• Room 02.003 - CCRCB Block 5 MBC Site

    United Kingdom

Accepting PhD Students

1986 …2019
If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

Kevin Prise is Professor of Radiation Biology, Queen’s University Belfast, where he has been since 2007. Prior to this, he was Head of the Cell and Molecular Radiation Biology Group at the Gray Cancer Institute in Northwood, London. A Biochemistry graduate of Aberdeen University, he received his PhD in Cell Biology and Biochemistry, from the University of Aberdeen, on the mechanisms of action of the chemotherapeutic methotrexate. He joined the Gray Laboratory in 1985 working with Barry Michael, Melvyn Folkard and Boris Vojnovic, under the directorship of Jack Fowler, Julie Denekamp and Ged Adams.

He has developed wide-ranging interests in radiation biology including research on low dose radiation risk, radiation quality, cell and tissue signalling mechanisms. He has played a major role in the application of microbeam technologies for delineating the response of cells to targeted single tracks of radiation. His seminal work defined the impact of bystander signalling after targeted irradiation and its implications for future advanced radiotherapy where immune signalling and abscopal responses have significant potential. His recent work, at Queen’s has involved the development of an Advanced Radiotherapy Group (ARG) integrating Radiation Oncology, under the leadership of Professor Joe O’Sullivan, and Clinical Radiotherapy Physics, under the leadership of Professor Alan Hounsell, with translational radiation biology.  Together they are developing new biological based models for optimising advanced radiotherapies such as Intensity Modulated Radiotherapy and particle therapies. A current focus is the application of radionuclide approaches in advanced prostate cancer.

He is currently Immediate Past-President of the US Radiation Research Society, a previous RRS Michael Fry award recipient and Friedrich Dessauer awardee of the German Radiation Research Societies. He was the 2018 Douglas Lea Lecturer, awarded by the Institute of Physics and Engineering in Medicine and the 2018 Bacq and Alexander awardee from the European Radiation Research Society. He has recently served on the UK Government Expert Committee on Medical Aspects of Radiation in the Environment (COMARE) and is currently Editor in Chief (Scientific) of the British Journal of Radiology.  He has supervised over 45 PhD students and numerous Master and undergraduate students. He has taught on the FRCR Part 1 course at the Christie Hospital for the last 12 years and also launched this course internationally with Prof Catharine West in Kolkata, India in 2015 and Kuala Lumpur, Malaysia in 2017. He is a previous part 1 examiner for the Royal College of Radiologists and a current honorary member. He has published over 310 papers (h=55), with over 9,500 citations.

Fingerprint Dive into the research topics where Kevin Prise is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Radiation Medicine & Life Sciences
Radiotherapy Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
Bystander Effect Medicine & Life Sciences
Linear Energy Transfer Medicine & Life Sciences
X-Rays Medicine & Life Sciences
deoxyribonucleic acid Physics & Astronomy
Relative Biological Effectiveness Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2018

Research Output 1986 2019

8 Citations (Scopus)

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 othersFries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
Clinical Medicine
Gadolinium
Nanoparticles
Radiation-Sensitizing Agents
Siloxanes
Neoplasm Grading
stratification
Prostatic Neoplasms
tomography
cancer

Diversity of ATM gene variants: a population-based genome data analysis for precision medicine

Fukunaga, H., Taki, Y. & Prise, K. M., 23 Aug 2019, In : Human genomics. 13, 1, p. 38

Research output: Contribution to journalArticle

Open Access
File
Ataxia Telangiectasia
Precision Medicine
Genome
Population
Genes
1 Citation (Scopus)

DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates

Hanton, F., Chaudhary, P., Doria, D., Gwynne, D., Maiorino, C., Scullion, C., Ahmed, H., Marshall, T., Naughton, K., Romagnani, L., Kar, S., Schettino, G., McKenna, P., Botchway, S. W., Symes, D. R., Rajeev, P. P., Prise, K. & Borghesi, M., 14 Mar 2019, In : Scientific Reports. 9, 1, 4471.

Research output: Contribution to journalArticle

Open Access
File
strands
deoxyribonucleic acid
dosage
irradiation
protons

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

Fukunaga, H., Kaminaga, K., Sato, T., Butterworth, K. T., Watanabe, R., Usami, N., Ogawa, T., Yokoya, A. & Prise, K. M., 01 Oct 2019, In : Scientific Reports. 9, 10 p., 12618.

Research output: Contribution to journalArticle

Open Access
File
Fertility Preservation
Radiotherapy
Testis
Spermatogenesis
Fertility

Prizes

European Radiation Research Society: 2018 Bacq and Alexander Award

Kevin Prise (Recipient), 22 Aug 2018

Prize: Prize (including medals and awards)

Research Personnel
Radiation
Research

Friedrich-Dessaur Prize -Association of Radiation Research Societies in Germany

Kevin Prise (Recipient), 28 Feb 2001

Prize: Prize (including medals and awards)

radiation
society

Honorary Membership Royal College of Radiologists

Kevin Prise (Recipient), 2017

Prize: National/international honour

Institute of Physics & Engineering in Medicine 2018 Douglas Lea Lecture

Kevin Prise (Recipient), 04 Jul 2018

Prize: National/international honour

Activities 2009 2017

  • 6 Contribution to the work of national or international committees and working groups
  • 1 Editorial activity
  • 1 Membership of board

President - US Radiation Research Society

Kevin Prise (Board Member)
01 Sep 201730 Sep 2018

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Vice-President US Radiation Research Society

Kevin Prise (Board Member)
01 Sep 201631 Aug 2017

Activity: Consultancy typesContribution to the work of national or international committees and working groups

British Journal of Radiology (Journal)

Kevin Prise (Editor-in-chief)
01 Sep 2015 → …

Activity: Publication peer-review and editorial work typesEditorial activity

Vice-President Elect US Radiation Research Society

Kevin Prise (Board Member)
01 Sep 201531 Aug 2016

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Member of UK Department of Health expert Committee on Medical Aspects of Radiation in the Environment (COMARE)

Kevin Prise (Member)
01 Jul 201530 Jun 2018

Activity: Consultancy typesContribution to the work of national or international committees and working groups

Press / Media

Tumour growth models shed light on radionuclide therapy

Kevin Prise, Francisco Liberal, Joseph O'Sullivan, Stephen McMahon & Hugo Moreira

06/03/2019

1 media contribution

Press/Media: Research

Thesis

Laser-Driven Acceleration of Ions: Biological Effects at Ultra-High Dose Rates

Author: Gwynne, D., Jul 2018

Supervisor: Borghesi, M. (Supervisor) & Prise, K. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

The Role of c-FLIP in Regulating Resistance to Ionizing Radiation

Author: McLaughlin, K. A. J., Jul 2016

Supervisor: Longley, D. (Supervisor) & Prise, K. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File