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20012019
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Personal profile

Interests

My interests are in translational research in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) with the aim of improving diagnosis, prognosis and prediction of therapeutic responses. 

Research Statement

The molecular and cytogenetic abnormalities in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS) are increasingly well defined and these are being implicated in stratification for diagnosis and prognosis.

We have a series of studies being undertaken to identify repurposed therapies to target different sub-groups of adult and paediatric AML; the MuSICAL and the CaUSAL are funded by Leuka 

Alongside these, are studies introducing clinically relevant mutations using the CRISPR-Cas mechanism to produce isogenic cell lines to further understand the molecular disruption caused by the mutation.  Our recent direction of research has involved investigating the role of DNA repair in sub-cohorts of MDS and AML supported with grants from the LLNI, Leuka and MDS UK

Several studies are being undertaken in collaboration with previous members of the EU funded COST Action on translating genomic and epigenetic studies of MDS and AML (EuGESMA) with partners in 22 countries including Spain,  Denmark, Italy, Germany, Serbia and Finland.

Current funding is from the Leukaemia & Lymphoma NI (LLNI), Leuka, , Children’s Cancer and Leukaemia Group (CCLG)/Little Princess Trust, MDS UK and the Department of Education and Learning (DEL) and with recent funding from Cancer Research UK, Myeloma UKBloodwise, Queen's University Belfast, Cancer Research UK, and the R&D Division of the NI HSC.   The laboratory is  an associated member of the IMI2 funded HARMONY project and a full partner in a recently (2019) awarded Erasmus Plus Knowledge Exchange Network (Nehmesis)

Teaching

Acting Deputy Director:  Centre for Biomedical Science Education

Associate Director for Undergraduate Teaching (CCRCB)

Coordinator for the CCRCB Summer School Programme

Module coordinator for Molecular Markers of Disease (BMS3104)

Module coordinator for Pathobiology (BMS2023) and Cellular & Molecular Haematology (BMS3009)

Teaching contributions to BMS2023, BMS 2106, BMS3009, BMS3104

Module coordinator for SCM81821 and SCM7046 within both the MSc in Computational Biology and Bioinformatics and the MSc in Molecular Pathology

Achievements

Chair of the Northern Ireland council of the Royal College of Pathologists (2016-2019)

Member of the Manx Health and Bioscience Advisory Board (2017-2019)

REF Advisor for the School of Health Sciences, Liverpool Hope University (2016-2018)

Fingerprint Dive into the research topics where Ken Mills is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 51 Similar Profiles
Acute Myeloid Leukemia Medicine & Life Sciences
Myelodysplastic Syndromes Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Genes Medicine & Life Sciences
Myeloid Cells Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Gene Expression Profiling Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2019

Selected Research Output 2001 2019

76 Citations (Scopus)

Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis

McCourt, C. M., McArt, D. G., Mills, K., Catherwood, M. A., Maxwell, P., Waugh, D. J., Hamilton, P., O'Sullivan, J. M. & Salto-Tellez, M., 26 Jul 2013, In : PLoS ONE. 8, 7, 10 p., e69604.

Research output: Contribution to journalArticle

Open Access
File
gold
Genes
Technology
mutation
Mutation
32 Citations (Scopus)

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia

Park, J. E., Yuen, H. F., Zhou, J. B., Al-Aidaroos, A. Q. O., Guo, K., Valk, P. J., Zhang, S. D., Chng, W. J., Hong, C. W., Mills, K. & Zeng, Q., 03 Sep 2013, In : EMBO Molecular Medicine. 5, 9, p. 1351-1366

Research output: Contribution to journalArticle

Open Access
File
Acute Myeloid Leukemia
Mutation
MAP Kinase Signaling System
Leukemia
Messenger RNA
25 Citations (Scopus)

Genome-wide profiling of methylation identifies novel targets with aberrant hyper-methylation and reduced expression in low-risk myelodysplastic syndromes

Del Rey, B. M., O'Hagan, K., Dellett, M., Aibar, S., Colyer, H. A. A., Alonso, M. E., Díez-Campelo, M., Armstrong, R. N., Sharpe, D. J., Gutiérrez, N. C., García, J. L., De Las Rivas, J., Mills, K. I. & Hernández-Rivas, J. M., 01 Mar 2013, In : Leukemia. 27, 3, p. 610-618

