• Room 06.027 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of Nanotherapeutics, radiobiology, radiopharmaceuticals, DNA damage, cancer stem cells, drug resistance, 3-dimentional bio-assays. - Gold nanoparticle/drug combinations - Solid tumour nanoparticle transport models

20072019

Research output per year

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Personal profile

Interests

Radiobiology

Functionalised gold nanoparticles

Targeting strategies

Gene Therapy

Nitric Oxide

Prostate Cancer

Chemokines

Tumour inflammation

Research Statement

Dr Jonathan Coulter obtained his PhD within the School of Pharmacy at Queens University Belfast in 2006. His project focused on tumour specific, transcriptionally targeted gene therapy strategies focused on over expressing inducible nitric oxide synthase with an aim to sensitise tumour cells to ionising radiation.

In October 2006, appointed as a research fellow he joined the multidisciplinary gold nanoparticle (AuNP) research group. This research aims to exploit the physical properties of gold (i.e. the high atomic number and the differential absorption coefficient between high Z materials and soft tissue) to sensitise cells to radiation treatment. He is specifically interest in the biological factors that influence the efficacy of these experimental therapies. 

Appointed as a Lecturer within the School of Pharmacy in June 2012, his research group has developed a functionalised-GNP capable of doubling the cell killing efficacy ionising radiation, with minimal cytotoxic effects when used as solo agents. In a separate strategy Dr Coulter is also investigating role of hypoxia in maintaining cancer stem cell populations, know to exhibit significant resistance to conventional therapeutics, including radiotherapy. 

Jonathan has published twenty scientific publications, written and edited a book, and has given numerous conference presentations. He was a visiting scientist at the University Hospital Network (UHN) in Toronto, working in Prof. Rob Bristow’s laboratories. He has received funding from Prostate Cancer UK, Breast Cancer Campaign and Cancer Research UK. He is a committee member on the Irish Radiation Research Society and the Association for Radiation Research, and an editorial board member of Cancer Nanotechnology, NanoDrugs and Clinical and Experimental Pharmacology. 

Teaching

Contributes to the following modules on the MPharm degree:

  • PMY1014 Introduction to Pharmacy Practice Skills
  • PMY2104 Pharmacological Basis of Therapeutics
  • PMY2105 Clinical Therapeutic 1 
  • PMY3175 Clinical Therapeutics 3
  • PMY3072 Pharmaceutical Biotechnology 
  • PMY4073 Infectious Diseases
  • PMY4005 Level 4 Project

 

Distance Learning Supervisor:

  • PG Diploma in Clinical Pharmacy
  • MSc Clinical Pharmacy

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Projects

Research Output

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Anderson, S. D., Hobbs, R. J., Gwenin, V. V., Ball, P., Bennie, L. A., Coulter, J. A. & Gwenin, C. D., 01 Oct 2019, In : Journal of Functional Biomaterials. 10, 4

Research output: Contribution to journalArticle

  • DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

    Cole, G., Ali, A. A., McErlean, E., Mulholland, E. J., Short, A., McCrudden, C. M., McCaffrey, J., Robson, T., Kett, V. L., Coulter, J. A., Dunne, N. J., Donnelly, R. F. & McCarthy, H. O., 09 Jul 2019, In : Acta Biomaterialia.

    Research output: Contribution to journalArticle

  • Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development

    Feng, J., Byrne, N. M., Al Jamal, W. & Coulter, J. A., 11 Dec 2019, In : Cancers. 11, 12, 25 p., 1989.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 14 Downloads (Pure)

    Nuclear Uptake of Gold Nanoparticles Deduced Using Dual-Angle X-Ray Fluorescence Mapping

    McCulloch, A., Bennie, L., Coulter, J. A., McCarthy, H. O., Dromey, B., Grimes, D. R., Quinn, P., Villagomez-Bernabe, B. & Currell, F., 01 Jan 2019, In : Particle and Particle Systems Characterization. 1900140.

    Research output: Contribution to journalArticle

  • Prizes

    ARR SIT Travel Award Bursary - Natalie Owen

    Natalie Owen (Recipient) & Jonathan Coulter (Recipient), 26 Jun 2017

    Prize: Other distinction

  • Best oral paper - Shannon O'Neill

    Shannon O'Neill (Recipient) & Jonathan Coulter (Recipient), Aug 2017

    Prize: Other distinction

  • Best oral paper - Shannon O'Neill

    Shannon O'Neill (Recipient) & Jonathan Coulter (Recipient), 12 Nov 2016

    Prize: Other distinction

  • Best poster prize - Dr James Nicol

    James Nicol (Recipient) & Jonathan Coulter (Recipient), 27 Jun 2016

    Prize: Other distinction

  • Established Researcher Travel Award

    Jonathan Coulter (Recipient), 08 Mar 2015

    Prize: Prize (including medals and awards)

  • Activities

    Association for Radiation Research (External organisation)

    Jonathan Coulter (Chair)
    01 Jul 201830 Jun 2020

    Activity: Membership typesMembership of external research organisation

    Aoife Carr

    Jonathan Coulter (Host)
    01 Feb 201830 Apr 2018

    Activity: Hosting a visitor typesHosting an academic visitor

    Association for Radiation Research 2018 Annual Meeting

    Jonathan Coulter (Conference committee co-chair)
    25 Jun 201827 Jun 2018

    Activity: Participating in or organising an event typesParticipation in conference

    Marios Sotiropoulos

    Jonathan Coulter (Host)
    01 Feb 201830 Apr 2018

    Activity: Hosting a visitor typesHosting an academic visitor

    School of Pharmacy - Work Experience Days

    Jonathan Coulter (Organiser), Daniel Corbett (Organiser)
    Jan 2018Feb 2018

    Activity: Other activity typesHosting a school group or open day