Karl Butterworth

2020

A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy

Petersson, K., Adrian, G., Butterworth, K. & McMahon, S. J., 04 Mar 2020, In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Evaluation of a Novel Liquid Fiducial Marker, BioXmark®, for Small Animal Image-Guided Radiotherapy Applications

Brown, K. H., Ghita, M., Schettino, G., Prise, K. M. & Butterworth, K. T., 18 May 2020, In : Cancers. 12, 5, 14 p., 1276.

Research output: Contribution to journal › Article

Open Access

File

Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S. & 22 others, Lux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, In : Physics in Medicine and Biology.

Research output: Contribution to journal › Article

2019

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journal › Article

Open Access

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13 Citations (Scopus)

238 Downloads (Pure)

Evolution of the Supermodel: Progress in Modelling Radiotherapy Response in Mice.

Butterworth, K., 11 Mar 2019, In : Clinical oncology (Royal College of Radiologists (Great Britain)). doi: 10.1016/j.clon.2019.02.008.

Research output: Contribution to journal › Review article

Open Access

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2 Citations (Scopus)

16 Downloads (Pure)

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In : Scientific Reports. 9, 10 p., 12618.

Research output: Contribution to journal › Article

Open Access

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1 Citation (Scopus)

76 Downloads (Pure)

Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

Butterworth, K., Ghita, M., Brown, K., Kelada, O. & Graves, E. E., 02 Feb 2019, In : Cancers. 11, 2

Research output: Contribution to journal › Review article

Open Access

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3 Citations (Scopus)

124 Downloads (Pure)

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In : The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

Research output: Contribution to journal › Article

Open Access

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2 Citations (Scopus)

67 Downloads (Pure)

Preclinical models of radiation induced lung damage: challenges and opportunities for small animal radiotherapy

Ghita, M., Dunne, V., Hanna, G. G., Prise, K. M., Williams, J. P. & Butterworth, K., 17 Jan 2019, In : British Journal of Radiology. p. 20180473

Research output: Contribution to journal › Article

Open Access

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4 Citations (Scopus)

42 Downloads (Pure)

2018

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journal › Article

Open Access

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3 Citations (Scopus)

164 Downloads (Pure)

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field

Ghita, M., Dunne, V. L., McMahon, S. J., Osman, S. O., Small, D. M., Weldon, S., Taggart, C. C., McGarry, C. K., Hounsell, A. R., Graves, E. E., Prise, K. M., Hanna, G. G. & Butterworth, K. T., 12 Dec 2018, In : International journal of radiation oncology, biology, physics.

Research output: Contribution to journal › Article

Open Access

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4 Citations (Scopus)

59 Downloads (Pure)

Radio-resistance of PTEN-deficient prostate tumours is enhanced by treatment-induced chemokine signalling and is associated with biochemical recurrence and development of metastasis.

Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., Butterworth, K., Oksana, L., Berlingeri, S., LaBonte Wilson, M., Walker, S., O'Sullivan, J., Salto-Tellez, M., Jain, S., Mills, I., Illidge, T., Kennedy, R., Prise, K. & Waugh, D., 01 Aug 2018.

Research output: Contribution to conference › Poster

2017

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journal › Article

Open Access

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18 Citations (Scopus)

164 Downloads (Pure)

An Overview of Current Practice in External Beam Radiation Oncology with Consideration to Potential Benefits and Challenges for Nanotechnology

King, R., McMahon, S., Hyland, W., Jain, S., Butterworth, K., Prise, K., Hounsell, A. & McGarry, C., Dec 2017, In : Cancer Nanotechnology. 8, 3, p. 3

Research output: Contribution to journal › Review article

Open Access

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4 Citations (Scopus)

242 Downloads (Pure)

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In : Cancer Nanotechnology. 8, 2, 25 p.

Research output: Contribution to journal › Article

Open Access

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58 Citations (Scopus)

231 Downloads (Pure)

Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of normal and urothelial cancer cells

Bill, M., Srivastava, K., Breen, C., Butterworth, K., McMahon, S., Prise, K. & McCloskey, K., 24 Oct 2017, In : Oncotarget.

