Research output per year
Research output per year
Personal profile
Research Interests
My research interests lie in the field of host-pathogen interactions and how Klebsiella pneumoniae interacts and modulates host immunity.
I am currently investigating how K. pneumoniae uses its type 6 secretion system to alter host immunity (in macrophages, epithelial cells and in vivo) using imaging and biochemical approaches, looking at host immune responses and overall host-microbe interactions.
Teaching
Teaching of the Generic Lab Skills Module on Western Blotting to PhD students in 2015 and 2016.
Mentorship of a master student (October 2015-August 2016).
Mentorship of a summer student as part of the CEM program (July-August 2016).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Sá-Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez-Escudero, I., Marshall, H., Ova, A., Schroeder, G. N., Barabas, P., Molina, M., Curtis, T., Cid, V. J. & Bengoechea, J. A., 16 Feb 2023, In: Nature Communications. 14, 20 p., 871.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Downloads (Pure) -
Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections
Calderon-Gonzalez, R., Lee, A., Lopez-Campos, G., Hancock, S. J., Sa-Pessoa, J., Dumigan, A., McMullan, R., Campbell, E. L. & Bengoechea, J. A., 28 Feb 2023, In: mBio. 14, 1, 19 p., e03121-22.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
Baran, M., Feriotti, C., McGinley, A., Carlile, S. R., Jiang, Z., Calderon-Gonzalez, R., Dumigan, A., Sá-Pessoa, J., Sutton, C. E., Kearney, J., McLoughlin, R. M., Mills, K. H. G., Fitzgerald, K. A., Bengeochea, J. A. & Bowie, A. G., 04 Apr 2023, (Early online date) In: Cell Reports. 42, 4, 26 p., 112341.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Visualisation of host-pathogen communication
Dumigan, A., Gonzalez, R. C., Morris, B. & Sá-Pessoa, J., 06 Apr 2023, Biomedical visualisation, Volume 15: Visualisation in teaching of biomedical and clinical subjects: anatomy, advanced microscopy and radiology. Meguid, E. A., Mishall, P. L., Nation, H. L. & Rea, P. M. (eds.). Springer Nature Switzerland AG, p. 19-39 21 p. (Advances in Experimental Medicine and Biology; vol. 1406).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection
Dumigan, A., Cappa, O., Morris, B., Sá Pessoa, J., Calderon-Gonzalez, R., Mills, G., Lancaster, R., Simpson, D., Kissenpfennig, A. & Bengoechea, J. A., 07 Dec 2022, In: EMBO Molecular Medicine. 14, 12, 26 p., e16888.Research output: Contribution to journal › Article › peer-review
Open AccessFile106 Downloads (Pure)