Karl Butterworth

Research output

Research output per year 2008 2021

• 62 Article
• 7 Review article
• 3 Poster
• 2 Meeting abstract
• 6 More
  • 2 Comment/debate
  • 1 Chapter
  • 1 Paper
  • 1 Literature review
  • 1 Special issue

Research output per year

Research output per year

Search results

• 2021

  Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

  Amoroso, F., Glass, K., Singh, R., Liberal, F., Steele, R. E., Maguire, S., Tarapore, R., Allen, J. E., Van Schaeybroeck, S., Butterworth, K. T., Prise, K., O'Sullivan, J. M., Jain, S., Waugh, D. J. & Mills, I. G., 19 Feb 2021, In: Scientific Reports. 11, 1, p. 4252

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TIC10 compound
  • Unfolded Protein Response
  • Radiation
  • Cell Death
  • Oxidative Phosphorylation
  1 Downloads (Pure)
• 2020

  A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy

  Petersson, K., Adrian, G., Butterworth, K. & McMahon, S. J., 04 Mar 2020, In: International Journal of Radiation Oncology Biology Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • oxygen tension
  • radiation therapy
  • quantitative analysis
  • Oxygen
  • Radiotherapy
  14 Citations (Scopus)

• ATM Kinase Inhibition Preferentially Sensitises PTEN-Deficient Prostate Tumour Cells to Ionising Radiation

  Hanna, C., Dunne, V. L., Walker, S. M., Butterworth, K. T., McCabe, N., Waugh, D. J. J., Kennedy, R. D. & Prise, K. M., 30 Dec 2020, In: Cancers. 13, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ionizing Radiation
  • Prostate
  • Phosphotransferases
  • Radiotherapy
  • Neoplasms
  16 Downloads (Pure)

• Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

  Ghita, M., Gill, E., Walls, G., Edgar, K., McMahon, S., Vasquez Osorio, E., Bergom, C., Grieve, D., Watson, C., McWilliam, A., Aznar, M., van herk, M., Williams, K. J. & Butterworth, K., 11 Jul 2020, In: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. DOI: 10.1016/j.radonc.2020.07.016 .

  Research output: Contribution to journal › Article › peer-review

  • Cardiac Volume
  • Radiation Tolerance
  • Heart
  • Radiotherapy
  • Animals
  2 Citations (Scopus)

• Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma

  LaBonte Wilson, M., Ong, C. W., Armstrong, C., Waugh, D., Maxwell, P., O'Sullivan, J., Prise, K., Butterworth, K., Coulter, J., Walker, S., Oksana, L., Gallagher, R., Jain, S., Bristow, R. G. & Mills, I., 03 Jul 2020, In: NAR Cancer. 2, 3, zcaa012.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ionizing Radiation
  • Prostate
  • CXC Chemokines
  • Radiotherapy
  • Carcinoma
  30 Downloads (Pure)

• Evaluation of a Novel Liquid Fiducial Marker, BioXmark®, for Small Animal Image-Guided Radiotherapy Applications

  Brown, K. H., Ghita, M., Schettino, G., Prise, K. M. & Butterworth, K. T., 18 May 2020, In: Cancers. 12, 5, 14 p., 1276.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fiducial Markers
  • Image-Guided Radiotherapy
  • Cone-Beam Computed Tomography
  • Artifacts
  • Animals
  25 Downloads (Pure)

• History and current perspectives on the biological effects of high-dose spatial fractionation and high dose-rate approaches: GRID, Microbeam & FLASH radiotherapy

  Griffin, R. J., Prise, K. M., McMahon, S. J., Zhang, X., Penagaricano, J. & Butterworth, K. T., 01 Sep 2020, In: British Journal of Radiology. 93, 1113

  Research output: Contribution to journal › Review article › peer-review

  • History
  • Radiotherapy
  • Organs at Risk
  • Ionizing Radiation
  • Neoplasms
  1 Citation (Scopus)

• Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

  Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S. & 22 others, Lux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, In: Physics in Medicine and Biology.

