Kienan Savage

Research output

Research output per year 2003 2011 2014 2015 2016 2017 2018 2019 2024

• 43 Article
• 18 Meeting abstract
• 14 Poster
• 3 Abstract
• 4 More
  • 2 Chapter
  • 1 Paper
  • 1 Other contribution

Research output per year

Research output per year

Search results

• 2024

  Ruthenium drug BOLD-100 regulates BRAFMT colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation

  Griffin, D., Carson, R., Moss, D., Sessler, T., Lavin, D., Tiwari, V., Karelia, S., Kennedy, R., Savage, K. I., McDade, S., Carie, A., Pankovich, J., Bazett, M. & Van Schaeybroeck, S., 04 Sept 2024, (Early online date) In: Molecular Cancer Research. 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ataxia Telangiectasia and Rad3 Related 100%
  • Unfolded Protein Response 40%
  • Cytochrome P450 1A1 12%
  12 Downloads (Pure)
• 2023

  ‘From R-lupus to cancer’: reviewing the role of R-loops in innate immune responses

  Bradley, L. & Savage, K. I., Nov 2023, In: DNA Repair. 131, 8 p., 103581.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Innate Immunity 100%
  • R-Loop 100%
  • Species 33%
  • Nucleic Acid 33%
  • Nucleic Acid Structure 33%
  3 Citations (Scopus)

  59 Downloads (Pure)
• 2022

  Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

  Parkes, E. E., Savage, K. I., Lioe, T., Boyd, C., Halliday, S., Walker, S. M., Lowry, K., Knight, L., Buckley, N. E., Grogan, A., Logan, G. E., Clayton, A., Hurwitz, J., Kirk, S. J., Xu, J., Sidi, F. A., Humphries, M. P., Bingham, V., Ang, M. & Askin, C. & 25 others, Bamford, L., Boyd, R., Buckley, M., Clarke, J., Darragh, L., Davis, E., Foreman, J., Gallagher, R., Gill, J., Hanna, M., Hill, N., Irwin, G., Mallon, P., McAleer, S., McAllister, J., Morris, M., Pierce, N., Refsum, S., Sloan, S., Treanor, S., James, J., James, C. R., Paul Harkin, D., Kennedy, R. D. & McIntosh, S. A., 01 Feb 2022, In: British Journal of Cancer. 126, 2, p. 247-258 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immune Response 100%
  • Breast Cancer 100%
  • Neoadjuvant Chemotherapy 100%
  • cGAS-STING signaling pathway 100%
  • Chemotherapy 100%
  20 Citations (Scopus)

  129 Downloads (Pure)

• Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

  Lappin, K. M., Barros, E. M., Jhujh, S. S., Irwin, G. W., McMillan, H., Liberante, F. G., Latimer, C., LaBonte, M. J., Mills, K. I., Harkin, D. P., Stewart, G. S. & Savage, K. I., 03 Mar 2022, In: Cancer Research. 82, 5, p. 819-830 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phenotype 100%
  • Mutation 100%
  • Poly ADP Ribose Polymerase 100%
  • SF3B1 100%
  • Homologous Recombination 33%
  29 Citations (Scopus)

  147 Downloads (Pure)

• The DNA damage induced immune response: implications for cancer therapy

  Barros, E. M., McIntosh, S. A. & Savage, K. I., Dec 2022, In: DNA Repair. 120, 7 p., 103409.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immune Response 100%
  • DNA Damage 100%
  • Cancer Therapy 100%
  • DNA 100%
  • Malignant Neoplasm 100%
  10 Citations (Scopus)

  427 Downloads (Pure)
• 2021

  COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks

  Suraweera, A., Gandhi, N., Sam , B., Joshua , B., Croft, L. V., Bolderson, E., Naqi, A., Ashton, N. W., Adams, M., Savage, K. I., Zhang, S., O'Byrne, K. J. & Richard, D. J., 19 Apr 2021, In: Communications Biology. 4, 11 p., 484.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Regulatory Mechanism 100%
  • Chromatin 100%
  • Genomic Instability 100%
  • DNA 100%
  • Histone H2A 100%
  9 Citations (Scopus)

