Research Output per year
Research Output 2000 2019
2019
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities
Li, M., Xi, X., Ma, C., Chen, X., Zhou, M., Burrows, J. F., Chen, T. & Wang, L., 18 Oct 2019, In : Biomolecules. 9, 10, 13 p., 628.Research output: Contribution to journal › Article
Open Access
File
Tarsiidae
Skin
Cells
Cell membranes
Microorganisms
Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients
Ying, Y., Wang, H., Xi, X., Ma, C., Liu, Y., Zhou, M., Du, Q., Burrows, J. F., Wei, M., Chen, T. & Wang, L., 24 Oct 2019, In : Biomolecules. 9, 11, 14 p., 646.Research output: Contribution to journal › Article
Open Access
File
Cystic Fibrosis
Dimyristoylphosphatidylcholine
Derivatives
Peptides
Hydrophobicity
Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor
Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280.Research output: Contribution to journal › Article
Open Access
File
Protease Inhibitors
Peptides
Trypsin
Skin
Lysine
Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Liu, Y., Du, Q., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J. F., Chen, T. & Wang, H., 23 Jan 2019, In : Drug Design, Development and Therapy. 13, p. 447-458 12 p.Research output: Contribution to journal › Article
Open Access
File
Structure-Activity Relationship
Hydrophobic and Hydrophilic Interactions
Peptides
Anti-Bacterial Agents
Skin
2018
A novel antimicrobial peptide, Ranatuerin-2PLx (R2PLx), showing therapeutic potential in inhibiting proliferation of cancer cells
Chen, X., Zhang, L., Ma, C., Zhang, Y., Xi, X., Wang, L., Zhou, M., Burrows, J. F. & Chen, T., Dec 2018, In : Bioscience Reports. 38, 6, 11 p., BSR20180710.Research output: Contribution to journal › Article
Open Access
File
Cells
Cell Proliferation
Peptides
Neoplasms
Ranidae
Biological activities of cationicity-enhanced and hydrophobicity-optimized analogues of an antimicrobial peptide, dermaseptin-PS3, from the skin secretion of Phyllomedusa sauvagii
Tan, Y., Chen, X., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J., Hang, F. K. & Chen, T., 07 Aug 2018, In : Toxins. 10, 8Research output: Contribution to journal › Article
Open Access
File
Hydrophobicity
Bioactivity
Hydrophobic and Hydrophilic Interactions
Skin
Peptides
Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus
Sang, M., Wu, Q., Xi, X., Ma, C., Wang, L., Zhou, M., Burrows, J. & Chen, T., 22 Jan 2018, In : Biochemical and Biophysical Research Communications. 495, 4, p. 2539-2546Research output: Contribution to journal › Article
Open Access
File
Anura
Skin
Bioactivity
Peptides
Bioassay
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues
Zhang, L., Chen, X., Zhang, Y., Ma, C., Xi, X., Wang, L., Zhou, M., Burrows, J. & Chen, T., 31 Jan 2018, In : Biochemical and Biophysical Research Communications. p. 1-11Research output: Contribution to journal › Article
Open Access
File
Ranidae
Skin
Peptides
Methicillin-Resistant Staphylococcus aureus
Cells
USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells
McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77Research output: Contribution to journal › Article
Open Access
File
Clathrin
Protein-Tyrosine Kinases
Exons
Chemical activation
Apoptosis
2016
Deubiquitylating enzymes in receptor endocytosis and trafficking
McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.Research output: Contribution to journal › Article
Ubiquitin
Endocytosis
Enzymes
Degradation
Cell membranes
Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages
Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.Research output: Contribution to journal › Article
Open Access
File
cathepsin S
Caspase 1
Macrophages
Biomarkers
Chemical activation
2015
Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation
Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.Research output: Contribution to journal › Article
Open Access
File
Sialic Acid Binding Immunoglobulin-like Lectins
N-Acetylneuraminic Acid
Nanoparticles
Inflammation
Sepsis
2014
