Projects per year
Functionalised gold nanoparticles
Dr Jonathan Coulter obtained his PhD within the School of Pharmacy at Queens University Belfast in 2006. His project focused on tumour specific, transcriptionally targeted gene therapy strategies focused on over expressing inducible nitric oxide synthase with an aim to sensitise tumour cells to ionising radiation.
In October 2006, appointed as a research fellow he joined the multidisciplinary gold nanoparticle (AuNP) research group. This research aims to exploit the physical properties of gold (i.e. the high atomic number and the differential absorption coefficient between high Z materials and soft tissue) to sensitise cells to radiation treatment. He is specifically interest in the biological factors that influence the efficacy of these experimental therapies.
Appointed as a Lecturer within the School of Pharmacy in June 2012, his research group has developed a functionalised-GNP capable of doubling the cell killing efficacy ionising radiation, with minimal cytotoxic effects when used as solo agents. In a separate strategy Dr Coulter is also investigating role of hypoxia in maintaining cancer stem cell populations, know to exhibit significant resistance to conventional therapeutics, including radiotherapy.
Jonathan has published twenty scientific publications, written and edited a book, and has given numerous conference presentations. He was a visiting scientist at the University Hospital Network (UHN) in Toronto, working in Prof. Rob Bristow’s laboratories. He has received funding from Prostate Cancer UK, Breast Cancer Campaign and Cancer Research UK. He is a committee member on the Irish Radiation Research Society and the Association for Radiation Research, and an editorial board member of Cancer Nanotechnology, NanoDrugs and Clinical and Experimental Pharmacology.
Contributes to the following modules on the MPharm degree:
- PMY1014 Introduction to Pharmacy Practice Skills
- PMY2104 Pharmacological Basis of Therapeutics
- PMY2105 Clinical Therapeutic 1
- PMY3175 Clinical Therapeutics 3
- PMY3072 Pharmaceutical Biotechnology
- PMY4073 Infectious Diseases
- PMY4005 Level 4 Project
Distance Learning Supervisor:
- PG Diploma in Clinical Pharmacy
- MSc Clinical Pharmacy
Expertise related to UN SDGs
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
R1007PMY: Anti-inflammatory radiosensitising gold nanoparticles for the treatment of prostate cancer
25/01/2019 → …
R1786PMY: Nanoengineered microneedle arrays for enhanced plasmonic photothermal therapy of basal cell carcinomma
03/07/2017 → …
14/12/2018 → 30/04/2019
08/04/2016 → 31/03/2017
Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiformeJena, L. N., Bennie, L. A., McErlean, E. M., Pentlavalli, S., Glass, K., Burrows, J. F., Kett, V. L., Buckley, N. E., Coulter, J. A., Dunne, N. J. & McCarthy, H. O., 04 May 2021, In: Journal of nanobiotechnology. 19, 1, p. 127
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Byrne, N. M., Tambe, P. & Coulter, J. A., 16 Jan 2021, In: Journal of Personalized Medicine. 11, 1, 15 p., 53.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile3 Downloads (Pure)
Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinomaLaBonte Wilson, M., Ong, C. W., Armstrong, C., Waugh, D., Maxwell, P., O'Sullivan, J., Prise, K., Butterworth, K., Coulter, J., Walker, S., Oksana, L., Gallagher, R., Jain, S., Bristow, R. G. & Mills, I., 03 Jul 2020, In: NAR Cancer. 2, 3, zcaa012.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile13 Downloads (Pure)
Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer CellsBennie, L., Belhout, S. A., Quinn, S. J. & Coulter, J. A., 19 Mar 2020, In: ACS Applied Nano Materials.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile12 Downloads (Pure)
Paredes, A., Volpe Zanutto, F., Permana, A., Murphy, A., Guerini, M., Coulter, J. & Donnelly, R., Jul 2020.
Research output: Contribution to conference › Abstract › peer-reviewOpen AccessFile4 Downloads (Pure)
Jonathan Coulter (Chair)01 Jul 2018 → 30 Jun 2020
Activity: Membership types › Membership of external research organisation
Jonathan Coulter (Conference committee co-chair)25 Jun 2018 → 27 Jun 2018
Activity: Participating in or organising an event types › Participation in conference