Projects per year
Personal profile
Research Interests
My research has been influenced by the dual need to decipher infection as microbe-cell cross-talks, and to analyse infectious diseases in an integrative dimension encompassing host responses. The long term goal of the laboratory is to decipher the network of interactions between pathogenic bacteria and various cell types contributing to the onset of the innate immunity responses by applying a multidisciplinary approach interfacing immunology, cell biology, and molecular microbiology. We are keen in defining the mechanisms by which pathogens manipulate for their own benefit early innate immune responses.
Our work involves the use of animal and tissue culture models of infection (mice, macrophages and epithelial cells) using Y. enterocolitica, nontypable Haemophilus influenzae, and K. pneumoniae as bacterial models. The diseases of interest to us include Yersinia-induced gastroenteritis, chronic diseases associated to smoking (COPD), and Klebsiella-induced pneumonia.
Overall, our research strategy is leading to the identification of novel pathogen-specific signatures implicated in manipulating the immune response as well as to define the elements belonging to a common host response against Gram negative pathogens, which could be targeted for therapeutic manipulation. This knowledge should speed up the development of new tools to control infectious diseases, the discovery of new antibacterial targets as well as the development of novel immunoadjuvants.
Please visit the lab web page for details.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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R1368CEM: Characterization of Klebseilla pneumoniae T6SS nanoweapon and its role in the dissemination of antimicrobial genes and virulence factors.
Bengoechea, J. (PI) & Collins, B. (CoI)
17/03/2021 → …
Project: Research
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R7886BSC: A map of host cell rewiring by pathogens
Collins, B. (PI), Bengoechea, J. (CoI) & Schroeder, G. N. (CoI)
12/05/2020 → …
Project: Research
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R1095CEM: Klebsiella anti-immunology: exploiting proteins with a eukaryotic SEFIR domain
Bengoechea, J. (PI), Moynagh, P. (CoI) & Schroeder, G. N. (CoI)
11/08/2019 → …
Project: Research
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R1012CEM: Identification of novel class of small compounds with anti-virulence properties againts multidrug resistant pathogens
Bengoechea, J. (PI)
21/01/2019 → 30/09/2020
Project: Research
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R1797CEM: MICA: Host-directed therapeutics to combat bacterial infections
Bengoechea, J. (PI) & Kissenpfennig, A. (CoI)
15/09/2017 → 30/11/2020
Project: Research
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In vivo single-cell high-dimensional mass cytometry analysis to track the interactions between Klebsiella pneumoniae and myeloid cells
Calderon-Gonzalez, R., Dumigan, A., Sá-Pessoa, J., Kissenpfennig, A. & Bengoechea, J. A., 05 Apr 2024, In: PLoS Pathogens. 20, 4, 30 p., e1011900.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)23 Downloads (Pure) -
"Phylogenomic insights into brucellaceae: The Pseudochrobactrum algeriensis case"
Loperena-Barber, M., Elizalde-Bielsa, A., Salvador-Bescós, M., Ruiz-Rodríguez, P., Pellegrini, J. M., Renau-Mínguez, C., Lancaster, R., Zúñiga-Ripa, A., Iriarte, M., Bengoechea, J. A., Coscollá, M., Gorvel, J.-P., Moriyón, I. & Conde-Álvarez, R., Sept 2024, In: Infection, Genetics and Evolution . 123, 15 p., 105625.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance
Chengan, K., Hind, C., Stanley, M., Wand, M. E., Nagappa, L. K., Howland, K., Hanson, T., Martín-Escolano, R., Tsaousis, A. D., Bengoechea, J. A., Mark Sutton, J., Smales, C. M. & Moore, S. J., 18 Dec 2023, In: npj Antimicrobials and Resistance. 1, 12 p., 16.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Downloads (Pure) -
A gas phase fractionation acquisition scheme integrating ion mobility for rapid diaPASEF library generation
Penny, J., Arefian, M., Schroeder, G. N., Bengoechea, J. A. & Collins, B. C., Apr 2023, In: Proteomics. 23, 7-8, 8 p., 2200038.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)72 Downloads (Pure) -
A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Sá-Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez-Escudero, I., Marshall, H., Ova, A., Schroeder, G. N., Barabas, P., Molina, M., Curtis, T., Cid, V. J. & Bengoechea, J. A., 16 Feb 2023, In: Nature Communications. 14, 20 p., 871.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)106 Downloads (Pure)
Prizes
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Fellow American Academy Microbiology
Bengoechea, J. (Recipient), 2023
Prize: Fellowship awarded competitively
Activities
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Workshop on Discovery AI for Health: Accelerating Health Research and Innovation
Wang, H. (Organiser), Styles, I. (Speaker), Bengoechea, J. (Speaker), McNulty, H. (Speaker), Hughes, C. (Speaker), Yang, G. (Speaker), Zwiggelaar, R. (Speaker), Diaz-Ordaz, K. (Speaker), Hospedales, T. (Speaker), Liang, X. (Organiser), Mai, T. S. (Participant), Gault, R. (Participant) & Hughes, C. (Participant)
23 Jun 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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External examiner PhD
Bengoechea, J. (Examiner)
24 Mar 2023Activity: Examination types › PhD external examination
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Escaping the antibiotic apocalypse
Bengoechea, J. (Keynote speaker)
02 Mar 2023Activity: Talk or presentation types › Invited talk
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Vaccines as tools to combat antimicrobial resistance
Bengoechea, J. (Invited speaker)
27 Feb 2023 → 28 Feb 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Dissecting the anti-immunology strategies of the antibtioc resistant pathogen K. pneumoniae
Bengoechea, J. (Invited speaker)
20 Jan 2023Activity: Talk or presentation types › Invited talk