Research output per year
Research output per year
- 1 - 50 out of 265 results
Search results
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2024
Multipurpose prevention technologies for HIV, STIs & pregnancies
Friedland, B. A., Thurman, A. R., Nuwagaba-Biribonwoha, H. & Malcolm, R. K., 19 Feb 2024, In: Frontiers in Reproductive Health. 6, 5 p., 1384153.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile43 Downloads (Pure) -
2023
A multipurpose ‘CZL’ vaginal ring for non-hormonal contraception and STI/HIV prevention
Zhao, X., Boyd, P., Dallal Bashi, Y., McCoy, C. F., Shen, X., Lamb, D., Kumar, N., Singer, P., Mitchell, L. & Malcolm, K., 13 Jan 2023.Research output: Contribution to conference › Poster › peer-review
Open AccessFile74 Downloads (Pure) -
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring
de Laat, W., Pagan, L., Malcolm, R. K., Wiegerinck, M., Nickolson, V., Huisman, B., Stuurman, R., van Esdonk, M. & Klarenbeek, N., 31 Dec 2023, In: Drug Delivery. 30, 1, 8 p., 2180113.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)94 Downloads (Pure) -
Formulation development of a multipurpose vaginal ring for non-hormonal contraception and HIV prevention
Shen, X., Boyd, P., McCoy, C. F., Dallal Bashi, Y., Zhu, X. & Malcolm, K., 13 Nov 2023.Research output: Contribution to conference › Poster › peer-review
Open AccessFile59 Downloads (Pure) -
Incorporation of copper and zinc nanoparticles and salts into medical-grade silicone as antibacterial candidates for prevention of capsular contracture
Guimier, E., Carson, L. (Editor), David, B. (Editor), Lambert, J. M. (Editor), Zupansic, J. (Editor), Heery, E. & Malcolm, R. K. (Editor), 24 Jul 2023.Research output: Contribution to conference › Poster › peer-review
Open AccessFile45 Downloads (Pure) -
Modulation of bacterial infection and inflammation by a lactide-loaded matrix system
Huang, K., Wylie, M., Malcolm, K. & Carson, L., 05 Apr 2023.Research output: Contribution to conference › Paper › peer-review
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Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis
Zhao, X., Boyd, P., Dallal Bashi, Y. H., McCoy, C. F. & Malcolm, R. K., 25 Sept 2023, In: International Journal of Pharmaceutics. 644, 11 p., 123296.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)87 Downloads (Pure) -
Poster abstract: A multipurpose vaginal ring releasing copper ions, zinc ions and dapivirine for HIV prevention and non-hormonal contraception
Shen, X., Malcolm, K., Boyd, P., Dallal Bashi, Y., McCoy, C. F., Zhao, X., Lamb, D., Mitchell, L., Kumar, N. & Singer, P., 08 Jun 2023, p. 1. 1 p.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile59 Downloads (Pure) -
Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention
Haeck, C. M., Boyd, P., Dimant, N., Barrail-Tran, A., Gouget, H., Le Grand, R., Desjardins, D. & Malcolm, R. K., Aug 2023, In: Journal of Drug Delivery Science and Technology. 85, 17 p., 104590.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)84 Downloads (Pure) -
Synergistic inhibitory effects of non-hormonal intravaginal contraceptive APIs on human sperm
Singer, P., Mitchell, L., Bolyakov, A., Kizima, L., Kumar, N., Malcolm, K., Teleshova, N., Haddad, L. & Lamb, D., 13 Nov 2023.Research output: Contribution to conference › Poster › peer-review
Open AccessFile23 Downloads (Pure) -
Two into one does go: formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis
Zhao, X., Boyd, P., Dallal Bashi, Y., Murphy, D. J., McCoy, C. F., Coulter, S., Laverty, G. & Malcolm, R. K., 15 Dec 2023, In: International Journal of Pharmaceutics. 648, 17 p., 123572.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)82 Downloads (Pure) -
2022
A subdermal implant for controlled release of dapivirine for HIV pre-exposure prophylaxis (PrEP)
Wang, S. & Malcolm, K., 10 Jun 2022.Research output: Contribution to conference › Abstract
Open AccessFile58 Downloads (Pure) -
Color, scent and size: exploring women's preferences around design characteristics of drug-releasing vaginal rings
