• Room 01.016 - Pharmacy & MCI Block 98 MBC Site

    United Kingdom

Accepting PhD Students

Willing to speak to media

1992 …2019
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Personal profile


* modified release drug delivery systems
* sustained and controlled release
* vaginal drug delivery
* vaginal ring technology
* polymeric drug delivery devices
* injection molding and extrusion technologies
* human immunodeficiency virus (HIV)
* HIV microbicides
* antiretrovirals for HIV prevention
* multipurpose prevention technologies (MPTs)
* mucosal vaccination
* silicone elastomers
* polyurethanes
* ethylene-vinyl acetate copolymers
* in vitro release testing of drug dosage forms
* protein drug delivery
* long-acting contraceptives
* long-acting injectables
* 3D-printing of drug delivery systems
* bacterial vaginosis (BV)
* estrogen replacement therapy
* cervical ripening
* induction of labour

Research Statement

Karl Malcolm is Professor of Drug Delivery in the School of Pharmacy, Queen's University Belfast. His research interests lie primarily within the pharmaceutical sciences, and particularly in the application of advanced drug delivery technologies to the treatment and prevention of disease in women. For the past 20 years, Karl has developed world-leading expertise in the design, development and testing of drug-releasing vaginal rings, most notably antiretroviral-releasing rings for the prevention of HIV infection. Karl’s research group reported the first microbicide-releasing vaginal rings back between 2003 and 2005. As part of an ongoing long-term partnership with the International Partnership for Microbicides, Karl’s research team has also contributed significantly to the development of the dapivirine-releasing vaginal, which completed two pivotal Phase III clinical studies in 2016 and is currently undergoing regulatory review by the European Medicine Agency.

Karl’s research is now heavily focused on second-generation combination and multipurpose rings that combine antiretrovirals for HIV prevention with contraceptive steroids and/or drugs for prevention/treatment of other sexually transmitted infections. Karl’s team at QUB – comprising pharmacists, pharmaceutical scientists, engineers and biological scientists – have a unique breadth of knowledge and expertise useful in developing implantable drug delivery and controlled release products. This knowledge and expertise supports collaborations and partnerships across the globe, including global health organisations, charities, pharmaceutical companies, and biotechnology companies.

Karl is always interested in new research partnerships. If you have an interesting project or product concept in mind that might benefit from input by the team at QUB, then please do not hesitate to contact Karl (k.malcolm@qub.ac.uk).


Professor Karl Malcolm teaches extensively as part of the MPharm, BSc Pharmaceutical Sciences, and BSc Pharmaceutical Biotechnology undergraduate degree programmes at the School of Pharmacy, Queen's University Belfast.

Karl is module coordinator for the L1 Physical Pharmaceutics (PMY1015) module. The module provides students with an understanding of the fundamental principles underlying pharmaceutics and drug formulation, including solubility, dissolution, pH, diffusion, partitioning, rheology, suspensions, emulsions, rheology, etc.

Karl also teaches on the L3 Drug Delivery module, focusing on the basic concepts of modified release drug delivery systems, vaginal drug delivery, and polymeric drug delivery systems.

At Level 1, Karl teaches extensively on the L1 Skills Module, focused on foundation aspects of numeracy, statistics, computer skills, literature searching skills, referencing in scientific articles, use of reference management software, etc.

Fingerprint Dive into the research topics where Karl Malcolm is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Female Contraceptive Devices Medicine & Life Sciences
Silicone Elastomers Medicine & Life Sciences
Anti-Infective Agents Medicine & Life Sciences
HIV Medicine & Life Sciences
Silicones Medicine & Life Sciences
Levonorgestrel Medicine & Life Sciences
Macaca Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2015

R1130PMY: MRC Centenary Award via Aberdeen

Malcolm, R.


Project: Research

R1441PMY: MRC CiC 2013

Malcolm, R.


Project: Research

Research Output 1992 2019

Silicone Elastomers
Female Contraceptive Devices
In Vitro Techniques
Female Contraceptive Devices
Pharmaceutical Preparations
2 Citations (Scopus)

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES

McBride, J. W., Malcolm, R. K., Dias, N., Cameron, D., Offord, R. E., Hartley, O., Kett, V. L., Devlin, B. & Boyd, P., 10 Jun 2019, In : International Journal of Pharmaceutics. 564, p. 207-213 7 p.

Research output: Contribution to journalArticle

Female Contraceptive Devices
Anti-Infective Agents
Silicone Elastomers
3 Citations (Scopus)
Female Contraceptive Devices
Drug Stability
Appointments and Schedules
Phase III Clinical Trials
Female Contraceptive Devices
Hot Temperature

Activities 1998 2019

'Challenges and considerations in the development and validation of in vitro drug release testing for intravaginal rings'

Karl Malcolm (Advisor)
10 Apr 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference


4th PQRI/FDA Conference on Advancing Product Quality: Patient-Centric Product Design, Drug Development and Manufacturing

Karl Malcolm (Participant)
09 Apr 201911 Apr 2019

Activity: Participating in or organising an event typesParticipation in conference

'All things rings'

Karl Malcolm (Advisor)
11 Apr 2019

Activity: Talk or presentation typesInvited talk


Benny David

Robert Malcolm (Host), Peter Boyd (Host)
25 Mar 2019

Activity: Hosting a visitor typesHosting of external, non-academic visitor

Nanotechnology-Based Strategies for Rectal Anti-HIV Pre-Exposure Prophylaxis / Rute Sofia Nunes

Karl Malcolm (Examiner)
06 Nov 2018

Activity: Examination typesPhD external examination


Protecting Women from HIV AIDS: Dapivirine Vaginal Ring HIV Microbicide

David Woolfson (Participant), Karl Malcolm (Participant), Stephen McCullagh (Participant), Martin Catney (Participant)

Impact: Health Impact