Karl Butterworth

Research output

Research output per year 2008 2011 2012 2013 2014 2015 2016 2017 2019 2020 2021 2023 2023

• 79 Article
• 9 Review article
• 3 Poster
• 2 Chapter
• 8 More
  • 2 Meeting abstract
  • 2 Comment/debate
  • 1 Paper
  • 1 Editorial
  • 1 Literature review
  • 1 Special issue

Research output per year

Research output per year

Search results

• 2023

  A pulmonary vein atlas for radiotherapy planning

  Walls, G. M., McCann, C., Ball, P., Atkins, K. M., Mak, R. H., Bedair, A., O'Hare, J., McAleese, J., Harrison, C., Tumelty, K. A., Crockett, C., Black, S-L., Nelson, C., O'Connor, J., Hounsell, A. R., McGarry, C. K., Butterworth, K. T., Cole, A. J., Jain, S. & Hanna, G. G., Jul 2023, In: Radiotherapy and Oncology. 184, 9 p., 109680.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy Planning 100%
  • Atlas 100%
  • Radiation Therapy 42%
  • Cardiac Dysrhythmia 42%
  • Patient 28%
  19 Downloads (Pure)

• Assessment of variabilities in lung-contouring methods on CBCT preclinical radiomics outputs

  Brown, K. H., Illyuk, J., Ghita, M., Walls, G. M., McGarry, C. K. & Butterworth, K. T., 09 May 2023, In: Cancers. 15, 10, 12 p., 2677.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Assessment 100%
  • Variability 100%
  • Output 100%
  • Cone 100%
  • Tomography 100%
  1 Citation (Scopus)

  26 Downloads (Pure)

• Association between statin therapy dose intensity and radiation cardiotoxicity in non-small cell lung cancer: results from the NI-HEART study

  Walls, G. M., O'Connor, J., Harbinson, M., McCarron, E. P., Duane, F., McCann, C., McKavanagh, P., Johnston, D. I., Erekkath, J., Giacometti, V., Gavin, A. T., McAleese, J., Hounsell, A. R., Cole, A. J., Butterworth, K. T., McGarry, C. K., Hanna, G. G. & Jain, S., Sep 2023, In: Radiotherapy and Oncology. 186, 9 p., 109762.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Patient 100%
  • Association 100%
  • Combination Therapy 100%
  • Non Small Cell Lung Cancer 100%
  • Statin 100%
  5 Downloads (Pure)

• Development and optimisation of a preclinical cone beam computed tomography-based radiomics workflow for radiation oncology research

  Brown, K. H., Payan, N., Osman, S., Ghita, M., Walls, G. M., Patallo, I. S., Schettino, G., Prise, K. M., McGarry, C. K. & Butterworth, K. T., 18 May 2023, In: Physics and Imaging in Radiation Oncology. 26, 9 p., 100446.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Research 100%
  • Optimization 100%
  • Cone 100%
  • Tomography 100%
  • Oncology 100%
  6 Downloads (Pure)

• Evaluation of radiosensitization and cytokine modulation by differentially PEGylated gold nanoparticles in glioblastoma cells

  Kerr, B. N., Duffy, D., McInerney, C. E., Hutchinson, A., Dabaja, I., Bazzi, R., Roux, S., Prise, K. M. & Butterworth, K. T., 12 Jun 2023, In: International Journal of Molecular Science. 24, 12, 21 p., 10032.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytokine 100%
  • Radiosensitization 100%
  • Modulation 100%
  • Gold Nanoparticle 100%
  • Glioblastoma 100%
  3 Downloads (Pure)

• Introduction to the principles of spatially fractionated radiotherapy

  Butterworth, K. T., Prezado, Y. & Prise, K. M., 01 Jun 2023, Spatially fractionated, microbeam and FLASH radiation therapy: a physics and multi-disciplinary approach . Zhang, H. & Mayr, N. A. (eds.). IOP Publishing Ltd., 17 p. (IPEM-IOP Series in Physics and Engineering in Medicine and Biology).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields

  Matsuya, Y., McMahon, S. J., Butterworth, K. T., Yachi, Y., Saga, R., Sato, T. & Prise, K. M., 07 May 2023, In: Physics in Medicine and Biology. 68, 9, 095008.