A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17
Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.Research output: Contribution to journal › Article
Open Access
File
Ubiquitin-Specific Proteases
Cell membranes
Protein Isoforms
Cell Membrane
Enzymes
Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen
Donley, C., McClelland, K., McKeen, H. D., Nelson, L., Yakkundi, A., Jithesh, P. V., Burrows, J., McClements, L., Valentine, A., Prise, K. M., McCarthy, H. O. & Robson, T., 2014, In : Oncogene. 33, p. 3441-3450 10 p.Research output: Contribution to journal › Article
Tamoxifen
Estrogen Receptors
Growth
Neoplasms
Clone Cells
6
Citations
(Scopus)
USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor
Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6964-6975 12 p.Research output: Contribution to journal › Article
Open Access
File
Clathrin
Endocytosis
Epidermal Growth Factor Receptor
Transferrin
Amino Acid Motifs
2013
A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity
Olwill, S. A., Joffroy, C., Gille, H., Vigna, E., Matschiner, G., Allersdorfer, A., Lunde, B., Jaworski, J., Burrows, J., Chiriaco, C., Christian, H., Hulsmeyer, M., Trentmann, S., Jensen, K., Hohlbaum, A. & Audoly, L., Nov 2013, In : Molecular Cancer Therapeutics. 12, 11, p. 2459-2571 13 p.Research output: Contribution to journal › Article
Ligands
Hepatocyte Growth Factor
Proteins
Heterografts
Therapeutics
Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation
Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.Research output: Contribution to journal › Article
Open Access
File
cathepsin S
Growth
Neoplasms
Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles
Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310Research output: Contribution to journal › Article
Thymidine Monophosphate
Photosensitizing Agents
Photosensitizers
Alginate
Chitosan
Testing Integration in the MPharm using Criterion Referenced Assessments (CRAs): (Innovations Showcase)
Haughey, S., Barry, J., Burrows, J., Donnelly, R., Gilmore, B., Johnson, C., Jones, D., Kett, V., Malcolm, K., Martin, L., McCoy, C., Migaud, M., Singh, T. R. R. & Tunney, M., Sep 2013.Research output: Contribution to conference › Poster
2012
12
Citations
(Scopus)
Regulation of cellular responses by deubiquitinating enzymes: an update
Burrows, J. F. & Johnston, J. A., 2012, In : Frontiers in bioscience : a journal and virtual library. 17, p. 1184-200 17 p.Research output: Contribution to journal › Article
Ubiquitin
Enzymes
Explosions
Monomers
Deubiquitinating Enzymes
2011
Added complexity in Ras and Rho family GTPase function: Added complexity in Ras and Rho family GTPase function
de la Vega, M., Burrows, J. F. & Johnston, J. A., 2011, In : Small GTPases. 2, 4, p. 192-201 10 p.Research output: Contribution to journal › Article
rho GTP-Binding Proteins
Ubiquitination
GTP Phosphohydrolases
Monomeric GTP-Binding Proteins
Prenylation
The Deubiquitinating Enzyme USP17 is Essential for GTPase Subcellular localization and Cell Motility
de la Vega, M., Kelvin, A. A., Dunican, D. J., McFarlane, C., Burrows, J. F., Jaworski, J., Stevenson, N. J., Dib, K., Rappoport, J. Z., Scott, C. J., Long, A. & Johnston, J. A., Mar 2011, In : Nature Communications. 2, 1, 259.Research output: Contribution to journal › Article
Ubiquitin-Specific Proteases
protease
locomotion
GTP Phosphohydrolases
Cell Movement
2010
The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected
de la Vega, M., Burrows, J. F., McFarlane, C., Govender, U., Scott, C. J. & Johnston, J. A., 16 Apr 2010, In : Journal of Biological Chemistry. 285, 16, p. 12028-12036 9 p.Research output: Contribution to journal › Article
Cell membranes
Chemical activation
Cell Membrane
Membranes
Epidermal Growth Factor
The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression
McFarlane, C., Kelvin, A. A., de la Vega, M., Govender, U., Scott, C. J., Burrows, J. F. & Johnston, J. A., 15 Apr 2010, In : Cancer Research. 70, null, p. 3329-3339 11 p.Research output: Contribution to journal › Article
