• Room 01.005 - CCRCB Block 5 MBC Site

    United Kingdom

19962019
If you made any changes in Pure these will be visible here soon.

Personal profile

Research Statement

My urology research programmes bring together cell physiology and molecular biology disciplines to understand the complex cellular signalling systems which underpin normal bladder function and become dysregulated in bladder disease.

We are also investigating the role of ion channels in the progression of urological cancers including bladder and prostate.

Research Interests

I obtained my PhD for research into ion channels on smooth muscle cells from the lower urinary tract. This generated my interest in the cellular basis of spontaneous activity in the bladder and set the focus of my independent research career which was marked by a New Investigator Award from BBSRC to study Kit-positive interstitial cells in the bladder. This work was carried out in the Centre for Biophotonics in the University of Strathclyde, Glasgow and formed the foundation for my application to the Wellcome Trust for a University Award (Senior Research Fellowship) in Queen's University Belfast. This award enabled the establishment of my research group in the Centre for Cancer Research and Cell Biology.

As co-PI in the first European Union funded consortium to study urinary incontinence ("INComb" FP7 grant), our group is has made a decisive contribution to the basic cellular mechanisms underlying a condition that affects an estimated 60 million people in Europe and for which there are few effective therapies.

Our current MRC-funded research on bladder toxicity as an adverse effect of radiation therapy will elucidate the molecular mechanisms driving typical lower urinary tract symptoms of urgency, urinary frequency, nocturia and voiding dysfunction that develop during treatment. This translational programme includes a clinical research trial in prostate cancer patients to identify predictive biomarkers of late radiation bladder toxicity.

My interdisciplinary programme on ion channels and cancer exploits electrophysiology, molecular pathology, cell and molecular oncology and biomarker discovery to advance our knowledge of tumour biology.

Other

Key Words

Urinary incontinence; urinary bladder; radiation therapy; smooth muscle; interstitial cells; Ca2+-signalling; electrophysiology; confocal microscopy; urothelial cancer; prostate cancer.

Teaching

 

Degree/ProgrammeRole/Module
Medicine

Lectures

Physiological Basis of Clinical Practice

Biomedical Science and Human Biology

Lectures/Tutorials/Research Training

Molecular Basis of Disease

Clinical Biochemistry

Research project and dissertation

MRes in Translational Medicine

Module coordinator

Research project and dissertation

USA Placement Programme

Programme Coordinator

Other

Fellowships

We are willing to host and support Fellowship applications for PhD or postdoctoral training.

Fingerprint Dive into the research topics where Karen McCloskey is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Urinary Bladder Medicine & Life Sciences
Interstitial Cells of Cajal Medicine & Life Sciences
Smooth Muscle Myocytes Medicine & Life Sciences
Smooth Muscle Medicine & Life Sciences
Sheep Medicine & Life Sciences
Guinea Pigs Medicine & Life Sciences
Urethra Medicine & Life Sciences
Mucous Membrane Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2018

Research Output 1996 2019

Spontaneous Activity and the Urinary Bladder

Fry, C. H. & McCloskey, K. D., 11 Jun 2019, Smooth Muscle Spontaneous Activity. Springer Nature Singapore Pte Ltd., Vol. 1124. p. 121-147 27 p. (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Urinary Bladder
Mucous Membrane
Pressure
Smooth Muscle
Urine
3 Citations (Scopus)

Acute radiation impacts contractility of guinea-pig bladder strips affecting mucosal-detrusor interactions

McDonnell, B. M., Buchanan, P. J., Prise, K. M. & McCloskey, K. D., 07 Mar 2018, In : PloS one. 13, 3, 15 p., e0193923.

Research output: Contribution to journalArticle

Open Access
File
bladder
guinea pigs
mucosa
Guinea Pigs
Urinary Bladder

The detrusor-free bladder - it can still hold its water

McCloskey, K. D., 22 Dec 2018, In : The Journal of Physiology.

Research output: Contribution to journalArticle

3 Citations (Scopus)

What are the origins and relevance of spontaneous bladder contractions? ICI-RS 2017

Drake, M. J., Fry, C. H., Hashitani, H., Kirschner-Hermanns, R., Rahnama'i, M. S., Speich, J. E., Tomoe, H., Kanai, A. J. & McCloskey, K. D., 23 Jan 2018, In : Neurourology and Urodynamics.

Research output: Contribution to journalReview article

Urinary Bladder
Research
Mucous Membrane
Urinary Tract
Smooth Muscle Myocytes
65 Citations (Scopus)

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Parkes, E. E., Walker, S. M., Taggart, L. E., McCabe, N., Knight, L. A., Wilkinson, R., McCloskey, K., Buckley, N. E., Savage, K. I., Salto-Tellez, M., McQuaid, S., Harte, M. T., Mullan, P. B., Harkin, D. P. & Kennedy, R. D., 01 Jan 2017, In : Journal of the National Cancer Institute. 109, 1

Research output: Contribution to journalArticle

Open Access
File
S Phase
DNA Damage
Breast Neoplasms
Immunohistochemistry
Chemokine CXCL10

Prizes

Sir Robin MacLellan Prize

Karen McCloskey (Recipient), 2002

Prize: Prize (including medals and awards)

Wellcome Trust Univeristy Award (Senior Research Fellowship)

Karen McCloskey (Recipient), 2004

Prize: Prize (including medals and awards)

Activities 2002 2016

  • 6 Membership of external research organisation
  • 1 Editorial activity

Radiation Research Society (External organisation)

Karen McCloskey (Member)
2016 → …

Activity: Membership typesMembership of external research organisation

American Association for Cancer Research Foundation (External organisation)

Karen McCloskey (Member)
2016 → …

Activity: Membership typesMembership of external research organisation

British Journal of Pharmacology (Journal)

Karen McCloskey (Editor)
20092017

Activity: Publication peer-review and editorial work typesEditorial activity

The Pharmacological Society (External organisation)

Karen McCloskey (Member)
2009 → …

Activity: Membership typesMembership of external research organisation

The International Continence Society (External organisation)

Karen McCloskey (Member)
2008 → …

Activity: Membership typesMembership of external research organisation