• Room 06.027 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of Nanotherapeutics, radiobiology, radiopharmaceuticals, DNA damage, cancer stem cells, drug resistance, 3-dimentional bio-assays. - Gold nanoparticle/drug combinations - Solid tumour nanoparticle transport models

20072019

Research output per year

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Research Output

2019

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Anderson, S. D., Hobbs, R. J., Gwenin, V. V., Ball, P., Bennie, L. A., Coulter, J. A. & Gwenin, C. D., 01 Oct 2019, In : Journal of Functional Biomaterials. 10, 4

Research output: Contribution to journalArticle

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Cole, G., Ali, A. A., McErlean, E., Mulholland, E. J., Short, A., McCrudden, C. M., McCaffrey, J., Robson, T., Kett, V. L., Coulter, J. A., Dunne, N. J., Donnelly, R. F. & McCarthy, H. O., 09 Jul 2019, In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development

Feng, J., Byrne, N. M., Al Jamal, W. & Coulter, J. A., 11 Dec 2019, In : Cancers. 11, 12, 25 p., 1989.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
26 Downloads (Pure)

Nuclear Uptake of Gold Nanoparticles Deduced Using Dual-Angle X-Ray Fluorescence Mapping

McCulloch, A., Bennie, L., Coulter, J. A., McCarthy, H. O., Dromey, B., Grimes, D. R., Quinn, P., Villagomez-Bernabe, B. & Currell, F., 01 Jan 2019, In : Particle and Particle Systems Characterization. 1900140.

Research output: Contribution to journalArticle

2018

Enhanced nanoparticle delivery exploiting tumour responsive formulations.

Bennie, L. A., McCarthy, H. & Coulter, J., 21 Nov 2018, In : Cancer Nanotechnology. 9, 10

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
207 Downloads (Pure)

Gene Therapy With RALA/iNOS Composite Nanoparticles Significantly Enhances Survival In A Model Of Metastatic Prostate Cancer

McCrudden, C., McBride, J., McCaffrey, J., McErlean, E., Dunne, N., Kett, V., Coulter, J., Robson, T. & McCarthy, H., 01 Jun 2018, In : Cancer Nanotechnology.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
176 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
157 Downloads (Pure)

Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework

Brown, J., Hanna, G., Lampe, N., Villagomez-Bernabe, B. A., Nicol, J., Coulter, J. & Currell, F., 09 Nov 2018, In : Cancer Nanotechnology. 9, 9

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
159 Downloads (Pure)

Unravelling the cell-type dependent radiosensitising effects of gold through the development of a multifunctional gold nanoparticle

Nicol, J. R., Harrison, E., O'Neill, S. M., Dixon, D., McCarthy, H. O. & Coulter, J. A., 01 Feb 2018, In : Nanomedicine: Nanotechnology, Biology and Medicine. 14, 2, p. 439-449

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
206 Downloads (Pure)
2017
Open Access
File
1 Citation (Scopus)
168 Downloads (Pure)

Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

Research output: Contribution to conferencePoster

Erythropoietin drives breast cancer progression by activation of its receptor EPOR

Chan, K. K., Matchett, K. B., Coulter, J. A., Hiu-Fung, Y., McCrudden, C. M., Zhang, S-D., Irwin, G. W., Davidson, M. A., Rülicke, T., Schober, S., Hengst, L., Jaekel, H., Platt-Higgins, A., Rudland, P. S., Mills, K. I., Maxwell, P., El-Tanani, M. & Lappin, T. R., 18 Mar 2017, In : Oncotarget. 8, 24, p. 38251-38263 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
265 Downloads (Pure)

Process Algebra with Layers: Multi-scale Integration Modelling Applied to Cancer Therapy

Coulter, J., 17 Oct 2017, Process Algebra with Layers: Multi-scale Integration Modelling Applied to Cancer Therapy. Springer, p. 118-133

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Systemic RALA/iNOS nanoparticles; a potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment

McCrudden, C. M., McBride, J. W., McCaffrey, J., Ali, A. A., Dunne, N. J., Kett, V. L., Coulter, J. A., Robson, T. & McCarthy, H. O., 17 Mar 2017, In : Molecular Therapy: Nucleic Acids. 6, p. 249-258 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
232 Downloads (Pure)

Using Surface Plasmon Resonance excitation to determine real-time subcellular distributions of gold nanoparticles in live cells

Bennie, L., McCulloch, A., O'Neill, S., Owen, N., Isonev, V., McCarthy, H., Currell, F. & Coulter, J., 05 Sep 2017.

Research output: Contribution to conferencePaper

2016
14 Citations (Scopus)

Development of TMTP-1 targeted designer biopolymers for gene delivery to prostate cancer

McBride, J. W., Massey, A. S., McCaffrey, J., McCrudden, C. M., Coulter, J. A., Dunne, N. J., Robson, T. & McCarthy, H. O., 16 Mar 2016, In : International Journal of Pharmaceutics. 500, 1-2, p. 144-153 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
227 Downloads (Pure)

Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker

Harrison, E., Coulter, J. A. & Dixon, D., Apr 2016, In : Nanomedicine. 11, 7, p. 851-865 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
254 Downloads (Pure)

Multifunctional and robust composite materials comprising gold nanoparticles at a spherical polystyrene particle surface

Belhout, S. A., Kim, J. Y., Hinds, D. T., Owen, N. J., Coulter, J. A. & Quinn, S. J., 28 Dec 2016, In : Chemical Communications. 52, 100, p. 14388-14391 4 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
192 Downloads (Pure)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
369 Downloads (Pure)

Prostate cancer cell sensitivity to the cytotoxic properties of NO: an iNOS gene therapy approach.

McCrudden, C., Robson, T., Coulter, J., Kett, V. & McCarthy, H., May 2016.

Research output: Contribution to conferencePaper

Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device

McCaffrey, J., McCrudden, C. M., Ali, A. A., Massey, A. S., McBride, J. W., McCrudden, M. T. C., Vicente-Perez, E. M., Coulter, J. A., Robson, T., Donnelly, R. F. & McCarthy, H. O., 28 Mar 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 226, p. 238-47 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2015

CD44 increases the efficiency of distant metastasis of breast cancer

McFarlane, S., Coulter, J. A., Tibbits, P., O'Grady, A., McFarlane, C., Montgomery, N., Hill, A., McCarthy, H. O., Young, L. S., Kay, E. W., Isacke, C. M. & Waugh, D. J. J., May 2015, In : Oncotarget. 6, 13, p. 11465-11476

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
230 Downloads (Pure)

CD74: a potential mediator of resistance in the treatment of Glioblastoma

Magorrian, S., Coulter, J., Flannery, T., Scott, C. & Burden, R., 01 Dec 2015, p. A40 . 1 p.

Research output: Contribution to conferenceAbstract

Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

Nicol, J. R., Dixon, D. & Coulter, J. A., 2015, In : Nanomedicine. 10, 8, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

File
38 Citations (Scopus)
1797 Downloads (Pure)

Imaging intracellular and systemic in vivo gold nanoparticles to enhance radiotherapy

Botchway, S. W., Coulter, J. A. & Currell, F. J., 01 Oct 2015, In : British Journal of Radiology. 88, 1054, 13 p., 20150170.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
103 Downloads (Pure)

Peptide-based Cationic Nanoparticles for the Targeted Gene Therapy of Metastatic Breast Cancer

McCrudden, C., McBride, J., Coulter, J., Robson, T., Kett, V. & McCarthy, H., Apr 2015.

Research output: Contribution to conferencePaper

Open Access
File
7 Citations (Scopus)
399 Downloads (Pure)

Viral mimetic systems: the next generation nonviral vectors

McCarthy, H. O. & Coulter, J. A., Oct 2015, Advances and Challenges in the Delivery of Nucleic Acid Therapeutics (Volume 1). Merkel, O. & Amiji, M. (eds.). Future Science Group, p. 70-81 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2014

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Nitric oxide synthase gene therapy:A potent therapeutic in metastatic breast cancer

McCrudden, C., McBride, J., Coulter, J., Kett, V., Robson, T. & McCarthy, H., Jun 2014, p. 111. 1 p.

Research output: Contribution to conferencePaper

2013

Abstract C215: Sensitivity of PTEN-deficient prostate carcinoma xenografts to ionizing radiation through inhibition of treatment-induced CXCL8 signaling

Armstrong, C. WD., Coulter, J. A., Walker, S., Kennedy, R. D., Prise, K. M., O'Sullivan, J. M. & Waugh, D. JJ., Nov 2013, Proceedings of the AACR-NCI-EORTC International Conference. Vol. 12.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

File
152 Downloads (Pure)

Potentiation of Inflammatory CXCL8 Signalling Sustains Cell Survival in PTEN-deficient Prostate Carcinoma

Maxwell, P. J., Coulter, J., Walker, S. M., McKechnie, M., Neisen, J., McCabe, N., Kennedy, R. D., Salto-Tellez, M., Albanese, C. & Waugh, D. J. J., Aug 2013, In : European Urology. 64, 2, p. 177-188 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Radiosensitising Nanoparticles as Novel Cancer Therapeutics — Pipe Dream or Realistic Prospect?