Research output: Contribution to journal › Article

Open Access

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147 Downloads (Pure)

Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

Research output: Contribution to conference › Poster

Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy

Dunne, V., Ghita, M., Small, D. M., Coffey, C. B. M., Weldon, S., Taggart, C. C., Osman, S. O., McGarry, C. K., Prise, K. M., Hanna, G. G. & Butterworth, K. T., 08 Jul 2017, In : Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 124, 3, p. 475-481

Research output: Contribution to journal › Article

Open Access

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10 Citations (Scopus)

235 Downloads (Pure)

Low-dose radiation-induced risk in spermatogenesis

Fukunaga, H., Butterworth, K. T., Yokoya, A., Ogawa, T. & Prise, K. M., 2017, In : International journal of radiation biology. 93, 12, p. 1291-1298 8 p.

Research output: Contribution to journal › Review article

Open Access

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6 Citations (Scopus)

186 Downloads (Pure)

Modelling responses to spatially fractionated radiation fields using preclinical image-guided radiotherapy

Butterworth, K. T., Ghita, M., McMahon, S. J., McGarry, C. K., Griffin, R. J., Hounsell, A. R. & Prise, K. M., Jan 2017, In : British Journal of Radiology. 1069

Research output: Contribution to journal › Article

Open Access

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4 Citations (Scopus)

160 Downloads (Pure)

Small field dosimetry for the small animal radiotherapy research platform (SARRP)

Ghita, M., McMahon, S. J., Thompson, H. F., McGarry, C. K., King, R., Osman, S. O. S., Kane, J. L., Tulk, A., Schettino, G., Butterworth, K. T., Hounsell, A. R. & Prise, K. M., 28 Dec 2017, In : Radiation oncology (London, England). 12, 1, p. 204

Research output: Contribution to journal › Article

Open Access

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11 Citations (Scopus)

243 Downloads (Pure)

The Impact of Hypoxia on Out-of-Field Cell Survival after Exposure to Modulated Radiation Fields

Thompson, H. F., Butterworth, K. T., McMahon, S. J., Ghita, M., Hounsell, A. R. & Prise, K. M., 11 Oct 2017, In : Radiation Research.

Research output: Contribution to journal › Article

1 Citation (Scopus)

2016

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journal › Article

Open Access

File

10 Citations (Scopus)

197 Downloads (Pure)

Gold nanoparticles for cancer radiotherapy: a review.

Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In : Cancer Nanotechnology. 7, 8, 20 p.

Research output: Contribution to journal › Review article

Open Access

File

121 Citations (Scopus)

409 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journal › Article

Open Access

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59 Citations (Scopus)

256 Downloads (Pure)

Impact of fractionation on out-of-field survival and DNA damage responses following exposure to intensity modulated radiation fields

Ghita, M., Coffey, C. B., Butterworth, K. T., McMahon, S. J., Schettino, G. & Prise, K. M., 21 Jan 2016, In : Physics in Medicine and Biology. 61, 2, p. 515-526 12 p.

Research output: Contribution to journal › Article

Open Access

File

5 Citations (Scopus)

181 Downloads (Pure)

New research in ionizing radiation and nanoparticles: the ARGENT project

Rosa, S., Prise, K., Butterworth, K., Currell, F., Ivosev, V. & de Vera, P., 08 Dec 2016, Nanoscale Insights into Ion-Beam Cancer Therapy. 1 ed. Springer International Publishing, p. 379-434 56 p. 12

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journal › Article

Open Access

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26 Citations (Scopus)

369 Downloads (Pure)

Preclinical radiotherapy technology, dosimetry and treatment planning

Butterworth, K., Ghita, M., McGarry, C. K., Jain, S., Hanna, G. G., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Apr 2016, In : Radiotherapy and Oncology. 119, Supplement 1 , p. S238-S239 2 p.

Research output: Contribution to journal › Meeting abstract

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In : Nanotechnology. 27, 21, 11 p., 215101.

Research output: Contribution to journal › Article

Open Access

File

17 Citations (Scopus)

160 Downloads (Pure)

2015

Cellular signalling effects in high precision radiotherapy

McMahon, S. J., McGarry, C. K., Butterworth, K. T., Jain, S., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., 07 Jun 2015, In : Physics in Medicine and Biology. 60, 11, p. 4551-4564 14 p.

