• Room 01.030 - School of Biological Sciences 19 Chlorine Gardens

    United Kingdom

19972017
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Research Output 1997 2017

2017
6 Citations (Scopus)

A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Habib, A. M., Matsuyama, A., Okorokov, A. L., Santana-Varela, S., Bras, J. T., Aloisi, A. M., Emery, E. C., Bogdanov, Y. D., Follenfant, M., Gossage, S. J., Gras, M., Humphrey, J., Kolesnikov, A., Le Cann, K., Li, S., Minett, M. S., Pereira, V., Ponsolles, C., Sikandar, S., Torres, J. M. & 13 othersYamaoka, K., Zhao, J., Komine, Y., Yamamori, T., Maniatis, N., Panov, K. I., Houlden, H., Ramirez, J. D., Bennett, D. L. H., Marsili, L., Bachiocco, V., Wood, J. N. & Cox, J. J., 14 Dec 2017, In : Brain.

Research output: Contribution to journalArticle

Open Access
File
Somatoform Disorders
Point Mutation
Pain
Analgesics
Exome
2016
13 Citations (Scopus)

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M., 05 Jan 2016, In : Nature Communications. 7, 14 p., 10174.

Research output: Contribution to journalArticle

Open Access
File
Histone Demethylases
ribonucleic acids
Ribosomal RNA
nutrients
Transcription
4 Citations (Scopus)

The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription

Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In : Oncotarget. 14 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Damage
Ribosomal DNA
Ribosomes
Holoenzymes
Nucleic Acid Regulatory Sequences
2013
15 Citations (Scopus)

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Ray, S., Johnston, R., Campbell, D. C., Nugent, S., McDade, S. S., Waugh, D. & Panov, K. I., 19 Apr 2013, In : Gene. 526, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Ribosomes
Androgens
Prostatic Neoplasms
Estrogens
Steroid Receptors
40 Citations (Scopus)

Old drug, New target. Ellipticines selectively inhibit RNA Polymerase I transcription

Andrews, W. J., Panova, T., Normand, C., Gadal, O., Tikhonova, I. G. & Panov, K. I., 15 Feb 2013, In : Journal of Biological Chemistry. 288, 7, p. 4567-4582 16 p.

Research output: Contribution to journalArticle

Ellipticines
RNA Polymerase I
Transcription
Ribosomes
ellipticine
15 Citations (Scopus)

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M., 19 Mar 2013, In : Nature Communications. 4, 12 p., 1598.

Research output: Contribution to journalArticle

Open Access
File
RNA Polymerase I
Type II DNA Topoisomerase
Transcription
Ribosomal DNA
Chemical activation
2011
38 Citations (Scopus)

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle.

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K., Zomerdijk, J. C., Schultz, P. & Gadal, O., 24 Jan 2011, In : The Journal of cell biology. 192, 2, p. 277-293 17 p.

Research output: Contribution to journalArticle

Ribosomal RNA
rRNA Genes
Cluster Analysis
Gene Dosage
Schizosaccharomyces
2010
22 Citations (Scopus)

Ribosomal 18S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

McMahon, M., Ayllon, V., Panov, K. & O`Connor, R., 11 Jun 2010, In : Journal of Biological Chemistry. 285, 24, p. 18309-18318 10 p.

Research output: Contribution to journalArticle

18S Ribosomal RNA
Cell proliferation
Insulin-Like Growth Factor I
Cells
Cell Proliferation
2009
63 Citations (Scopus)

FACT facilitates chromatin transcription by RNA polymerases I and III

Birch, J. L., Tan, B. C., Panov, K., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S. C. & Zomerdijk, J. C., 08 Apr 2009, In : The EMBO Journal. 28, 7, p. 854-865 12 p.

Research output: Contribution to journalArticle

RNA Polymerase I
RNA Polymerase III
Transcription
Chromatin
Genes
2008
59 Citations (Scopus)

Regulation of cyclin D1 RNA stability by SNIP1

Bracken, C. P., Wall, S. J., Barre, B., Panov, K., Ajuh, P. M. & Perkins, N. D., 15 Sep 2008, In : Cancer Research. 68, 18, p. 7621-7628 8 p.

Research output: Contribution to journalArticle

Cyclin D1
RNA Stability
RNA
bcl-1 Genes
G1 Phase
2007
50 Citations (Scopus)

A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription.

Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C., 21 Mar 2007, In : The EMBO Journal. 26(6), 6, p. 1560-1568 9 p.

Research output: Contribution to journalArticle

2006
42 Citations (Scopus)

Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.

Panova, T. B., Panov, K., Russell, J. & Zomerdijk, J. C., Aug 2006, In : Molecular and Cellular Biology. 26(16), 16, p. 5957-5968 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

Panov, K., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. & Zomerdijk, J. C., Jul 2006, In : Molecular and Cellular Biology. 26(14), 14, p. 5436-5448 13 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

UBF activates RNA polymerase I transcription by stimulating promoter escape.

Panov, K., Friedrich, J. K., Russell, J. & Zomerdijk, J. C., 26 Jul 2006, In : The EMBO Journal. 25(14), 14, p. 3310-3322 13 p.

Research output: Contribution to journalArticle

2005
42 Citations (Scopus)

TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.

Friedrich, J. K., Panov, K., Cabart, P., Russell, J. & Zomerdijk, J. C., 19 Aug 2005, In : Journal of Biological Chemistry. 280(33), 33, p. 29551-29558 8 p.

Research output: Contribution to journalArticle

2002
20 Citations (Scopus)

The structure of substrate-free microbial ribonuclease binase and of its complexes with 3'GMP and sulfate ions.

Polyakov, K. M., Lebedev, A. A., Okorokov, A. L., Panov, K., Schulga, A. A., Pavlovsky, A. G., Karpeisky, M. Y. & Dodson, G. G., 2002, In : Acta crystallographica. Section D, Biological crystallography. 58(Pt 5), 5, p. 744-750 7 p.

Research output: Contribution to journalArticle

2001
44 Citations (Scopus)

A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription.

Panov, K., Friedrich, J. K. & Zomerdijk, J. C., 2001, In : Molecular and Cellular Biology. 21(8), 8, p. 2641-2649 9 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.

Miller, G., Panov, K., Friedrich, J. K., Trinkle-Mulcahy, L., Lamond, A. I. & Zomerdijk, J. C., 15 Mar 2001, In : The EMBO Journal. 20(6), 6, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

2000
148 Citations (Scopus)

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

Ajuh, P., Kuster, B., Panov, K., Zomerdijk, J. C., Mann, M. & Lamond, A. I., 01 Dec 2000, In : The EMBO Journal. 19(23), 23, p. 6569-6581 13 p.

Research output: Contribution to journalArticle

1997
12 Citations (Scopus)

RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations.

Okorokov, A. L., Panov, K., Offen, W. A., Mukhortov, V. G., Anston, A. A., Ya, K. M., Wilkson, A. J. & Dodson, G. G., 1997, In : Protein Engineering. 10(3), p. 273-278 6 p.

Research output: Contribution to journalArticle