• Room 02.009 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr Butterworth is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: -Radiation Biology, Radiation Oncology and Cancer Imaging. -Nanomedicine. -Preclinical models and small animal radiotherapy. Previous research experience is desirable although not essential.

20082020

Research output per year

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Research Output

Article
30 Citations (Scopus)

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
250 Downloads (Pure)

A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In : PloS one. 8, 1, 12 p., e54526.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
148 Downloads (Pure)

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
172 Downloads (Pure)
21 Citations (Scopus)
1 Citation (Scopus)
19 Citations (Scopus)

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

McMahon, S., Hyland, W., Muir, M., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., 20 Jun 2011, In : Nature Scientific Reports. 1, 18.

Research output: Contribution to journalArticle

File
236 Citations (Scopus)
217 Downloads (Pure)

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In : Cancer Nanotechnology. 8, 2, 25 p.

Research output: Contribution to journalArticle

Open Access
File
60 Citations (Scopus)
238 Downloads (Pure)
Open Access
File
34 Citations (Scopus)
196 Downloads (Pure)

Cell survival responses after exposure to modulated radiation fields.

Trainor, C., Butterworth, K., McGarry, C., Liberante, F., O'Sullivan, J., Hounsell, A. & Prise, K., Jan 2012, In : Radiation Research. 177, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

Coulter, J. A., Jain, S., Butterworth, K. T., Taggart, L. E., Dickson, G. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Trainor, C., Hounsell, A. R., O'Sullivan, J. M., Schettino, G., Currell, F. J., Hirst, D. G. & Prise, K. M., 2012, In : International Journal of Nanomedicine. 7, null, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

Open Access
File
123 Citations (Scopus)
594 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
248 Downloads (Pure)
5 Citations (Scopus)
205 Downloads (Pure)
2 Citations (Scopus)

DNA damage responses following exposure to modulated radiation fields

Trainor, C., Butterworth, K. T., McGarry, C. K., McMahon, S. J., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., 17 Aug 2012, In : PLoS ONE. 7, 8, 13 p., e43326.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
174 Downloads (Pure)
25 Citations (Scopus)
Open Access
File
152 Downloads (Pure)

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

McMahon, S., Hyland, W. B., Brun, E., Butterworth, K., Coulter, J., Douki, T., Hirst, D., Jain, S., Kavanagh, A., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K., Requardt, H., Sanche, L., Schettino, G., Currell, F. & Sicard-Roselli, C., 20 Oct 2011, In : Journal of Physical Chemistry C. 115, 41, p. 20160-20167 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
Open Access
File
3 Downloads (Pure)

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.

Butterworth, K., Jain, S., Coulter, J., Folker, J., McMahon, S., Schettino, G., Prise, K., Currell, F. & Hirst, D., Jun 2010, In : Nanotechnology. 21(29), 29, p. 295101-295110 10 p., 295101.

Research output: Contribution to journalArticle

151 Citations (Scopus)

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
205 Downloads (Pure)

Fragmentation and plasmid strand breaks in pure and gold-doped DNA irradiated by beams of fast hydrogen atoms

Wyer, J. A., Butterworth, K., Hirst, D., Latimer, C., Montenegro, E. C., Shah, M. & Currell, F., 2009, In : Physics in Medicine and Biology. 54, 15, p. 4705-4721 17 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In : Scientific Reports. 9, 10 p., 12618.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
78 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
257 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
185 Downloads (Pure)
16 Citations (Scopus)
39 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
243 Downloads (Pure)
9 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
213 Downloads (Pure)
15 Citations (Scopus)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
213 Downloads (Pure)

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
171 Downloads (Pure)
Open Access
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5 Citations (Scopus)
162 Downloads (Pure)

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

McMahon, S., Hyland, W., Muir, M. F., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., Sep 2011, In : Radiotherapy and Oncology. 100, 3, p. 412-416 5 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
61 Citations (Scopus)

Physical basis and biological mechanisms of gold nanoparticle radiosensitization

Butterworth, K. T., McMahon, S. J., Currell, F. J. & Prise, K. M., 21 Aug 2012, In : Nanoscale. 4, 16, p. 4830-8 9 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In : The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
70 Downloads (Pure)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
373 Downloads (Pure)
4 Citations (Scopus)
62 Downloads (Pure)
Open Access
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4 Citations (Scopus)
50 Downloads (Pure)

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In : Nanotechnology. 27, 21, 11 p., 215101.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
164 Downloads (Pure)
44 Citations (Scopus)

Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries

Butterworth, K. T., McGarry, C. K., Clasie, B., Carabe-Fernandez, A., Schuemann, J., Depauw, N., Tang, S., McMahon, S. J., Schettino, G., O'Sullivan, J. M., Lu, H-M., Kooy, H., Paganetti, H., Hounsell, A. R., Held, K. D. & Prise, K. M., 21 Oct 2012, In : Physics in Medicine and Biology. 57, 20, p. 6671-6680 10 p., 6671.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S. & 22 others, Lux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, In : Physics in Medicine and Biology.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
153 Downloads (Pure)