• Room 0G.021 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor Heaney is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: - asthma - medication adherence - precision medicine in asthma and COPD Previous research experience is desirable although not essential.

1993 …2020

Research output per year

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Personal profile

Research Statement

My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.

A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver  early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.

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Projects

Research Output

Determinants of lung function improvement with omalizumab in adults with allergic asthma

Hanania, N. A., Djukanovic, R., Heaney, L. G., Yang, M., Yoo, B., Iqbal, A., Griffin, N. M. & Chipps, B. E., 22 Jan 2020, In : The journal of allergy and clinical immunology. In practice.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Different endotypes and phenotypes drive the heterogeneity in severe asthma

McDowell, P. J. & Heaney, L. G., 17 Feb 2020, In : Allergy. 75, 2, p. 302-310

Research output: Contribution to journalReview article

  • 6 Citations (Scopus)

    International Severe Asthma Registry (ISAR): protocol for a global registry

    Mark FitzGerald, J., Tran, T. N., Alacqua, M., Altraja, A., Backer, V., Bjermer, L., Bjornsdottir, U., Bourdin, A., Brusselle, G., Bulathsinhala, L., Busby, J., Canonica, G. W., Carter, V. A., Chaudhry, I., Cho, Y. S., Christoff, G., Cosio, B. G., Costello, R. W., Eleangovan, N., Gibson, P. G. & 28 others, Heaney, L., Heffler, E., Hew, M., Hosseini, N., Iwanaga, T., Jackson, D. J., Jones, R. C., Koh, M. S., Le, T., Lehtimäki, L., Ludviksdottir, D., Maitland-van der Zee, A. H., Menzies-Gow, A., Murray, R. B., Papadopoulos, N. G., Perez de Llano, L., Peters, M., Pfeffer, P. E., Popov, T. A., Porsbjerg, C., Price, C. A., Rhee, C. K., Sadatsafavi, M., Tohda, Y., Eileen, W., Wechsler, M. E., Zangrilli, J. & Price, D. B., 25 Jun 2020, (Accepted) In : BMC Medical Research Methodology.

    Research output: Contribution to journalArticle

  • Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

    Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., Grotenboer, N. S., Obeidat, M., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Pogson, Z. E., Fogarty, A., McKeever, T. M., Nickle, D. C., Bossé, Y., van den Berge, M., Faiz, A., Brouwer, S. & 23 others, Vonk, J. M., de Vos, P., Brandsma, C-A., Vermeulen, C. J., Singapuri, A., Heaney, L. G., Mansur, A. H., Chaudhuri, R., Thomson, N. C., Holloway, J. W., Lockett, G. A., Howarth, P. H., Niven, R., Simpson, A., Blakey, J. D., Tobin, M. D., Postma, D. S., Hall, I. P., Wain, L. V., Nawijn, M. C., Brightling, C. E., Koppelman, G. H. & Sayers, I., 23 Apr 2020, In : JCI insight. 5, 8, p. 1-19

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Downloads (Pure)

    Reducing the hidden burden of severe asthma recognition and referrals from primary practice

    Humbert, M., Bourdin, A., Papadopoulos, N. G., Holgate, S. T., Hanania, N. A., Halpin, D. M. G., Chapman, K. R., Gavornikova, M., Price, D. B., Kaplan, A. & Heaney, L. G., 13 May 2020, In : Journal of Asthma. p. 1-6

    Research output: Contribution to journalArticle

  • Impact

    Improved management of airway disorders in children

    Liam Heaney (Participant), Ian Cadden (Participant), Michael Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant) & Timothy Warke (Participant)

    Impact: Health Impact, Quality of Life Impact

    Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults

    Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)

    Impact: Health Impact, Quality of Life Impact

    Thesis

    Corticosteroid-Induced Morbidity in Asthma : Costs and Consequence

    Author: Barry, L., Jul 2020

    Supervisor: Heaney, L. (Supervisor) & O'Neill, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy