Projects per year
Personal profile
Research Interests
Kevin Prise is Professor of Radiation Biology, at the Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, where he has been since 2007. Prior to this, he was Head of the Cell and Molecular Radiation Biology Group at the Gray Cancer Institute in Northwood, London. A Biochemistry graduate of Aberdeen University, he received his PhD in Cell Biology and Biochemistry, from the University of Aberdeen, on the mechanisms of action of the chemotherapeutic methotrexate. He joined the Gray Laboratory in 1985 working with Barry Michael, Melvyn Folkard and Boris Vojnovic, under the directorships of Jack Fowler, Julie Denekamp and Ged Adams. In 2007 he was recruited by Professor Paddy Johnston to setup a Translational Radiation Biology program at the newly opened Centre for Cancer Research and Cell Biology at Queen's University Belfast. He served as Deputy Director of the Centre from 2010 to 2018 under the directorships of Professor Dennis McCancer and then Professor David Waugh.
He has developed wide-ranging interests in radiation biology including research on low dose radiation risk, radiation quality, cell and tissue signalling mechanisms. He has played a major role in the application of microbeam technologies for delineating the response of cells to targeted single tracks of radiation. His seminal work defined the impact of bystander signalling after targeted irradiation and its implications for future advanced radiotherapy where immune signalling and abscopal responses have significant potential. At Queen’s he developed an Advanced Radiotherapy Group (ARG) integrating Radiation Oncology, under the leadership of Professor Joe O’Sullivan, and Clinical Radiotherapy Physics, under the leadership of Professor Alan Hounsell, with translational radiation biology. Together they are developing new biological based models for optimising advanced radiotherapies such as Intensity Modulated Radiotherapy and particle therapies. A current focus is the application of radionuclide approaches in advanced prostate cancer.
He is a Past-President of the US Radiation Research Society, a previous RRS Michael Fry award recipient and Friedrich Dessauer awardee of the German Radiation Research Societies. He was the 2024 recipient of the Weiss Medal from the UK Association for Radiation Research, the 2018 Douglas Lea Lecturer, awarded by the Institute of Physics and Engineering in Medicine and the 2018 Bacq and Alexander awardee from the European Radiation Research Society. He has recently served on the UK Government Expert Committee on Medical Aspects of Radiation in the Environment (COMARE) and previously Editor in Chief (Scientific) of the British Journal of Radiology. He has supervised over 50 PhD students and numerous Masters and undergraduate students. He has taught on the FRCR Part 1 course at the Christie Hospital for the last 15 years and also launched this course internationally with Prof Catharine West in Kolkata, India in 2015 and Kuala Lumpur, Malaysia in 2017. He is a previous Part 1 examiner for the Royal College of Radiologists and a current Honorary Member. He has published over 380 papers (h=68), with over 15,000 citations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R6633CNR: ORIGIN: Optical fibRe dose ImaGINg for adaptive brachytherapy
Prise, K. (PI) & Jain, S. (CoI)
11/11/2019 → …
Project: Research
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R9247CNR: PARADIGM data analytics for information discovery
McArt, D. (CoI) & Prise, K. (CoI)
05/11/2018 → …
Project: Research
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R2459CNR: Clinical Research Fellowship in Radiotherapy
O'Sullivan, J. (PI), Cole, A. (CoI), McCloskey, K. (CoI) & Prise, K. (CoI)
05/03/2018 → …
Project: Research
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R6426CNR: Advanced Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies
Prise, K. (PI) & Currell, F. (CoI)
17/01/2014 → …
Project: Research
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An objective measure of response on whole-body MRI in metastatic hormone sensitive prostate cancer treated with androgen deprivation therapy, external beam radiotherapy, and radium-223
Giacometti, V., Grey, A. C., McCann, A. J., Prise, K. M., Hounsell, A. R., McGarry, C. K., Turner, P. G. & O'Sullivan, J. M., Apr 2024, In: British Journal of Radiology. 97, 1156, p. 794-802 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
