Konstantin Panov

2024

CX-5461 preferentially induces Top2α-dependent DNA breaks at ribosomal DNA loci

Cameron, D. P., Sornkom, J., Alsahafi, S., Drygin, D., Poortinga, G., McArthur, G. A., Hein, N., Hannan, R. & Panov, K. I., 08 Jul 2024, In: Biomedicines. 12, 7, 1514.

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2022

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans

Daiß, J. L., Pilsl, M., Straub, K., Bleckmann, A., Höcherl, M., Heiss, F. B., Abascal-Palacios, G., Ramsay, E. P., Tlučková, K., Mars, J.-C., Fürtges, T., Bruckmann, A., Rudack, T., Bernecky, C., Lamour, V., Panov, K., Vannini, A., Moss, T. & Engel, C., 01 Sept 2022, In: Life Science Alliance. 5, 11, e202201568.

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6 Citations (Scopus)

68 Downloads (Pure)

2021

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

Andrews, W. J., Ray, S., Panova, T., Engel, C. & Panov, K. I., 14 Sept 2021, In: Genes. 12, 9, 20 p., 1412.

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10 Citations (Scopus)

123 Downloads (Pure)

Functional microRNA targetome undergoes degeneration-induced shift in the retina

Chu-Tan, J. A., Cioanca, A. V., Feng, Z.-P., Wooff, Y., Schumann, U., Aggio-Bruce, R., Patel, H., Rutar, M., Hannan, K., Panov, K., Provis, J. & Natoli, R., 31 Aug 2021, In: Molecular Neurodegeneration. 16, 60.

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12 Citations (Scopus)

103 Downloads (Pure)

2017

A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Habib, A. M., Matsuyama, A., Okorokov, A. L., Santana-Varela, S., Bras, J. T., Aloisi, A. M., Emery, E. C., Bogdanov, Y. D., Follenfant, M., Gossage, S. J., Gras, M., Humphrey, J., Kolesnikov, A., Le Cann, K., Li, S., Minett, M. S., Pereira, V., Ponsolles, C., Sikandar, S. & Torres, J. M. & 13 others, Yamaoka, K., Zhao, J., Komine, Y., Yamamori, T., Maniatis, N., Panov, K. I., Houlden, H., Ramirez, J. D., Bennett, D. L. H., Marsili, L., Bachiocco, V., Wood, J. N. & Cox, J. J., 14 Dec 2017, (Early online date) In: Brain. 141, 2, p. 365

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33 Citations (Scopus)

89 Downloads (Pure)

2016

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

Salifou, K., Ray, S., Verrier, L., Aguirrebengoa, M., Trouche, D., Panov, K. I. & Vandromme, M., 05 Jan 2016, In: Nature Communications. 7, 14 p., 10174.

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31 Citations (Scopus)

332 Downloads (Pure)

The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription

Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In: Oncotarget. 14 p.

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15 Citations (Scopus)

369 Downloads (Pure)

2013

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Ray, S., Johnston, R., Campbell, D. C., Nugent, S., McDade, S. S., Waugh, D. & Panov, K. I., 19 Apr 2013, In: Gene. 526, 1, p. 46-53 8 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Old drug, New target. Ellipticines selectively inhibit RNA Polymerase I transcription

Andrews, W. J., Panova, T., Normand, C., Gadal, O., Tikhonova, I. G. & Panov, K. I., 15 Feb 2013, In: Journal of Biological Chemistry. 288, 7, p. 4567-4582 16 p.

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M., 19 Mar 2013, In: Nature Communications. 4, 12 p., 1598.

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50 Citations (Scopus)

247 Downloads (Pure)

2011

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle.

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K., Zomerdijk, J. C., Schultz, P. & Gadal, O., 24 Jan 2011, In: The Journal of cell biology. 192, 2, p. 277-293 17 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

2010

Ribosomal 18S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

McMahon, M., Ayllon, V., Panov, K. & O`Connor, R., 11 Jun 2010, In: Journal of Biological Chemistry. 285, 24, p. 18309-18318 10 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

2009

FACT facilitates chromatin transcription by RNA polymerases I and III

Birch, J. L., Tan, B. C., Panov, K., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S. C. & Zomerdijk, J. C., 08 Apr 2009, In: The EMBO Journal. 28, 7, p. 854-865 12 p.

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

2008

Regulation of cyclin D1 RNA stability by SNIP1

Bracken, C. P., Wall, S. J., Barre, B., Panov, K., Ajuh, P. M. & Perkins, N. D., 15 Sept 2008, In: Cancer Research. 68, 18, p. 7621-7628 8 p.

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

2007

A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription.

Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C., 21 Mar 2007, In: The EMBO Journal. 26(6), 6, p. 1560-1568 9 p.

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

2006

Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.

Panova, T. B., Panov, K., Russell, J. & Zomerdijk, J. C., Aug 2006, In: Molecular and Cellular Biology. 26(16), 16, p. 5957-5968 12 p.

