• Room 02.009 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr Butterworth is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: -Radiation Biology, Radiation Oncology and Cancer Imaging. -Nanomedicine. -Preclinical models and small animal radiotherapy. Previous research experience is desirable although not essential.

20082020

Research output per year

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Research Output

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2020
1 Citation (Scopus)
Open Access
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Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S. & 22 others, Lux, F., McMahon, S. J., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Ridwan, S. M., Rudek, B., Sanche, L., Singh, B., Smilowitz, H. M., Sokolov, K. V., Sridhar, S., Stanishevskiy, Y., Sung, W., Tillement, O., Virani, N. A., Yantasee, W. & Krishnan, S., 07 May 2020, In : Physics in Medicine and Biology.

Research output: Contribution to journalArticle

2019

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
240 Downloads (Pure)

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In : Scientific Reports. 9, 10 p., 12618.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
76 Downloads (Pure)

Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity?

Fukunaga, H., Yokoya, A., Taki, Y., Butterworth, K. T. & Prise, K. M., 11 Apr 2019, In : The Tohoku Journal of Experimental Medicine. 247, 4, p. 223-235 13 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
68 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
43 Downloads (Pure)
2018

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
165 Downloads (Pure)
4 Citations (Scopus)
59 Downloads (Pure)
2017

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
164 Downloads (Pure)

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation

Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T. & Prise, K. M., 02 Feb 2017, In : Cancer Nanotechnology. 8, 2, 25 p.

Research output: Contribution to journalArticle

Open Access
File
58 Citations (Scopus)
231 Downloads (Pure)
Open Access
File
147 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
235 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
160 Downloads (Pure)

Small field dosimetry for the small animal radiotherapy research platform (SARRP)

Ghita, M., McMahon, S. J., Thompson, H. F., McGarry, C. K., King, R., Osman, S. O. S., Kane, J. L., Tulk, A., Schettino, G., Butterworth, K. T., Hounsell, A. R. & Prise, K. M., 28 Dec 2017, In : Radiation oncology (London, England). 12, 1, p. 204

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
243 Downloads (Pure)
1 Citation (Scopus)
2016

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
198 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
256 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
183 Downloads (Pure)

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy

Butterworth, K. T., Nicol, J. R., Ghita, M., Rosa, S., Chaudhary, P., McGarry, C. K., McCarthy, H. O., Jimenez-Sanchez, G., Bazzi, R., Roux, S., Tillement, O., Coulter, J. A. & Prise, K. M., Aug 2016, In : Nanomedicine. 11, 16, p. 2035-47 13 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
369 Downloads (Pure)

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In : Nanotechnology. 27, 21, 11 p., 215101.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
161 Downloads (Pure)
2015
Open Access
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8 Citations (Scopus)
244 Downloads (Pure)
4 Citations (Scopus)
199 Downloads (Pure)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
208 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
189 Downloads (Pure)
2014

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
9 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
211 Downloads (Pure)
Open Access
File
37 Citations (Scopus)
145 Downloads (Pure)

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In : Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
263 Downloads (Pure)
2013

A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In : PloS one. 8, 1, 12 p., e54526.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
143 Downloads (Pure)
21 Citations (Scopus)
Open Access
File
34 Citations (Scopus)
190 Downloads (Pure)
16 Citations (Scopus)
39 Downloads (Pure)
43 Citations (Scopus)
2012
30 Citations (Scopus)

Cell survival responses after exposure to modulated radiation fields.

Trainor, C., Butterworth, K., McGarry, C., Liberante, F., O'Sullivan, J., Hounsell, A. & Prise, K., Jan 2012, In : Radiation Research. 177, 1, p. 44-51 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

Coulter, J. A., Jain, S., Butterworth, K. T., Taggart, L. E., Dickson, G. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Trainor, C., Hounsell, A. R., O'Sullivan, J. M., Schettino, G., Currell, F. J., Hirst, D. G. & Prise, K. M., 2012, In : International Journal of Nanomedicine. 7, null, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

Open Access
File
121 Citations (Scopus)
582 Downloads (Pure)
2 Citations (Scopus)

DNA damage responses following exposure to modulated radiation fields

Trainor, C., Butterworth, K. T., McGarry, C. K., McMahon, S. J., O'Sullivan, J. M., Hounsell, A. R. & Prise, K. M., 17 Aug 2012, In : PLoS ONE. 7, 8, 13 p., e43326.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
171 Downloads (Pure)
25 Citations (Scopus)
15 Citations (Scopus)

Physical basis and biological mechanisms of gold nanoparticle radiosensitization

Butterworth, K. T., McMahon, S. J., Currell, F. J. & Prise, K. M., 21 Aug 2012, In : Nanoscale. 4, 16, p. 4830-8 9 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries

Butterworth, K. T., McGarry, C. K., Clasie, B., Carabe-Fernandez, A., Schuemann, J., Depauw, N., Tang, S., McMahon, S. J., Schettino, G., O'Sullivan, J. M., Lu, H-M., Kooy, H., Paganetti, H., Hounsell, A. R., Held, K. D. & Prise, K. M., 21 Oct 2012, In : Physics in Medicine and Biology. 57, 20, p. 6671-6680 10 p., 6671.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

McMahon, S., Hyland, W., Muir, M., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., 20 Jun 2011, In : Nature Scientific Reports. 1, 18.

Research output: Contribution to journalArticle

File
234 Citations (Scopus)
214 Downloads (Pure)

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

McMahon, S., Hyland, W. B., Brun, E., Butterworth, K., Coulter, J., Douki, T., Hirst, D., Jain, S., Kavanagh, A., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K., Requardt, H., Sanche, L., Schettino, G., Currell, F. & Sicard-Roselli, C., 20 Oct 2011, In : Journal of Physical Chemistry C. 115, 41, p. 20160-20167 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

McMahon, S., Hyland, W., Muir, M. F., Coulter, J., Jain, S., Butterworth, K., Schettino, G., Dickson, G., Hounsell, A., O'Sullivan, J., Prise, K., Hirst, D. & Currell, F., Sep 2011, In : Radiotherapy and Oncology. 100, 3, p. 412-416 5 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)
61 Citations (Scopus)
16 Citations (Scopus)
2010
19 Citations (Scopus)