Laura Smyth

2024

Cohort profile: DNA methylation in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) – recruitment and participant characteristics

Potter, C., Hill, C., Smyth, L. J., Neville, C., Scott, A., Kee, F., McGuinness, B. & McKnight, A., 13 Sept 2024, In: BMJ Open. 14, 9, 8 p., e085652.

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Exploring accelerated ageing in diabetic kidney disease: Epigenetic clocks in UK-Ireland participants

Hill, C., Smyth, L. & McKnight, A. J., 17 May 2024.

Research output: Contribution to conference › Abstract › peer-review

Genetic variants affecting mitochondrial function provide further insights for kidney disease

Cañadas-Garre, M., Baños-Jaime, B., Maqueda, J., Smyth, L. J., Cappa, R., Skelly, R., Hill, C., Brennan, E. P., Doyle, R., Godson, C., Maxwell, A. P. & McKnight, A. J., 10 Jun 2024, In: BMC Genomics. 25, 20 p., 576.

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1 Citation (Scopus)

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Integrated multiomic analyses: an approach to improve understanding of diabetic kidney disease

Hill, C., McKnight, A. J. & Smyth, L. J., 26 Oct 2024, (Early online date) In: Diabetic Medicine. 19 p., e15447.

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1 Citation (Scopus)

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2023

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

VA Million Veteran Program & Global Lipids Genetics Consortium, 26 May 2023, (Early online date) In: Nature. 618, p. E19-E20

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Differential methylation in CD44 and SEC23A is associated with time preference in older individuals.

Northern Ireland COhort for the Longitudinal study of Ageing collaborative group, Apr 2023, In: Economics and Human Biology. 49

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1 Citation (Scopus)

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Four missense genetic variants in CUBN are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: a genetic association study in Europeans

Uglebjerg, N., Ahmadizar, F., Aly, D., Cañadas-Garre, M., Hill, C., Naber, A., Singh, S., Smyth, L., Tregouet, D.-A., Chaker, L., Ghanbari, M., Ahlqvist, E., Hadjadj, S., van Hoek, M., Kavousi, M., McKnight, A. J., Sijbrands, E., Simons, M., Rossing, P. & Ahluwalia, T. S., 28 Feb 2023, In: Frontiers in Endocrinology. 14, 1081741.

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3 Citations (Scopus)

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Longitudinal epigenome-wide analysis of kidney transplant recipients pretransplant and posttransplant

Smyth, L. J., Kerr, K. R., Kilner, J., McGill, Á. E., Maxwell, A. P. & McKnight, A. J., 01 Feb 2023, In: Kidney International Reports. 8, 2, p. 330-340 11 p.

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6 Citations (Scopus)

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2022

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K.-H. H., Ntalla, I., Hui, Q. & Klarin, D. & 31 others, Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Weir, D. R., Brown, M. R., Smyth, L. J., Cañadas-Garre, M., Li, X., Nelson, C. P., McKnight, A. J., Kee, F., Wilson, P., Brown, C. D. & Million Veterans Program, 04 Aug 2022, In: The American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

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20 Citations (Scopus)

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An investigation into DNA methylation patterns associated with risk preference in older individuals

Smyth, L. J., Cruise, S. M., Tang, J., Young, I., McGuinness, B., Kee, F., McKnight, A. J. & On behalf of NICOLA , 01 Oct 2022, In: Epigenetics. 17, 10, p. 1159-1172 14 p.

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2 Citations (Scopus)

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A saturated map of common genetic variants associated with human height

Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S.-H., Ferreira, T., Highland, H. H. & Ji, Y. & 31 others, Karaderi, T., Lin, K., Lüll, K., Malden, D. E., Medina-Gomez, C., Machado, M., Moore, A., Rüeger, S., Sim, X., Vrieze, S., Ahluwalia, T. S., Akiyama, M., Allison, M. A., Alvarez, M., Andersen, M. K., Ani, A., Appadurai, V., Arbeeva, L., Cai, H., Cañadas-Garre, M., Li, X., Nelson, C. P., Smyth, L. J., Sun, L., Wang, Z., Cole, J. W., Cooper, R. S., Kee, F., McKnight, A. J., Weir, D. R. & 23andMe Research Team, 12 Oct 2022, (Early online date) In: Nature.