A potential biomarker of radiosensitivity in metastatic hormone sensitive prostate cancer patients treated with combination external beam radiotherapy and radium-223
Redmond, K. M., Turner, P. G., Cole, A., Jain, S., Prise, K. M. & O'Sullivan, J. M., Feb 2024, In: Radiotherapy and Oncology. 191, 9 p., 110063.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Downloads (Pure) -
Cell cycle dependence of cell survival following exposure to X-rays in synchronous HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators
Seino, R., Uno, H., Prise, K. M. & Fukunaga, H., 02 Feb 2024, In: Biomedical Research (Japan). 45, 1, p. 25-31 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Editorial: Harnessing the potential of FLASH: questions we must address prior to effective clinical translation
Poulsen, P. R., Prise, K. M. & MacKay, R. I., 13 Nov 2024, In: Frontiers in Oncology. 14, 1515325.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile -
Laser-driven electron source suitable for of biological cells at dose rates exceeding 1010 Gy/s
McAnespie, C. A., Chaudhary, P., Calvin, L., Streeter, M. J. V., Nersysian, G., McMahon, S. J., Prise, K. M. & Sarri, G., 12 Sept 2024, (Early online date) In: Physical Review E. 110, 3, 035204 .Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure)
Datasets
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Dataset for "Cellular irradiations with laser-driven carbon ions at ultra-high dose rates"
Chaudhary, P. (Creator), Borghesi, M. (Supervisor), Prise, K. (Supervisor), Ahmed, H. (Contributor), Doria, D. (Contributor), McIlvenny, A. (Contributor) & Romagnani, L. (Contributor), Queen's University Belfast, 20 Dec 2022
DOI: 10.17034/642ccd19-b32c-4682-809f-4f34a91c8d94
Dataset
File
Prizes
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Elected Fellow of the British Institute of Radiology
Prise, K. (Recipient), 01 Oct 2020
Prize: National/international honour
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European Radiation Research Society: 2018 Bacq and Alexander Award
Prise, K. (Recipient), 22 Aug 2018
Prize: Prize (including medals and awards)
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Friedrich-Dessaur Prize -Association of Radiation Research Societies in Germany
Prise, K. (Recipient), 28 Feb 2001
Prize: Prize (including medals and awards)
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Honorary Membership Royal College of Radiologists
Prise, K. (Recipient), 2017
Prize: National/international honour
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Institute of Physics & Engineering in Medicine 2018 Douglas Lea Lecture
Prise, K. (Recipient), 04 Jul 2018
Prize: National/international honour
Activities
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President - US Radiation Research Society
Prise, K. (Board Member)
01 Sept 2017 → 30 Sept 2018Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Vice-President US Radiation Research Society
Prise, K. (Board Member)
01 Sept 2016 → 31 Aug 2017Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Vice-President Elect US Radiation Research Society
Prise, K. (Board Member)
01 Sept 2015 → 31 Aug 2016Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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British Journal of Radiology (Journal)
Prise, K. (Editor-in-chief)
01 Sept 2015 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Member of UK Department of Health expert Committee on Medical Aspects of Radiation in the Environment (COMARE)
Prise, K. (Member)
01 Jul 2015 → 30 Jun 2018Activity: Consultancy types › Contribution to the work of national or international committees and working groups
Press/Media
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Tumour growth models shed light on radionuclide therapy
Prise, K., Liberal, F., O'Sullivan, J., McMahon, S. & Moreira, H.
06/03/2019
1 Media contribution
Press/Media: Research
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Radiosensitivity model addresses personalized therapy
McMahon, S., McNamara, A. L., Schuemann, J., Paganetti, H. & Prise, K.
06/10/2017
1 item of Media coverage
Press/Media: Research
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Radiosensitization: which element is optimal?
McMahon, S., Paganetti, H. & Prise, K.
10/02/2016
1 item of Media coverage
Press/Media: Research