Cell Cycle
Biopsy
ras Proteins
Neoplasms
rho GTP-Binding Proteins
The DUB/USP17 deubiquitinating enzymes: A gene family within a tandemly repeated sequence, is also embedded within the copy number variable Beta-defensin cluste
Burrows, J. F., Scott, C. J. & Johnston, J. A., 19 Apr 2010, In : BMC Genomics. 11, 11 p., 250.Research output: Contribution to journal › Article
Open Access
File
beta-Defensins
Genes
Chromosomes
Cytokines
Tandem Repeat Sequences
2009
USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity
Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.Research output: Contribution to journal › Article
Cell proliferation
Chemical activation
Cell Proliferation
Enzymes
Membranes
2007
CD33 reponses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
Scott, C., Orr, S. J., Johnston, J., Morgan, N. M., Elliott, J., Burrows, J. & McVickar, D. W., 01 Feb 2007, In : Blood. 109(3), 3, p. 1061-1068 8 p.Research output: Contribution to journal › Article
Cytokines
Tyrosine
Sialic Acid Binding Immunoglobulin-like Lectins
Degradation
Cytokine Receptors
Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase
Elliott, J., Lynch, O., Suessmuth, Y., Qian, P., Boyd, C., Burrows, J., Buick, L., Stevenson, N., Touzelet, O., Gadina, M., Power, U. & Johnston, J., Apr 2007, In : Journal of Virology. 81, 7, p. 3428-3436 9 p.Research output: Contribution to journal › Article
STAT2 Transcription Factor
Cullin Proteins
Ubiquitin-Protein Ligases
Respiratory Syncytial Viruses
ligases
SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses
Orr, S. J., Johnston, J., Elliott, J., Morgan, N. M., Buick, R. J., Boyd, C. R., Burrows, J., Jefferies, C. A. & Crocker, P. R., 09 Feb 2007, In : Journal of Biological Chemistry. 282(6), 6, p. 3418-3422 5 p.Research output: Contribution to journal › Article
Sialic Acid Binding Ig-like Lectin 3
Sialic Acid Binding Immunoglobulin-like Lectins
Cytokines
Degradation
Tyrosine
2006
De-ubiquitinating enzymes: intracellular signalling and disease.
Johnston, J. & Burrows, J., Nov 2006, In : Biochemical society transactions. 34(Pt 5), 5, p. 764-769 6 p.Research output: Contribution to journal › Article
2005
The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence
Burrows, J., McGrattan, M. J. & Johnston, J., Apr 2005, In : Genomics. 85(4), 4, p. 524-529 6 p.Research output: Contribution to journal › Article
Multigene Family
Genes
Forensic Anthropology
Conserved Sequence
Open Reading Frames
2004
DUB-3, a Cytokine inducible Deubiquitinating Enzyme That Blocks Profileration
Burrows, J., McGrattan, M. J., Johnston, J., Rascle, A., Humbert, M. & Baek, K. H., 02 Apr 2004, In : Journal of Biological Chemistry. 279(14), 14, p. 13993-14000 8 p.Research output: Contribution to journal › Article
Cells
Cytokines
Cell Line
Burkitt Lymphoma
Interleukin-3
2003
Altered expression of the septin gene, SEPT9, in ovarian neoplasia.
Burrows, J., Chanduloy, S., Godwin, A. K., McIlhatton, M. A., Nagar, H., Yeates, K., Donaghy, P., Price, J., Johnston, P. & Russell, H., Nov 2003, In : Journal of Pathology. 201(4), 4, p. 581-588 8 p.Research output: Contribution to journal › Article
Septins
Tumor Cell Line
Gene Expression
Genes
Azacitidine
2001
Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3
McIlhatton, M. A., Burrows, J., Donaghy, P., Chanduloy, S., Johnston, P. & Russell, H., 13 Sep 2001, In : Oncogene. 20(41), 41, p. 5930-5939 10 p.Research output: Contribution to journal › Article
Septins
Chromosomes
Protein Isoforms
3' Untranslated Regions
Genes
2000
88
Citations
(Scopus)
Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.
Russell, H., McIlhatton, M. A., Burrows, J., Donaghy, P. G., Chanduloy, S., Petty, E. M., Kalikin, L. M., Church, S., McIlroy, S., Harkin, P., Keilty, G. W., Cranston, A. N., Weissenbach, J., Hickey, I. & Johnston, P., 01 Sep 2000, In : Cancer Research. 60(17), 17, p. 4729-4734 6 p.Research output: Contribution to journal › Article