  Research output: Contribution to journal › Article › peer-review

  • Metal Nanoparticles
  • Direction compound
  • Radiotherapy
  • Bismuth
  • Theranostic Nanomedicine
  9 Citations (Scopus)

• Spatially Fractionated Microbeam Analysis of Tissue-sparing Effect for Spermatogenesis

  Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 23 Dec 2020, In: Radiation Research. 194, 6, p. 698-706 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • spermatogenesis
  • microbeams
  • Spermatogenesis
  • stem cells
  • slits
  39 Downloads (Pure)
• 2019

  AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

  Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In: British Journal of Radiology. 92, 1093, 19 p., 20180365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Theranostic Nanomedicine
  • Clinical Medicine
  • Gadolinium
  • Nanoparticles
  • Siloxanes
  36 Citations (Scopus)

  371 Downloads (Pure)

• Evolution of the Supermodel: Progress in Modelling Radiotherapy Response in Mice.

  Butterworth, K., 11 Mar 2019, In: Clinical oncology (Royal College of Radiologists (Great Britain)). doi: 10.1016/j.clon.2019.02.008.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiobiology
  • Radiotherapy
  • Animals
  • Neoplasms
  • Carcinogenesis
  5 Citations (Scopus)

  40 Downloads (Pure)

• High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

  Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In: Scientific Reports. 9, 10 p., 12618.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fertility Preservation
  • Testis
  • Radiotherapy
  • Spermatogenesis
  • Fertility
  4 Citations (Scopus)

  104 Downloads (Pure)

• Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

  Butterworth, K., Ghita, M., Brown, K., Kelada, O. & Graves, E. E., 02 Feb 2019, In: Cancers. 11, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiotherapy
  • Biological Models
  • Radiation Oncology
  • Molecular Imaging
  • Translational Medical Research
  5 Citations (Scopus)

  171 Downloads (Pure)

• Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

  Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In: The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiotherapy
  • Risk assessment
  • Radiation Tolerance
  • Risk Assessment
  • Precision Medicine
  4 Citations (Scopus)

  102 Downloads (Pure)

• Preclinical models of radiation induced lung damage: challenges and opportunities for small animal radiotherapy

  Ghita, M., Dunne, V., Hanna, G. G., Prise, K. M., Williams, J. P. & Butterworth, K., 17 Jan 2019, In: British Journal of Radiology. p. 20180473

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation
  • Radiotherapy
  • Lung
  • Animals
  • Radiation Exposure
  5 Citations (Scopus)

  93 Downloads (Pure)
• 2018

  Microbeam evolution: From single cell irradiation to pre-clinical studies

  Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In: International journal of radiation biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation
  • Synchrotrons
  • Clinical Studies
  • Radiotherapy
  • Organelles
  6 Citations (Scopus)

  223 Downloads (Pure)

• Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field

  Ghita, M., Dunne, V. L., McMahon, S. J., Osman, S. O., Small, D. M., Weldon, S., Taggart, C. C., McGarry, C. K., Hounsell, A. R., Graves, E. E., Prise, K. M., Hanna, G. G. & Butterworth, K. T., 12 Dec 2018, In: International journal of radiation oncology, biology, physics. 103, 5, p. 1231-1240 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • toxicity
  • lungs
  • dosage
  • evaluation
  • Lung
  5 Citations (Scopus)

  113 Downloads (Pure)

• Radio-resistance of PTEN-deficient prostate tumours is enhanced by treatment-induced chemokine signalling and is associated with biochemical recurrence and development of metastasis.

  Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., Butterworth, K., Oksana, L., Berlingeri, S., LaBonte Wilson, M., Walker, S., O'Sullivan, J., Salto-Tellez, M., Jain, S., Mills, I., Illidge, T., Kennedy, R., Prise, K. & Waugh, D., 01 Aug 2018.

