• Room 0G.021 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor Heaney is open to wide-ranging PhD applications from candidates with a basic science or clinical background.
His fields of interest include:
- asthma
- medication adherence
- precision medicine in asthma and COPD
Previous research experience is desirable although not essential.

1993 …2024

Research activity per year

Personal profile

Research Statement

My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.

A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver  early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education

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  • 1 Similar Profiles

Collaborations and top research areas from the last five years

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  • 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study

    Leavy, O. C., Russell, R. J., Harrison, E. M., Lone, N. I., Kerr, S., Docherty, A. B., Sheikh, A., Richardson, M., Elneima, O., Greening, N. J., Harris, V. C., Houchen-Wolloff, L., McAuley, H. J. C., Saunders, R. M., Sereno, M., Shikotra, A., Singapuri, A., Aul, R., Beirne, P. & Bolton, C. E. & 53 others, Brown, J. S., Choudhury, G., Diar Bakerly, N., Easom, N., Echevarria, C., Fuld, J., Hart, N., Hurst, J. R., Jones, M., Parekh, D., Pfeffer, P., Rahman, N. M., Rowland-Jones, S., Shah, A. M., Wootton, D. G., Jolley, C., Thompson, A. A. R., Chalder, T., Davies, M. J., De Soyza, A., Geddes, J. R., Greenhalf, W., Heller, S., Howard, L., Jacob, J., Jenkins, R. G., Lord, J. M., Man, W.D.-C., McCann, G. P., Neubauer, S., Openshaw, P. J. M., Porter, J., Rowland, M. J., Scott, J. T., Semple, M. G., Singh, S. J., Thomas, D., Toshner, M., Lewis, K., Heaney, L. G., Briggs, A., Zheng, B., Thorpe, M., Quint, J. K., Chalmers, J. D., Ho, L.-P., Horsley, A., Marks, M., Poinasamy, K., Raman, B., Wain, L. V., Brightling, C. E. & Evans, R. A., 30 Sept 2024, In: ERJ Open Research. 10, 5, 00474-2024.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    2 Downloads (Pure)
  • Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma

    Howell, I., Yang, F., Brown, V., Cane, J., Marchi, E., Azim, A., Busby, J., McDowell, P. J., Diver, S. E., Borg, C., Heaney, L. G., Pavord, I. D., Brightling, C. E., Chaudhuri, R. & Hinks, T. S. C., Nov 2024, In: Journal of Allergy and Clinical Immunology. 154, 5, p. 1146-1158

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

    Scelo, G., Torres-Duque, C. A., Maspero, J. F., Tran, T. N., Murray, R. B., Menzies-Gow, A., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron, C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., Boulet, L. P., Bhutani, M., Sadatsafavi, M. & Jiménez-Maldonado, L. & 62 others, Duran-Silva, M., Rodriguez, B., Celis-Preciado, C. A., Cano-Rosales, D. J., Solarte, I., Fernandez-Sanchez, M. J., Parada-Tovar, P., von Bülow, A., Bjerrum, A. S., Suppli Ulrik, C., Assing, K. D., Hansen, S., Altraja, A., Bourdin, A., Taillé, C., Charriot, J., Roche, N., Papaioannou, A. I., Kostikas, K., Papadopoulos, N. G., Salvi, S., Long, D., Mitchell, P., Costello, R. W., Sirena, C., Cardini, C., Heffler, E., Puggioni, F., Canonica, G. W., Guida, G., Iwanaga, T., Al-Ahmad, M., Larenas-Linnemann, D., García, U., Kuna, P., Fonseca, J. A., Al-Lehebi, R., Koh, M. S., Rhee, C. K., Cosio, B. G., Perez de Llano, L., Perng Steve, D.-W., Wan-Chun Huang, E., Tsai, M., Mahboub, B., Salameh, L. I. J., Busby, J., Heaney, L. G., Pfeffer, P. E., Goddard, A. G., Wang, E., Hoyte, F., Wechsler, M. E., Chapman, N., Katial, R., Carter, V., Bulathsinhala, L., Eleangovan, N., Ariti, C., Lyu, J., Price, D. & Porsbjerg, C., Jan 2024, In: Annals of Allergy, Asthma and Immunology. 132, 1, p. 42-53 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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    11 Citations (Scopus)
    54 Downloads (Pure)
  • An international consensus on the use of asthma biologics in pregnancy

    Naftel, J., Jackson, D. J., Coleman, M., d'Ancona, G., Heaney, L. G., Dennison, P., Bossios, A. & Rupani, H., 28 Aug 2024, (Early online date) In: The Lancet. Respiratory medicine.

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)
  • Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma

    Porsbjerg, C. M., Townend, J., Bergeron, C., Christoff, G. C., Katsoulotos, G. P., Larenas-Linnemann, D., Tran, T. N., Al-Lehebi, R., Bosnic-Anticevich, S. Z., Busby, J., Hew, M., Kostikas, K., Papadopoulos, N. G., Pfeffer, P. E., Popov, T. A., Rhee, C. K., Sadatsafavi, M., Tsai, M.-J., Ulrik, C. S. & Al-Ahmad, M. & 30 others, Altraja, A., Beastall, A., Bulathsinhala, L., Carter, V., Cosio, B. G., Fletton, K., Hansen, S., Heaney, L. G., Hubbard, R. B., Kuna, P., Murray, R. B., Nagano, T., Pini, L., Cano Rosales, D. J., Schleich, F., Wechsler, M. E., Amaral, R., Bourdin, A., Brusselle, G. G., Chen, W., Chung, L. P., Denton, E., Fonseca, J. A., Hoyte, F., Jackson, D. J., Katial, R., Kirenga, B. J., Koh, M. S., Ławkiedraj, A. & Lehtimäki, L., 19 Apr 2024, In: Frontiers in Immunology. 15, 21 p., 1361891.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    26 Downloads (Pure)