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Open to MPhil / PhD applications in DNA synthesis; nucleic acid enzymes; nucleic acid analogues; anionic drug delivery; photoswitchable nucleic acids

1988 …2019
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Fingerprint Dive into the research topics where Joseph Samuel Vyle is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Oligonucleotides Chemical Compounds
Nucleosides Chemical Compounds
Ball mills Chemical Compounds
DNA Chemical Compounds
Phosphites Chemical Compounds
Ball milling Chemical Compounds
Nucleotides Chemical Compounds
Oligodeoxyribonucleotides Chemical Compounds

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Projects 2008 2014

R9193CHM: Functional DNA-Based Assemblies

Vyle, J. S.

01/08/200815/03/2014

Project: Research

Research Output 1988 2019

45 Downloads (Pure)

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Conlon, P., Eguaogie, O., Wilson, J., Sweet, J., Steinhoegl, J., Englert, K., Hancox, O., Law, C., Allman, S., Tucker, J. H. R., Hall, J. & Vyle, J., 11 Oct 2019, In : Chemical Science. 12 p., DOI: 10.1039/C9SC04098F.

Research output: Contribution to journalArticle

Open Access
File
X ray crystallography
Dimers
Organophosphonates
Oligodeoxyribonucleotides
DNA
140 Downloads (Pure)

Mechanochemistry of nucleosides, nucleotides and related materials

Eguaogie, O., Vyle, J. S., Conlon, P. F., Gîlea, M. A. & Liang, Y., 27 Apr 2018, In : Beilstein Journal of Organic Chemistry . 14, p. 955-970 16 p.

Research output: Contribution to journalReview article

Open Access
File
Nucleosides
Nucleotides
Ball milling
Nucleic Acids
Carbon Nanotubes
125 Downloads (Pure)

Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes

Duprey, J-L. H. A., Bassani, D. M., Hyde, E. I., Jonusauskas, G., Ludwig, C., Rodger, A., Spencer, N., Vyle, J. S., Wilkie, J., Zhao, Z-Y. & Tucker, J. H. R., 2018, In : Organic & biomolecular chemistry. 16, 35, p. 6576-6585 10 p.

Research output: Contribution to journalArticle

Open Access
File
anthracene
deoxyribonucleic acid
oligonucleotides
strands
probes
119 Downloads (Pure)

Vibration Ball Milling for the Synthesis of 5'-Thioadenosine 5'-Pyrophosphate (P'→5') Adenosine (dASppA)

Eguaogie, O. & Vyle, J. S., 13 Feb 2018, In : Current protocols in nucleic acid chemistry. 70, p. 1.41.1-1.41.12

Research output: Contribution to journalArticle

Open Access
File
Ball milling
Vibration
Adenosine
Adenosine Diphosphate
Phosphites
3 Citations (Scopus)
205 Downloads (Pure)

Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill

Eguaogie, O., Conlon, P. F., Ravalico, F., Sweet, J., Elder, T. B., Conway, L. P., Lennon, M. E., Hodgson, D. R. W. & Vyle, J. S., 13 Jan 2017, In : Beilstein Journal of Organic Chemistry. 13, p. 87–92 6 p.

Research output: Contribution to journalArticle

Open Access
File
Ball mills
Nucleosides
Salts
Purine Nucleosides
Cyclization

Activities 2009 2012

  • 6 Participation in conference
  • 1 Invited talk

8th Nucleic Acids Forum

Joseph Samuel Vyle (Session chair)
06 Jul 2012

Activity: Participating in or organising an event typesParticipation in conference

The Preparation and evaluation of Photoswitchable nucleic acids

Joseph Samuel Vyle (Speaker)
03 Oct 2012

Activity: Talk or presentation typesInvited talk

Nucleic Acids Chemistry & Biology 6th Cambridge Symposium

Joseph Samuel Vyle (Participant)
04 Sep 201107 Sep 2011

Activity: Participating in or organising an event typesParticipation in conference

7th Nucleic Acids Forum

Joseph Samuel Vyle (Speaker)
08 Jul 2011

Activity: Participating in or organising an event typesParticipation in conference

Nucleic Acids Chemistry & Biology 6th Cambridge Symposium

Joseph Samuel Vyle (Participant)
04 Sep 201107 Sep 2011

Activity: Participating in or organising an event typesParticipation in conference