  124 Downloads (Pure)

• Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy

  Ali, R. M. M., McIntosh, S. A. & Savage, K. I., May 2021, In: Genes Chromosomes and Cancer. 60, 5, p. 358-372 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Development 100%
  • Combination Therapy 100%
  • Breast Cancer 100%
  • Homologous Recombination 100%
  • Cancer Risk 100%
  22 Citations (Scopus)

  427 Downloads (Pure)

• Molecular and genetic characterisation of contralateral breast cancer (CBC): the importance of CBC risk stratification and management

  McIlmunn, C. G., Dobson, G., Bannon, F., Fitzpatrick, D., Gonzalez de Castro, D., James, J., Savage, K. I. & McIntosh, S. A., 15 Sept 2021, In: Familial Cancer. 21, 3, p. 256 1 p., S2-PP3.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Robustness of differential gene expression analysis of RNA-seq

  Stupnikov, A., McInerney, C. E., Savage, K. I., McIntosh, S. A., Emmert-Streib, F., Kennedy, R., Salto-Tellez, M., Prise, K. M. & McArt, D. G., 26 May 2021, In: Computational and Structural Biotechnology Journal. 19, p. 3470-3481 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA Sequencing 100%
  • Gene Expression Profiling 100%
  • Differential Gene Expression 100%
  • Gene Expression 100%
  • RNA-Seq 100%
  44 Citations (Scopus)

  242 Downloads (Pure)

• Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer

  Davison, C., Ladner, R., Morelli, R., Knowlson, C., McKechnie, M., Carson, R., McLaughlin, K., Prise, V., Stachtea, X., Savage, K., Wilson, R., Mulligan, K., Wilson, P. & LaBonte Wilson, M., 06 Apr 2021, In: npj Breast Cancer. 7, p. 3 13 p., 38.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antimetabolite 100%
  • Anthracycline 100%
  • Triple Negative Breast Cancer 100%
  • Deoxyuridine 100%
  • Nucleotide Metabolism 100%
  10 Citations (Scopus)

  127 Downloads (Pure)
• 2020

  Abstract P1-10-17: cGAS-STING driven immune activation predicts response to neoadjuvant chemotherapy and suggests rational IO combination therapies: Results of the Neo-DDIR study

  McIntosh, S. A., Savage, K. I., James, C., Lioe, T., Walker, S., Lowry, K., Knight, L., McGavigan, A., Logan, G., Hurwitz, J., Kirk, S. J., Harkin, P., Kennedy, R. D. & Parkes, E. E., 14 Feb 2020, In: Cancer Res. 80, 4 Supplement, P1-10-17.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Chronic loss of STAG2 leads to altered chromatin structure contributiong to de-regulated transcription in AML

  Smith, J., Lappin, K., Craig, S., Liberante, F., McDade, S., Thompson, A., Mills, K. & Savage, K., 03 Sept 2020, In: Journal of Translational Medicine. 18, p. 339-357 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene Expression 100%
  • Transcription 100%
  • Myeloid 100%
  • Chromatin Structure 100%
  • Genomic Structure 100%
  18 Citations (Scopus)

  77 Downloads (Pure)

• Early circulating tumour DNA kinetics measured by ultra-deep next-generation sequencing during radical radiotherapy for non-small cell lung cancer: a feasibility study

  Walls, G. M., McConnell, L., McAleese, J., Murray, P., Lynch, T. B., Savage, K., Hanna, G. G. & de Castro, D. G., 29 May 2020, In: Radiation oncology (London, England). 15, 1, p. 132

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Patient 100%
  • Non Small Cell Lung Cancer 100%
  • Radiation Therapy 100%
  • Circulating Tumor DNA 100%
  • Kinetics 100%
  17 Citations (Scopus)