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260 Citations (Scopus)

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DNA methylation at ten loci is a risk factor for kidney failure in individuals with type 1 diabetes and diabetic kidney disease

Syreeni, A., Dahlström, E. H., Smyth, L. J., Forsblom, C., Kilner, J., McKay, G. J., Maxwell, A. P., McKnight, A. J., Groop, P.-H. & Sandholm, N., 27 May 2022.

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DNA methylation is a risk factor for kidney failure in individuals with type 1 diabetes

Syreeni, A., Dahlström, E. H., Smyth, L. J., Gupta, Y., Forsblom, C., Kilner, J., McKay, G. J., Maxwell, A., McKnight, A., Groop, P.-H. & Sandholm, N., 30 Oct 2022, In: Diabetologia. 65, Supplement 1, p. S21 1 p., 38.

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Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Smyth, L. J., Dahlström, E. H., Syreeni, A., Kerr, K., Kilner, J., Doyle, R., Brennan, E., Nair, V., Fermin, D., Nelson, R. G., Looker, H. C., Wooster, C., Andrews, D., Anderson, K., McKay, G. J., Cole, J. B., Salem, R. M., Conlon, P. J., Kretzler, M. & Hirschhorn, J. N. & 9 others, Sadlier, D., Godson, C., Florez, J. C., GENIE Consortium, Forsblom, C., Maxwell, A. P., Groop, P. H., Sandholm, N. & McKnight, A. J., 22 Dec 2022, In: Nature Communications. 13, 16 p., 7891.

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14 Citations (Scopus)

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Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Sandholm, N., Cole, J. B., Nair, V., Sheng, X., Liu, H., Ahlqvist, E., Van Zuydam, N., Dahlström, E. H., Fermin, D., Smyth, L., Salem, R. M., Forsblom, C., Valo, E., Harjutsalo, V., Brennan, E. P., McKay, G., Andrews, D., Doyle, R., Looker, H. & Nelson, R. & 11 others, Palmer, C., McKnight, A. J., Godson, C., Maxwell, P., Groop, L., McCarthy, M., Kretzler, M., Susztak, K., Hirschhorn, J. N., Florez, J. C. & Groop, P.-H., 28 Jun 2022, (Early online date) In: Diabetologia.

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Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K.-H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z. & Xue, C. & 518 others, Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J.-H., Matsuda, F., Jang, H.-M., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Yousri, N. A., Mitchell, R. E., Chai, J. F., Aadahl, M., Bjerregaard, A. A., Yao, J., Manichaikul, A., Hwu, C.-M., Hung, Y.-J., Warren, H. R., Ramirez, J., Bork-Jensen, J., Kårhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Mauro, P., Matteo, F., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, L. T., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Ruotsalainen, S. E., Daw, E., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Vazquez-Moreno, M., Feitosa, M. F., Wojczynski, M. K., Wang, Z., Preuss, M. H., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Tsao, N. L., Verma, A., Slieker, R. C., Lo, K. S., Zilhao, N. R., Le, P., Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Demirkan, A., Leonard, H. L., Marten, J., Frank, M., Schmidt, B., Smyth, L. J., Cañadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kähönen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Nongmaithem, S. S., Bayyana, S., Stringham, H. M., Irvin, M. R., Oldmeadow, C., Kim, H.-N., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Prasad, G., Lorés-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Banas, B., Nardone, G. G., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A.-E., Hofer, E., Lin, M., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkänen, N., Cade, B. E., van der Laan, S. W., Chitrala, K. N., Weiss, S., Bentley, A. R., Doumatey, A. P., Adeyemo, A. A., Lee, J. Y., Petersen, E. R. B., Nielsen, A. A., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S.-Y., Wang, J.-S., Couture, C., Lyytikäinen, L.-P., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hidalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Liang, J., Tang, H., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Kawaguchi, T., Thiery, J., Bis, J. C., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jäger, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X.-O., Rallidis, L. S., Pedersen, O., Hansen, T., Mitchell, P., Hewitt, A. W., Kähönen, M., Pérusse, L., Bouchard, C., Tönjes, A., Chen, Y.-D. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellström, D., Cho, Y. S., Lee, H., Yuan, J.-M., Koh, W.-P., Rhee, S. Y., Woo, J.-T., Heid, I. M., Stark, K. J., Zimmermann, M. E., Völzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Peyser, P. A., Kato, N., Schulze, M. B., Girotto, G., Böger, C. A., Jung, B., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Tusié-Luna, T., Aguilar-Salinas, C. A., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J.-Y., Zheng, W., Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C.-K., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H.-L., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Hunt, S. C., Walker, M., Koistinen, H. A., Chandak, G. R., Mercader, J. M., Costanzo, M. C., Jang, D., Burtt, N. P., Villalpando, C. G., Orozco, L., Fornage, M., Tai, E., van Dam, R. M., Lehtimäki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jöckel, K.-H., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Jin, Z.-B., Qu, J., Hishigaki, H., Lin, X., März, W., Gudnason, V., Tardif, J.-C., Lettre, G., Hart, L. M. '., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, R. J. F., Province, M. A., Parra, E. J., Cruz, M., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Rotimi, C. N., Christensen, K., Ripatti, S., Widén, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, A., Jukema, J. W., Khera, A. V., Männikkö, M., Jarvelin, M.-R., Kutalik, Z., Francesco, C., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, N., Sever, P., Poulter, N., Chuang, L.-M., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C.-Y., Wong, T.-Y., Khor, C. C., Li, H., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., Willemsen, A. H. M., Cupples, L., van Meurs, J. B. J., Ghanbari, M., Gordon-Larsen, P., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., Hazelhurst, S., Ramsay, M., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W.-Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B.-J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, Y., Ho, Y.-L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K.-M., Cho, K., O'Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., 27 Dec 2022, In: Genome Biology. 23, 1, 268.