  Research output: Contribution to conference › Poster › peer-review
• 2017

  A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

  Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In: Scientific Reports. 7, 44752 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • microbeams
  • gold
  • nanoparticles
  • irradiation
  • depolarization
  25 Citations (Scopus)

  204 Downloads (Pure)

• An Overview of Current Practice in External Beam Radiation Oncology with Consideration to Potential Benefits and Challenges for Nanotechnology

  King, R., McMahon, S., Hyland, W., Jain, S., Butterworth, K., Prise, K., Hounsell, A. & McGarry, C., Dec 2017, In: Cancer Nanotechnology. 8, 3, p. 3

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Oncology
  • Radiation Oncology
  • Nanotechnology
  • nanotechnology
  • Radiotherapy
  6 Citations (Scopus)

  288 Downloads (Pure)

• Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

  Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In: Cancer Nanotechnology. 8, 2, 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gold nanoparticles
  • Gold
  • Nanoparticles
  • gold
  • nanoparticles
  88 Citations (Scopus)

  287 Downloads (Pure)

• Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of normal and urothelial cancer cells

  Bill, M., Srivastava, K., Breen, C., Butterworth, K., McMahon, S., Prise, K. & McCloskey, K., 24 Oct 2017, In: Oncotarget.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bystander Effect
  • Radiation Effects
  • Apoptosis
  • Survival
  • Neoplasms
  2 Citations (Scopus)

  199 Downloads (Pure)

• Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

  Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy

  Dunne, V., Ghita, M., Small, D. M., Coffey, C. B. M., Weldon, S., Taggart, C. C., Osman, S. O., McGarry, C. K., Prise, K. M., Hanna, G. G. & Butterworth, K. T., 08 Jul 2017, In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 124, 3, p. 475-481

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AZD6738
  • Ataxia Telangiectasia
  • Therapeutic Index
  • Non-Small Cell Lung Carcinoma
  • Radiation Pneumonitis
  14 Citations (Scopus)

  328 Downloads (Pure)

• Low-dose radiation-induced risk in spermatogenesis

  Fukunaga, H., Butterworth, K. T., Yokoya, A., Ogawa, T. & Prise, K. M., 2017, In: International journal of radiation biology. 93, 12, p. 1291-1298 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Spermatogenesis
  • Radiation
  • Germ Cells
  • Fertility
  • Spermatozoa
  11 Citations (Scopus)

  275 Downloads (Pure)

• Modelling responses to spatially fractionated radiation fields using preclinical image-guided radiotherapy

  Butterworth, K. T., Ghita, M., McMahon, S. J., McGarry, C. K., Griffin, R. J., Hounsell, A. R. & Prise, K. M., Jan 2017, In: British Journal of Radiology. 1069

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Image-Guided Radiotherapy
  • Radiation
  • Radiotherapy
  • Tumor Burden
  • Therapeutics
  7 Citations (Scopus)

  197 Downloads (Pure)

• Small field dosimetry for the small animal radiotherapy research platform (SARRP)

  Ghita, M., McMahon, S. J., Thompson, H. F., McGarry, C. K., King, R., Osman, S. O. S., Kane, J. L., Tulk, A., Schettino, G., Butterworth, K. T., Hounsell, A. R. & Prise, K. M., 28 Dec 2017, In: Radiation oncology (London, England). 12, 1, p. 204

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cone-Beam Computed Tomography
  • Radiotherapy
  • Radiobiology
  • Particle Accelerators
  • Animals
  14 Citations (Scopus)

  289 Downloads (Pure)

• The Impact of Hypoxia on Out-of-Field Cell Survival after Exposure to Modulated Radiation Fields

  Thompson, H. F., Butterworth, K. T., McMahon, S. J., Ghita, M., Hounsell, A. R. & Prise, K. M., 11 Oct 2017, In: Radiation Research.

  Research output: Contribution to journal › Article › peer-review

  • hypoxia
  • radiation distribution
  • Hypoxia
  • Cell Survival
  • Radiation
  2 Citations (Scopus)
• 2016

  FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

  McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In: Molecular Cancer Therapeutics. p. 2432-2441 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ionizing Radiation
  • Non-Small Cell Lung Carcinoma
  • Radiation
  • Caspase 8
  • entinostat
  13 Citations (Scopus)

  235 Downloads (Pure)

• Gold nanoparticles for cancer radiotherapy: a review.

  Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In: Cancer Nanotechnology. 7, 8, 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Gold nanoparticles
  • Radiotherapy
  • Gold
  • radiation therapy
  • Nanoparticles
  166 Citations (Scopus)

  464 Downloads (Pure)

• Imaging and radiation effects of gold nanoparticles in tumour cells

  McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In: Scientific Reports. 6, 10 p., 19442.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Effects
  • Gold
  • Nanoparticles
  • DNA Damage
  • Neoplasms
  75 Citations (Scopus)

  295 Downloads (Pure)

• Impact of fractionation on out-of-field survival and DNA damage responses following exposure to intensity modulated radiation fields

  Ghita, M., Coffey, C. B., Butterworth, K. T., McMahon, S. J., Schettino, G. & Prise, K. M., 21 Jan 2016, In: Physics in Medicine and Biology. 61, 2, p. 515-526 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage
  • Appointments and Schedules
  • Radiation
  • Cell Line
  • Survival
  5 Citations (Scopus)

  236 Downloads (Pure)

• New research in ionizing radiation and nanoparticles: the ARGENT project

  Rosa, S., Prise, K., Butterworth, K., Currell, F., Ivosev, V. & de Vera, P., 08 Dec 2016, Nanoscale Insights into Ion-Beam Cancer Therapy. 1 ed. Springer International Publishing, p. 379-434 56 p. 12

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  3 Citations (Scopus)

• Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

  Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In: Nanomedicine. 11, 16, p. 2035-47 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Theranostic Nanomedicine
  • Pentetic Acid
  • Radiotherapy
  • Gold
  • Nanoparticles
  28 Citations (Scopus)

  409 Downloads (Pure)

• Preclinical radiotherapy technology, dosimetry and treatment planning

  Butterworth, K., Ghita, M., McGarry, C. K., Jain, S., Hanna, G. G., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Apr 2016, In: Radiotherapy and Oncology. 119, Supplement 1 , p. S238-S239 2 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

  Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In: Nanotechnology. 27, 21, 11 p., 215101.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gold nanoparticles
  • Protein Disulfide-Isomerases
  • Nanoparticles
  • Cells
  • Proteins
  21 Citations (Scopus)

  199 Downloads (Pure)
• 2015

  Cellular signalling effects in high precision radiotherapy

  McMahon, S. J., McGarry, C. K., Butterworth, K. T., Jain, S., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., 07 Jun 2015, In: Physics in Medicine and Biology. 60, 11, p. 4551-4564 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiotherapy
  • Uncertainty
  • Cell Survival
  • Radiation
  • Neoplasms
  10 Citations (Scopus)

  289 Downloads (Pure)

• Conventional in vivo irradiation procedures are insufficient to accurately determine tumor responses to non-uniform radiation fields

  Butterworth, K. T., Redmond, K. M., McMahon, S. J., Cole, A. J., Jain, S., McCarthy, H. O., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Mar 2015, In: International journal of radiation biology. 91, 3, p. 257-261 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation
  • Neoplasms
  • Tumor Burden
  • Survival
  • Prostate
  5 Citations (Scopus)

  255 Downloads (Pure)

• High dose bystander effects in spatially fractionated radiation therapy

  Asur, R., Butterworth, K. T., Penagaricano, J. A., Prise, K. M. & Griffin, R. J., 01 Jan 2015, In: Cancer Letters. 356, 1, p. 52-57 6 p.

  Research output: Contribution to journal › Special issue › peer-review

  Open Access

  File

  • Bystander Effect
  • Intensity-Modulated Radiotherapy
  • Radiotherapy
  • Radiation
  • Conformal Radiotherapy
  47 Citations (Scopus)

  447 Downloads (Pure)

• Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

  McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In: Cancer Research. 75, 11, p. 2159-2165 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ataxia Telangiectasia
  • DNA Damage
  • Phosphotransferases
  • Neoplasms
  • 2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
  35 Citations (Scopus)

  257 Downloads (Pure)

• Prostate cancer radiotherapy: potential applications of metal nanoparticles for imaging and therapy

  Coulter, J. A., Butterworth, K. T. & Jain, S., 01 Jul 2015, In: British Journal of Radiology. 88, 1054, 9 p., 20150256.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Metal Nanoparticles
  • Radiotherapy
  • Image-Guided Radiotherapy
  • Neoplasms
  • Therapeutics
  8 Citations (Scopus)

  450 Downloads (Pure)

• Time and Cell Type Dependency of Survival Responses in Co-cultured Tumor and Fibroblast Cells after Exposure to Modulated Radiation Fields

  Butterworth, K. T., McMahon, S. J., McKee, J. C., Patel, G., Ghita, M., Cole, A. J., McGarry, C. K., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Jun 2015, In: Radiation Research. 183, 6, p. 656-664 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cultured Tumor Cells
  • fibroblasts
  • radiation distribution
  • tumors
  • Radiation
  5 Citations (Scopus)

  255 Downloads (Pure)
• 2014

  Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

  Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In: Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Investigating the Potential Impact of Four-dimensional Computed Tomography (4DCT) on Toxicity, Outcomes and Dose Escalation for Radical Lung Cancer Radiotherapy

  Cole, A. J., O'Hare, J. M., McMahon, S. J., McGarry, C. K., Butterworth, K. T., McAleese, J., Jain, S., Hounsell, A. R., Prise, K. M., Hanna, G. G. & O'Sullivan, J. M., Mar 2014, In: Clinical Oncology. 26, 3, p. 142-50 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Four-Dimensional Computed Tomography
  • Lung Neoplasms
  • Radiotherapy
  • Organs at Risk
  • Dyspnea
  9 Citations (Scopus)

• Investigation into the radiobiological consequences of pre-treatment verification imaging with megavoltage X-rays in radiotherapy

  Hyland, W. B., McMahon, S. J., Butterworth, K. T., Cole, A. J., King, R. B., Redmond, K. M., Prise, K. M., Hounsell, A. R. & McGarry, C. K., Apr 2014, In: British Journal of Radiology. 87, 1036, 10 p., 20130781.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • X-Rays
  • Radiotherapy
  • Cell Survival
  • Therapeutics
  • Non-Small Cell Lung Carcinoma
  3 Citations (Scopus)

  249 Downloads (Pure)

• Nanoparticle technology: future opportunities in cancer treatment

  Jain, S. & Butterworth, K., 10 Jul 2014.

  Research output: Contribution to conference › Paper

  • Gold nanoparticles
  • Oncology
  • Nanoparticles
  • Ionizing radiation
  • Drug delivery

• Small animal image-guided radiotherapy: status, considerations and potential for translational impact.

  Butterworth, K. T., Prise, K. M. & Verhaegen, F., 26 Nov 2014, In: British Journal of Radiology. 88, 1045, 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Image-Guided Radiotherapy
  • Radiobiology
  • Radiation Oncology
  • Animals
  • Animal Models
  41 Citations (Scopus)

  185 Downloads (Pure)

• The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

  Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In: Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gold nanoparticles
  • Gold
  • Nanoparticles
  • gold
  • nanoparticles
  63 Citations (Scopus)

  308 Downloads (Pure)

• The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

  Sancey, L., Lux, F., Kotb, S., Roux, S., Dufort, S., Bianchi, A., Cremillieux, Y., Fries, P., Coll, J-L., Rodriguez-Lafrasse, C., Janier, M., Dutreix, M., Barberi-Heyob, M., Boschetti, F., Denat, F., Louis, C., Porcel, E., Lacombe, S., Le Duc, G., Deutsch, E. & 9 others, Perfettini, J-L., Detappe, A., Verry, C., Berbeco, R., Butterworth, K. T., Mcmahon, S. J., Prise, K. M., Perriat, P. & Tillement, O., Sep 2014, In: British Journal of Radiology. 87, 1041, 15 p., 20140134.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File
  111 Citations (Scopus)

  334 Downloads (Pure)
• 2013

  A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

  McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In: PloS one. 8, 1, 12 p., e54526.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bystander Effect
  • Radiation
  • cell communication
  • Kinetics
  • Biological Models
  41 Citations (Scopus)

  184 Downloads (Pure)