  101 Downloads (Pure)

• Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers

  McCrorie, A. D., Ashfield, S., Begley, A., Mcilmunn, C., Morrison, P. J., Boyd, C., Eccles, B., Greville-Heygate, S., Copson, E. R., Cutress, R. I., Eccles, D. M., Savage, K. I. & McIntosh, S. A., Apr 2020, In: Journal of Pathology: Clinical Research. 6, 2, p. 146-153 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • BRCA1 100%
  • Breast Cancer 100%
  • BRCA2 100%
  • Mutation 100%
  • Estrogen Receptor 100%
  16 Citations (Scopus)

  89 Downloads (Pure)
• 2019

  Abstract: 27. Multifocality in BRCA-associated breast cancer: a cross-sectional analysis

  McCrorie, A., Ashfield, S., McIlmunn, C., Boyd, C., Savage, K., Morrison, P. & McIntosh, S., May 2019, In: European Journal of Surgical Oncology. 45, 5, p. 883-884 2 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Abstract P1-09-10: Molecular and genetic characterisation of contralateral breast cancers in Northern Ireland: Opportunities for personalised surgery

  McIlmunn, C., Bannon, F., Fitzpatrick, D., Ervine, A., Boyd, C., Cameron, I., Harita, T., James, J., Gonzalez de Castro, D., Savage, K. & McIntosh, S., 15 Feb 2019, In: Cancer Res. 79, 4 Supplement, p. P1-09-10

  Research output: Contribution to journal › Meeting abstract › peer-review

• Abstract P3-11-12: Biomarker phase neo-DDRD trial: Predicting response to neoadjuvant chemotherapy (NAC) in early breast cancer using the DNA damage repair deficiency (DDRD) assay

  Parkes, E., James, C., Lioe, T., Walker, S., Savage, K., Lowry, K., Knight, L., McCavigan, A., Logan, G., Hurwitz, J., Kirk, S., Harkin, P., Kennedy, R. & McIntosh, S., 15 Feb 2019, In: Cancer Research. 79, 4 Supplement, p. P3-11-12

  Research output: Contribution to journal › Meeting abstract › peer-review

  • Biological Marker 100%
  • Assay 100%
  • Breast Cancer 100%
  • Neoadjuvant Chemotherapy 100%
  • DNA 100%

• Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

  Liberante, F. G., Lappin, K., Barros, E. M., Vohhodina, J., Grebien, F., Savage, K. I. & Mills, K. I., 25 Feb 2019, (Early online date) In: Scientific Reports. 9, 13 p., 2678.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Combination Therapy 100%
  • Myelodysplastic Syndrome 100%
  • Mutant 100%
  • Amino Acid Transfer RNA Ligase 100%
  • SF3B1 100%
  14 Citations (Scopus)

  301 Downloads (Pure)

• Assessing the Impact of Non-coding Mutations on Hereditary Breast Cancer Gene Function and Risk

  Ali, R., Savage, A., McIlmunn, C., Harkin, P., McIntosh, S. & Savage, K., 21 Feb 2019.

  Research output: Contribution to conference › Poster › peer-review

  File

  • Neoplasm 100%
  • Gene Function 100%
  • Breast Cancer 100%
  • Tumor Gene 100%
  • RNA Sequencing 100%
  58 Downloads (Pure)

• A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

  Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, (Early online date) In: Cancer Research. 79, 8, p. 2072

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Association 100%
  • Genetic Algorithm 100%
  • Evolutionary Genetics 100%
  • Estrogen Receptor 100%
  • RNA Sequence 100%
  6 Citations (Scopus)

  211 Downloads (Pure)

• Clinico-pathological features of synchronous breast cancers in Northern Ireland, 2000-2015

  Dobson, G., McIlmunn, C., Savage, K. & McIntosh, S., 01 May 2019, In: European Journal of Surgical Oncology. 45, 5, p. 899 1 p., P051.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Immune based classification of solid tumours (ICST): an online software package

  Rafiee, G., McCabe, N., Knight, L., McCavigan, A., Savage, K. & Kennedy, R., 2019, (Early online date)

  Research output: Other contribution

  • Immunity 100%
  • Classification 100%
  • Solid 100%
  • Software 100%
  • Neoplasm 100%

• Topoisomerase II inhibitors enhance STING-dependent cytokine release and immune checkpoint activation

  Savage, K., 15 Apr 2019.

