• Room 02.018 - H.S.B

    United Kingdom

Accepting PhD Students

PhD projects

Prof Savage is open to wide-ranging PhD applications from candidates with a basic science or clinical background.
His fields of interest include:
- DNA repair
- DNA damage Response
- DNA damage driven Immune Responses
- Breast Cancer
-Inherited Breast Cancer
Previous research experience is desirable although not essential.

20032023

Research activity per year

Personal profile

Research Focus

My group focuses on understanding the cellular DNA damage response (DDR) and how defects in this pathway contribute to the development of cancer and response to therapies. More recently, my group has focused on the link between the DDR and the innate immune response linking DNA repair defects, such as those found in BRCA1/2 deficient cells, to activation of the cGAS/STING response. In line with this, much of our current work is focused on modulating the cGAS/STING response to enhance responses to immune checkpoint blockade therapies and the development of rationalised combination therapies for the treatment of a range of solid tumours and blood cancers.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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Collaborations and top research areas from the last five years

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