• Room 02.009 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr Butterworth is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: -Radiation Biology, Radiation Oncology and Cancer Imaging. -Nanomedicine. -Preclinical models and small animal radiotherapy. Previous research experience is desirable although not essential.

20082020

Research output per year

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Research Output

Variation of strand break yield for plasmid DNA irradiated with high-Z metal nanoparticles.

Butterworth, K., Wyer, J. A., Brennan-Fournet, M., Latimer, C., Shah, M., Currell, F. & Hirst, D., Sep 2008, In : Radiation Research. 170, 3, p. 381-387 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2009

Fragmentation and plasmid strand breaks in pure and gold-doped DNA irradiated by beams of fast hydrogen atoms

Wyer, J. A., Butterworth, K., Hirst, D., Latimer, C., Montenegro, E. C., Shah, M. & Currell, F., 2009, In : Physics in Medicine and Biology. 54, 15, p. 4705-4721 17 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2010
19 Citations (Scopus)

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.

Butterworth, K., Jain, S., Coulter, J., Folker, J., McMahon, S., Schettino, G., Prise, K., Currell, F. & Hirst, D., Jun 2010, In : Nanotechnology. 21(29), 29, p. 295101-295110 10 p., 295101.

Research output: Contribution to journalArticle

151 Citations (Scopus)
2011

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

McMahon, S., Hyland, W., Muir, M., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., 20 Jun 2011, In : Nature Scientific Reports. 1, 18.

Research output: Contribution to journalArticle

File
236 Citations (Scopus)
217 Downloads (Pure)

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

McMahon, S., Hyland, W. B., Brun, E., Butterworth, K., Coulter, J., Douki, T., Hirst, D., Jain, S., Kavanagh, A., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K., Requardt, H., Sanche, L., Schettino, G., Currell, F. & Sicard-Roselli, C., 20 Oct 2011, In : Journal of Physical Chemistry C. 115, 41, p. 20160-20167 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Erratum: Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles (Scientific Reports (2011) 1 (018) DOI:10.1038/srep00018)

McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., Prise, K. M., Hirst, D. G. & Currell, F. J., 20 Jun 2011, In : Scientific Reports. 3, 1725.

Research output: Contribution to journalComment/debate

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

McMahon, S., Hyland, W., Muir, M. F., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., Sep 2011, In : Radiotherapy and Oncology. 100, 3, p. 412-416 5 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
61 Citations (Scopus)
16 Citations (Scopus)
2012
30 Citations (Scopus)

Cell survival responses after exposure to modulated radiation fields.

Trainor, C., Butterworth, K., McGarry, C., Liberante, F., O'Sullivan, J., Hounsell, A. & Prise, K., Jan 2012, In : Radiation Research. 177, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

Coulter, J. A., Jain, S., Butterworth, K. T., Taggart, L. E., Dickson, G. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Trainor, C., Hounsell, A. R., O'Sullivan, J. M., Schettino, G., Currell, F. J., Hirst, D. G. & Prise, K. M., 2012, In : International Journal of Nanomedicine. 7, null, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

Open Access
File
123 Citations (Scopus)
594 Downloads (Pure)
2 Citations (Scopus)

DNA damage responses following exposure to modulated radiation fields

Trainor, C., Butterworth, K. T., McGarry, C. K., McMahon, S. J., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., 17 Aug 2012, In : PLoS ONE. 7, 8, 13 p., e43326.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
174 Downloads (Pure)
25 Citations (Scopus)
15 Citations (Scopus)

Physical basis and biological mechanisms of gold nanoparticle radiosensitization

Butterworth, K. T., McMahon, S. J., Currell, F. J. & Prise, K. M., 21 Aug 2012, In : Nanoscale. 4, 16, p. 4830-8 9 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries

Butterworth, K. T., McGarry, C. K., Clasie, B., Carabe-Fernandez, A., Schuemann, J., Depauw, N., Tang, S., McMahon, S. J., Schettino, G., O'Sullivan, J. M., Lu, H-M., Kooy, H., Paganetti, H., Hounsell, A. R., Held, K. D. & Prise, K. M., 21 Oct 2012, In : Physics in Medicine and Biology. 57, 20, p. 6671-6680 10 p., 6671.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013

A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In : PloS one. 8, 1, 12 p., e54526.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
148 Downloads (Pure)
21 Citations (Scopus)
Open Access
File
34 Citations (Scopus)
196 Downloads (Pure)
Open Access
File
114 Downloads (Pure)
16 Citations (Scopus)
39 Downloads (Pure)
44 Citations (Scopus)
2014

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
9 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
213 Downloads (Pure)

Nanoparticle technology: future opportunities in cancer treatment

Jain, S. & Butterworth, K., 10 Jul 2014.

Research output: Contribution to conferencePaper

Open Access
File
37 Citations (Scopus)
153 Downloads (Pure)

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In : Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
266 Downloads (Pure)

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

Sancey, L., Lux, F., Kotb, S., Roux, S., Dufort, S., Bianchi, A., Cremillieux, Y., Fries, P., Coll, J-L., Rodriguez-Lafrasse, C., Janier, M., Dutreix, M., Barberi-Heyob, M., Boschetti, F., Denat, F., Louis, C., Porcel, E., Lacombe, S., Le Duc, G., Deutsch, E. & 9 others, Perfettini, J-L., Detappe, A., Verry, C., Berbeco, R., Butterworth, K. T., Mcmahon, S. J., Prise, K. M., Perriat, P. & Tillement, O., Sep 2014, In : British Journal of Radiology. 87, 1041, 15 p., 20140134.

Research output: Contribution to journalLiterature review

Open Access
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93 Citations (Scopus)
246 Downloads (Pure)
2015
Open Access
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9 Citations (Scopus)
248 Downloads (Pure)
5 Citations (Scopus)
205 Downloads (Pure)

High dose bystander effects in spatially fractionated radiation therapy

Asur, R., Butterworth, K. T., Penagaricano, J. A., Prise, K. M. & Griffin, R. J., 01 Jan 2015, In : Cancer Letters. 356, 1, p. 52-57 6 p.

Research output: Contribution to journalSpecial issue

Open Access
File
31 Citations (Scopus)
371 Downloads (Pure)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
213 Downloads (Pure)
Open Access
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7 Citations (Scopus)
407 Downloads (Pure)
Open Access
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4 Citations (Scopus)
193 Downloads (Pure)
2016

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
205 Downloads (Pure)

Gold nanoparticles for cancer radiotherapy: a review.

Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In : Cancer Nanotechnology. 7, 8, 20 p.

Research output: Contribution to journalReview article

Open Access
File
124 Citations (Scopus)
415 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
259 Downloads (Pure)
Open Access
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5 Citations (Scopus)
185 Downloads (Pure)

New research in ionizing radiation and nanoparticles: the ARGENT project

Rosa, S., Prise, K., Butterworth, K., Currell, F., Ivosev, V. & de Vera, P., 08 Dec 2016, Nanoscale Insights into Ion-Beam Cancer Therapy. 1 ed. Springer International Publishing, p. 379-434 56 p. 12

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
373 Downloads (Pure)

Preclinical radiotherapy technology, dosimetry and treatment planning

Butterworth, K., Ghita, M., McGarry, C. K., Jain, S., Hanna, G. G., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., Apr 2016, In : Radiotherapy and Oncology. 119, Supplement 1 , p. S238-S239 2 p.

Research output: Contribution to journalMeeting abstract