Zhao, X., Milford, C., Smit, J., Zulu, B., Boyd, P., Malcolm, R. K. & Beksinska, M., Sept 2022, In: AIDS and Behavior. 26, 9, p. 2954–2968 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)85 Downloads (Pure) -
Incorporation and controlled release of dexamethasone, triamcinolone acetonide, simvastatin and montelukast from silicone elastomer dispersions to reduce capsular contracture
Guimier, E., Malcolm, R. K., Carson, L., David, B., Lambert, J., Heery, E. & Zupansic, J., 10 Jun 2022.Research output: Contribution to conference › Poster
Open AccessFile80 Downloads (Pure) -
Incorporation of metallic nanoparticles in silicone breast implants for reduction of capsular contracture
Guimier, E., Quinn, J., Shen, X., Carson, L., David, B., Lambert, J., Zupancich, J., Heery, E. & Malcolm, K., 04 Sept 2022.Research output: Contribution to conference › Poster › peer-review
Open AccessFile92 Downloads (Pure) -
Multipurpose vaginal rings for HIV prevention and non-hormonal contraception
Shen, X., Boyd, P., Bashi, Y. D., McCoy, C. & Malcolm, K., 03 Nov 2022, (Early online date) In: British Journal of Pharmacy. 7, 2, 1137.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Downloads (Pure) -
Pharmacological approaches for the prevention of breast implant capsular contracture
Guimier, E., Carson, L., David, B., Lambert, J. M., Heery, E. & Malcolm, R. K., Dec 2022, In: Journal of Surgical Research. 280, p. 129–150 22 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile7 Citations (Scopus)355 Downloads (Pure) -
Poster abstract: Formulation and in vitro tests of silicone elastomer vaginal rings containing lyoprotectant and metronidazole
Wang, C., Malcolm, R. K., Kett, V. & Gilpin, D., 10 Jun 2022.Research output: Contribution to conference › Abstract
Open AccessFile42 Downloads (Pure) -
Poster abstract: Multipurpose vaginal rings for HIV prevention and non-hormonal contraception
Shen, X., Boyd, P., McCoy, C. F., Dallal Bashi, Y. & Malcolm, K., 10 Jun 2022.Research output: Contribution to conference › Abstract
Open AccessFile43 Downloads (Pure) -
The ex vivo pharmacology of HIV-1 antiretrovirals differs between macaques and humans
Herrera, C., Cottrell, M. L., Prybylski, J., Kashuba, A. D. M., Veazey, R. S., García-Pérez, J., Olejniczak, N., McCoy, C. F., Ziprin, P., Richardson-Harman, N., Alcami, J., Malcolm, K. R. & Shattock, R. J., 17 Jun 2022, In: iScience. 25, 6, 104409.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)60 Downloads (Pure) -
Vaginal formulations containing prebiotics and probiotics for treatment of bacterial vaginosis
Wang, C., Kett, V., Gilpin, D. & Malcolm, R. K., 04 Nov 2022, (Early online date) In: British Journal of Pharmacy. 7, 2, p. S1-S2 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Downloads (Pure) -
2021
Colour, fragrance and size: exploring women's preferences around design characteristics of drug-releasing vaginal rings
Malcolm, K., Milford, C., Beksinska, M., Zulu, B., Zhao, X., Boyd, P. & Smith, J., 01 Sept 2021, (Accepted).Research output: Contribution to conference › Poster › peer-review
Open AccessFile63 Downloads (Pure) -
Custom silicone elastomers for improved mechanical performance and reduced hormone binding in a dapivirine/levonorgestrel vaginal ring
Malcolm, K., Dallal Bashi, Y., McCoy, C. F., Murphy, D., Boyd, P., Devlin, B., Kleinbeck, K., Spence, P., Dangi, B., Hansraj, B., McMullen, N., Brown, L., Martin, F. & Kihara, M., 27 Mar 2021.Research output: Contribution to conference › Poster › peer-review
Open AccessFile132 Downloads (Pure) -
Formulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003
Malcolm, K., Murphy, D., McCoy, C. F., Dallal Bashi, Y., Devlin, B., Nuttall, J., Blanda, W. & Boyd, P., 27 Jan 2021.Research output: Contribution to conference › Poster › peer-review
Open AccessFile112 Downloads (Pure) -
In vitro modelling of in vivo discoloration of the dapivirine-levonorgestrel vaginal ring using a range of simulated vaginal and menstrual fluids
