• Room 01.030 - Biological Sciences

    United Kingdom

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Research Statement

The level of ribosomal RNA synthesis by RNA polymerase-I (Pol-I) is a key stage of ribosome biogenesis and therefore has a major influence on the cellular capacity for protein production, making Pol-I transcription fundamental to life. The production of ribosomal RNA is tightly linked to cell growth and proliferation in eukaryotes. Deregulated rRNA production can have a dramatic effect on the fate of cells: insufficient rRNA production is lethal, whilst excessive rRNA production can lead to defects in cell proliferation, cell death, or uncontrolled growth of cell size. These defects might contribute to oncogenic transformation of cell or developmental defects. Further research into the basic mechanisms of Pol-I transcription and its regulation will have a significant impact on our understanding of the interplay between fundamental cellular processes such as ribosome biogenesis and cell proliferation, and have the potential to drive the development of novel drugs targeting diseases associated with hyperproliferation and abnormal cell size including cancer and heart disease. Because elevated levels of rRNA synthesis are required to support the unrestrained proliferation of cancer cells, rRNA biosynthesis represents a valid target for anticancer therapy as well as providing opportunities for the diagnosis of cancer. Furthermore, drugs promoting rRNA synthesis might be useful for stimulation of cell growth and proliferation in cell-replacement therapy strategies.

My main research interest are: the biochemistry of Pol I transcription, molecular and cellular mechanisms involved in the regulation of rRNA synthesis, signalling pathways and epigenetic based regulatory mechanisms targeting rRNA synthesis and ribosome biogenesis and discovery of novel drug targets related to ribosome biogenesis.

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  • 1 Similar Profiles
RNA Polymerase I Chemical Compounds
Transcription Chemical Compounds
Ribosomes Medicine & Life Sciences
Ribosomal DNA Medicine & Life Sciences
rRNA Genes Medicine & Life Sciences
Ribosomal RNA Medicine & Life Sciences
ribonuclease T(2) Medicine & Life Sciences
Cell proliferation Chemical Compounds

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Projects 2008 2009

Research Output 1996 2017

6 Citations (Scopus)
34 Downloads (Pure)

A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Habib, A. M., Matsuyama, A., Okorokov, A. L., Santana-Varela, S., Bras, J. T., Aloisi, A. M., Emery, E. C., Bogdanov, Y. D., Follenfant, M., Gossage, S. J., Gras, M., Humphrey, J., Kolesnikov, A., Le Cann, K., Li, S., Minett, M. S., Pereira, V., Ponsolles, C., Sikandar, S., Torres, J. M. & 13 others, Yamaoka, K., Zhao, J., Komine, Y., Yamamori, T., Maniatis, N., Panov, K. I., Houlden, H., Ramirez, J. D., Bennett, D. L. H., Marsili, L., Bachiocco, V., Wood, J. N. & Cox, J. J., 14 Dec 2017, In : Brain.

Research output: Contribution to journalArticle

Open Access
Somatoform Disorders
Point Mutation
13 Citations (Scopus)
195 Downloads (Pure)

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M., 05 Jan 2016, In : Nature Communications. 7, 14 p., 10174.

Research output: Contribution to journalArticle

Open Access
Histone Demethylases
ribonucleic acids
Ribosomal RNA
4 Citations (Scopus)
237 Downloads (Pure)

The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription

Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In : Oncotarget. 14 p.

Research output: Contribution to journalArticle

Open Access
DNA Damage
Ribosomal DNA
Nucleic Acid Regulatory Sequences
16 Citations (Scopus)

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Ray, S., Johnston, R., Campbell, D. C., Nugent, S., McDade, S. S., Waugh, D. & Panov, K. I., 19 Apr 2013, In : Gene. 526, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Steroid Receptors
40 Citations (Scopus)

Old drug, New target. Ellipticines selectively inhibit RNA Polymerase I transcription

Andrews, W. J., Panova, T., Normand, C., Gadal, O., Tikhonova, I. G. & Panov, K. I., 15 Feb 2013, In : Journal of Biological Chemistry. 288, 7, p. 4567-4582 16 p.

Research output: Contribution to journalArticle

RNA Polymerase I

Activities 2009 2011

  • 2 Membership of external research organisation
  • 1 Membership of peer review panel or committee

Russian Ministry Education and Science (External organisation)

Konstantin Panov (Chair)
2011 → …

Activity: Membership typesMembership of peer review panel or committee

National Science Foundation (External organisation)

Konstantin Panov (Member)

Activity: Membership typesMembership of external research organisation

Biochemical Society (External organisation)

Konstantin Panov (Member)

Activity: Membership typesMembership of external research organisation