• Room 0G.029 - WWIEM Block 6 MBC Site

    United Kingdom

Accepting PhD Students

19952019
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Personal profile

Research Interests

My research has been influenced by the dual need to decipher infection as microbe-cell cross-talks, and to analyse infectious diseases in an integrative dimension encompassing host responses. The long term goal of the laboratory is to decipher the network of interactions between pathogenic bacteria and various cell types contributing to the onset of the innate immunity responses by applying a multidisciplinary approach interfacing immunology, cell biology, and molecular microbiology. We are keen in defining the mechanisms by which pathogens manipulate for their own benefit early innate immune responses.

Our work involves the use of animal and tissue culture models of infection (mice, macrophages and epithelial cells) using Y. enterocolitica, nontypable Haemophilus influenzae, and K. pneumoniae as bacterial models. The diseases of interest to us include Yersinia-induced gastroenteritis, chronic diseases associated to smoking (COPD), and Klebsiella-induced pneumonia.

Overall, our research strategy is leading to the identification of novel pathogen-specific signatures implicated in manipulating the immune response as well as to define the elements belonging to a common host response against Gram negative pathogens, which could be targeted for therapeutic manipulation. This knowledge should speed up the development of new tools to control infectious diseases, the discovery of new antibacterial targets as well as the development of novel immunoadjuvants.

Please visit the lab web page for details.

Fingerprint Dive into the research topics where Jose Bengoechea is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 35 Similar Profiles
Klebsiella pneumoniae Medicine & Life Sciences
Yersinia enterocolitica Medicine & Life Sciences
Lipopolysaccharides Medicine & Life Sciences
Lipid A Medicine & Life Sciences
Haemophilus influenzae Medicine & Life Sciences
Virulence Medicine & Life Sciences
Infection Medicine & Life Sciences
Peptides Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2017

Research Output 1995 2019

2-hydroxylation of Acinetobacter baumannii lipid A contributes to virulence

Bartholomew, T. L., Kidd, T. J., Sá Pessoa, J., Conde Álvarez, R. & Bengoechea, J. A., 25 Mar 2019, In : Infection and Immunity.

Research output: Contribution to journalArticle

Open Access
File
Acinetobacter baumannii
Lipid A
Hydroxylation
Virulence
Interleukin-10
1 Citation (Scopus)
Open Access
File
Klebsiella Infections
Klebsiella pneumoniae
Gentamicins
Bacterial Infections
Lymphoid Tissue

P347 A survey of cardiovascular disease in UK cystic fibrosis centres

Downey, D. G., Bengoechea, J., Curtis, T., Grieve, D. & Harbinson, M., Jun 2019, In : Journal of Cystic Fibrosis. 18, p. S155-S156

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)

The intrinsic resistome of Klebsiella pneumoniae

Bernardini, A., Cuesta, T., Tomás, A., Bengoechea, J. A., Martínez, J. L. & Sánchez, M. B., 01 Jan 2019, In : International Journal of Antimicrobial Agents. 53, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

Klebsiella pneumoniae
Bacterial Physiological Phenomena
Genes
Plasmids
Chromosomes, Human, Pair 15
2 Citations (Scopus)
Open Access
File
Klebsiella Infections
Klebsiella pneumoniae
Gentamicins
Nanoparticles
Microbial Viability

Activities 2014 2019

Klebsiella pneumoniae: a master tactician of immune evasion

Jose Bengoechea (Invited speaker)
21 May 2019

Activity: Talk or presentation typesInvited talk

What is new in the pathogenesis of Kp?

Jose Bengoechea (Keynote speaker)
21 Aug 201923 Aug 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Three to tango: lung inflammation, Klebsiella pneumonia, immune evasion

Jose Bengoechea (Invited speaker)
08 Apr 201911 Apr 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Klebsiella pneumoniae T6SS: a weapon for trans kingdom warfare

Jose Bengoechea (Invited speaker)
12 Sep 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Multidrug resistant infections, and immune evasion: the perfect storm

Jose Bengoechea (Invited speaker)
20 Aug 2019

Activity: Talk or presentation typesInvited talk

Thesis

The role of lipid A in the virulence of ESKAPE pathogens

Author: Bartholomew, T., 2019

Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy