Projects per year
Personal profile
Research Focus
I am a driven and focused Senior Lecturer in Molecular Oncology. I have an established national and international track record in DNA repair and related cancer research (breast, ovarian and blood cancers), with a growing reputation in cancer immunology wuth publications linking DNA epair defects/DNA damage with immuno activaiton through the cGAS/STING pathway. My focus is delivering, high quality, patient centric, impactful and collaborative research and have recenlty been awarded a prestigious Cancer Research UK Programme Foundation Award. I have pubclished papers in the high-ipact journals, Nature, Cancer Research, Molecular Cell, Nucleic Acids Research, etc.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R2301CNR: DNA repair mechanisms as therapeutic targets in myeloid blood cancers
25/05/2016 → 31/12/2019
Project: Research
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R1311CNR: Functional characterisation of a novel BRCA1-mRNA splicing complex that is mutated in multiple cancers
Harkin, P. & Savage, K.
01/08/2012 → 01/08/2018
Project: Research
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Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer
Parkes, E. E., Savage, K. I., Lioe, T., Boyd, C., Halliday, S., Walker, S. M., Lowry, K., Knight, L., Buckley, N. E., Grogan, A., Logan, G. E., Clayton, A., Hurwitz, J., Kirk, S. J., Xu, J., Sidi, F. A., Humphries, M. P., Bingham, V., Ang, M., Askin, C., & 25 others, 01 Feb 2022, In: British Journal of Cancer. 126, 2, p. 247-258 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile84 Downloads (Pure) -
Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Lappin, K. M., Barros, E. M., Jhujh, S. S., Irwin, G. W., McMillan, H., Liberante, F. G., Latimer, C., LaBonte, M. J., Mills, K. I., Harkin, D. P., Stewart, G. S. & Savage, K. I., 03 Mar 2022, In: Cancer Research. 82, 5, p. 819-830 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile74 Downloads (Pure) -
The DNA damage induced immune response: implications for cancer therapy
Barros, E. M., McIntosh, S. A. & Savage, K. I., Dec 2022, In: DNA Repair. 120, 7 p., 103409.Research output: Contribution to journal › Article › peer-review
Open AccessFile99 Downloads (Pure) -
COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks
Suraweera, A., Gandhi, N., Sam, B., Joshua, B., Croft, L. V., Bolderson, E., Naqi, A., Ashton, N. W., Adams, M., Savage, K. I., Zhang, SD., O'Byrne, K. J. & Richard, D. J., 19 Apr 2021, In: Communications Biology. 4, 11 p., 484.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure) -
Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy
Ali, R. M. M., McIntosh, S. A. & Savage, K. I., May 2021, In: Genes Chromosomes and Cancer. 60, 5, p. 358-372 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)248 Downloads (Pure)
Datasets
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BCLAF1 Chip-chip control (siGFP) and BRCA1 depleted (siBRCA1) 293T cells in the absense or presense of Etoposide
Savage, K. (Creator), Gene Expression Omnibus, 25 Apr 2014
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE47016
Dataset
Prizes
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Belfast Top 40 under 40 - Belfast's brightest and most promising stars recognised for the contribution they continue to make to our society and economy
Savage, Kienan (Recipient), 23 Jan 2011
Prize: Prize (including medals and awards)
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Activities
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Experimental Cancer Medicine Centres (ECMC), Junior Investigator Network (JING) - Training the Next Generation of Cancer Research Leaders - Leicester, UK
Kienan Savage (Advisory board member)
05 Feb 2023 → 07 Feb 2023Activity: Participating in or organising an event types › Participation in conference
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French National Cancer Institute (External organisation)
Kienan Savage (Member)
01 Feb 2023 → 31 Jul 2026Activity: Membership types › Membership of peer review panel or committee
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San Antonio Breast Cancer Symposium 2022
Kienan Savage (Participant)
05 Dec 2022 → 09 Dec 2022Activity: Participating in or organising an event types › Participation in conference
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Invited Speaker at the 6th World Congress on Controversies in Breast Cancer (Australia) - "Anthracyclines induce cGAS-STING dependent inflammation and immune checkpoint induction in breast cancer"
Kienan Savage (Invited speaker)
14 Oct 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Invited Speaker at The DNA damage response, immunity and aging (Singapore) - "The Relationship Between Spliceosome Mutations and Immune Activation in Cancer"
Kienan Savage (Advisor)
13 Oct 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
Press/Media
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Belfast Experimental Cancer Medicine Centre Funding Award
25/01/2023
1 Media contribution
Press/Media: Research
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Funding Announcement of Belfast Experimental Cancer Medicine Centre Award
25/01/2023
1 Media contribution
Press/Media: Research
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NI scientists launch new £1.3m breast cancer study
04/02/2021
1 Media contribution
Press/Media: Research
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Queen’s University Belfast awarded research grant to improve bone marrow cancer treatment
Ken Mills, Kienan Savage & Katrina Lappin
25/11/2019
1 item of Media coverage
Press/Media: Research
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Researchers at Queen’s University Belfast receive the 1st scientific research grant awarded by MDS UK
Ken Mills, Kienan Savage & Katrina Lappin
25/11/2019
1 Media contribution
Press/Media: Research