Projects per year
Personal profile
Research Statement
My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.
A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.
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Network
Projects
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R1917CNR: Health Data Research UK (HDR UK)
Lawler, M., Blayney, J., Coleman, H., Dunne, P., Heaney, L., Kee, F., McArt, D., Nikolopoulos, D., O'Reilly, D., Overton, I., Salto-Tellez, M. & Woods, R.
29/10/2018 → …
Project: Research
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R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L., Coyle, P. & McGarvey, L.
01/05/2015 → …
Project: Research
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R1297CII: The redulatory importance of SOCS molecules in the immune responses and disease
Kissenpfennig, A., Heaney, L. & Johnston, J.
01/08/2010 → …
Project: Research
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Research Output
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A randomised trial of treatment optimisation in patients with severe asthma using composite type-2 biomarkers to adjust corticosteroid dose versus a symptom/risk-based algorithm
Heaney, L. G., Busby, J., Hanratty, C. E., Djukanovic, R., Woodcock, A., Walker, S. M., Hardman, T. C. & Arron, J. R., 01 Aug 2020, (Accepted) In : The Lancet Respiratory Medicine.Research output: Contribution to journal › Article › peer-review
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Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era
Jackson, D. J., Busby, J., Pfeffer, P. E., Menzies-Gow, A., Brown, T., Gore, R., Doherty, M., Mansur, A., Message, S., Niven, R., Patel, M. & Heaney, L., 16 Oct 2020, (Accepted) In : Thorax.Research output: Contribution to journal › Article › peer-review
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Determinants of lung function improvement with omalizumab in adults with allergic asthma
Hanania, N. A., Djukanovic, R., Heaney, L. G., Yang, M., Yoo, B., Iqbal, A., Griffin, N. M. & Chipps, B. E., 22 Jan 2020, In : The journal of allergy and clinical immunology. In practice.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Different endotypes and phenotypes drive the heterogeneity in severe asthma
McDowell, P. J. & Heaney, L. G., 17 Feb 2020, In : Allergy. 75, 2, p. 302-310Research output: Contribution to journal › Review article › peer-review
15 Citations (Scopus) -
Factors associated with frequent exacerbations in the UK Severe Asthma Registry
Yang, F., Busby, J., Heaney, L., Menzies-Gow, A., Pfeffer, P. E., Jackson, D. J., Mansur, A. H., Siddiqui, S., Brightling, C. E., Niven, R., Thomson, N. C. & Chaudhuri, R., 01 Dec 2020, (Accepted) In : Journal of Allergy and Clinical Immunology: In Practice (.Research output: Contribution to journal › Article › peer-review
Impact
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Improved management of airway disorders in children
Liam Heaney (Participant), Ian Cadden (Participant), Michael Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant) & Timothy Warke (Participant)
Impact: Health Impact, Quality of Life Impact
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact