Lei Wang

Dr

  • Room 02.006 - Clinical Science A

    United Kingdom

Accepting PhD Students

20072020
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Research Output 2007 2020

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Article
2020
Open Access
File
Peptides
Skin
Cytotoxicity
Derivatives
Ranidae
2019
95 Downloads (Pure)
Open Access
File
Bombesin
Smooth Muscle
Muscle
Rats
Skin
80 Downloads (Pure)
Open Access
File
Bradykinin
Anura
Smooth Muscle
Muscle
Skin
33 Downloads (Pure)
Open Access
File
Tarsiidae
Skin
Cells
Cell membranes
Microorganisms
51 Downloads (Pure)

A Novel Kunitzin-Like Trypsin Inhibitor Isolated from Defensive Skin Secretion of Odorrana versabilis

Dong, Y., Shi, D., Ying, Y., Xi, X., Chen, X., Wang, L., Zhou, M., Wu, Q., Ma, C. & Chen, T., 28 Jun 2019, In : Biomolecules. 9, 7, 14 p., 254.

Research output: Contribution to journalArticle

Open Access
File
Trypsin Inhibitors
Trypsin
Skin
Peptides
Bamboo
6 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Methicillin Resistance
Methicillin
Cystic Fibrosis
Anura
Skin
1 Citation (Scopus)
64 Downloads (Pure)

Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and Its Truncated Analogues

Zhou, X., Shi, D., Zhong, R., Ye, Z., Ma, C., Zhou, M., Xi, X., Wang, L., Chen, T. & Kwok, H. F., 25 Jun 2019, In : Biomolecules. 9, 6, 15 p., 249.

Research output: Contribution to journalArticle

Open Access
File
Rana pipiens
Anura
Skin
Peptides
Staphylococcus aureus

Cloning of a Novel Trypsin Inhibitor from the Traditional Chinese Medicine Decoction Pieces, Radix Trichosanthis

Sang, M., Ying, Y., Wu, Q., Ma, C., Xi, X., Zhou, M., Wang, L., Bininda-Emonds, O. & Chen, T., 01 Mar 2019, In : Analytical Biochemistry.

Research output: Contribution to journalArticle

Trypsin Inhibitors
Cloning
Chinese Traditional Medicine
Medicine
Organism Cloning
30 Downloads (Pure)
Open Access
File
Cystic Fibrosis
Dimyristoylphosphatidylcholine
Derivatives
Peptides
Hydrophobicity
70 Downloads (Pure)

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor

Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280.

Research output: Contribution to journalArticle

Open Access
File
Protease Inhibitors
Peptides
Trypsin
Skin
Lysine
4 Citations (Scopus)
62 Downloads (Pure)
Open Access
File
secretions
Bioactivity
peptides
Skin
membranes
1 Citation (Scopus)
21 Downloads (Pure)
Open Access
File
Anura
Skin
Peptides
Cloning
Firearms
133 Downloads (Pure)
Open Access
File
Hydrophobic and Hydrophilic Interactions
Peptides
Anti-Bacterial Agents
Skin
Solid-Phase Synthesis Techniques
37 Downloads (Pure)

Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae)

Proaño-Bolaños, C., Blasco-Zúñiga, A., Rafael Almeida, J., Wang, L., Angel Llumiquinga, M., Rivera, M., Zhou, M., Chen, T. & Shaw, C., 30 Oct 2019, In : Biomolecules. 9, 11, 20 p., 667.

Research output: Contribution to journalArticle

Open Access
File
Anura
Skin
Peptides
Microbial Sensitivity Tests
Candida
2018
2 Citations (Scopus)
159 Downloads (Pure)

A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea

Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In : Scientific Reports. 8, 9 p., 5851.

Research output: Contribution to journalArticle

Open Access
File
Chymotrypsin
Peptides
Proteasome Endopeptidase Complex
Trypsin Inhibitors
Cloning
3 Citations (Scopus)
142 Downloads (Pure)

A novel antimicrobial peptide, Ranatuerin-2PLx (R2PLx), showing therapeutic potential in inhibiting proliferation of cancer cells

Chen, X., Zhang, L., Ma, C., Zhang, Y., Xi, X., Wang, L., Zhou, M., Burrows, J. F. & Chen, T., Dec 2018, In : Bioscience Reports. 38, 6, 11 p., BSR20180710.

Research output: Contribution to journalArticle

Open Access
File
Cells
Cell Proliferation
Peptides
Neoplasms
Ranidae
2 Citations (Scopus)
136 Downloads (Pure)
Open Access
File
Potassium Channels
Insulin
Peptides
Anura
Glucose
4 Citations (Scopus)
159 Downloads (Pure)
Open Access
File
Hydrophobicity
Bioactivity
Hydrophobic and Hydrophilic Interactions
Skin
Peptides
86 Downloads (Pure)

Comparative Profiling of Three Atheris Snake Venoms: A. squamigera, A. nitschei and A. chlorechis

Wang, H., Chen, X., König, E., Zhou, M., Wang, L., Chen, T. & Shaw, C., Aug 2018, In : The Protein Journal. 37, 4, p. 353-360

Research output: Contribution to journalArticle

Open Access
File
Snake Venoms
Venoms
Proteins
Proteomics
Size exclusion chromatography
3 Citations (Scopus)
122 Downloads (Pure)

Discovery of Distinctin-Like-Peptide-PH (DLP-PH) from the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide

Wu, D., Gao, Y., Tan, Y., Liu, Y., Wang, L., Zhou, M., Xi, X., Ma, C., Bininda-Emonds, O. R. P., Chen, T. & Shaw, C., 23 Mar 2018, In : Frontiers in Microbiology. 9, 11 p., 541.

Research output: Contribution to journalArticle

Open Access
File
Skin
Peptides
Anura
Complementary DNA
distinctin
114 Downloads (Pure)
Open Access
File
Anura
Skin
Smooth Muscle
Muscle
Rats
3 Citations (Scopus)
134 Downloads (Pure)
Open Access
File
Cytotoxicity
skin (animal)
cytotoxicity
Skin
Fusion reactions
3 Citations (Scopus)
138 Downloads (Pure)
Open Access
File
Ranidae
Bioactivity
Anura
Skin
Peptides
8 Citations (Scopus)
158 Downloads (Pure)

Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

Chen, X., Zhang, L., Wu, Y., Wang, L., Ma, C., Xi, X., Bininda-Emonds, O., Shaw, C., Chen, T. & Zhou, M., 01 May 2018, In : International Journal of Biological Sciences. 14, 6, p. 599-607 9 p.

Research output: Contribution to journalArticle

Open Access
File
Wasp Venoms
venom
bioactivity
venoms
wasp
4 Citations (Scopus)
153 Downloads (Pure)
Open Access
File
Anura
Skin
Bioactivity
Peptides
Bioassay
2 Citations (Scopus)
122 Downloads (Pure)
Open Access
File
Ranidae
Skin
Peptides
Methicillin-Resistant Staphylococcus aureus
Cells
2 Citations (Scopus)
134 Downloads (Pure)
Open Access
File
Ranidae
Bacteria
Peptides
Methicillin-Resistant Staphylococcus aureus
Infection
2 Citations (Scopus)
145 Downloads (Pure)

Novel peptide dermaseptin‐PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling

Long, Q., Li, L., Wang, H., Li, M., Wang, L., Zhou, M., Su, Q., Chen, T. & Wu, Y., 21 Nov 2018, In : Journal of Cellular and Molecular Medicine. 23, 2, p. 1300-1312 13 p.

Research output: Contribution to journalArticle

Open Access
File
Apoptosis
Peptides
Cell Membrane
Anura
Neoplasms
2017
3 Citations (Scopus)
171 Downloads (Pure)

Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats

Liu, S., Long, Q., Xu, Y., Wang, J., Xu, Z., Wang, L., Zhou, M., Wu, Y., Chen, T. & Shaw, C., 30 Nov 2017, In : Oncotarget. 8, 67, p. 111369-111386

Research output: Contribution to journalArticle

Open Access
File
Klebsiella pneumoniae
Wound Healing
Bacteria
Peptides
Re-Epithelialization
8 Citations (Scopus)
183 Downloads (Pure)

A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri

Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticle

Open Access
File
Tryptases
Protease Inhibitors
Anura
Trypsin
Skin
16 Citations (Scopus)
175 Downloads (Pure)
Open Access
File
Skin
Peptides
Cytotoxicity
Bioactivity
Bacteria
7 Citations (Scopus)
188 Downloads (Pure)
Open Access
File
frogs
secretions
Gram-Positive Bacteria
cultured cells
Non-Small Cell Lung Carcinoma
2 Citations (Scopus)
170 Downloads (Pure)

Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis

Du, Q., Wang, H., Ma, C., Wu, Y., Xi, X., Zhou, M., Chen, T., Shaw, C. & Wang, L., 19 Jul 2017, In : Molecules. 22, 9 p., 1215.

Research output: Contribution to journalArticle

Open Access
File
Skin
Amides
Peptides
Molecular mass
Muscle
4 Citations (Scopus)
140 Downloads (Pure)

Novel Kazal-type Protease inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer

Proaño Bolaños, C., Li, R., Zhou, M., Wang, L., Xi, X., Tapia, E. E., Coloma, L. A., Chen, T. & Shaw, C., Jun 2017, In : EuPA Open Proteomics. 15, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
File
Protease Inhibitors
Anura
Skin
Biological Phenomena
Cloning
2 Citations (Scopus)
163 Downloads (Pure)
Open Access
File
Bombesin
Muscle
Skin
Peptides
Chromatography
6 Citations (Scopus)
227 Downloads (Pure)
Open Access
File
secretions
biofilms
Biofilms
Cytotoxicity
lungs
2 Citations (Scopus)
158 Downloads (Pure)

Ranatensin-HL: A Bombesin-Related Tridecapeptide from the Skin Secretion of the Broad-Folded Frog, Hylarana latouchii

Lin, Y., Chen, T., Zhou, M., Wang, L., Su, S. & Shaw, C., 04 Jul 2017, In : Molecules. 22, 7, 1110.

Research output: Contribution to journalArticle

Open Access
File
frogs
Bombesin
secretions
Anura
peptides
14 Citations (Scopus)
Open Access
Tarsiidae
Amphibians
Methicillin-Resistant Staphylococcus aureus
Biofilms
Peptides
3 Citations (Scopus)
223 Downloads (Pure)
Open Access
File
Anura
Skin
Adenosine Monophosphate
Leucine
Peptides
2016
8 Citations (Scopus)
1065 Downloads (Pure)
Open Access
File
secretions
Cloning
Molecular Cloning
peptides
Skin
1 Citation (Scopus)
177 Downloads (Pure)

Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea

Shi, D., Xi, X., Wang, L., Gao, Y., Ma, C., Chen, H., Zhou, M., Chen, T. & Shaw, C., 08 Jul 2016, In : Toxins. 8, 7, 10 p., 213.

Research output: Contribution to journalArticle

Open Access
File
Anura
Skin
Peptides
Smooth Muscle
Muscle
6 Citations (Scopus)
1185 Downloads (Pure)
Open Access
File
Anura
Skin
Peptides
Bacteria
High performance liquid chromatography
3 Citations (Scopus)
209 Downloads (Pure)
Open Access
File
Bradykinin
Anura
Smooth Muscle
Muscle
Rats
2 Citations (Scopus)
Bradykinin
Bioactivity
Anura
Skin
Ranidae
4 Citations (Scopus)
214 Downloads (Pure)
Open Access
File
Bioactivity
Anura
Skin
Bacteria
Substitution reactions
17 Citations (Scopus)
784 Downloads (Pure)
Open Access
File
Skin
Peptides
Candida
Lysine
Toxicity
3 Citations (Scopus)
300 Downloads (Pure)

Identification of Miscellaneous Peptides from the Skin Secretion of the European Edible Frog, Pelophylax kl. Esculentus

Chen, X., Wang, H., Wang, L., Zhou, M., Chen, T. & Shaw, C., Aug 2016, In : The Protein Journal. 35, 4, p. 291-299 9 p.

Research output: Contribution to journalArticle

Open Access
File
Anura
Peptides
Skin
Rana ridibunda
Bombesin
6 Citations (Scopus)
182 Downloads (Pure)

Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs

Chen, X., Wang, H., Chen, Y., Wang, L., Zhou, M., Chen, T. & Shaw, C., 19 Aug 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 302-9 8 p.

Research output: Contribution to journalArticle

Open Access
File
Protease Inhibitors
Anura
Skin
Trypsin Inhibitors
Peptides
2 Citations (Scopus)
349 Downloads (Pure)
Open Access
File
Phospholipases A2
Venoms
Snake Venoms
Cloning
Proteins
4 Citations (Scopus)
245 Downloads (Pure)

Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer

Proaño Bolaños, C., Zhou, M., Wang, L., Luis, C., Chen, T. & Shaw, C., 02 Sep 2016, In : Journal of proteomics. 146, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
File
Anura
Peptides
Bacteria
Skin
Candida