  Research output: Contribution to conference › Abstract › peer-review

  • Breast Cancer 100%
  • Cytokine Release 100%
  • Topoisomerase 100%
  • Immune Checkpoints 100%
  • Immunity 100%
• 2018

  Chemoprevention in BRCA1 mutation carriers (CIBRAC): A proof of concept clinical trial

  Campbell, A., Savage, K. & McIntosh, S., 2018.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

• Chemoprevention in BRCA1 mutation carriers (CIBRAC): A proof of concept clinical trial

  Campbell, A., Savage, K. & McIntosh, S., 14 Feb 2018, In: Cancer Research. 78, 4S

  Research output: Contribution to journal › Meeting abstract › peer-review

• Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment

  Campbell, A. M., Morris, M., Gallagher, R., Boyd, R., Carson, H., Harkin, D. P., Wielogorska, E., Elliott, C., Savage, K. I. & McIntosh, S. A., 22 Dec 2018, In: BMJ Open. 8, 12, p. e023115

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Therapeutic Procedure 100%
  • BRCA1 100%
  • Tamoxifen 100%
  • Chemoprophylaxis 100%
  • Anastrozole 100%
  3 Citations (Scopus)

  217 Downloads (Pure)

• Imbalanced nucleotide metabolism sensitizes breast cancer cells to standard of care chemotherapy.

  Davison, C., Ladner, R., Chevallier, O., Carson, R., Oliver Esteve, J. A., Elliott, C., Mullan, P., Wilson, R., Savage, K. & LaBonte Wilson, M., Apr 2018.

  Research output: Contribution to conference › Poster › peer-review

• Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

  Stupnikov, A., O’Reilly, P. G., McInerney, C., Roddy, A., Dunne, P., Gilmore, A., Ellis, H. P., Flannery, T., Healy, E., McIntosh, S., Savage, K., Kurian, K. M., Emmert-Streib, F., Prise, K., Salto-Tellez, M. & McArt, D., 13 Sept 2018, In: JCO Precision Oncology. p. 1-16

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene 100%
  • Disease Exacerbation 100%
  • Ganglioglioma 100%
  • Gene Expression Profiling 100%
  • RNA Sequence 100%
  3 Citations (Scopus)

  429 Downloads (Pure)

• Inhibition of dUTPase induces a state of nucleotide pool and DNA repair imbalance that sensitizes triple negative breast cancer cells to standard of care chemotherapies.

  Davison, C., Knowlson, C., McKechnie, M., Savage, K., Wilson, R., Ladner, R. & LaBonte Wilson, M., 13 Nov 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inhibition of dUTPase represents a novel therapeutic strategy in triple negative breast cancer.

  Ladner, R., Davison, C., Knowlson, C., Savage, K., Mulligan, K., Wilson, P. & Johnston, P., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Molecular and genetic characterisation of contralateral breast cancer (CBC) and the identification of markers of CBC risk: opportunities for personalised surgery

  McIlmunn, C., Gonzalez de Castro, D., James, J., Fitzpatrick, D., Savage, K. & McIntosh, S., May 2018.

  Research output: Contribution to conference › Poster › peer-review

• Poster: Chemoprevention in BRCA1 mutation carriers (CIBRAC): a proof of concept clinical trial

  Campbell, A., Savage, K. & McIntosh, S., Jan 2018, In: Breast Cancer Research and Treatment. 167, 1

  Research output: Contribution to journal › Meeting abstract › peer-review
  2 Citations (Scopus)

• Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring

  Deevi, R. K., Javadi, A., McClements, J., Vohhodina, J., Savage, K., Loughrey, M. B., Evergren, E. & Campbell, F. C., 09 Mar 2018, (Early online date) In: Journal of Pathology. p. 1-15

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phenotype 100%
  • Protein Kinase C 100%
  • Interphase 100%
  • Centrosome 100%
  • Morphology 62%
  4 Citations (Scopus)

  259 Downloads (Pure)

• The effect of clinical and tumour factors on prognosis after contralateral breast cancer in Northern Ireland

  McIlmunn, C., Bannon, F., Fitzpatrick, D., Savage, K. & McIntosh, S., 23 Feb 2018, (Accepted).

  Research output: Contribution to conference › Abstract › peer-review
• 2017

  Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

  Parkes, E. E., Walker, S. M., Taggart, L. E., McCabe, N., Knight, L. A., Wilkinson, R., McCloskey, K., Buckley, N. E., Savage, K. I., Salto-Tellez, M., McQuaid, S., Harte, M. T., Mullan, P. B., Harkin, D. P. & Kennedy, R. D., 01 Jan 2017, In: Journal of the National Cancer Institute. 109, 1, djw199.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage 100%
  • DNA Damage Response 100%
  • Breast Cancer 100%
  • S Phase 100%
  • Immunity 100%
  348 Citations (Scopus)

  13722 Downloads (Pure)

• BRCA ‘variants of unknown significance’ need regular review to facilitate optimal patient management

  Irwin, G., Freitas, C., McIntosh, S. & Savage, K., May 2017, In: European Journal of Surgical Oncology. 43, 5, p. S25 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Chemoprevention in BRCA1 mutation carriers (CIBRAC): A proof of concept clinical trial

  Campbell, A., Savage, K. & McIntosh, S., 2017, (Unpublished).

  Research output: Contribution to conference › Poster › peer-review

  • Clinical Trial 100%
  • BRCA1 100%
  • Chemoprophylaxis 100%
  • Antiestrogen 50%
  • Therapeutic Procedure 44%

• Poster: Bilateral synchronous breast cancer: Histological concordance and surgical management

  Dobson, G., McIlmunn, C., Savage, K. & McIntosh, S., May 2017, In: European Journal of Surgical Oncology. 43, 5, p. S51 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Poster: Contralateral breast cancer in Northern Ireland: A retrospective review from 1993 to 2016

  McIlmunn, C., Fitzpatrick, D., Savage, K., Murray, L. & McIntosh, S., 2017, In: European Journal of Surgical Oncology. 43, 5, p. S18 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

  Crean, C., Mills, K. I. & Savage, K. I., Aug 2017, In: Journal of Cancer Therapy. 8, 8, p. 691-698 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Acute Myeloid Leukemia 100%
  • DNA Repair 100%
  • Myeloid 100%
  • Combination Therapy 50%
  • Diseases 25%
  1354 Downloads (Pure)

• The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

  Vohhodina, J., Barros, E. M., Savage, A. L., Liberante, F. G., Manti, L., Bankhead, P., Cosgrove, N., Madden, A. F., Harkin, D. P. & Savage, K. I., 03 Nov 2017, In: Nucleic Acids Research. 45, 22, p. 1-18 18 p., gkx1046.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Regulatory Mechanism 100%
  • DNA Damage Response 100%
  • RNA Splicing 100%
  • RNA Processing 100%
  • Nuclear Export 100%
  77 Citations (Scopus)

  322 Downloads (Pure)
• 2016

  Breast cancer outcomes following predictive BRCA testing in Northern Ireland

  Hinds, G., Irwin, G., McFaul, L., Stewart, R., Morton, L., Savage, K. I., Morrison, P. J. & McIntosh, S. A., Jun 2016, In: Current Oncology. 23, 3, p. e298 P043.

  Research output: Contribution to journal › Meeting abstract › peer-review

  • Breast Cancer 100%
  • Mastectomy 100%
  • Woman 90%
  • Follow up 36%
  • Cancer Diagnosis 36%
  7 Citations (Scopus)

• Breast cancer outcomes following predictive BRCA testing in Northern Ireland

  Hinds, G., Irwin, G., McFaul, L., Stewart, R., Morton, L., Savage, K. I., Morrison, P. J. & McIntosh, S. A., Jun 2016, p. e298.

  Research output: Contribution to conference › Poster › peer-review

  • Breast Cancer 100%
  • Mastectomy 100%
  • Woman 90%
  • Follow up 36%
  • Cancer Diagnosis 36%

• Chemoprevention in BRCA1 Mutation Carriers—A Proof-of-Concept Study

  Campbell, A., Savage, K., McIntosh, S. & Harkin, D., May 2016, p. e290. 1 p.

  Research output: Contribution to conference › Poster › peer-review

  • BRCA1 100%
  • Estrogen 100%
  • Chemoprophylaxis 100%
  • Mutation 100%
  • Metabolite 62%

• Chemoprevention in BRCA1 Mutation Carriers—A Proof-of-Concept Study

  Campbell, A., Savage, K., McIntosh, S. & Harkin, D., May 2016, In: Current Oncology. 23, 3, p. e290 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

  • BRCA1 100%
  • Estrogen 100%
  • Chemoprophylaxis 100%
  • Mutation 100%
  • Metabolite 62%

• Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes

  Dolatshad, H., Pellagatti, A., Liberante, F. G., Llorian, M., Repapi, E., Steeples, V., Roy, S., Scifo, L., Armstrong, R. N., Shaw, J., Yip, B. H., Killick, S., Kušec, R., Taylor, S., Mills, K. I., Savage, K. I., Smith, C. W. J. & Boultwood, J., Dec 2016, In: Leukemia. 30, p. 2322-2331 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nested Gene 100%
  • Iron 100%
  • Mutant 100%
  • SF3B1 100%
  • Nonsense-Mediated Decay 37%
  104 Citations (Scopus)

  286 Downloads (Pure)

• Dual roles of DNA repair enzymes in RNA biology/post-transcriptional control

  Vohhodina, J., Harkin, D. P. & Savage, K. I., Oct 2016, In: Wiley interdisciplinary reviews. RNA. 7, 5, p. 604-619

  Research output: Contribution to journal › Article › peer-review

  • RNA 100%
  • DNA Repair Enzyme 100%
  • Posttranscriptional Regulation 100%
  • DNA Repair 50%
  • Base Excision Repair 50%
  17 Citations (Scopus)

• Identification of potentially pathogenic variants in candidate breast and ovarian cancer susceptibility genes in BRCAX patients

  Savage, A. L., Chenevix-Trench, G., Jun Li, J., McDade, S. S., Morrison, P. J., McIntosh, S. A., Harkin, D. P. & Savage, K. I., Jun 2016, In: Current Oncology. 23, 3, p. e308 1 p., P089.

  Research output: Contribution to journal › Meeting abstract › peer-review

  • Patient 100%
  • Gene 100%
  • Breast Cancer 100%
  • Ovarian Cancer 100%
  • Cancer Susceptibility 100%

• Loss of Function Cohesin Complex Gene Mutations Create Neomorphic Cell States Advantageous to Oncogeneisis

  Smith, J., Savage, K., Thompson, A. & Mills, K., 22 Oct 2016, p. 1564-1565. 2 p.

  Research output: Contribution to conference › Poster › peer-review

• Loss of Function Cohesin Complex Gene Mutations Create Neomorphic Cell States Advantageous to Oncogeneisis

  Smith, J., Savage, K., Thompson, A. & Mills, K., 22 Oct 2016, In: Blood. 128, p. 1564-1565 2 p.

  Research output: Contribution to journal › Meeting abstract › peer-review