• Room 0G.021 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor Heaney is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: - asthma - medication adherence - precision medicine in asthma and COPD Previous research experience is desirable although not essential.

1993 …2019

Research output per year

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Personal profile

Research Statement

My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.

A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver  early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.

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Projects

Research Output

Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study

Busby, J., Holweg, C., Chai, A., Bradding, P., Cai, F., Chaudhuri, R., Mansur, A., Lordan, J., Matthews, J. G., Menzies-Gow, A., Niven, R., Staton, T., Heaney, L. G. & Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 02 Apr 2019, In : Thorax. 4 p.

Research output: Contribution to journalArticle

Open Access
File
  • 1 Citation (Scopus)
    152 Downloads (Pure)

    Characterization of severe asthma worldwide: data from the International Severe Asthma Registry (ISAR)

    Eileen, W., Wechsler, M. E., Tran, T. N., Heaney, L. G., Jones, R. C., Menzies-Gow, A. N., Busby, J., Jackson, D. J., Pfeffer, P. E., Rhee, C. K., Cho, Y. S., Canonica, G. W., Heffler, E., Gibson, P. G., Hew, M., Peters, M., Harvey, E. S., Alacqua, M., Zangrilli, J., Bulathsinhala, L. & 6 others, Carter, V. A., Chaudhry, I., Eleangovan, N., Hosseini, N., Murray, R. B. & Price, D. B., 27 Nov 2019, In : Chest.

    Research output: Contribution to journalArticle

  • Open Access
    File
  • 18 Citations (Scopus)
    10 Downloads (Pure)

    Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Non-Adherence in Severe Asthma

    Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 15 Feb 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 4

    Research output: Contribution to journalArticle

    Open Access
    File
  • 9 Citations (Scopus)
    280 Downloads (Pure)

    Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

    Bloechliger, M., Reinau, D., Spoendlin, J., Chang, S-C., Kuhlbusch, K., Heaney, L. G., Jick, S. S. & Meier, C. R., 27 Apr 2018, In : Respiratory Research. 19, 13 p., 75.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    153 Downloads (Pure)

    Impact

    Improved management of airway disorders in children

    Liam Heaney (Participant), Ian Cadden (Participant), Mike Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant), Timothy Warke (Participant)

    Impact: Health Impact, Quality of Life Impact

    Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults

    Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant), Chris Patterson (Participant)

    Impact: Health Impact, Quality of Life Impact