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27 Citations (Scopus)

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Prevalence and risk factors for age-related macular degeneration in a population-based cohort study of older adults in Northern Ireland using multimodal imaging: NICOLA Study

Hogg, R. E., Wright, D. M., Quinn, N. B., Muldrew, K. A., Hamill, B., Smyth, L., McKnight, A. J., Woodside, J., Tully, M. A., Cruise, S., McGuinness, B., Young, I. S., Kee, F., Peto, T. & Chakravarthy, U., 10 Oct 2022, (Early online date) In: British Journal of Ophthalmology. 7 p.

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6 Citations (Scopus)

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2021

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study

Smyth, L., Kilner, J., Nair, V., Liu, H., Brennan, E. P., Kerr, K., Sandholm, N., Cole, J. B., Dahlström, E., Syreeni, A., Salem, R. M., Nelson, R., Looker, H., Wooster, C., Anderson, K., McKay, G., Kee, F., Young, I., Andrews, D. & Forsblom, C. & 8 others, Hirschhorn, J. N., Godson, C., Groop, P.-H., Maxwell, P., Susztak, K., Kretzler, M., Florez, J. C. & McKnight, A. J., 01 May 2021, In: Clinical Epigenetics.

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31 Citations (Scopus)

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Biochemical biomarkers

Cañadas-Garre, M., Smyth, L., Neville, C., Vijayakumar, A., Kee, F., Woodside, J. & McKnight, A. J., 15 Jun 2021, Objective measures of health and wellbeing of older adults in Northern Ireland: the NICOLA Study Wave 1. Kee, F., Neville, C., McGuinness, B. & Hogg, R. (eds.). Queen's University Belfast, p. 103-127

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Epigenome-wide association study identifies differentially methylated DNA sites for diabetic kidney disease in type 1 diabetes: Oral Presentation

Dahlström, E. H., Smyth, L. J., Syreeni, A., Kilner, J., McKay, G. J., Sandholm, N., Forsblom, C., Maxwell, A., McKnight, A. & Groop, P.-H., 01 Sept 2021, In: Diabetologia. 64, p. S127 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

3 Citations (Scopus)

Longitudinal epigenome wide analysis of kidney transplant recipients pre- and post-transplant identifies differentially methylated genes.

Kerr, K., Kilner, J., Maxwell, P., McKnight, A. J. & Smyth, L., 05 Oct 2021.

