Projects per year
Personal profile
Research Statement
My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.
A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1917CNR: Health Data Research UK (HDR UK)
Lawler, M., Blayney, J., Coleman, H., Dunne, P., Heaney, L., Kee, F., McArt, D., Nikolopoulos, D., O'Reilly, D., Overton, I., Salto-Tellez, M. & Woods, R.
29/10/2018 → …
Project: Research
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R1297CII: The redulatory importance of SOCS molecules in the immune responses and disease
Kissenpfennig, A., Heaney, L. & Johnston, J.
01/08/2010 → …
Project: Research
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R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L., Coyle, P. & McGarvey, L.
01/05/2015 → 09/10/2021
Project: Research
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Adverse perception of cough in patients with severe asthma: a discrete choice experiment
Holmes, J., O'Neill, V., McGarvey, L. P. & Heaney, L. G., 01 Jan 2023, In: ERJ Open Research. 9, 1, 10 p., 00442-2022.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
A longitudinal study of measurement invariance of the Asthma Control Questionnaire in relation to the initiation of biologic therapies among patients with severe asthma
McDowell, R., Heaney, L., Brown, T., Bunting, B., Chaudhuri, R., Jackson, D. J., Mansur, A., Patel, M., Patel, P., Pfeffer, P. E. & Busby, J., 15 May 2023.Research output: Contribution to conference › Poster › peer-review
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Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry
Scelo, G., Torres-Duque, C. A., Maspero, J. F., Tran, T. N., Murray, R. B., Menzies-Gow, A., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron, C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., Boulet, L. P., Bhutani, M., Sadatsafavi, M., Jiménez-Maldonado, L., & 62 others , 12 Aug 2023, (Accepted) In: Annals of Allergy, Asthma and Immunology.Research output: Contribution to journal › Article › peer-review
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A randomized trial of a composite T2-biomarker strategy adjusting corticosteroid treatment in severe asthma: a post- hoc analysis by sex
Eastwood, M. C., Busby, J., Jackson, D. J., Pavord, I. D., Hanratty, C. E., Djukanovic, R., Woodcock, A., Walker, S., Hardman, T. C., Arron, J. R., Choy, D. F., Bradding, P., Brightling, C. E., Chaudhuri, R., Cowan, D., Mansur, A. H., Fowler, S. J., Howarth, P., Lordan, J., Menzies-Gow, A., & 6 others , Apr 2023, In: The Journal of Allergy and Clinical Immunology: In Practice. 11, 4, p. 1233-1242.e5 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Asthma exacerbations in severe asthma: why systemic corticosteroids may not always be the best treatment option
McDowell, P. J., Busby, J. & Heaney, L. G., 25 Feb 2023, (Early online date) In: Current Treatment Options in Allergy. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure)
Impact
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Improved management of airway disorders in children
Liam Heaney (Participant), Ian Cadden (Participant), Michael Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant) & Timothy Warke (Participant)
Impact: Health Impact, Quality of Life Impact
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact