• Room 0G.029 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Prof Bengoechea is keen to PhD applications from candidates with a basic or clinical background. My laboratory focus is to understand the host-pathogen interface, with major focus on multidrug reistant pathogens, to develop new therapeutics. We employ in vitro and in vivo models of disease, and exploit a multidisciplinary approach bridging Microbiology, Immunology and Molecular Biology. Previous research experience is desirable although not essential.

19952020

Research output per year

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Personal profile

Research Interests

My research has been influenced by the dual need to decipher infection as microbe-cell cross-talks, and to analyse infectious diseases in an integrative dimension encompassing host responses. The long term goal of the laboratory is to decipher the network of interactions between pathogenic bacteria and various cell types contributing to the onset of the innate immunity responses by applying a multidisciplinary approach interfacing immunology, cell biology, and molecular microbiology. We are keen in defining the mechanisms by which pathogens manipulate for their own benefit early innate immune responses.

Our work involves the use of animal and tissue culture models of infection (mice, macrophages and epithelial cells) using Y. enterocolitica, nontypable Haemophilus influenzae, and K. pneumoniae as bacterial models. The diseases of interest to us include Yersinia-induced gastroenteritis, chronic diseases associated to smoking (COPD), and Klebsiella-induced pneumonia.

Overall, our research strategy is leading to the identification of novel pathogen-specific signatures implicated in manipulating the immune response as well as to define the elements belonging to a common host response against Gram negative pathogens, which could be targeted for therapeutic manipulation. This knowledge should speed up the development of new tools to control infectious diseases, the discovery of new antibacterial targets as well as the development of novel immunoadjuvants.

Please visit the lab web page for details.

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Projects

Research Output

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent

Storey, D., McNally, A., Åstrand, M., Sa-Pessoa Graca Santos, J., Rodriguez-Escudero, I., Elmore, B., Palacios, L., Marshall, H., Hobley, L., Molina, M., Cid, V. J., Salminen, T. A. & Bengoechea, J. A., 19 Mar 2020, In : PLoS Pathogens. 16, 3, e1007969.

Research output: Contribution to journalArticle

Open Access
  • 2-hydroxylation of Acinetobacter baumannii lipid A contributes to virulence

    Bartholomew, T. L., Kidd, T. J., Sá Pessoa, J., Conde Álvarez, R. & Bengoechea, J. A., 25 Mar 2019, In : Infection and Immunity.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    113 Downloads (Pure)

    A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis

    Dumigan, A., Fitzgerald, M., Santos, J. S. P. G., Hamid, U., O’kane, C. M., McAuley, D. F. & Bengoechea, J. A., 01 Nov 2019, In : mBio. 10, 6, e02802-19.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 43 Downloads (Pure)

    Control of Klebsiella pneumoniae infection in mice using dissolving microarray patches containing gentamicin

    Rodgers, A. M., McCrudden, M. T. C., Courtenay, A. J., Kearney, M-C., Edwards, K. L., Ingram, R. J., Bengoechea, J. & Donnelly, R. F., 01 May 2019, In : Antimicrobial Agents and Chemotherapy. 63, 5, p. e02612-e02618 7 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    132 Downloads (Pure)

    Activities

    Microbiology Society (External organisation)

    Jose Bengoechea (Chair)
    20202023

    Activity: Membership typesMembership of board

    Medical Research Council (External organisation)

    Jose Bengoechea (Board Member)
    20202023

    Activity: Membership typesMembership of peer review panel or committee

    Agence Nationale De La Recherche (External organisation)

    Jose Bengoechea (Member)
    2020 → …

    Activity: Membership typesMembership of peer review panel or committee

    Multidrug resistant infections, and immune evasion: the perfect storm

    Jose Bengoechea (Invited speaker)
    20 Aug 2019

    Activity: Talk or presentation typesInvited talk

    Klebsiella pneumoniae: a master tactitian in immune evasion

    Jose Bengoechea (Keynote speaker)
    05 Apr 2019

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    Thesis

    The role of lipid A in the virulence of ESKAPE pathogens

    Author: Bartholomew, T., 2019

    Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy