Projects per year
Personal profile
Research Statement
My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.
A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.
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Projects
R1917CNR: Health Data Research UK (HDR UK)
Lawler, M., Blayney, J., Coleman, H., Dunne, P., Heaney, L., Kee, F., McArt, D., Nikolopoulos, D., O'Reilly, D., Overton, I., Salto-Tellez, M. & Woods, R.
29/10/2018 → …
Project: Research
R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L., Coyle, P. & McGarvey, L.
01/05/2015 → …
Project: Research
R1297CII: The redulatory importance of SOCS molecules in the immune responses and disease
Kissenpfennig, A., Heaney, L. & Johnston, J.
01/08/2010 → …
Project: Research
Research Output
Determinants of lung function improvement with omalizumab in adults with allergic asthma
Hanania, N. A., Djukanovic, R., Heaney, L. G., Yang, M., Yoo, B., Iqbal, A., Griffin, N. M. & Chipps, B. E., 22 Jan 2020, In : The journal of allergy and clinical immunology. In practice.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Different endotypes and phenotypes drive the heterogeneity in severe asthma
McDowell, P. J. & Heaney, L. G., 17 Feb 2020, In : Allergy. 75, 2, p. 302-310Research output: Contribution to journal › Review article
6
Citations
(Scopus)
International Severe Asthma Registry (ISAR): protocol for a global registry
Mark FitzGerald, J., Tran, T. N., Alacqua, M., Altraja, A., Backer, V., Bjermer, L., Bjornsdottir, U., Bourdin, A., Brusselle, G., Bulathsinhala, L., Busby, J., Canonica, G. W., Carter, V. A., Chaudhry, I., Cho, Y. S., Christoff, G., Cosio, B. G., Costello, R. W., Eleangovan, N., Gibson, P. G. & 28 others, , 25 Jun 2020, (Accepted) In : BMC Medical Research Methodology.Research output: Contribution to journal › Article
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., Grotenboer, N. S., Obeidat, M., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Pogson, Z. E., Fogarty, A., McKeever, T. M., Nickle, D. C., Bossé, Y., van den Berge, M., Faiz, A., Brouwer, S. & 23 others, , 23 Apr 2020, In : JCI insight. 5, 8, p. 1-19Research output: Contribution to journal › Article
Open Access
File
Reducing the hidden burden of severe asthma recognition and referrals from primary practice
Humbert, M., Bourdin, A., Papadopoulos, N. G., Holgate, S. T., Hanania, N. A., Halpin, D. M. G., Chapman, K. R., Gavornikova, M., Price, D. B., Kaplan, A. & Heaney, L. G., 13 May 2020, In : Journal of Asthma. p. 1-6Research output: Contribution to journal › Article
Impact
Improved management of airway disorders in children
Liam Heaney (Participant), Ian Cadden (Participant), Michael Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant) & Timothy Warke (Participant)
Impact: Health Impact, Quality of Life Impact
Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact
Thesis
Corticosteroid-Induced Morbidity in Asthma : Costs and Consequence
Author: Barry, L., Jul 2020Supervisor: Heaney, L. (Supervisor) & O'Neill, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy