James Burrows

Research output

Research output per year 2000 2020

• 39 Article
• 1 Poster

Research output per year

Research output per year

Search results

• 2020

  Brevinin-2GHk from Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity

  Chen, G., Miao, Y., Ma, C., Zhou, M., Shi, Z., Chen, X., Burrows, J., Xi, X., Chen, T. & Wang, L., 14 Feb 2020, In: Antibiotics. 9, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Peptides
  • Cytotoxicity
  • Skin
  • Circular Dichroism
  • Derivatives
  2 Citations (Scopus)

  68 Downloads (Pure)

• Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer

  Sereesongsaeng, N., McDowell, S. H., Burrows, J. F., Scott, C. J. & Burden, R. E., 09 Dec 2020, In: Breast Cancer Research. 22, 1, p. 139

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cathepsins
  • Breast Neoplasms
  • Proteins
  • Cysteine Proteases
  • Proteasome Endopeptidase Complex
  2 Downloads (Pure)

• Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

  Greene, M. K., Chen, T., Robinson, E., Straubinger, N. L., Minx, C., Chan, D. K. W., Wang, J., Burrows, J. F., Van Schaeybroeck, S., Baker, J. R., Caddick, S., Longley, D. B., Mager, D. E., Straubinger, R. M., Chudasama, V. & Scott, C. J., 11 Sep 2020, In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

• Modification and Targeted Design of N-Terminal Truncates Derived from Brevinin with Improved Therapeutic Efficacy

  He, H., Chen, Y., Ye, Z., Chen, X., Ma, C., Zhou, M., Xi, X., Burrows, J., Chen, T. & Wang, L., 06 Aug 2020, In: Biology. 9, 14 p., 209.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • therapeutics
  • anti-infective agents
  • Peptides
  • Hydrophobicity
  • Toxicity
  18 Downloads (Pure)

• Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells

  Greene, M., Nogueira, J., Tracey, S., Richards, D., McDaid, W., Burrows, J., Campbell, K., Longley, D., Chudasama, V. & Scott, C., 14 May 2020, In: Nanoscale. 2020, 12, 11647.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antigens
  • Antibodies
  • Nanoparticles
  • Cells
  • Cetuximab
  2 Citations (Scopus)

  36 Downloads (Pure)
• 2019

  A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities

  Li, M., Xi, X., Ma, C., Chen, X., Zhou, M., Burrows, J. F., Chen, T. & Wang, L., 18 Oct 2019, In: Biomolecules. 9, 10, 13 p., 628.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tarsiidae
  • dermaseptin
  • Skin
  • Cells
  • Cell membranes
  3 Citations (Scopus)

  79 Downloads (Pure)

• Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients

  Ying, Y., Wang, H., Xi, X., Ma, C., Liu, Y., Zhou, M., Du, Q., Burrows, J. F., Wei, M., Chen, T. & Wang, L., 24 Oct 2019, In: Biomolecules. 9, 11, 14 p., 646.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • dermaseptin
  • Dimyristoylphosphatidylcholine
  • Cystic Fibrosis
  • Derivatives
  • cyclohexylalanine
  5 Citations (Scopus)

  83 Downloads (Pure)

• Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor

  Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In: Biomolecules. 9, 7, 13 p., 280.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protease Inhibitors
  • Peptides
  • Trypsin
  • Skin
  • Lysine
  4 Citations (Scopus)

  128 Downloads (Pure)

• Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities

  Liu, Y., Du, Q., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J. F., Chen, T. & Wang, H., 23 Jan 2019, In: Drug Design, Development and Therapy. 13, p. 447-458 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydrophobic and Hydrophilic Interactions
  • Peptides
  • Solid-Phase Synthesis Techniques
  • Anti-Bacterial Agents
  • Amphibians
  7 Citations (Scopus)

  185 Downloads (Pure)
• 2018

  A novel antimicrobial peptide, Ranatuerin-2PLx (R2PLx), showing therapeutic potential in inhibiting proliferation of cancer cells

  Chen, X., Zhang, L., Ma, C., Zhang, Y., Xi, X., Wang, L., Zhou, M., Burrows, J. F. & Chen, T., Dec 2018, In: Bioscience Reports. 38, 6, 11 p., BSR20180710.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ranatuerin
  • Cells
  • Cell Proliferation
  • Peptides
  • Ranidae
  7 Citations (Scopus)

  216 Downloads (Pure)

• Biological activities of cationicity-enhanced and hydrophobicity-optimized analogues of an antimicrobial peptide, dermaseptin-PS3, from the skin secretion of Phyllomedusa sauvagii

  Tan, Y., Chen, X., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J., Hang, F. K. & Chen, T., 07 Aug 2018, In: Toxins. 10, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • dermaseptin
  • Bioactivity
  • Hydrophobicity
  • Hydrophobic and Hydrophilic Interactions
  • Skin
  6 Citations (Scopus)

  223 Downloads (Pure)

• Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus

  Sang, M., Wu, Q., Xi, X., Ma, C., Wang, L., Zhou, M., Burrows, J. & Chen, T., 22 Jan 2018, In: Biochemical and Biophysical Research Communications. 495, 4, p. 2539-2546

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • temporin
  • Anura
  • Bioactivity
  • Skin
  • Peptides
  6 Citations (Scopus)

  240 Downloads (Pure)

• Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues

  Zhang, L., Chen, X., Zhang, Y., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J. & Chen, T., 31 Jan 2018, In: Biochemical and Biophysical Research Communications. p. 1-11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ranidae
  • Skin
  • Peptides
  • Methicillin-Resistant Staphylococcus aureus
  • Cells
  2 Citations (Scopus)

  204 Downloads (Pure)

• USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

  McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In: Cell communication and signaling : CCS. 16, 1, p. 77

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clathrin
  • Protein-Tyrosine Kinases
  • Chemical activation
  • Exons
  • Confocal microscopy
  5 Citations (Scopus)

  172 Downloads (Pure)
• 2016

  Deubiquitylating enzymes in receptor endocytosis and trafficking

  McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In: Biochemical Journal. 473, 24, p. 4507-4525 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocytosis
  • Ubiquitin
  • Enzymes
  • Degradation
  • Cell membranes
  11 Citations (Scopus)

• Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

  Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In: Particle and fibre toxicology. 13, 19, 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages
  • cathepsin S
  • Biomarkers
  • Caspase 1
  • Interleukin-1
  19 Citations (Scopus)

  300 Downloads (Pure)
• 2015

  Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

  Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, Kissenpfennig, A. & Scott, C. J., 02 Sep 2015, In: Science Translational Medicine. 7, 303, 12 p., 140.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sialic Acid Binding Immunoglobulin-like Lectins
  • N-Acetylneuraminic Acid
  • Nanoparticles
  • Inflammation
  • Adult Respiratory Distress Syndrome
  74 Citations (Scopus)

  931 Downloads (Pure)
• 2014

  A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

  Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In: Biochemical Journal. 457, 2, p. 289-300 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-Specific Proteases
  • Cell membranes
  • Protein Isoforms
  • Cell Membrane
  • Enzymes
  11 Citations (Scopus)

  296 Downloads (Pure)

• Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen

  Donley, C., McClelland, K., McKeen, H. D., Nelson, L., Yakkundi, A., Jithesh, P. V., Burrows, J., McClements, L., Valentine, A., Prise, K. M., McCarthy, H. O. & Robson, T., 2014, In: Oncogene. 33, p. 3441-3450 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tamoxifen
  • Estrogen Receptors
  • Growth
  • HSP90 Heat-Shock Proteins
  • Neoplasms
  16 Citations (Scopus)

• USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor

  Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In: Oncotarget. 5, 16, p. 6964-6975 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clathrin
  • Endocytosis
  • ErbB Receptors
  • Transferrin
  • Deubiquitinating Enzymes
  7 Citations (Scopus)

  362 Downloads (Pure)
• 2013

  A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity

  Olwill, S. A., Joffroy, C., Gille, H., Vigna, E., Matschiner, G., Allersdorfer, A., Lunde, B., Jaworski, J., Burrows, J., Chiriaco, C., Christian, H., Hulsmeyer, M., Trentmann, S., Jensen, K., Hohlbaum, A. & Audoly, L., Nov 2013, In: Molecular Cancer Therapeutics. 12, 11, p. 2459-2571 13 p.

