2003, In : Journal of Pathology. 201(4), 4, p. 581-588 8 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2001

Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3

McIlhatton, M. A., Burrows, J., Donaghy, P., Chanduloy, S., Johnston, P. & Russell, H., 13 Sep 2001, In : Oncogene. 20(41), 41, p. 5930-5939 10 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2000

Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.

Russell, H., McIlhatton, M. A., Burrows, J., Donaghy, P. G., Chanduloy, S., Petty, E. M., Kalikin, L. M., Church, S., McIlroy, S., Harkin, P., Keilty, G. W., Cranston, A. N., Weissenbach, J., Hickey, I. & Johnston, P., 01 Sep 2000, In : Cancer Research. 60(17), 17, p. 4729-4734 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)