Research output: Contribution to journalArticle

Open Access
File
Myelodysplastic Syndromes
Methylation
Genome
Epigenomics
Genes
7 Citations (Scopus)

Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts

Gelsi-Boyer, V., Cervera, N., Bertucci, F., Brecqueville, M., Finetti, P., Murati, A., Arnoulet, C., Mozziconacci, M. J., Mills, K. I., Cross, N. C. P., Vey, N. & Birnbaum, D., 01 Apr 2013, In : HAEMATOLOGICA. 98, 4, p. 576-583

Research output: Contribution to journalArticle

Open Access
File
Leukemia, Myelomonocytic, Chronic
Refractory Anemia
Myelodysplastic Syndromes
Transcriptome
Mutation
5 Citations (Scopus)

High and low, but not intermediate, PRAME expression levels are poor prognostic markers in myelodysplastic syndrome at disease presentation

Liberante, F. G., Pellagatti, A., Boncheva, V., Bowen, D. T., Mills, K. I., Boultwood, J. & Guinn, B-A., 02 Jul 2013, In : British Journal of Haematology. 162, 2, p. 282-285

Research output: Contribution to journalArticle

16 Citations (Scopus)

Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of CN-AML.

Ramsey, J., Kettyle, L., Sharpe, D., Mulgrew, N., Dickson, G., Bijl, J., Austin, P., Mayotte, N., Cellot, S., Lappin, T., Zhang, S-D., Mills, K., Krosl, J., Sauvageau, G. & Thompson, A., Jul 2013, In : Stem Cells. 31, 7, p. 1434-1445 12 p.

Research output: Contribution to journalArticle

Oncogenes
Leukemia
Maintenance
Acute Myeloid Leukemia
Histone Deacetylase Inhibitors
17 Citations (Scopus)

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy

Dickson, G. J., Liberante, F. G., Kettyle, L. M., O'Hagan, K., Finnegan, D. P. J., Bullinger, L., Geerts, D., McMullin, M. F., Lappin, T. R. J., Mills, K. I. & Thompson, A., 01 Aug 2013, In : HAEMATOLOGICA. 98, 8, p. 1216-1225 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Drug Therapy
Growth
Leukemia
3 Citations (Scopus)

Differential expression of SHP-1 in chronic myeloid leukemia

Kaeda, J., Neuman, D., Bonecker, S., Mills, K., Oberender, C., Amini, L., Ringel, F., Serra, A., Schwarz, M., Dörken, B., Zalcberg, I. & Coutre, P. L., May 2015, In : Leukemia & lymphoma. 56, 5, p. 1547-1549 3 p.

Research output: Contribution to journalLetter

Open Access
File

Prizes

Chair of the NI Regional Council of the Royal College of Pathologists

Ken Mills (Recipient), 14 Nov 2016

Prize: Election to learned society

Capacity Building
Ireland
Neoplasms
Lead

Fellow of RCPath

Ken Mills (Recipient), 20 Dec 1999

Prize: Election to learned society

Selected Activities 2007 2019

IRON II

Ken Mills (Participant)
10 Jul 201311 Jul 2013

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

British Lymphoma Pathology Group

Ken Mills (Invited speaker)
28 Jun 2013

Activity: Participating in or organising an event typesParticipation in conference

NCRI Annual Leukaemia Trials Review Meeting

Ken Mills (Participant)
24 Jun 2013

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

NILRF AGM and Annual Scientific Report

Ken Mills (Contributor)
19 Jun 2013

Activity: Consultancy typesWork on advisory panels for social community and cultural engagement

EU COST BMBS Domian Annual Progress Committee

Ken Mills (Speaker)
03 Jun 201304 Jun 2013

Activity: Consultancy typesContribution to the work of national or international committees and working groups

European Commission Research & Innovation: Framework Programme and COST - Cooperation in Science and Technology - Joint Workshop on Relationship between Genome and Epigenome

Ken Mills (Chair)
14 Feb 201315 Feb 2013

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Press / Media

Blood Cancer BBC Appeal

Ken Mills

27/08/2017

1 media contribution

Press/Media: Public Engagement Activities

Medical Colleges NI

Ken Mills

25/08/201725/08/2017

1 item of media coverage, 1 media contribution

Press/Media: Expert Comment