• Room 0G.021 - WWIEM Block 6 MBC Site

    United Kingdom

Accepting PhD Students

1993 …2019
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Personal profile

Research Statement

My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.

A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver  early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.

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  • 31 Similar Profiles
Asthma Medicine & Life Sciences
Adrenal Cortex Hormones Medicine & Life Sciences
Bronchoalveolar Lavage Medicine & Life Sciences
Registries Medicine & Life Sciences
Mast Cells Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Cough Medicine & Life Sciences
Pediatrics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2010 2018

Research Output 1993 2019

Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study

Busby, J., Holweg, C., Chai, A., Bradding, P., Cai, F., Chaudhuri, R., Mansur, A., Lordan, J., Matthews, J. G., Menzies-Gow, A., Niven, R., Staton, T., Heaney, L. G. & Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 02 Apr 2019, In : Thorax. 4 p.

Research output: Contribution to journalArticle

Open Access
Adrenal Cortex Hormones
14 Citations (Scopus)
Open Access
Genome-Wide Association Study
Odds Ratio
8 Citations (Scopus)

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Non-Adherence in Severe Asthma

Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 15 Feb 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 4

Research output: Contribution to journalArticle

Open Access
Adrenal Cortex Hormones
Nitric Oxide
9 Citations (Scopus)

Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

Bloechliger, M., Reinau, D., Spoendlin, J., Chang, S-C., Kuhlbusch, K., Heaney, L. G., Jick, S. S. & Meier, C. R., 27 Apr 2018, In : Respiratory Research. 19, 13 p., 75.

Research output: Contribution to journalArticle

Open Access
Adrenal Cortex Hormones
Cohort Studies
Peptic Ulcer
177 Citations (Scopus)

After asthma: redefining airways diseases

Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., Frey, U., Gibson, P., Heaney, L. G., Holt, P. G., Humbert, M., Lloyd, C. M., Marks, G., Martinez, F. D., Sly, P. D., von Mutius, E. & 3 othersWenzel, S., Zar, H. J. & Bush, A., 27 Jan 2018, In : Lancet. 391, 10118, p. 350-400 51 p.

Research output: Contribution to journalReview article


Improved management of airway disorders in children

Liam Heaney (Participant), Ian Cadden (Participant), Mike Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant), Timothy Warke (Participant)

Impact: Health Impact, Quality of Life Impact

Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults

Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant), Chris Patterson (Participant)

Impact: Health Impact, Quality of Life Impact