Research output: Contribution to conference › Poster › peer-review

Molecular biomarkers

Cañadas-Garre, M., Smyth, L., Neville, C., Kee, F., Woodside, J. & McKnight, A. J., 15 Jun 2021, Objective measures of health and wellbeing of older adults in Northern Ireland: the NICOLA Study Wave 1. Kee, F., Neville, C., McGuinness, B. & Hogg, R. (eds.). Queen's University Belfast, p. 128-147

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Poster abstract: Epigenetic analyses of diabetic kidney disease attributed to type 1 diabetes in European populations

Smyth, L., Dahlström, E., Kilner, J., Syreeni, A., McKay, G., Sandholm, N., Forsblom, C., Maxwell, P., Groop, P.-H. & McKnight, A. J., 21 May 2021.

Research output: Contribution to conference › Abstract › peer-review

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The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A. & Trivedi, B. & 30 others, Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Weir, D. R., Brown, M. R., Smyth, L. J., Cañadas-Garre, M., Li, X., Nelson, C. P., McKnight, A. J., Kee, F., Wilson, P. & Brown, C. D., 23 Dec 2021, In: Nature. 600, 7890, p. 675-679 5 p.

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388 Citations (Scopus)

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2020

An integrative multi-omic approach to expanding are disease research in Northern Ireland: crystal award

Kerr, K., McAneney, H., Smyth, L., Bailie, C., McKee, S. & McKnight, A. J., 28 Feb 2020.

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A scoping review and proposed workflow for multi-omic rare disease research

Kerr, K., McAneney, H., Smyth, L., Bailie, C., McKee, S. & McKnight, A. J., 30 Apr 2020, In: Orphanet J Rare Dis. 15, 107

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27 Citations (Scopus)

147 Downloads (Pure)

DNA methylation associated with diabetic kidney disease in blood-derived DNA

Smyth, L. J., Patterson, C. C., Swan, E., Maxwell, A. P. & McKnight, A. J., 15 Oct 2020, In: Frontiers in Cell and Developmental Biology.

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23 Citations (Scopus)

135 Downloads (Pure)

Epigenome-Wide Microarray Analysis of Pre- and Post-Transplant Methylation Profiles in Kidney Transplant Recipients: Oral Presentation

Kerr, K., Smyth, L., Kilner, J., Maxwell, P., McAneney, H. & McKnight, A. J., 01 Oct 2020, p. 29. 30 p.

Research output: Contribution to conference › Other contribution to conference › peer-review

Genetic risk factors in mitochondrial DNA associated with diabetic kidney disease – GWAS discovery and meta-analysis

Skelly, R., Smyth, L., Cole, J., Maxwell, A., GENIE Consortium, .., Consortium, D. & McKnight, A., 01 Jan 2020.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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77 Downloads (Pure)

Genetic strategies to understand human diabetic nephropathy: in silico strategies for molecular data - association studies

Cañadas-Garre, M., Smyth, L., Anderson, K., Kerr, K. & McKnight, A., 01 Jan 2020, Methods in Molecular Biology: Molecular Methods in Diabetic Nephropathy. Springer Nature US, Vol. 2067. p. 241-275

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Genetic strategies to understand human diabetic nephropathy: wet-lab approaches

Smyth, L., Kerr, K., Duffy, S., Kilner, J. & McKnight, A., 01 Jan 2020, Methods in Molecular Biology: Molecular Methods in Diabetic Nephropathy. Springer Nature US, Vol. 2067. p. 205-240 26 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

1 Citation (Scopus)

Genome-wide DNA methylation analysis for diabetic kidney disease in a UK-ROI population: Oral Presentation

Smyth, L., Sandholm, N., Wooster, C., Kilner, J., Forsblom, C., Groop, P.-H., Maxwell, A., McKnight, A. & GENIE Consortium, 18 Feb 2020, p. 47-69.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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75 Downloads (Pure)

Genome-wide DNA methylation analysis for type 1 diabetes

Smyth, L., Wooster, C., Kilner, J., Kee, F., Young, I., McGuinness, B., Maxwell, A., McKay, G., McKnight, A., GENIE Consortium & On behalf of NICOLA , 2020, In: The Ulster Medical Journal. 89, 1, p. 48 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Identification of differentially methylated genes in individuals with end-stage kidney disease attributed to diabetic kidney disease: Oral Presentation

Smyth, L., Kerr, K., Wooster, C., Kilner, J., Maxwell, P. & McKnight, A. J., 05 Oct 2020.

