• Room 01.030 - Biological Sciences

    United Kingdom

Accepting PhD Students

PhD projects

Currently I am offering only self-funded PhD positions.

19962020

Research output per year

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Research Output

2020

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

Ferreira, R., Schneekloth, J. S., Panov, K. I., Hannan, K. M. & Hannan, R. D., 21 Jan 2020, In : Cells. 9, 2

Research output: Contribution to journalReview article

Open Access
File
16 Downloads (Pure)
2017

A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Habib, A. M., Matsuyama, A., Okorokov, A. L., Santana-Varela, S., Bras, J. T., Aloisi, A. M., Emery, E. C., Bogdanov, Y. D., Follenfant, M., Gossage, S. J., Gras, M., Humphrey, J., Kolesnikov, A., Le Cann, K., Li, S., Minett, M. S., Pereira, V., Ponsolles, C., Sikandar, S., Torres, J. M. & 13 others, Yamaoka, K., Zhao, J., Komine, Y., Yamamori, T., Maniatis, N., Panov, K. I., Houlden, H., Ramirez, J. D., Bennett, D. L. H., Marsili, L., Bachiocco, V., Wood, J. N. & Cox, J. J., 14 Dec 2017, In : Brain.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
36 Downloads (Pure)
2016

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M., 05 Jan 2016, In : Nature Communications. 7, 14 p., 10174.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
245 Downloads (Pure)

The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription

Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In : Oncotarget. 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
282 Downloads (Pure)
2013

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Ray, S., Johnston, R., Campbell, D. C., Nugent, S., McDade, S. S., Waugh, D. & Panov, K. I., 19 Apr 2013, In : Gene. 526, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Old drug, New target. Ellipticines selectively inhibit RNA Polymerase I transcription

Andrews, W. J., Panova, T., Normand, C., Gadal, O., Tikhonova, I. G. & Panov, K. I., 15 Feb 2013, In : Journal of Biological Chemistry. 288, 7, p. 4567-4582 16 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M., 19 Mar 2013, In : Nature Communications. 4, 12 p., 1598.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
178 Downloads (Pure)
2011

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle.

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K., Zomerdijk, J. C., Schultz, P. & Gadal, O., 24 Jan 2011, In : The Journal of cell biology. 192, 2, p. 277-293 17 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2010

Ribosomal 18S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

McMahon, M., Ayllon, V., Panov, K. & O`Connor, R., 11 Jun 2010, In : Journal of Biological Chemistry. 285, 24, p. 18309-18318 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2009

FACT facilitates chromatin transcription by RNA polymerases I and III

Birch, J. L., Tan, B. C., Panov, K., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S. C. & Zomerdijk, J. C., 08 Apr 2009, In : The EMBO Journal. 28, 7, p. 854-865 12 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2008

Regulation of cyclin D1 RNA stability by SNIP1

Bracken, C. P., Wall, S. J., Barre, B., Panov, K., Ajuh, P. M. & Perkins, N. D., 15 Sep 2008, In : Cancer Research. 68, 18, p. 7621-7628 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2007

A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription.

Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C., 21 Mar 2007, In : The EMBO Journal. 26(6), 6, p. 1560-1568 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2006

Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.

Panova, T. B., Panov, K., Russell, J. & Zomerdijk, J. C., Aug 2006, In : Molecular and Cellular Biology. 26(16), 16, p. 5957-5968 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

Panov, K., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. & Zomerdijk, J. C., Jul 2006, In : Molecular and Cellular Biology. 26(14), 14, p. 5436-5448 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

UBF activates RNA polymerase I transcription by stimulating promoter escape.

Panov, K., Friedrich, J. K., Russell, J. & Zomerdijk, J. C., 26 Jul 2006, In : The EMBO Journal. 25(14), 14, p. 3310-3322 13 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2005

TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.

Friedrich, J. K., Panov, K., Cabart, P., Russell, J. & Zomerdijk, J. C., 19 Aug 2005, In : Journal of Biological Chemistry. 280(33), 33, p. 29551-29558 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2002

The structure of substrate-free microbial ribonuclease binase and of its complexes with 3'GMP and sulfate ions.

Polyakov, K. M., Lebedev, A. A., Okorokov, A. L., Panov, K., Schulga, A. A., Pavlovsky, A. G., Karpeisky, M. Y. & Dodson, G. G., 2002, In : Acta crystallographica. Section D, Biological crystallography. 58(Pt 5), 5, p. 744-750 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2001

A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription.

Panov, K., Friedrich, J. K. & Zomerdijk, J. C., 2001, In : Molecular and Cellular Biology. 21(8), 8, p. 2641-2649 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.

Miller, G., Panov, K., Friedrich, J. K., Trinkle-Mulcahy, L., Lamond, A. I. & Zomerdijk, J. C., 15 Mar 2001, In : The EMBO Journal. 20(6), 6, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)
2000

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

Ajuh, P., Kuster, B., Panov, K., Zomerdijk, J. C., Mann, M. & Lamond, A. I., 01 Dec 2000, In : The EMBO Journal. 19(23), 23, p. 6569-6581 13 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)
1997

RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations.

Okorokov, A. L., Panov, K., Offen, W. A., Mukhortov, V. G., Anston, A. A., Ya, K. M., Wilkson, A. J. & Dodson, G. G., 1997, In : Protein Engineering. 10(3), p. 273-278 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1996

Site-directed mutagenesis of the base recognition loop of ribonuclease from Bacillus intermedius (binase)

Okorokov, A. L., Panov, K. I., Kolbanovskaya, E. Y., Karpeisky, M. Y., Polyakov, K. M., Wilkinson, A. J. & Dodson, G. G., 15 Apr 1996, In : FEBS Letters. 384, 2, p. 143-146 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)