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The level of ribosomal RNA synthesis by RNA polymerase-I (Pol-I) is a key stage of ribosome biogenesis and therefore has a major influence on the cellular capacity for protein production, making Pol-I transcription fundamental to life. The production of ribosomal RNA is tightly linked to cell growth and proliferation in eukaryotes. Deregulated rRNA production can have a dramatic effect on the fate of cells: insufficient rRNA production is lethal, whilst excessive rRNA production can lead to defects in cell proliferation, cell death, or uncontrolled growth of cell size. These defects might contribute to oncogenic transformation of cell or developmental defects. Further research into the basic mechanisms of Pol-I transcription and its regulation will have a significant impact on our understanding of the interplay between fundamental cellular processes such as ribosome biogenesis and cell proliferation, and have the potential to drive the development of novel drugs targeting diseases associated with hyperproliferation and abnormal cell size including cancer and heart disease. Because elevated levels of rRNA synthesis are required to support the unrestrained proliferation of cancer cells, rRNA biosynthesis represents a valid target for anticancer therapy as well as providing opportunities for the diagnosis of cancer. Furthermore, drugs promoting rRNA synthesis might be useful for stimulation of cell growth and proliferation in cell-replacement therapy strategies.
My main research interest are: the biochemistry of Pol I transcription, molecular and cellular mechanisms involved in the regulation of rRNA synthesis, signalling pathways and epigenetic based regulatory mechanisms targeting rRNA synthesis and ribosome biogenesis and discovery of novel drug targets related to ribosome biogenesis.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 2 Active
01/08/2009 → …
R1992BBC: The role of Toposiomerase II-alpha in regulated transcription of human ribosomal RNA genes
01/08/2008 → …
DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of TranscriptionAndrews, W. J., Ray, S., Panova, T., Engel, C. & Panov, K. I., 14 Sep 2021, In: Genes. 12, 9, 20 p., 1412.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Downloads (Pure)
Panov, K., Provis, J. & Natoli, R., 31 Aug 2021, In: Molecular Neurodegeneration. 16, 60.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile12 Downloads (Pure)
Panov, K. I., Hannan, K., Hannan, R. D. & Hein, N., 18 May 2021, In: Genes. 12, 5, 17 p., 763.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile41 Downloads (Pure)
Panov, K. I., Hannan, K. M. & Hannan, R. D., 21 Jan 2020, In: Cells. 9, 2
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile
& 13 others, , 14 Dec 2017, (Early online date) In: Brain. 141, 2, p. 365
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Konstantin Panov (Chair)2011 → …
Activity: Membership types › Membership of peer review panel or committee
Konstantin Panov (Member)2011 → 2013
Activity: Membership types › Membership of external research organisation