Research output: Contribution to journal › Article

Open Access

File

8 Citations (Scopus)

244 Downloads (Pure)

Conventional in vivo irradiation procedures are insufficient to accurately determine tumor responses to non-uniform radiation fields

Butterworth, K. T., Redmond, K. M., McMahon, S. J., Cole, A. J., Jain, S., McCarthy, H. O., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Mar 2015, In : International journal of radiation biology. 91, 3, p. 257-261 5 p.

Research output: Contribution to journal › Article

Open Access

File

4 Citations (Scopus)

198 Downloads (Pure)

High dose bystander effects in spatially fractionated radiation therapy

Asur, R., Butterworth, K. T., Penagaricano, J. A., Prise, K. M. & Griffin, R. J., 01 Jan 2015, In : Cancer Letters. 356, 1, p. 52-57 6 p.

Research output: Contribution to journal › Special issue

Open Access

File

30 Citations (Scopus)

357 Downloads (Pure)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journal › Article

Open Access

File

27 Citations (Scopus)

208 Downloads (Pure)

Prostate cancer radiotherapy: potential applications of metal nanoparticles for imaging and therapy

Coulter, J. A., Butterworth, K. T. & Jain, S., 01 Jul 2015, In : British Journal of Radiology. 88, 1054, 9 p., 20150256.

Research output: Contribution to journal › Review article

Open Access

File

7 Citations (Scopus)

400 Downloads (Pure)

Time and Cell Type Dependency of Survival Responses in Co-cultured Tumor and Fibroblast Cells after Exposure to Modulated Radiation Fields

Butterworth, K. T., McMahon, S. J., McKee, J. C., Patel, G., Ghita, M., Cole, A. J., McGarry, C. K., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Jun 2015, In : Radiation Research. 183, 6, p. 656-664 9 p.

Research output: Contribution to journal › Article

Open Access

File

4 Citations (Scopus)

189 Downloads (Pure)

2014

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journal › Article

47 Citations (Scopus)

Investigating the Potential Impact of Four-dimensional Computed Tomography (4DCT) on Toxicity, Outcomes and Dose Escalation for Radical Lung Cancer Radiotherapy

Cole, A. J., O'Hare, J. M., McMahon, S. J., McGarry, C. K., Butterworth, K. T., McAleese, J., Jain, S., Hounsell, A. R., Prise, K. M., Hanna, G. G. & O'Sullivan, J. M., Mar 2014, In : Clinical Oncology. 26, 3, p. 142-50 9 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Investigation into the radiobiological consequences of pre-treatment verification imaging with megavoltage X-rays in radiotherapy

Hyland, W. B., McMahon, S. J., Butterworth, K. T., Cole, A. J., King, R. B., Redmond, K. M., Prise, K. M., Hounsell, A. R. & McGarry, C. K., Apr 2014, In : British Journal of Radiology. 87, 1036, 10 p., 20130781.

Research output: Contribution to journal › Article

Open Access

File

2 Citations (Scopus)

211 Downloads (Pure)

Nanoparticle technology: future opportunities in cancer treatment

Jain, S. & Butterworth, K., 10 Jul 2014.

Research output: Contribution to conference › Paper

Small animal image-guided radiotherapy: status, considerations and potential for translational impact.

Butterworth, K. T., Prise, K. M. & Verhaegen, F., 26 Nov 2014, In : British Journal of Radiology. 88, 1045, 3 p.

Research output: Contribution to journal › Article

Open Access

File

37 Citations (Scopus)

145 Downloads (Pure)

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In : Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

Research output: Contribution to journal › Article

Open Access

File

54 Citations (Scopus)

263 Downloads (Pure)

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

Sancey, L., Lux, F., Kotb, S., Roux, S., Dufort, S., Bianchi, A., Cremillieux, Y., Fries, P., Coll, J-L., Rodriguez-Lafrasse, C., Janier, M., Dutreix, M., Barberi-Heyob, M., Boschetti, F., Denat, F., Louis, C., Porcel, E., Lacombe, S., Le Duc, G., Deutsch, E. & 9 others, Perfettini, J-L., Detappe, A., Verry, C., Berbeco, R., Butterworth, K. T., Mcmahon, S. J., Prise, K. M., Perriat, P. & Tillement, O., Sep 2014, In : British Journal of Radiology. 87, 1041, 15 p., 20140134.

Research output: Contribution to journal › Literature review

Open Access

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93 Citations (Scopus)

238 Downloads (Pure)

2013