  Research output: Contribution to journal › Article › peer-review

  • Radiosensitivity 100%
  • Radiation Field 100%
  • Cell Communication 75%
  • Survival 50%
  • Dose Response 50%

• Roadmap for precision preclinical x-ray radiation studies

  Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H. J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C. G. G., Staut, N., Subiel, A., Vaes, R. D. W., van Hoof, S., Verginadis, I. L., & 3 othersWilkens, J. J., Williams, K. J. & Wilson, G. D., 31 Mar 2023, In: Physics in Medicine and Biology. 68, 6, 06RM01.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiation 100%
  • Model 33%
  • Accuracy 22%
  • Development 11%
  • Malignant Neoplasm 11%
  17 Downloads (Pure)

• Spatial gene expression changes in the mouse heart after base-targeted irradiation

  Walls, G. M., Ghita, M., Queen, R., Edgar, K. S., Gill, E. K., Kuburas, R., Grieve, D. J., Watson, C. J., McWilliam, A., Van Herk, M., Williams, K. J., Cole, A. J., Jain, S. & Butterworth, K. T., 01 Feb 2023, In: International Journal of Radiation Oncology Biology Physics. 115, 2, p. 453-463 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heart 100%
  • Base 75%
  • Gene Expression 75%
  • Radiation 50%
  • Gene 37%
  24 Downloads (Pure)
• 2022

  A scoping review of small animal image-guided radiotherapy research: advances, impact and future opportunities in translational radiobiology

  Brown, K. H., Ghita, M., Dubois, L. J., de Ruysscher, D., Prise, K. M., Verhaegen, F. & Butterworth, K. T., May 2022, In: Clinical and Translational Radiation Oncology. 34, p. 112-119 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Animal 80%
  • Development 40%
  • Radiation Biology 40%
  • Clinical Trial 40%
  25 Downloads (Pure)

• Murine models of radiation cardiotoxicity: a systematic review and recommendations for future studies

  Walls, G. M., O'Kane, R., Ghita, M., Kuburas, R., McGarry, C. K., Cole, A. J., Jain, S. & Butterworth, K. T., 01 Aug 2022, In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 173, p. 19-31

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiation 100%
  • Heart 62%
  • Irradiation 50%
  • Radiation Dose Fractionation 37%
  • Study Design 25%
  35 Downloads (Pure)

• Radiomics for predicting lung cancer outcomes following radiotherapy: a systematic review

  Walls, G. M., Osman, S. O. S., Brown, K. H., Butterworth, K. T., Hanna, G. G., Hounsell, A. R., McGarry, C. K., Leijenaar, R. T. H., Lambin, P., Cole, A. J. & Jain, S., 01 Mar 2022, In: Clinical oncology (Royal College of Radiologists (Great Britain)). 34, 3, p. E107-E122

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiomics 100%
  • Lung Cancer 66%
  • Radiation Therapy 44%
  • Clinical Trial 33%
  • Prospective Study 33%
  174 Downloads (Pure)

• Validation of an established deep learning auto-segmentation tool for cardiac substructures in 4D radiotherapy planning scans

  Walls, G. M., Giacometti, V., Apte, A., Thor, M., McCann, C., Hanna, G. G., O'Connor, J., Deasy, J. O., Hounsell, A. R., Butterworth, K. T., Cole, A. J., Jain, S. & McGarry, C. K., 02 Aug 2022, In: Physics and Imaging in Radiation Oncology. 23, p. 118-126

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy Planning 100%
  • 3D Computed Tomography 100%
  • Computer Assisted Tomography 100%
  • Four Dimensional Computed Tomography 66%
  • Learning 66%
  41 Downloads (Pure)
• 2021

