Karim Dib

Phone028 90 972634, +44 (0)28 9097 2634
Emailk.dibqub.acuk

Room 03.009 - Medical Biology Centre
United Kingdom

Accepting PhD Students

PhD projects

Title of the project: To investigate the role of the histamine four receptor in the pathogenesis of chronic lung infections.
We would like to test the hypothesis that accumulation of histamine in lung fluids impairs airways neutrophils in chronic lung diseases by engaging the histamine four receptor (H4R) in neutrophils. Engagement of the H4R may block the ability of neutrophils to kill pathogens. We will investigate whether H4R antagonists can be used to boost the anti-microbial functions of pulmonary neutrophils during chronic lung infections.

Research activity per year

1 Active
2 Finished

3 results

Active

R3158CII: The chemoattractant fMLP activates the monomeric GTPhase Rap1 in human neutrophils through production of nitric oxide and phosphorylation
Dib, K. (PI)
01/08/2009 → …
Project: Research
Finished

R1778CEM: To evaluate the role of the histamine four recpetor in the clearance of lung pathogens
Dib, K. (PI) & Valvano, M. A. (CoI)
26/05/2017 → 31/12/2020
Project: Research
R1636CEM: MRC P2D 2015 - Feasibility studies using H4Rantagonists - development of a collaboration with a Clinical Stage Biotech Company
Dib, K. (PI)
06/06/2016 → 30/11/2016
Project: Research

Karim Dib

Projects

Search results

R3158CII: The chemoattractant fMLP activates the monomeric GTPhase Rap1 in human neutrophils through production of nitric oxide and phosphorylation

R1778CEM: To evaluate the role of the histamine four recpetor in the clearance of lung pathogens

R1636CEM: MRC P2D 2015 - Feasibility studies using H4Rantagonists - development of a collaboration with a Clinical Stage Biotech Company