Konstantin Panov

Phone+44 (0)28 9097 2119
Emailk.panov@qub.ac.uk

Room 01.030 - Biological Sciences
United Kingdom

Accepting PhD Students

PhD projects

Currently I am offering only self-funded PhD positions.

Research output per year

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Personal profile

Research Statement

The level of ribosomal RNA synthesis by RNA polymerase-I (Pol-I) is a key stage of ribosome biogenesis and therefore has a major influence on the cellular capacity for protein production, making Pol-I transcription fundamental to life. The production of ribosomal RNA is tightly linked to cell growth and proliferation in eukaryotes. Deregulated rRNA production can have a dramatic effect on the fate of cells: insufficient rRNA production is lethal, whilst excessive rRNA production can lead to defects in cell proliferation, cell death, or uncontrolled growth of cell size. These defects might contribute to oncogenic transformation of cell or developmental defects. Further research into the basic mechanisms of Pol-I transcription and its regulation will have a significant impact on our understanding of the interplay between fundamental cellular processes such as ribosome biogenesis and cell proliferation, and have the potential to drive the development of novel drugs targeting diseases associated with hyperproliferation and abnormal cell size including cancer and heart disease. Because elevated levels of rRNA synthesis are required to support the unrestrained proliferation of cancer cells, rRNA biosynthesis represents a valid target for anticancer therapy as well as providing opportunities for the diagnosis of cancer. Furthermore, drugs promoting rRNA synthesis might be useful for stimulation of cell growth and proliferation in cell-replacement therapy strategies.

My main research interest are: the biochemistry of Pol I transcription, molecular and cellular mechanisms involved in the regulation of rRNA synthesis, signalling pathways and epigenetic based regulatory mechanisms targeting rRNA synthesis and ribosome biogenesis and discovery of novel drug targets related to ribosome biogenesis.

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Projects

2 Active

R2410BSC: Arole for tumour suppressor BRCA1 in the regulation of ribosome biogensis

Panov, K.

01/08/2009 → …

Project: Research

R1992BBC: The role of Toposiomerase II-alpha in regulated transcription of human ribosomal RNA genes

Panov, K.

01/08/2008 → …

Project: Research

Research Output

21 Article
1 Review article

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

Ferreira, R., Schneekloth, J. S., Panov, K. I., Hannan, K. M. & Hannan, R. D., 21 Jan 2020, In : Cells. 9, 2

Research output: Contribution to journal › Review article

Open Access

File

25 Downloads (Pure)

A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Habib, A. M., Matsuyama, A., Okorokov, A. L., Santana-Varela, S., Bras, J. T., Aloisi, A. M., Emery, E. C., Bogdanov, Y. D., Follenfant, M., Gossage, S. J., Gras, M., Humphrey, J., Kolesnikov, A., Le Cann, K., Li, S., Minett, M. S., Pereira, V., Ponsolles, C., Sikandar, S., Torres, J. M. & 13 others, Yamaoka, K., Zhao, J., Komine, Y., Yamamori, T., Maniatis, N., Panov, K. I., Houlden, H., Ramirez, J. D., Bennett, D. L. H., Marsili, L., Bachiocco, V., Wood, J. N. & Cox, J. J., 14 Dec 2017, In : Brain.

Research output: Contribution to journal › Article

Open Access

File

9 Citations (Scopus)

36 Downloads (Pure)

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M., 05 Jan 2016, In : Nature Communications. 7, 14 p., 10174.

Research output: Contribution to journal › Article

Open Access

File