  A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

  Fukunaga, H., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 26 Aug 2021, (Early online date) In: Clinical oncology (Royal College of Radiologists (Great Britain)).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Microbeam 71%
  • Obstetric Delivery 28%
  • Radiation Biology 28%
  • Drug Megadose 14%
  1 Citation (Scopus)

  24 Downloads (Pure)

• Animal Models for Radiotherapy Research: All (Animal) Models Are Wrong but Some Are Useful

  Butterworth, K. T. & Williams, J. P., 16 Mar 2021, In: Cancers. 13, 6, 4 p., 1319.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  52 Downloads (Pure)

• Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Condition

  Adrian, G., Konradsson, E., Beyer, S., Wittrup, A., Butterworth, K. T., McMahon, S. J., Ghita, M., Petersson, K. & Ceberg, C., 29 Jul 2021, (Early online date) In: Frontiers in Oncology. 11, 9 p., 686142.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Line 100%
  • Low Drug Dose 42%
  • Irradiation 42%
  • Drug Megadose 14%
  • Radiation 14%
  57 Downloads (Pure)

• Impact of superparamagnetic iron oxide nanoparticles on in vitro and in vivo radiosensitisation of cancer cells

  Russell, E., Dunne, V., Russell, B., Mohamud, H., Ghita, M., McMahon, S. J., Butterworth, K. T., Schettino, G., McGarry, C. K. & Prise, K. M., 12 Jun 2021, In: Radiation oncology (London, England). 16, 104.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Superparamagnetic Iron Oxide Nanoparticle 100%
  • DNA Damage 42%
  • Radiation 28%
  • Cells 28%
  • U87 21%
  122 Downloads (Pure)

• Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

  Amoroso, F., Glass, K., Singh, R., Liberal, F., Steele, R. E., Maguire, S., Tarapore, R., Allen, J. E., Van Schaeybroeck, S., Butterworth, K. T., Prise, K., O'Sullivan, J. M., Jain, S., Waugh, D. J. & Mills, I. G., 19 Feb 2021, In: Scientific Reports. 11, 1, p. 4252

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Unfolded Protein Response 100%
  • Prostate Cancer 80%
  • Radiation 80%
  • Cancer Cell 60%
  • Programmed Cell Death 40%
  2 Citations (Scopus)

  134 Downloads (Pure)

• Oxygen enhancement ratios of cancer cells after exposure to intensity modulated x-ray fields: DNA damage and cell survival

  Matsuya, Y., McMahon, S. J., Butterworth, K. T., Naijo, S., Nara, I., Yachi, Y., Saga, R., Ishikawa, M., Sato, T., Date, H. & Prise, K. M., 06 Apr 2021, In: Physics in Medicine and Biology. 66, 7, 12 p., 075014.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 100%
  • Radiosensitivity 100%
  • Radioresistance 100%
  • Radiation 80%
  • Cancer Cell 60%
  74 Downloads (Pure)

• Radiobiology of the flash effect

  Friedl, A. A., Prise, K. M., Butterworth, K. T., Montay-Gruel, P. & Favaudon, V., 23 Aug 2021, (Early online date) In: Medical Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drug Megadose 100%
  • Tumor Cell 60%
  • Radiation Therapy 40%
  • Irradiation 40%
  • Radiation Exposure 40%
  40 Downloads (Pure)

• The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia

  Zhang, J., Zhang, Y., Mo, F., Patel, G., Butterworth, K., Shao, C. & Prise, K., 25 Mar 2021, In: Frontiers in Cell and Developmental Biology. 9, 14 p., 637454.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 100%
  • Hypoxia Inducible Factor 1 53%
  • Hypoxia-Inducible Factor 1 53%
  • Bystander Effect 46%
  • Radiation 38%
  113 Downloads (Pure)
• 2020

  A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy

  Petersson, K., Adrian, G., Butterworth, K. & McMahon, S. J., 04 Mar 2020, (Early online date) In: International Journal of Radiation Oncology Biology Physics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oxygen 100%
  • Radiation 54%
  • Radiation Therapy 45%
  • Depletion 36%
  • Oxygen Tension 36%
  33 Citations (Scopus)