McCoy, C. F., Murphy, D. J., Dallal Bashi, Y. H., Boyd, P., Spence, P., Devlin, B., Kleinbeck, K., Dangi, B., Derrick, T. & Malcolm, R. K., 27 Jan 2021.Research output: Contribution to conference › Poster › peer-review
Open AccessFile90 Downloads (Pure) -
Preclinical development of an injectable multipurpose prevention technology (MPT) formulation
Haeck, C. M., Boyd, P., Dimant, N., Desjardins, D. & Malcolm, R. K., 10 May 2021, (Accepted).Research output: Contribution to conference › Abstract › peer-review
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Preliminary formulation development of silicone elastomer vaginal rings for sustained release of metronidazole, sucrose and lactobacillus
Malcolm, K., Wang, C., Gilpin, D. & Kett, V., 13 Oct 2021.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile54 Downloads (Pure) -
Recent advances in electrospun nanofiber vaginal formulations for women's sexual and reproductive health
Cazorla Luna, R., Ruiz-Caro, R., Veiga, M.-D., Malcolm, K. & Lamprou, D., 25 Sept 2021, In: International Journal of Pharmaceutics. 607, 121040.Research output: Contribution to journal › Review article › peer-review
Open AccessFile15 Citations (Scopus)261 Downloads (Pure) -
Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance
Murphy, D. J., Lim, D., Armstrong, R., McCoy, C. F., Dallal Bashi, Y., Boyd, P., Derrick, T., Spence, P., Devlin, B. & Malcolm, K., 21 Oct 2021, (Early online date) In: Drug Delivery and Translational Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)75 Downloads (Pure) -
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel
Dallal Bashi, Y. H., Murphy, D. J., McCoy, C. F., Boyd, P., Brown, L., Kihara, M., Martin, F., McMullen, N., Kleinbeck, K., Dangi, B., Spence, P., Hansraj, B., Devlin, B. & Malcolm, R. K., Dec 2021, In: International Journal of Pharmaceutics: X. 3, 9 p., 100091.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)163 Downloads (Pure) -
The vaginal microbiota, bacterial biofilms and polymeric drug-releasing vaginal rings
Carson, L., Merkatz, R., Martinelli, E., Boyd, P., Variano, B., Sallent, T. & Malcolm, R. K., 19 May 2021, In: Pharmaceutics. 13, 5, 29 p., 751.Research output: Contribution to journal › Review article › peer-review
Open AccessFile21 Citations (Scopus)273 Downloads (Pure) -
2020
The Ins and Outs of Drug-Releasing Vaginal Rings: A Literature Review of Expulsions and Removals
Malcolm, K., Boyd, P., Merkatz, R. & Variano, B., 20 Jul 2020, (Early online date) In: Expert Opinion on Drug Delivery. IEDD 1798927.Research output: Contribution to journal › Review article › peer-review
Open AccessFile17 Citations (Scopus)645 Downloads (Pure) -
2019
Comparison of in vitro release testing methods for the release of DL-lactide from a silicone elastomer
Young, V.-L., Malcolm, R. & Boyd, P., 02 May 2019.Research output: Contribution to conference › Poster › peer-review
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Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing
Welsh, N. R., Malcolm, R. K., Devlin, B. & Boyd, P., 15 Dec 2019, In: International Journal of Pharmaceutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)411 Downloads (Pure) -
Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES
McBride, J. W., Malcolm, R. K., Dias, N., Cameron, D., Offord, R. E., Hartley, O., Kett, V. L., Devlin, B. & Boyd, P., 10 Jun 2019, In: International Journal of Pharmaceutics. 564, p. 207-213 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)245 Downloads (Pure) -
Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions
Murphy, D. J., McCoy, C. F., Boyd, P., Derrick, T., Spence, P., Devlin, B. & Malcolm, R. K., 30 Jun 2019, In: International Journal of Pharmaceutics. 565, p. 351-357 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)223 Downloads (Pure) -
Effect of density on dapivirine release from thermoplastic vaginal rings fabricated by additive manufacturing
Welsh, N., Malcolm, R. & Boyd, P., 2019, (Accepted).Research output: Contribution to conference › Poster › peer-review
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In vitro release testing methods for drug-releasing vaginal rings
Boyd, P., Variano, B., Spence, P., McCoy, C. F., Murphy, D., Dallal Bashi, Y. & Malcolm, R. K., 15 Oct 2019, (Early online date) In: Journal of Controlled Release.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)900 Downloads (Pure) -
Mechanical testing methods for drug-releasing vaginal rings
McCoy, C. F., Millar, B. G., Murphy, D. J., Blanda, W., Hansraj, B., Devlin, B., Malcolm, R. K. & Boyd, P., 25 Mar 2019, In: International Journal of Pharmaceutics. 559, p. 182-191Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)816 Downloads (Pure) -
Multipurpose vaginal rings for HIV prevention and treatment of bacterial vaginosis
Zhao, X., Boyd, P. & Malcolm, R., 2019, (Accepted).Research output: Contribution to conference › Abstract › peer-review
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Pioneering an Unconscious Bias Educational Activity with Pharmacy Students
Hanna, L.-A., Craig, R., Coulter, J., Malcolm, K., Al-Jamal, W., Haughey, S. & Hall, M., 15 Oct 2019. 1 p.Research output: Contribution to conference › Poster › peer-review
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Post-use ring weight, residual drug content and drug depletion zone thickness as objective measures of user adherence to a contraceptive progesterone vaginal ring
Murphy, D. J., McCoy, C. F., Plagianos, M., RamaRao, S., Merkatz, R., Clark, H., Boyd, P., Variano, B. & Malcolm, R. K., Sept 2019, In: Contraception. 100, 3, p. 241-246 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)266 Downloads (Pure) -
Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers
Malcolm, R., Dallal Bashi, Y., McCoy, C. F., Murphy, D., Boyd, P., Spence, P., Kleinbeck, K. & Devlin, B., 05 Oct 2019, In: International Journal of Pharmaceutics. 569, Oct 2019, 118574.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)212 Downloads (Pure) -
Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES
McBride, J. W., Boyd, P., Dias, N., Cameron, D., Offord, R. E., Hartley, O., Kett, V. L. & Malcolm, R. K., 01 Mar 2019, In: Journal of Controlled Release. 298, p. 1-11Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)411 Downloads (Pure) -
2018
Comparison of dissolution testing methods for the 25 mg dapivirine vaginal ring
Malcolm, R., McCoy, C., Murphy, D., Boyd, P., Derrick, T., Spence, P. & Devlin, B., 25 Oct 2018. 1 p.Research output: Contribution to conference › Poster › peer-review
File131 Downloads (Pure) -
Density Mediated Drug Release From Dapivirine Vaginal Rings Produced by Additive Manufacturing
Malcolm, R., Welsh, N., McCoy, C. F., Murphy, D., Devlin, B. & Boyd, P., 25 Oct 2018, p. P09.19.Research output: Contribution to conference › Poster › peer-review
Open AccessFile214 Downloads (Pure) -
Effect of exposure of the 25 mg dapivirine vaginal ring to cleaning solutions and personal lubricants
Murphy, D., McCoy, C. F., Boyd, P., Derrick, T., Spence, P., Devlin, B. & Malcolm, R., 25 Oct 2018. 1 p.Research output: Contribution to conference › Poster › peer-review
Open AccessFile72 Downloads (Pure) -
Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques
Murphy, D. J., Desjardins, D., Boyd, P., Dereuddre-Bosquet, N., Stimmer, L., Caldwell, A., Le Grande, R., Kelly, C., Van Roey, J. & Malcolm, R. K., 25 Aug 2018, (Early online date) In: International Journal of Pharmaceutics. 550, p. 300–308 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)360 Downloads (Pure) -
Intravaginal rings for continuous low-dose administration of cervical ripening agents
Wang, Y., Boyd, P., Hunter, A. & Malcolm, R. K., Oct 2018, In: International Journal of Pharmaceutics. 549, p. 124–132 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)408 Downloads (Pure) -
INTRAVAGINAL RINGS FOR CONTROLLED RELEASE OF CERVICAL RIPENING AGENTS
Malcolm, R., Boyd, P., Wang, Y. & Hunter, A., 2018.Research output: Contribution to conference › Abstract › peer-review