• Room 06.027 - Medical Biology Centre Block 97 MBC Site

    United Kingdom

Accepting PhD Students

20072019
If you made any changes in Pure these will be visible here soon.

Personal profile

Interests

Radiobiology

Functionalised gold nanoparticles

Targeting strategies

Gene Therapy

Nitric Oxide

Prostate Cancer

Chemokines

Tumour inflammation

Research Statement

Dr Jonathan Coulter obtained his PhD within the School of Pharmacy at Queens University Belfast in 2006. His project focused on tumour specific, transcriptionally targeted gene therapy strategies focused on over expressing inducible nitric oxide synthase with an aim to sensitise tumour cells to ionising radiation.

In October 2006, appointed as a research fellow he joined the multidisciplinary gold nanoparticle (AuNP) research group. This research aims to exploit the physical properties of gold (i.e. the high atomic number and the differential absorption coefficient between high Z materials and soft tissue) to sensitise cells to radiation treatment. He is specifically interest in the biological factors that influence the efficacy of these experimental therapies. 

Appointed as a Lecturer within the School of Pharmacy in June 2012, his research group has developed a functionalised-GNP capable of doubling the cell killing efficacy ionising radiation, with minimal cytotoxic effects when used as solo agents. In a separate strategy Dr Coulter is also investigating role of hypoxia in maintaining cancer stem cell populations, know to exhibit significant resistance to conventional therapeutics, including radiotherapy. 

Jonathan has published twenty scientific publications, written and edited a book, and has given numerous conference presentations. He was a visiting scientist at the University Hospital Network (UHN) in Toronto, working in Prof. Rob Bristow’s laboratories. He has received funding from Prostate Cancer UK, Breast Cancer Campaign and Cancer Research UK. He is a committee member on the Irish Radiation Research Society and the Association for Radiation Research, and an editorial board member of Cancer Nanotechnology, NanoDrugs and Clinical and Experimental Pharmacology. 

Teaching

Contributes to the following modules on the MPharm degree:

  • PMY1014 Introduction to Pharmacy Practice Skills
  • PMY2104 Pharmacological Basis of Therapeutics
  • PMY2105 Clinical Therapeutic 1 
  • PMY3175 Clinical Therapeutics 3
  • PMY3072 Pharmaceutical Biotechnology 
  • PMY4073 Infectious Diseases
  • PMY4005 Level 4 Project

 

Distance Learning Supervisor:

  • PG Diploma in Clinical Pharmacy
  • MSc Clinical Pharmacy

Fingerprint Dive into the research topics where Jonathan Coulter is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Nanoparticles Medicine & Life Sciences
Gold Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Radiotherapy Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Radiation Medicine & Life Sciences
Supervisory personnel Engineering & Materials Science
Tumors Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2019

Research Output 2007 2019

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Anderson, S. D., Hobbs, R. J., Gwenin, V. V., Ball, P., Bennie, L. A., Coulter, J. A. & Gwenin, C. D., 01 Oct 2019, In : Journal of Functional Biomaterials. 10, 4

Research output: Contribution to journalArticle

Nitroreductases
Cell-Penetrating Peptides
Prodrugs
Peptides
Enzymes

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Cole, G., Ali, A. A., McErlean, E., Mulholland, E. J., Short, A., McCrudden, C. M., McCaffrey, J., Robson, T., Kett, V. L., Coulter, J. A., Dunne, N. J., Donnelly, R. F. & McCarthy, H. O., 09 Jul 2019, In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Antigens
Stem cells
Nanoparticles
Tumors

Nuclear Uptake of Gold Nanoparticles Deduced Using Dual-Angle X-Ray Fluorescence Mapping

McCulloch, A., Bennie, L., Coulter, J. A., McCarthy, H. O., Dromey, B., Grimes, D. R., Quinn, P., Villagomez-Bernabe, B. & Currell, F., 01 Jan 2019, In : Particle and Particle Systems Characterization. 1900140.

Research output: Contribution to journalArticle

Gold
Fluorescence
gold
Nanoparticles
X rays
Pharmacy Students
Education
Teaching
Students
Knowledge Bases
2 Citations (Scopus)

Enhanced nanoparticle delivery exploiting tumour responsive formulations.

Bennie, L. A., McCarthy, H. & Coulter, J., 21 Nov 2018, In : Cancer Nanotechnology. 9, 10

Research output: Contribution to journalArticle

Open Access
File
Tumor Microenvironment
Nanoparticles
Tumors
delivery
tumors

Prizes

ARR SIT Travel Award Bursary - Natalie Owen

Natalie Owen (Recipient) & Jonathan Coulter (Recipient), 26 Jun 2017

Prize: Other distinction

Supervisory personnel

Best oral paper - Shannon O'Neill

Shannon O'Neill (Recipient) & Jonathan Coulter (Recipient), Aug 2017

Prize: Other distinction

Supervisory personnel

Best oral paper - Shannon O'Neill

Shannon O'Neill (Recipient) & Jonathan Coulter (Recipient), 12 Nov 2016

Prize: Other distinction

Supervisory personnel

Best poster prize - Dr James Nicol

James Nicol (Recipient) & Jonathan Coulter (Recipient), 27 Jun 2016

Prize: Other distinction

supervisors
honors and awards

Established Researcher Travel Award

Jonathan Coulter (Recipient), 08 Mar 2015

Prize: Prize (including medals and awards)

Costs

Activities 2012 2018

Aoife Carr

Jonathan Coulter (Host)
01 Feb 201830 Apr 2018

Activity: Hosting a visitor typesHosting an academic visitor

Association for Radiation Research (External organisation)

Jonathan Coulter (Chair)
01 Jul 201830 Jun 2020

Activity: Membership typesMembership of external research organisation

Association for Radiation Research 2018 Annual Meeting

Jonathan Coulter (Conference committee co-chair)
25 Jun 201827 Jun 2018

Activity: Participating in or organising an event typesParticipation in conference

Marios Sotiropoulos

Jonathan Coulter (Host)
01 Feb 201830 Apr 2018

Activity: Hosting a visitor typesHosting an academic visitor

School of Pharmacy - Work Experience Days

Jonathan Coulter (Organiser), Daniel Corbett (Organiser)
Jan 2018Feb 2018

Activity: Other activity typesHosting a school group or open day