  317 Downloads (Pure)

• ATM Kinase Inhibition Preferentially Sensitises PTEN-Deficient Prostate Tumour Cells to Ionising Radiation

  Hanna, C., Dunne, V. L., Walker, S. M., Butterworth, K. T., McCabe, N., Waugh, D. J. J., Kennedy, R. D. & Prise, K. M., 30 Dec 2020, In: Cancers. 13, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Prostate Cancer 100%
  • Cells 75%
  • Therapeutic Procedure 75%
  • Clinical Trial 75%
  47 Downloads (Pure)

• Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

  Ghita, M., Gill, E., Walls, G., Edgar, K., McMahon, S., Vasquez Osorio, E., Bergom, C., Grieve, D., Watson, C., McWilliam, A., Aznar, M., van herk, M., Williams, K. J. & Butterworth, K., 11 Jul 2020, In: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. DOI: 10.1016/j.radonc.2020.07.016 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heart 100%
  • Base 45%
  • Radiation Therapy 27%
  • Therapeutic Procedure 18%
  • Irradiation 18%
  4 Citations (Scopus)

  173 Downloads (Pure)

• Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma

  Armstrong, C., Ong, C. W., Maxwell, P., O'Sullivan, J., Prise, K., Butterworth, K., Coulter, J., Walker, S., Oksana, L., Gallagher, R., Jain, S., Bristow, R. G., Mills, I., Waugh, D. & LaBonte Wilson, M., Sep 2020, In: NAR Cancer. 2, 3, zcaa012.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tumor Suppressor Protein 100%
  • Alpha Chemokine 100%
  • Tumor Progression 66%
  • Hazard Ratio 66%
  • Association 66%
  71 Downloads (Pure)

• Evaluation of a Novel Liquid Fiducial Marker, BioXmark®, for Small Animal Image-Guided Radiotherapy Applications

  Brown, K. H., Ghita, M., Schettino, G., Prise, K. M. & Butterworth, K. T., 18 May 2020, In: Cancers. 12, 5, 14 p., 1276.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Animal 100%
  • Cone Beam Computed Tomography 75%
  • Tumor Growth 50%
  • Neoplasm 25%
  • X-Ray 25%
  67 Downloads (Pure)

• History and current perspectives on the biological effects of high-dose spatial fractionation and high dose-rate approaches: GRID, Microbeam & FLASH radiotherapy

  Griffin, R. J., Prise, K. M., McMahon, S. J., Zhang, X., Penagaricano, J. & Butterworth, K. T., 01 Sep 2020, In: British Journal of Radiology. 93, 1113

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Dose 100%
  • Obstetric Delivery 57%
  • Drug Megadose 57%
  • Procedure 42%
  • Development 28%
  5 Citations (Scopus)

  186 Downloads (Pure)

• Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

  Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S., & 22 othersLux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, (Early online date) In: Physics in Medicine and Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vaccine Adjuvant 100%
  • Drug Delivery Vehicle 100%
  • Radiation 100%
  • Enhancer 66%
  • Potential 66%
  24 Citations (Scopus)

  657 Downloads (Pure)

• Spatially Fractionated Microbeam Analysis of Tissue-sparing Effect for Spermatogenesis

  Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 23 Dec 2020, In: Radiation Research. 194, 6, p. 698-706 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tissues 100%
  • Spermiogenesis 41%
  • Microbeam 33%
  • Stem Cell 25%
  • X-Ray 16%
  1 Citation (Scopus)

  104 Downloads (Pure)
• 2019

  AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

  Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S., & 28 othersFries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In: British Journal of Radiology. 92, 1093, 19 p., 20180365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Animal 100%
  • Toxicity 100%
  • Haplorhini 50%
  • Clinical Trial 50%
  • Biodistribution 50%
  46 Citations (Scopus)

  411 Downloads (Pure)

• Evolution of the Supermodel: Progress in Modelling Radiotherapy Response in Mice.

  Butterworth, K., 11 Mar 2019, In: Clinical oncology (Royal College of Radiologists (Great Britain)). doi: 10.1016/j.clon.2019.02.008.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiation Biology 100%
  • Radiation Therapy 100%
  • Animal 75%
  • Mouse Model 75%
  • Human 50%
  10 Citations (Scopus)

  59 Downloads (Pure)

• High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

  Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In: Scientific Reports. 9, 10 p., 12618.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microbeam 100%
  • Radiation Therapy 71%
  • Tissues 71%
  • Testes 42%
  • Male Fertility 42%
  7 Citations (Scopus)

  131 Downloads (Pure)

• Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

  Butterworth, K., Ghita, M., Brown, K., Kelada, O. & Graves, E. E., 02 Feb 2019, In: Cancers. 11, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiation Therapy 100%
  • Functional Imaging 66%
  • Oncology 33%
  • Patient 33%
  • Diseases 33%
  8 Citations (Scopus)

  223 Downloads (Pure)

• Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

  Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In: The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation 100%
  • Risk Assessment 100%
  • Radiation Therapy 100%
  • Personalized Medicine 60%
  • Radiosensitivity 60%
  6 Citations (Scopus)

  117 Downloads (Pure)

• Preclinical models of radiation induced lung damage: challenges and opportunities for small animal radiotherapy

  Ghita, M., Dunne, V., Hanna, G. G., Prise, K. M., Williams, J. P. & Butterworth, K., 17 Jan 2019, (Early online date) In: British Journal of Radiology. p. 20180473

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation 100%
  • Lung Injury 83%
  • Animal 50%
  • Toxicity 16%
  • Preclinical Study 16%
  8 Citations (Scopus)

  125 Downloads (Pure)
• 2018

  Microbeam evolution: From single cell irradiation to pre-clinical studies

  Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, (Early online date) In: International journal of radiation biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microbeam 100%
  • Development 50%
  • Cells 37%
  • Irradiation 37%
  • Aptitude 25%
  12 Citations (Scopus)

  261 Downloads (Pure)

• Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field

  Ghita, M., Dunne, V. L., McMahon, S. J., Osman, S. O., Small, D. M., Weldon, S., Taggart, C. C., McGarry, C. K., Hounsell, A. R., Graves, E. E., Prise, K. M., Hanna, G. G. & Butterworth, K. T., 12 Dec 2018, (Early online date) In: International journal of radiation oncology, biology, physics. 103, 5, p. 1231-1240 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation 100%
  • Marker 33%
  • Volume CT 33%
  • Fibrosis 33%
  • Toxicity 33%
  6 Citations (Scopus)

  256 Downloads (Pure)

• Radio-resistance of PTEN-deficient prostate tumours is enhanced by treatment-induced chemokine signalling and is associated with biochemical recurrence and development of metastasis.

  Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., Butterworth, K., Oksana, L., Berlingeri, S., LaBonte Wilson, M., Walker, S., O'Sullivan, J., Salto-Tellez, M., Jain, S., Mills, I., Illidge, T., Kennedy, R., Prise, K. & Waugh, D., 01 Aug 2018.

  Research output: Contribution to conference › Poster › peer-review
• 2017

  A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

  Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In: Scientific Reports. 7, 44752 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gold Nanoparticle 100%
  • Gold Nanoparticles 100%
  • Microbeam 88%
  • X-Ray 33%
  • Radiosensitization 33%
  31 Citations (Scopus)

  218 Downloads (Pure)

• An Overview of Current Practice in External Beam Radiation Oncology with Consideration to Potential Benefits and Challenges for Nanotechnology

  King, R., McMahon, S., Hyland, W., Jain, S., Butterworth, K., Prise, K., Hounsell, A. & McGarry, C., Dec 2017, In: Cancer Nanotechnology. 8, 3, p. 3

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Nanotechnology 100%
  • Electric Potential 75%
  • Radiation Oncology 75%
  • Radiotherapy 50%
  • Patient 50%
  6 Citations (Scopus)