Research output: Contribution to conference › Other contribution to conference › peer-review

2019

Comparison of methylation patterns generated from genomic and cell-line derived DNA using the Illumina Infinium MethylationEPIC BeadChip array

Smyth, L. J., Kilner, J., Maxwell, A. P. & McKnight, A. J., 21 Dec 2019, In: BMC Research Notes. 12, 8 p., 821.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

80 Downloads (Pure)

Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis

Smyth, L. J., Cañadas-Garre, M., Cappa, R. C., Maxwell, A. P. & McKnight, A. J., 01 May 2019, In: BMJ Open. 9, 4, 9 p., :e026777.

Research output: Contribution to journal › Article › peer-review

Open Access

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44 Citations (Scopus)

243 Downloads (Pure)

Genetic susceptibility to chronic kidney disease – some more pieces for the heritability puzzle: genetic predisposition to kidney disease

Cañadas-Garre, M., Anderson, K., Cappa, R., Skelly, R., Smyth, L. J., McKnight, A. J. & Maxwell, A. P., 31 May 2019, In: Frontiers in Genetics. 10, 16 p., 453.

Research output: Contribution to journal › Review article › peer-review

Open Access

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72 Citations (Scopus)

261 Downloads (Pure)

Identification of differentially expressed genes from kidney transplant recipients in Northern Ireland

Kerr, K., Smyth, L., Kilner, J., Maxwell, A., McAneney, H., Young, I., McGuinness, B., Kee, F., On behalf of NICOLA & McKnight, A., 23 Jul 2019, (Accepted).

Research output: Contribution to conference › Poster › peer-review

Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

Kunzmann, A., Cañadas-Garre, M., Thrift, A., McMenamin, U., Johnston, B., Cardwell, C., Anderson, L., Spence, A., Lagergren, J., Xie, S.-H., Smyth, L., McKnight, A. & Coleman, H., 01 Jan 2019, In: Gastroenterology. 156, 1, p. 43-45

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

435 Downloads (Pure)

Systematic review of differential methylation in rare ophthalmic diseases

Kerr, K., McAneney, H., Smyth, L., Flanagan, C., Silvestri, J., Nesbitt, M. A., Wooster, C. & McKnight, A., 13 Nov 2019, In: BMJ Open Ophthalmology.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

123 Downloads (Pure)

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

Stapleton, C. P., Heinzel, A., Guan, W., van der Most, P. J., van Setten, J., Lord, G. M., Keating, B. J., Israni, A. K., de Borst, M. H., Bakker, S. J. L., Snieder, H., Weale, M. E., Delaney, F., Hernandez-Fuentes, M. P., Reindl-Schwaighofer, R., Oberbauer, R., Jacobson, P. A., Mark, P. B., Chapman, F. A. & Phelan, P. J. & 15 others, Sexton, D., Murray, S., Jardine, A., Traynor, J. P., McKnight, A. J., Maxwell, A. P., Smyth, L. J., Oetting, W. S., Matas, A. J., Mannon, R. B., Schladt, D. P., Iklé, D. N., Cavalleri, G. L., Conlon, P. J. & UK Ireland Renal Transplant Consortium, 27 Feb 2019, (Early online date) In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2018

An investigation into the DNA methylation patterns of CKD in older individuals: Oral Presentation

Smyth, L. J., Cruise, S., Kilner, J., Maxwell, A. P., McGuinness, B., Kee, F. & McKnight, A. J., 25 Oct 2018, In: Journal of the American Society of Nephrology. Abstract Supplement 2018, p. 24 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

An investigation into the DNA methylation patterns of risk and time preference in older individuals: Oral Presentation

Smyth, L., Cruise, S., Young, I., McGuinness, B., Tang, J., Kee, F. & McKnight, A., 11 Oct 2018.

Research output: Contribution to conference › Other contribution to conference › peer-review

Genetic and epigenetic analysis in genes affecting mitochondrial function are associated with chronic kidney disease in an older population

McKnight, A. J., Cappa, R. C., Smyth, L. J., Cañadas Garre, M., De Campos, C. P., Skelly, R., Cruise, S., Kee, F., McGuinness, B., Godson, C. & Maxwell, A. P., 25 Oct 2018.

Research output: Contribution to conference › Abstract › peer-review

Open Access