• Room 02.009 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr Butterworth is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: -Radiation Biology, Radiation Oncology and Cancer Imaging. -Nanomedicine. -Preclinical models and small animal radiotherapy. Previous research experience is desirable although not essential.

20082020

Research output per year

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Research Output

2020
1 Citation (Scopus)
Open Access
File

Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S. & 22 others, Lux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, In : Physics in Medicine and Biology.

Research output: Contribution to journalArticle

2019

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
238 Downloads (Pure)

Evolution of the Supermodel: Progress in Modelling Radiotherapy Response in Mice.

Butterworth, K., 11 Mar 2019, In : Clinical oncology (Royal College of Radiologists (Great Britain)). doi: 10.1016/j.clon.2019.02.008.

Research output: Contribution to journalReview article

Open Access
File
2 Citations (Scopus)
16 Downloads (Pure)

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In : Scientific Reports. 9, 10 p., 12618.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
76 Downloads (Pure)

Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

Butterworth, K., Ghita, M., Brown, K., Kelada, O. & Graves, E. E., 02 Feb 2019, In : Cancers. 11, 2

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
124 Downloads (Pure)

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In : The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
67 Downloads (Pure)
Open Access
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4 Citations (Scopus)
42 Downloads (Pure)
2018

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
164 Downloads (Pure)
4 Citations (Scopus)
59 Downloads (Pure)
2017

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
164 Downloads (Pure)
Open Access
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4 Citations (Scopus)
242 Downloads (Pure)

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In : Cancer Nanotechnology. 8, 2, 25 p.

Research output: Contribution to journalArticle

Open Access
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58 Citations (Scopus)
231 Downloads (Pure)
Open Access
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147 Downloads (Pure)

Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

Research output: Contribution to conferencePoster

Open Access
File
10 Citations (Scopus)
235 Downloads (Pure)

Low-dose radiation-induced risk in spermatogenesis

Fukunaga, H., Butterworth, K. T., Yokoya, A., Ogawa, T. & Prise, K. M., 2017, In : International journal of radiation biology. 93, 12, p. 1291-1298 8 p.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
186 Downloads (Pure)
Open Access
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4 Citations (Scopus)
160 Downloads (Pure)

Small field dosimetry for the small animal radiotherapy research platform (SARRP)

Ghita, M., McMahon, S. J., Thompson, H. F., McGarry, C. K., King, R., Osman, S. O. S., Kane, J. L., Tulk, A., Schettino, G., Butterworth, K. T., Hounsell, A. R. & Prise, K. M., 28 Dec 2017, In : Radiation oncology (London, England). 12, 1, p. 204

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
243 Downloads (Pure)
1 Citation (Scopus)
2016

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
197 Downloads (Pure)

Gold nanoparticles for cancer radiotherapy: a review.

Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In : Cancer Nanotechnology. 7, 8, 20 p.

Research output: Contribution to journalReview article

Open Access
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121 Citations (Scopus)
409 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
256 Downloads (Pure)
Open Access
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5 Citations (Scopus)
181 Downloads (Pure)

New research in ionizing radiation and nanoparticles: the ARGENT project

Rosa, S., Prise, K., Butterworth, K., Currell, F., Ivosev, V. & de Vera, P., 08 Dec 2016, Nanoscale Insights into Ion-Beam Cancer Therapy. 1 ed. Springer International Publishing, p. 379-434 56 p. 12

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
369 Downloads (Pure)

Preclinical radiotherapy technology, dosimetry and treatment planning

Butterworth, K., Ghita, M., McGarry, C. K., Jain, S., Hanna, G. G., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Apr 2016, In : Radiotherapy and Oncology. 119, Supplement 1 , p. S238-S239 2 p.

Research output: Contribution to journalMeeting abstract

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In : Nanotechnology. 27, 21, 11 p., 215101.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
160 Downloads (Pure)
2015
Open Access
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8 Citations (Scopus)
244 Downloads (Pure)
4 Citations (Scopus)
198 Downloads (Pure)

High dose bystander effects in spatially fractionated radiation therapy

Asur, R., Butterworth, K. T., Penagaricano, J. A., Prise, K. M. & Griffin, R. J., 01 Jan 2015, In : Cancer Letters. 356, 1, p. 52-57 6 p.

Research output: Contribution to journalSpecial issue

Open Access
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30 Citations (Scopus)
357 Downloads (Pure)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
208 Downloads (Pure)
Open Access
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7 Citations (Scopus)
400 Downloads (Pure)
Open Access
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4 Citations (Scopus)
189 Downloads (Pure)
2014

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
9 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
211 Downloads (Pure)

Nanoparticle technology: future opportunities in cancer treatment

Jain, S. & Butterworth, K., 10 Jul 2014.

Research output: Contribution to conferencePaper

Open Access
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37 Citations (Scopus)
145 Downloads (Pure)

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In : Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
263 Downloads (Pure)

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

Sancey, L., Lux, F., Kotb, S., Roux, S., Dufort, S., Bianchi, A., Cremillieux, Y., Fries, P., Coll, J-L., Rodriguez-Lafrasse, C., Janier, M., Dutreix, M., Barberi-Heyob, M., Boschetti, F., Denat, F., Louis, C., Porcel, E., Lacombe, S., Le Duc, G., Deutsch, E. & 9 others, Perfettini, J-L., Detappe, A., Verry, C., Berbeco, R., Butterworth, K. T., Mcmahon, S. J., Prise, K. M., Perriat, P. & Tillement, O., Sep 2014, In : British Journal of Radiology. 87, 1041, 15 p., 20140134.

Research output: Contribution to journalLiterature review

Open Access
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93 Citations (Scopus)
238 Downloads (Pure)
2013

A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In : PloS one. 8, 1, 12 p., e54526.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
143 Downloads (Pure)
21 Citations (Scopus)
Open Access
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34 Citations (Scopus)
188 Downloads (Pure)
Open Access
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110 Downloads (Pure)
16 Citations (Scopus)
39 Downloads (Pure)
42 Citations (Scopus)
2012
30 Citations (Scopus)