  334 Downloads (Pure)

• Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

  Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In: Cancer Nanotechnology. 8, 2, 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gold Nanoparticle 100%
  • Gold Nanoparticles 100%
  • Biological Product 75%
  • Radiosensitization 50%
  • Comprehension 50%
  104 Citations (Scopus)

  327 Downloads (Pure)

• Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of normal and urothelial cancer cells

  Bill, M., Srivastava, K., Breen, C., Butterworth, K., McMahon, S., Prise, K. & McCloskey, K., 24 Oct 2017, In: Oncotarget.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 100%
  • Urothelial Cancer 62%
  • Survival 50%
  • Radiation 50%
  • Adenosine Triphosphate 50%
  4 Citations (Scopus)

  212 Downloads (Pure)

• Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

  Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy

  Dunne, V., Ghita, M., Small, D. M., Coffey, C. B. M., Weldon, S., Taggart, C. C., Osman, S. O., McGarry, C. K., Prise, K. M., Hanna, G. G. & Butterworth, K. T., 08 Jul 2017, (Early online date) In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 124, 3, p. 475-481

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation 100%
  • Non Small Cell Lung Cancer 83%
  • Radiation Induced Fibrosis 66%
  • Ataxia Telangiectasia 66%
  • In Vitro 33%
  18 Citations (Scopus)

  558 Downloads (Pure)

• Low-dose radiation-induced risk in spermatogenesis

  Fukunaga, H., Butterworth, K. T., Yokoya, A., Ogawa, T. & Prise, K. M., 2017, In: International journal of radiation biology. 93, 12, p. 1291-1298 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Spermiogenesis 100%
  • Low Drug Dose 83%
  • Radiation 66%
  • Male Fertility 33%
  • Stem Cell 33%
  12 Citations (Scopus)

  539 Downloads (Pure)

• Modelling responses to spatially fractionated radiation fields using preclinical image-guided radiotherapy

  Butterworth, K. T., Ghita, M., McMahon, S. J., McGarry, C. K., Griffin, R. J., Hounsell, A. R. & Prise, K. M., Jan 2017, In: British Journal of Radiology. 1069

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation 100%
  • Radiation Therapy 66%
  • Therapeutic Procedure 33%
  • Combination Therapy 33%
  • Cell Communication 33%
  9 Citations (Scopus)

  221 Downloads (Pure)

• Small field dosimetry for the small animal radiotherapy research platform (SARRP)

  Ghita, M., McMahon, S. J., Thompson, H. F., McGarry, C. K., King, R., Osman, S. O. S., Kane, J. L., Tulk, A., Schettino, G., Butterworth, K. T., Hounsell, A. R. & Prise, K. M., 28 Dec 2017, In: Radiation oncology (London, England). 12, 1, p. 204

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dosimetry 100%
  • Radiation Therapy 60%
  • Thrombectomy Device 40%
  • Reproducibility 20%
  • Image-Guided Radiation Therapy 20%
  18 Citations (Scopus)

  339 Downloads (Pure)

• The Impact of Hypoxia on Out-of-Field Cell Survival after Exposure to Modulated Radiation Fields

  Thompson, H. F., Butterworth, K. T., McMahon, S. J., Ghita, M., Hounsell, A. R. & Prise, K. M., 11 Oct 2017, (Early online date) In: Radiation Research.

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Hypoxia 100%
  • Oxygen 74%
  • Cell Survival 74%
  • Survival 50%
  4 Citations (Scopus)
• 2016

  FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

  McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In: Molecular Cancer Therapeutics. p. 2432-2441 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ionizing Radiation 100%
  • Non Small Cell Lung Cancer 87%
  • Apoptosis 50%
  • Cell Death 50%
  • Death Receptor 25%
  14 Citations (Scopus)

  272 Downloads (Pure)

• Gold nanoparticles for cancer radiotherapy: a review.

  Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In: Cancer Nanotechnology. 7, 8, 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Radiation 100%
  • X-Ray 50%
  • Neoplasm 50%
  • Gold Nanoparticle 50%
  • Absence 25%
  203 Citations (Scopus)

  512 Downloads (Pure)