Coulter, J. A., Hyland, W. B., Nicol, J. & Currell, F. J., Oct 2013, In : Clinical Oncology. 25, 10, p. 593-603 11 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
342 Downloads (Pure)

The contribution of N₂O₃ to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation

Ali, A. A., Coulter, J. A., Ogle, C. H., Migaud, M. M., Hirst, D. G., Robson, T. & McCarthy, H. O., 01 Apr 2013, In : Bioscience Reports. 33, 2, p. 333-349 23 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
179 Downloads (Pure)
2012

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

Coulter, J. A., Jain, S., Butterworth, K. T., Taggart, L. E., Dickson, G. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Trainor, C., Hounsell, A. R., O'Sullivan, J. M., Schettino, G., Currell, F. J., Hirst, D. G. & Prise, K. M., 2012, In : International Journal of Nanomedicine. 7, null, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

Open Access
File
121 Citations (Scopus)
576 Downloads (Pure)
2011

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

McMahon, S., Hyland, W., Muir, M., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., 20 Jun 2011, In : Nature Scientific Reports. 1, 18.

Research output: Contribution to journalArticle

File
234 Citations (Scopus)
214 Downloads (Pure)

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

McMahon, S., Hyland, W. B., Brun, E., Butterworth, K., Coulter, J., Douki, T., Hirst, D., Jain, S., Kavanagh, A., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K., Requardt, H., Sanche, L., Schettino, G., Currell, F. & Sicard-Roselli, C., 20 Oct 2011, In : Journal of Physical Chemistry C. 115, 41, p. 20160-20167 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Erratum: Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles (Scientific Reports (2011) 1 (018) DOI:10.1038/srep00018)

McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., Prise, K. M., Hirst, D. G. & Currell, F. J., 20 Jun 2011, In : Scientific Reports. 3, 1725.

Research output: Contribution to journalComment/debate

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

McMahon, S., Hyland, W., Muir, M. F., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., Sep 2011, In : Radiotherapy and Oncology. 100, 3, p. 412-416 5 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
2010

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.

Butterworth, K., Jain, S., Coulter, J., Folker, J., McMahon, S., Schettino, G., Prise, K., Currell, F. & Hirst, D., Jun 2010, In : Nanotechnology. 21(29), 29, p. 295101-295110 10 p., 295101.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Nitric Oxide Methods and Protocols

McCarthy, H. (ed.) & Coulter, J. (ed.), Dec 2010, Humana Press. 226 p.

Research output: Book/ReportBook

Transcriptional regulation of inducible nitric oxide synthase gene therapy: targeting early stage and advanced prostate cancer.

Coulter, J., Page, N., Worthington, J., Robson, T., Hirst, D. & McCarthy, H., Sep 2010, In : The Journal of Gene Medicine. 12(9), 9, p. 755-765 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009

Nitric oxide synthase gene therapy enhances the toxicity of cisplatin in cancer cells.

Adams, C., McCarthy, H., Coulter, J., Worthington, J., Murphy, C., Robson, T. & Hirst, D., Feb 2009, In : The Journal of Gene Medicine. 11(2), 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2008

Development of a novel PSMA-driven gene therapy strategy for the treatment of prostate cancer

Page, N. L., Coulter, J., Robson, T., Mc Carthy, H. O. & Hirst, D., Apr 2008, In : Human Gene Therapy. 19, p. 422-422 1 p.

Research output: Contribution to journalArticle

Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions.

McCarthy, H., Coulter, J., Robson, T. & Hirst, D., Aug 2008, In : Journal of Pharmacy and Pharmacology. 60(8), 8, p. 999-1017 19 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

hOC/iNOS - A novel gene therapy approach for the treatment of advanced hormone refractory prostate cancer

McCarthy, H., Coulter, J., Page, N., Robson, T. & Hirst, D., Apr 2008, p. 407-407. 1 p.

Research output: Contribution to conferencePaper