Projects per year
Personal profile
Research Statement
My major research area spans the clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence to therapy. Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics. I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma and holds the NICE (UK) Bronchial Thermoplasty Registry. Our non-adherence research programme defined the significant scale of this problem in difficult asthma (30 - 50% of subjects) and our current research is developing methods to better identify and manage this problem in the clinic using biomarker based assessments of corticosteroid exposure and response.
A major evolving area is disease stratification to deliver personalised therapeutics in severe asthma and I lead the Medical Research Council UK Refractory Stratification Programme (RASP-UK). This programme will deliver early ‘proof of concept' studies in stratified well phenotypes patients in severe asthma in partnership with the Industrial Partners in this programme. Our Group has substantial experience of Phase II / III clinical trials including study concept and design, establishment of methodology, final protocol review and data analysis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1297CII: The redulatory importance of SOCS molecules in the immune responses and disease
Kissenpfennig, A. (PI), Heaney, L. (CoI) & Johnston, J. (CoI)
01/08/2010 → …
Project: Research
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R1917CNR: Health Data Research UK (HDR UK)
Lawler, M. (PI), Blayney, J. (CoI), Coleman, H. (CoI), Dunne, P. (CoI), Heaney, L. (CoI), Kee, F. (CoI), McArt, D. (CoI), Nikolopoulos, D. (CoI), O'Reilly, D. (CoI), Overton, I. (CoI), Salto-Tellez, M. (CoI) & Woods, R. (CoI)
29/10/2018 → 31/03/2023
Project: Research
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R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L. (PI), Coyle, P. (CoI) & McGarvey, L. (CoI)
01/05/2015 → 09/10/2021
Project: Research
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R1422CII: UK Refractory Asthma Stratification Programme
Heaney, L. (PI)
12/06/2014 → 31/10/2014
Project: Research
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1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
Leavy, O. C., Russell, R. J., Harrison, E. M., Lone, N. I., Kerr, S., Docherty, A. B., Sheikh, A., Richardson, M., Elneima, O., Greening, N. J., Harris, V. C., Houchen-Wolloff, L., McAuley, H. J. C., Saunders, R. M., Sereno, M., Shikotra, A., Singapuri, A., Aul, R., Beirne, P. & Bolton, C. E. & 53 others, , 30 Sept 2024, In: ERJ Open Research. 10, 5, 00474-2024.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Airway proteomics reveals broad residual anti-inflammatory effects of prednisolone in mepolizumab-treated asthma
Howell, I., Yang, F., Brown, V., Cane, J., Marchi, E., Azim, A., Busby, J., McDowell, P. J., Diver, S. E., Borg, C., Heaney, L. G., Pavord, I. D., Brightling, C. E., Chaudhuri, R. & Hinks, T. S. C., 01 Aug 2024, (Early online date) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry
Scelo, G., Torres-Duque, C. A., Maspero, J. F., Tran, T. N., Murray, R. B., Menzies-Gow, A., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron, C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., Boulet, L. P., Bhutani, M., Sadatsafavi, M. & Jiménez-Maldonado, L. & 62 others, , Jan 2024, In: Annals of Allergy, Asthma and Immunology. 132, 1, p. 42-53 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)68 Downloads (Pure) -
An international consensus on the use of asthma biologics in pregnancy
Naftel, J., Jackson, D. J., Coleman, M., d'Ancona, G., Heaney, L. G., Dennison, P., Bossios, A. & Rupani, H., 28 Aug 2024, (Early online date) In: The Lancet. Respiratory medicine.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma
Porsbjerg, C. M., Townend, J., Bergeron, C., Christoff, G. C., Katsoulotos, G. P., Larenas-Linnemann, D., Tran, T. N., Al-Lehebi, R., Bosnic-Anticevich, S. Z., Busby, J., Hew, M., Kostikas, K., Papadopoulos, N. G., Pfeffer, P. E., Popov, T. A., Rhee, C. K., Sadatsafavi, M., Tsai, M.-J., Ulrik, C. S. & Al-Ahmad, M. & 30 others, , 19 Apr 2024, In: Frontiers in Immunology. 15, 21 p., 1361891.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Downloads (Pure)
Impacts
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Improved management of airway disorders in children
Heaney, L. (Participant), Cadden, I. (Participant), Shields, M. (Participant), Ennis, M. (Participant), Schock, B. (Participant), Brown, V. (Participant), Ryan, M. (Participant), Carson, D. (Participant) & Warke, T. (Participant)
Impact: Health Impact, Quality of Life Impact
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Heaney, L. (Participant), Stevenson, M. (Participant), McNicholl, D. (Participant), McGarvey, L. (Participant), Sweeney, J. (Participant) & Patterson, C. (Participant)
Impact: Health Impact, Quality of Life Impact