• Room 02.009 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr Butterworth is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: -Radiation Biology, Radiation Oncology and Cancer Imaging. -Nanomedicine. -Preclinical models and small animal radiotherapy. Previous research experience is desirable although not essential.

20082020

Research output per year

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Research Output

30 Citations (Scopus)

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
251 Downloads (Pure)

A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In : PloS one. 8, 1, 12 p., e54526.

Research output: Contribution to journalArticle

Open Access
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38 Citations (Scopus)
149 Downloads (Pure)

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
173 Downloads (Pure)
21 Citations (Scopus)
Open Access
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4 Citations (Scopus)
247 Downloads (Pure)
2 Citations (Scopus)
19 Citations (Scopus)

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

McMahon, S., Hyland, W., Muir, M., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., 20 Jun 2011, In : Nature Scientific Reports. 1, 18.

Research output: Contribution to journalArticle

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237 Citations (Scopus)
220 Downloads (Pure)

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In : Cancer Nanotechnology. 8, 2, 25 p.

Research output: Contribution to journalArticle

Open Access
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60 Citations (Scopus)
238 Downloads (Pure)
Open Access
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34 Citations (Scopus)
196 Downloads (Pure)

Cell survival responses after exposure to modulated radiation fields.

Trainor, C., Butterworth, K., McGarry, C., Liberante, F., O'Sullivan, J., Hounsell, A. & Prise, K., Jan 2012, In : Radiation Research. 177, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

Coulter, J. A., Jain, S., Butterworth, K. T., Taggart, L. E., Dickson, G. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Trainor, C., Hounsell, A. R., O'Sullivan, J. M., Schettino, G., Currell, F. J., Hirst, D. G. & Prise, K. M., 2012, In : International Journal of Nanomedicine. 7, null, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

Open Access
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124 Citations (Scopus)
598 Downloads (Pure)
Open Access
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9 Citations (Scopus)
249 Downloads (Pure)
Open Access
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3 Downloads (Pure)
5 Citations (Scopus)
206 Downloads (Pure)
2 Citations (Scopus)

DNA damage responses following exposure to modulated radiation fields

Trainor, C., Butterworth, K. T., McGarry, C. K., McMahon, S. J., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., 17 Aug 2012, In : PLoS ONE. 7, 8, 13 p., e43326.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
175 Downloads (Pure)
25 Citations (Scopus)
Open Access
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154 Downloads (Pure)

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

McMahon, S., Hyland, W. B., Brun, E., Butterworth, K., Coulter, J., Douki, T., Hirst, D., Jain, S., Kavanagh, A., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K., Requardt, H., Sanche, L., Schettino, G., Currell, F. & Sicard-Roselli, C., 20 Oct 2011, In : Journal of Physical Chemistry C. 115, 41, p. 20160-20167 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

Research output: Contribution to conferencePoster

Erratum: Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles (Scientific Reports (2011) 1 (018) DOI:10.1038/srep00018)

McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., Prise, K. M., Hirst, D. G. & Currell, F. J., 20 Jun 2011, In : Scientific Reports. 3, 1725.

Research output: Contribution to journalComment/debate

Open Access
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3 Downloads (Pure)

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.

Butterworth, K., Jain, S., Coulter, J., Folker, J., McMahon, S., Schettino, G., Prise, K., Currell, F. & Hirst, D., Jun 2010, In : Nanotechnology. 21(29), 29, p. 295101-295110 10 p., 295101.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Evolution of the Supermodel: Progress in Modelling Radiotherapy Response in Mice.

Butterworth, K., 11 Mar 2019, In : Clinical oncology (Royal College of Radiologists (Great Britain)). doi: 10.1016/j.clon.2019.02.008.

Research output: Contribution to journalReview article

Open Access
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2 Citations (Scopus)
22 Downloads (Pure)

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
205 Downloads (Pure)

Fragmentation and plasmid strand breaks in pure and gold-doped DNA irradiated by beams of fast hydrogen atoms

Wyer, J. A., Butterworth, K., Hirst, D., Latimer, C., Montenegro, E. C., Shah, M. & Currell, F., 2009, In : Physics in Medicine and Biology. 54, 15, p. 4705-4721 17 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Gold nanoparticles for cancer radiotherapy: a review.

Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., V. Solov’yov, A., Prise, K. M., Golding, J. & Mason, N. J., 03 Nov 2016, In : Cancer Nanotechnology. 7, 8, 20 p.

Research output: Contribution to journalReview article

Open Access
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126 Citations (Scopus)
415 Downloads (Pure)

High dose bystander effects in spatially fractionated radiation therapy

Asur, R., Butterworth, K. T., Penagaricano, J. A., Prise, K. M. & Griffin, R. J., 01 Jan 2015, In : Cancer Letters. 356, 1, p. 52-57 6 p.

Research output: Contribution to journalSpecial issue

Open Access
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31 Citations (Scopus)
373 Downloads (Pure)

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In : Scientific Reports. 9, 10 p., 12618.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
80 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
259 Downloads (Pure)
Open Access
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115 Downloads (Pure)
Open Access
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5 Citations (Scopus)
185 Downloads (Pure)
16 Citations (Scopus)
39 Downloads (Pure)
Open Access
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10 Citations (Scopus)
243 Downloads (Pure)

Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

Butterworth, K., Ghita, M., Brown, K., Kelada, O. & Graves, E. E., 02 Feb 2019, In : Cancers. 11, 2

Research output: Contribution to journalReview article

Open Access
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3 Citations (Scopus)
129 Downloads (Pure)
9 Citations (Scopus)
Open Access
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2 Citations (Scopus)
213 Downloads (Pure)
15 Citations (Scopus)

Low-dose radiation-induced risk in spermatogenesis

Fukunaga, H., Butterworth, K. T., Yokoya, A., Ogawa, T. & Prise, K. M., 2017, In : International journal of radiation biology. 93, 12, p. 1291-1298 8 p.

Research output: Contribution to journalReview article

Open Access
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6 Citations (Scopus)
198 Downloads (Pure)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
215 Downloads (Pure)

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
171 Downloads (Pure)
Open Access
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5 Citations (Scopus)
163 Downloads (Pure)

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

McMahon, S., Hyland, W., Muir, M. F., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., Sep 2011, In : Radiotherapy and Oncology. 100, 3, p. 412-416 5 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Nanoparticle technology: future opportunities in cancer treatment

Jain, S. & Butterworth, K., 10 Jul 2014.

Research output: Contribution to conferencePaper