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.

Panov, K., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. & Zomerdijk, J. C., Jul 2006, In: Molecular and Cellular Biology. 26(14), 14, p. 5436-5448 13 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

UBF activates RNA polymerase I transcription by stimulating promoter escape.

Panov, K., Friedrich, J. K., Russell, J. & Zomerdijk, J. C., 26 Jul 2006, In: The EMBO Journal. 25(14), 14, p. 3310-3322 13 p.

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

2005

TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.

Friedrich, J. K., Panov, K., Cabart, P., Russell, J. & Zomerdijk, J. C., 19 Aug 2005, In: Journal of Biological Chemistry. 280(33), 33, p. 29551-29558 8 p.

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

2002

The structure of substrate-free microbial ribonuclease binase and of its complexes with 3'GMP and sulfate ions.

Polyakov, K. M., Lebedev, A. A., Okorokov, A. L., Panov, K., Schulga, A. A., Pavlovsky, A. G., Karpeisky, M. Y. & Dodson, G. G., 2002, In: Acta crystallographica. Section D, Biological crystallography. 58(Pt 5), 5, p. 744-750 7 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

2001

A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription.

Panov, K., Friedrich, J. K. & Zomerdijk, J. C., 2001, In: Molecular and Cellular Biology. 21(8), 8, p. 2641-2649 9 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.

Miller, G., Panov, K., Friedrich, J. K., Trinkle-Mulcahy, L., Lamond, A. I. & Zomerdijk, J. C., 15 Mar 2001, In: The EMBO Journal. 20(6), 6, p. 1373-1382 10 p.

Research output: Contribution to journal › Article › peer-review

160 Citations (Scopus)

2000

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

Ajuh, P., Kuster, B., Panov, K., Zomerdijk, J. C., Mann, M. & Lamond, A. I., 01 Dec 2000, In: The EMBO Journal. 19(23), 23, p. 6569-6581 13 p.

Research output: Contribution to journal › Article › peer-review

176 Citations (Scopus)

1997

RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations.

Okorokov, A. L., Panov, K., Offen, W. A., Mukhortov, V. G., Anston, A. A., Ya, K. M., Wilkson, A. J. & Dodson, G. G., 1997, In: Protein Engineering. 10(3), p. 273-278 6 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

1996

Ribonuclease A mutants His¹¹⁹ Asn: The role of histidine in catalysis

Panov, K. I., Kolbanovskaya, E. Y., Okorokov, A. L., Panova, T. B., Terwisscha Van Scheltinga, A. C., Karpeisky, M. Y. & Beintema, J. J., 25 Nov 1996, In: FEBS Letters. 398, 1, p. 57-60 4 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Site-directed mutagenesis of the base recognition loop of ribonuclease from Bacillus intermedius (binase)

Okorokov, A. L., Panov, K. I., Kolbanovskaya, E. Y., Karpeisky, M. Y., Polyakov, K. M., Wilkinson, A. J. & Dodson, G. G., 15 Apr 1996, In: FEBS Letters. 384, 2, p. 143-146 4 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

1995

An efficient system for active bovine pancreatic ribonuclease expression in escherichia coli

Okorokov, A. L., Panov, K. I., Poele, R. H., Breukelman, H. J., Furia, A., Karpeisky, M. Y. & Beintema, J. J., Aug 1995, In: Protein Expression and Purification. 6, 4, p. 472-480 9 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

1994

An improved system for ribonuclease ba expression

Okorokov, A. L., Hartley, R. W. & Panov, K. I., Dec 1994, In: Protein Expression and Purification. 5, 6, p. 547-552 6 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

High-level expression of binase in Escherichia coli

Schulga, A. A., Okorokov, A. L., Panov, K. I., Kurbanov, F. T., Chernov, B. K., Skryabin, K. G. & Kirpichnikov, M. P., 01 Jan 1994, In: Molekulyarnaya Biologiya. 28, 2, p. 453-463 11 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Mutant barnazy Ser57Ala: poluchenie i svoistva.

Translated title of the contribution: Barnase mutant Ser57Ala: preparation and propertiesKolbanovskaia, E. I., Okorokov, A. L., Panov, K. I., Poliakov, K. M., Hartley, R. W. & Karpeiskii, M. I., 01 Jan 1994, In: Molekuliarnaia biologiia. 28, 3, p. 602-609 8 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Purification of bacilli ribonucleases by reversed-phase high-performance liquid chromatography

Panov, K. I., 03 Jun 1994, In: Journal of Chromatography A. 670, 1-2, p. 229-233 5 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

1989

Convenient synthesis of 5′-methyl-2′-desoxyuridines

Mikhailov, S. N., Padyukova, N. S. & Panov, K. I., Feb 1989, In: Chemistry of Heterocyclic Compounds. 25, 2, p. 203-205 3 p.

Research output: Contribution to journal › Article › peer-review

Konstantin Panov

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