  Research output: Contribution to journal › Article › peer-review

  • PRS-110
  • Ligands
  • Hepatocyte Growth Factor
  • Proteins
  • Heterografts
  23 Citations (Scopus)

• Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

  Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In: International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cathepsin S
  • Growth
  • Neoplasms
  • Peptide Hydrolases
  • Colorectal Neoplasms
  57 Citations (Scopus)

  358 Downloads (Pure)

• Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

  Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In: Biomacromolecules. 14, 2, p. 302-310

  Research output: Contribution to journal › Article › peer-review

  • porphine
  • Photosensitizers
  • Thymidine Monophosphate
  • Alginate
  • Chitosan
  62 Citations (Scopus)

• Testing Integration in the MPharm using Criterion Referenced Assessments (CRAs): (Innovations Showcase)

  Haughey, S., Barry, J., Burrows, J., Donnelly, R., Gilmore, B., Johnson, C., Jones, D., Kett, V., Malcolm, K., Martin, L., McCoy, C., Migaud, M., Singh, T. R. R. & Tunney, M., Sep 2013.

  Research output: Contribution to conference › Poster › peer-review
• 2012

  Regulation of cellular responses by deubiquitinating enzymes: an update

  Burrows, J. F. & Johnston, J. A., 2012, In: Frontiers in bioscience : a journal and virtual library. 17, p. 1184-200 17 p.

  Research output: Contribution to journal › Article

  • Deubiquitinating Enzymes
  • Ubiquitin
  • Enzymes
  • Explosions
  • Monomers
  12 Citations (Scopus)
• 2011

  Added complexity in Ras and Rho family GTPase function: Added complexity in Ras and Rho family GTPase function

  de la Vega, M., Burrows, J. F. & Johnston, J. A., 2011, In: Small GTPases. 2, 4, p. 192-201 10 p.

  Research output: Contribution to journal › Article

  • rho GTP-Binding Proteins
  • GTP Phosphohydrolases
  • Ubiquitination
  • Monomeric GTP-Binding Proteins
  • Methylation
  13 Citations (Scopus)

• The Deubiquitinating Enzyme USP17 is Essential for GTPase Subcellular localization and Cell Motility

  de la Vega, M., Kelvin, A. A., Dunican, D. J., McFarlane, C., Burrows, J. F., Jaworski, J., Stevenson, N. J., Dib, K., Rappoport, J. Z., Scott, C. J., Long, A. & Johnston, J. A., Mar 2011, In: Nature Communications. 2, 1, 259.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin-Specific Proteases
  • protease
  • Deubiquitinating Enzymes
  • locomotion
  • GTP Phosphohydrolases
  40 Citations (Scopus)
• 2010

  The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected

  de la Vega, M., Burrows, J. F., McFarlane, C., Govender, U., Scott, C. J. & Johnston, J. A., 16 Apr 2010, In: Journal of Biological Chemistry. 285, 16, p. 12028-12036 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Deubiquitinating Enzymes
  • Cell membranes
  • Chemical activation
  • Membranes
  • Cell Membrane
  24 Citations (Scopus)

• The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression

  McFarlane, C., Kelvin, A. A., de la Vega, M., Govender, U., Scott, C. J., Burrows, J. F. & Johnston, J. A., 15 Apr 2010, In: Cancer Research. 70, null, p. 3329-3339 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Deubiquitinating Enzymes
  • Cell Cycle
  • Biopsy
  • ras Proteins
  • Enzyme Activation
  52 Citations (Scopus)

• The DUB/USP17 deubiquitinating enzymes: A gene family within a tandemly repeated sequence, is also embedded within the copy number variable Beta-defensin cluste

  Burrows, J. F., Scott, C. J. & Johnston, J. A., 19 Apr 2010, In: BMC Genomics. 11, 11 p., 250.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • beta-Defensins
  • Deubiquitinating Enzymes
  • Genes
  • Chromosomes
  • Tandem Repeat Sequences
  16 Citations (Scopus)

  167 Downloads (Pure)
• 2009

  USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

  Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In: Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell proliferation
  • Chemical activation
  • Cell Proliferation
  • Enzymes
  • Membranes
  59 Citations (Scopus)
• 2007

  CD33 reponses are blocked by SOCS3 through accelerated proteasomal-mediated turnover

  Scott, C., Orr, S. J., Johnston, J., Morgan, N. M., Elliott, J., Burrows, J. & McVickar, D. W., 01 Feb 2007, In: Blood. 109(3), 3, p. 1061-1068 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytokines
  • Tyrosine
  • Degradation
  • Pathogen-Associated Molecular Pattern Molecules
  • Cytokine Receptors
  65 Citations (Scopus)

• Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase

  Elliott, J., Lynch, O., Suessmuth, Y., Qian, P., Boyd, C., Burrows, J., Buick, L., Stevenson, N., Touzelet, O., Gadina, M., Power, U. & Johnston, J., Apr 2007, In: Journal of Virology. 81, 7, p. 3428-3436 9 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT2 Transcription Factor
  • Elongin
  • Respiratory syncytial virus
  • Cullin Proteins
  • Respiratory Syncytial Viruses
  124 Citations (Scopus)

• SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses

  Orr, S. J., Johnston, J., Elliott, J., Morgan, N. M., Buick, R. J., Boyd, C. R., Burrows, J., Jefferies, C. A. & Crocker, P. R., 09 Feb 2007, In: Journal of Biological Chemistry. 282(6), 6, p. 3418-3422 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Degradation
  • Cytokines
  • Tyrosine
  • Suppressor of Cytokine Signaling Proteins
  46 Citations (Scopus)
• 2006

  De-ubiquitinating enzymes: intracellular signalling and disease.

  Johnston, J. & Burrows, J., Nov 2006, In: Biochemical society transactions. 34(Pt 5), 5, p. 764-769 6 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)
• 2005

  The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence

  Burrows, J., McGrattan, M. J. & Johnston, J., Apr 2005, In: Genomics. 85(4), 4, p. 524-529 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Deubiquitinating Enzymes
  • Multigene Family
  • Genes
  • Forensic Anthropology
  • Conserved Sequence
  32 Citations (Scopus)
• 2004

  DUB-3, a Cytokine inducible Deubiquitinating Enzyme That Blocks Profileration

  Burrows, J., McGrattan, M. J., Johnston, J., Rascle, A., Humbert, M. & Baek, K. H., 02 Apr 2004, In: Journal of Biological Chemistry. 279(14), 14, p. 13993-14000 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Deubiquitinating Enzymes
  • Cells
  • Cell proliferation
  • Fibroblasts
  • Cloning
  65 Citations (Scopus)
• 2003

  Altered expression of the septin gene, SEPT9, in ovarian neoplasia.

  Burrows, J., Chanduloy, S., Godwin, A. K., McIlhatton, M. A., Nagar, H., Yeates, K., Donaghy, P., Price, J., Johnston, P. & Russell, H., Nov 2003, In: Journal of Pathology. 201(4), 4, p. 581-588 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Septins
  • Tumor Cell Line
  • Gene Expression
  • Azacitidine
  • Membrane Fusion
  72 Citations (Scopus)
• 2001

  Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3

  McIlhatton, M. A., Burrows, J., Donaghy, P., Chanduloy, S., Johnston, P. & Russell, H., 13 Sep 2001, In: Oncogene. 20(41), 41, p. 5930-5939 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Septins
  • Chromosomes
  • Protein Isoforms
  • septin 3
  • 3' Untranslated Regions
  64 Citations (Scopus)
• 2000

  Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.

  Russell, H., McIlhatton, M. A., Burrows, J., Donaghy, P. G., Chanduloy, S., Petty, E. M., Kalikin, L. M., Church, S., McIlroy, S., Harkin, P., Keilty, G. W., Cranston, A. N., Weissenbach, J., Hickey, I. & Johnston, P., 01 Sep 2000, In: Cancer Research. 60(17), 17, p. 4729-4734 6 p.

  Research output: Contribution to journal › Article › peer-review

  91 Citations (Scopus)