Projects per year
Personal profile
Research Statement
My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.
A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.
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Projects
R1917CNR: Health Data Research UK (HDR UK)
Lawler, M., Blayney, J., Coleman, H., Dunne, P., Heaney, L., Kee, F., McArt, D., Nikolopoulos, D., O'Reilly, D., Overton, I., Salto-Tellez, M. & Woods, R.
29/10/2018 → …
Project: Research
R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L., Coyle, P. & McGarvey, L.
01/05/2015 → …
Project: Research
R1297CII: The redulatory importance of SOCS molecules in the immune responses and disease
Kissenpfennig, A., Heaney, L. & Johnston, J.
01/08/2010 → 17/12/2019
Project: Research
Research Output
Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study
Busby, J., Holweg, C., Chai, A., Bradding, P., Cai, F., Chaudhuri, R., Mansur, A., Lordan, J., Matthews, J. G., Menzies-Gow, A., Niven, R., Staton, T., Heaney, L. G. & Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 02 Apr 2019, In : Thorax. 4 p.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
151
Downloads
(Pure)
Characterization of severe asthma worldwide: data from the International Severe Asthma Registry (ISAR)
Eileen, W., Wechsler, M. E., Tran, T. N., Heaney, L. G., Jones, R. C., Menzies-Gow, A. N., Busby, J., Jackson, D. J., Pfeffer, P. E., Rhee, C. K., Cho, Y. S., Canonica, G. W., Heffler, E., Gibson, P. G., Hew, M., Peters, M., Harvey, E. S., Alacqua, M., Zangrilli, J., Bulathsinhala, L. & 6 others, , 27 Nov 2019, In : Chest.Research output: Contribution to journal › Article
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
Heaney, L. G., 01 Jan 2019, In : The Lancet Respiratory Medicine. 7, 1, p. 20-34Research output: Contribution to journal › Article
Open Access
File
18
Citations
(Scopus)
10
Downloads
(Pure)
Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Non-Adherence in Severe Asthma
Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK), 15 Feb 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 4Research output: Contribution to journal › Article
Open Access
File
9
Citations
(Scopus)
278
Downloads
(Pure)
Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis
Bloechliger, M., Reinau, D., Spoendlin, J., Chang, S-C., Kuhlbusch, K., Heaney, L. G., Jick, S. S. & Meier, C. R., 27 Apr 2018, In : Respiratory Research. 19, 13 p., 75.Research output: Contribution to journal › Article
Open Access
File
11
Citations
(Scopus)
150
Downloads
(Pure)
Impact
Improved management of airway disorders in children
Liam Heaney (Participant), Ian Cadden (Participant), Mike Shields (Participant), Madeleine Ennis (Participant), Bettina Schock (Participant), Vanessa Brown (Participant), Michael Ryan (Participant), Dennis Carson (Participant), Timothy Warke (Participant)
Impact: Health Impact, Quality of Life Impact
Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant), Chris Patterson (Participant)
Impact: Health Impact, Quality of Life Impact