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Research Statement
The level of ribosomal RNA synthesis by RNA polymerase-I (Pol-I) is a key stage of ribosome biogenesis and therefore has a major influence on the cellular capacity for protein production, making Pol-I transcription fundamental to life. The production of ribosomal RNA is tightly linked to cell growth and proliferation in eukaryotes. Deregulated rRNA production can have a dramatic effect on the fate of cells: insufficient rRNA production is lethal, whilst excessive rRNA production can lead to defects in cell proliferation, cell death, or uncontrolled growth of cell size. These defects might contribute to oncogenic transformation of cell or developmental defects. Further research into the basic mechanisms of Pol-I transcription and its regulation will have a significant impact on our understanding of the interplay between fundamental cellular processes such as ribosome biogenesis and cell proliferation, and have the potential to drive the development of novel drugs targeting diseases associated with hyperproliferation and abnormal cell size including cancer and heart disease. Because elevated levels of rRNA synthesis are required to support the unrestrained proliferation of cancer cells, rRNA biosynthesis represents a valid target for anticancer therapy as well as providing opportunities for the diagnosis of cancer. Furthermore, drugs promoting rRNA synthesis might be useful for stimulation of cell growth and proliferation in cell-replacement therapy strategies.
My main research interest are: the biochemistry of Pol I transcription, molecular and cellular mechanisms involved in the regulation of rRNA synthesis, signalling pathways and epigenetic based regulatory mechanisms targeting rRNA synthesis and ribosome biogenesis and discovery of novel drug targets related to ribosome biogenesis.
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Projects
- 2 Active
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R2410BSC: Arole for tumour suppressor BRCA1 in the regulation of ribosome biogensis
01/08/2009 → …
Project: Research
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R1992BBC: The role of Toposiomerase II-alpha in regulated transcription of human ribosomal RNA genes
01/08/2008 → …
Project: Research
Research Output
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Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age
Ferreira, R., Schneekloth, J. S., Panov, K. I., Hannan, K. M. & Hannan, R. D., 21 Jan 2020, In : Cells. 9, 2Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
A novel human pain insensitivity disorder caused by a point mutation in ZFHX2
Habib, A. M., Matsuyama, A., Okorokov, A. L., Santana-Varela, S., Bras, J. T., Aloisi, A. M., Emery, E. C., Bogdanov, Y. D., Follenfant, M., Gossage, S. J., Gras, M., Humphrey, J., Kolesnikov, A., Le Cann, K., Li, S., Minett, M. S., Pereira, V., Ponsolles, C., Sikandar, S., Torres, J. M. & 13 others, , 14 Dec 2017, In : Brain.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)41 Downloads (Pure) -
The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M., 05 Jan 2016, In : Nature Communications. 7, 14 p., 10174.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)287 Downloads (Pure) -
The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription
Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In : Oncotarget. 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)322 Downloads (Pure) -
Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner
Ray, S., Johnston, R., Campbell, D. C., Nugent, S., McDade, S. S., Waugh, D. & Panov, K. I., 19 Apr 2013, In : Gene. 526, 1, p. 46-53 8 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus)
Activities
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Russian Ministry Education and Science (External organisation)
Konstantin Panov (Chair)
2011 → …Activity: Membership types › Membership of peer review panel or committee
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National Science Foundation (External organisation)
Konstantin Panov (Member)
2011 → 2013Activity: Membership types › Membership of external research organisation
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Biochemical Society (External organisation)
Konstantin Panov (Member)
2009 → 2013Activity: Membership types › Membership of external research organisation