• Room 06.027 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of Nanotherapeutics, radiobiology, radiopharmaceuticals, DNA damage, cancer stem cells, drug resistance, 3-dimentional bio-assays. - Gold nanoparticle/drug combinations - Solid tumour nanoparticle transport models

20072020

Research output per year

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Research Output

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Article
2020
2019

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Anderson, S. D., Hobbs, R. J., Gwenin, V. V., Ball, P., Bennie, L. A., Coulter, J. A. & Gwenin, C. D., 01 Oct 2019, In : Journal of Functional Biomaterials. 10, 4

Research output: Contribution to journalArticle

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Cole, G., Ali, A. A., McErlean, E., Mulholland, E. J., Short, A., McCrudden, C. M., McCaffrey, J., Robson, T., Kett, V. L., Coulter, J. A., Dunne, N. J., Donnelly, R. F. & McCarthy, H. O., 09 Jul 2019, In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Nuclear Uptake of Gold Nanoparticles Deduced Using Dual-Angle X-Ray Fluorescence Mapping

McCulloch, A., Bennie, L., Coulter, J. A., McCarthy, H. O., Dromey, B., Grimes, D. R., Quinn, P., Villagomez-Bernabe, B. & Currell, F., 01 Jan 2019, In : Particle and Particle Systems Characterization. 1900140.

Research output: Contribution to journalArticle

2018

Gene Therapy With RALA/iNOS Composite Nanoparticles Significantly Enhances Survival In A Model Of Metastatic Prostate Cancer

McCrudden, C., McBride, J., McCaffrey, J., McErlean, E., Dunne, N., Kett, V., Coulter, J., Robson, T. & McCarthy, H., 01 Jun 2018, In : Cancer Nanotechnology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
177 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
158 Downloads (Pure)

Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework

Brown, J., Hanna, G., Lampe, N., Villagomez-Bernabe, B. A., Nicol, J., Coulter, J. & Currell, F., 09 Nov 2018, In : Cancer Nanotechnology. 9, 9

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
160 Downloads (Pure)

Unravelling the cell-type dependent radiosensitising effects of gold through the development of a multifunctional gold nanoparticle

Nicol, J. R., Harrison, E., O'Neill, S. M., Dixon, D., McCarthy, H. O. & Coulter, J. A., 01 Feb 2018, In : Nanomedicine: Nanotechnology, Biology and Medicine. 14, 2, p. 439-449

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
207 Downloads (Pure)
2017
Open Access
File
1 Citation (Scopus)
170 Downloads (Pure)

Erythropoietin drives breast cancer progression by activation of its receptor EPOR

Chan, K. K., Matchett, K. B., Coulter, J. A., Hiu-Fung, Y., McCrudden, C. M., Zhang, S-D., Irwin, G. W., Davidson, M. A., Rülicke, T., Schober, S., Hengst, L., Jaekel, H., Platt-Higgins, A., Rudland, P. S., Mills, K. I., Maxwell, P., El-Tanani, M. & Lappin, T. R., 18 Mar 2017, In : Oncotarget. 8, 24, p. 38251-38263 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
265 Downloads (Pure)

Systemic RALA/iNOS nanoparticles; a potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment

McCrudden, C. M., McBride, J. W., McCaffrey, J., Ali, A. A., Dunne, N. J., Kett, V. L., Coulter, J. A., Robson, T. & McCarthy, H. O., 17 Mar 2017, In : Molecular Therapy: Nucleic Acids. 6, p. 249-258 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
232 Downloads (Pure)
2016
14 Citations (Scopus)

Development of TMTP-1 targeted designer biopolymers for gene delivery to prostate cancer

McBride, J. W., Massey, A. S., McCaffrey, J., McCrudden, C. M., Coulter, J. A., Dunne, N. J., Robson, T. & McCarthy, H. O., 16 Mar 2016, In : International Journal of Pharmaceutics. 500, 1-2, p. 144-153 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
227 Downloads (Pure)

Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker

Harrison, E., Coulter, J. A. & Dixon, D., Apr 2016, In : Nanomedicine. 11, 7, p. 851-865 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
256 Downloads (Pure)

Multifunctional and robust composite materials comprising gold nanoparticles at a spherical polystyrene particle surface

Belhout, S. A., Kim, J. Y., Hinds, D. T., Owen, N. J., Coulter, J. A. & Quinn, S. J., 28 Dec 2016, In : Chemical Communications. 52, 100, p. 14388-14391 4 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
193 Downloads (Pure)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
369 Downloads (Pure)

Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device

McCaffrey, J., McCrudden, C. M., Ali, A. A., Massey, A. S., McBride, J. W., McCrudden, M. T. C., Vicente-Perez, E. M., Coulter, J. A., Robson, T., Donnelly, R. F. & McCarthy, H. O., 28 Mar 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 226, p. 238-47 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2015

CD44 increases the efficiency of distant metastasis of breast cancer

McFarlane, S., Coulter, J. A., Tibbits, P., O'Grady, A., McFarlane, C., Montgomery, N., Hill, A., McCarthy, H. O., Young, L. S., Kay, E. W., Isacke, C. M. & Waugh, D. J. J., May 2015, In : Oncotarget. 6, 13, p. 11465-11476

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
232 Downloads (Pure)

Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

Nicol, J. R., Dixon, D. & Coulter, J. A., 2015, In : Nanomedicine. 10, 8, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

File
38 Citations (Scopus)
1803 Downloads (Pure)

Imaging intracellular and systemic in vivo gold nanoparticles to enhance radiotherapy

Botchway, S. W., Coulter, J. A. & Currell, F. J., 01 Oct 2015, In : British Journal of Radiology. 88, 1054, 13 p., 20150170.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
103 Downloads (Pure)
2014

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2013

Potentiation of Inflammatory CXCL8 Signalling Sustains Cell Survival in PTEN-deficient Prostate Carcinoma

Maxwell, P. J., Coulter, J., Walker, S. M., McKechnie, M., Neisen, J., McCabe, N., Kennedy, R. D., Salto-Tellez, M., Albanese, C. & Waugh, D. J. J., Aug 2013, In : European Urology. 64, 2, p. 177-188 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Radiosensitising Nanoparticles as Novel Cancer Therapeutics — Pipe Dream or Realistic Prospect?

Coulter, J. A., Hyland, W. B., Nicol, J. & Currell, F. J., Oct 2013, In : Clinical Oncology. 25, 10, p. 593-603 11 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
343 Downloads (Pure)

The contribution of N₂O₃ to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation

Ali, A. A., Coulter, J. A., Ogle, C. H., Migaud, M. M., Hirst, D. G., Robson, T. & McCarthy, H. O., 01 Apr 2013, In : Bioscience Reports. 33, 2, p. 333-349 23 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
180 Downloads (Pure)
2012

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

Coulter, J. A., Jain, S., Butterworth, K. T., Taggart, L. E., Dickson, G. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Trainor, C., Hounsell, A. R., O'Sullivan, J. M., Schettino, G., Currell, F. J., Hirst, D. G. & Prise, K. M., 2012, In : International Journal of Nanomedicine. 7, null, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

Open Access
File
121 Citations (Scopus)
580 Downloads (Pure)
2011

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

McMahon, S., Hyland, W., Muir, M., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., 20 Jun 2011, In : Nature Scientific Reports. 1, 18.

Research output: Contribution to journalArticle

File
234 Citations (Scopus)
214 Downloads (Pure)

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

McMahon, S., Hyland, W. B., Brun, E., Butterworth, K., Coulter, J., Douki, T., Hirst, D., Jain, S., Kavanagh, A., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K., Requardt, H., Sanche, L., Schettino, G., Currell, F. & Sicard-Roselli, C., 20 Oct 2011, In : Journal of Physical Chemistry C. 115, 41, p. 20160-20167 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

McMahon, S., Hyland, W., Muir, M. F., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., Sep 2011, In : Radiotherapy and Oncology. 100, 3, p. 412-416 5 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
2010

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.

Butterworth, K., Jain, S., Coulter, J., Folker, J., McMahon, S., Schettino, G., Prise, K., Currell, F. & Hirst, D., Jun 2010, In : Nanotechnology. 21(29), 29, p. 295101-295110 10 p., 295101.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Transcriptional regulation of inducible nitric oxide synthase gene therapy: targeting early stage and advanced prostate cancer.

Coulter, J., Page, N., Worthington, J., Robson, T., Hirst, D. & McCarthy, H., Sep 2010, In : The Journal of Gene Medicine. 12(9), 9, p. 755-765 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009

Nitric oxide synthase gene therapy enhances the toxicity of cisplatin in cancer cells.

Adams, C., McCarthy, H., Coulter, J., Worthington, J., Murphy, C., Robson, T. & Hirst, D., Feb 2009, In : The Journal of Gene Medicine. 11(2), 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2008

Development of a novel PSMA-driven gene therapy strategy for the treatment of prostate cancer

Page, N. L., Coulter, J., Robson, T., Mc Carthy, H. O. & Hirst, D., Apr 2008, In : Human Gene Therapy. 19, p. 422-422 1 p.

Research output: Contribution to journalArticle

Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions.

McCarthy, H., Coulter, J., Robson, T. & Hirst, D., Aug 2008, In : Journal of Pharmacy and Pharmacology. 60(8), 8, p. 999-1017 19 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Nitric oxide-A novel therapeutic for cancer.

Coulter, J., McCarthy, H., Xiang, J., Roedl, W., Wagner, E., Robson, T. & Hirst, D., Sep 2008, In : Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 19(2), 2, p. 192-198 7 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation

Coulter, JA., McCarthy, HO., Worthington, J., Robson, T., Scott, S. & Hirst, DG., Apr 2008, In : Gene Therapy. 15, 7, p. 495-503 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2007

Human Osteocalcin: a strong promoter for nitric oxide synthase gene therapy, with specificity for hormone refractory prostate cancer.

McCarthy, H., Coulter, J., Worthington, J., Robson, T. & Hirst, D., May 2007, In : The Journal of Gene Medicine. 9(6), 6, p. 511-520 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)