Lisa Crawford

Phone+44 (0)28 9097 2783, +44 (0)28 9097 2794
Emaillisa.crawfordqub.acuk

Room 0G.013 - PGJCCR
United Kingdom

Accepting PhD Students

PhD projects

Primary field of interest relates to investigating the molecular mechanisms involved in dysregulation of the ubiquitin proteasome system in multiple myeloma and applying this knowledge to identify therapeutic opportunities.

Research activity per year

26 Article
10 Meeting abstract
3 Chapter (peer-reviewed)
3 Review article
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- 1 Comment/debate

26 results

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2024
TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors
McAvera, R. M., Morgan, J. J., Herrero, A. B., Mills, K. I. & Crawford, L. J., 16 Apr 2024, In: Scientific Reports. 14, 11 p., 8797.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

32 Downloads (Pure)
2020
The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in Multiple Myeloma
Crawford, L. J., Campbell, D. C., Morgan, J., Lawson, M. A., Down, J. M., Chauhan, D., McAvera, R. M., Morris, T. C., Hamilton, C., Krishnan, A., Rajalingam, K., Chantry, A. D. & Irvine, A. E., 10 Jun 2020, (Early online date) In: Oncogene. 39, p. 5001–5014 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
20 Citations (Scopus)

124 Downloads (Pure)
2019
TRAF6 Silencing Attenuates Multiple Myeloma Cell Adhesion to Bone Marrow Stromal Cells
Morgan, J. J., McAvera, R. M. & Crawford, L. J., 06 Feb 2019, In: International journal of molecular sciences. 20, 3
Research output: Contribution to journal › Article › peer-review

Open Access
File
12 Citations (Scopus)

226 Downloads (Pure)
2017
TRIM proteins in blood cancers
Crawford, L. J., Johnston, C. K. & Irvine, A. E., 06 Nov 2017, (Early online date) In: Journal of Cell Communication and Signaling. p. 1-9
Research output: Contribution to journal › Article › peer-review

Open Access
File
49 Citations (Scopus)

318 Downloads (Pure)
2016
Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma
Crawford, L. J., Anderson, G., Johnston, C. K. & Irvine, A. E., 15 Sept 2016, In: Oncotarget. 7, 43, p. 70481-70493
Research output: Contribution to journal › Article › peer-review

Open Access
File
21 Citations (Scopus)

250 Downloads (Pure)
The role of the CCN family of proteins in blood cancers
Crawford, L. J. & Irvine, A. E., 03 Aug 2016, In: Journal of Cell Communication and Signaling. 10, 3, p. 197-205 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

226 Downloads (Pure)
2014
Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models
Crawford, L., Chan, E., Aujay, M., Holyoake, T., Melo, J., Jorgensen, H., Suresh, S., Walker, B. & Irvine, A., Mar 2014, In: ONCOGENESIS. 3, 2, 10 p., e90.
Research output: Contribution to journal › Article › peer-review

Open Access
File
20 Citations (Scopus)

257 Downloads (Pure)
2013
Targeting the ubiquitin proteasome system in haematological malignancies
Crawford, L. J. & Irvine, A. E., Nov 2013, In: Blood Reviews. 27, 6, p. 297-304 8 p.
Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus)
The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia
Suresh, S., McCallum, L., Crawford, L. J., Lu, W. H., Sharpe, D. J. & Irvine, A. E., Nov 2013, In: Journal of Pathology. 231, 3, p. 378-87 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Citations (Scopus)

232 Downloads (Pure)
2011
Proteasome inhibitors in cancer therapy
Crawford, L., Walker, B. & Irvine, A., Jun 2011, In: Journal of Cell Communication and Signaling. 5, 2, p. 101-110 10 p.
Research output: Contribution to journal › Article › peer-review
265 Citations (Scopus)
2010
Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis
Crawford, L., Peake, R., Price, S., Morris, T. & Irvine, A., Oct 2010, In: Journal of Leukocyte Biology. 88, 4, p. 807-811 5 p.
Research output: Contribution to journal › Article › peer-review
51 Citations (Scopus)
Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells
Heaney, N. B., Pellicano, F., Zhang, B., Crawford, L., Chu, S., Kazmi, S. M. A., Allan, E. K., Jorgensen, H. G., Irvine, A., Bhatia, R. & Holyoake, T. L., 18 Mar 2010, In: Blood. 115, 11, p. 2241-2250 10 p.
Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus)
Methods for measuring proteasome activity: Current limitations and future developments
Liggett, A., Crawford, L., Walker, B., Morris, T. & Irvine, A., Nov 2010, In: Leukemia research. 34, 11, p. 1403-1409 7 p.
Research output: Contribution to journal › Article › peer-review
36 Citations (Scopus)
2009

Proteasome proteolytic profile is linked to Bcr-Abl expression.
Crawford, L., Windrum, P., Magill, L., Melo, J. V., McCallum, L., McMullin, M., Ovaa, H., Walker, B. & Irvine, A., Mar 2009, In: Experimental Hematology. 37(3), 3, p. 357-366 10 p.
Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)
2008

Adiponectin is a negative regulator of granulopoiesis, produced by lymphocytes
Crawford, L., Peake, R., Price, S., Morris, T. & Irvine, A., Apr 2008, In: British Journal of Haematology. 141, p. 120-120 1 p.
Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)
Ber-Abl Positive Cells Display Increased Proteasome Activity and Greater Sensitivity to Proteasome Inhibition
Crawford, L., Windrum, P., Magill, L., Melo, J. V., McCallum, L., McMullin, M. F., Ovaa, H., Walker, B. & Irvine, A., Dec 2008, In: Blood. 112, p. 1095-1096 2 p.
Research output: Contribution to journal › Article › peer-review
Bortezomib has anti-proliferative and apoptotic effects against quiescent CML stem cells and cells expressing the T3151 mutation
Heaney, N. B., Pellicano, F., Crawford, L., Kazmi, S. M. A., Irvine, A. & Holyoake, T. L., Apr 2008, In: British Journal of Haematology. 141, p. 58-58 1 p.
Research output: Contribution to journal › Article › peer-review
Proteasome inhibitors: a therapeutic strategy for haematological malignancy
Crawford, L., Walker, B. & Irvine, A., 2008, In: Frontiers in bioscience : a journal and virtual library. 13, 11, p. 4285-4296 12 p.
Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus)
2007

Bortezomib has anti-proliferative and apoptotic effects against CML stem cells, including the quiescent population
Heaney, N., Pellicano, F., Crawford, L., Irvine, A. & Holyoake, T. L., Dec 2007, In: Blood. 110, p. 865A-865A
Research output: Contribution to journal › Article › peer-review
Profiling of proteasome catalytic activities in chronic lymphocytic leukaemia
Ong, Y. L., Crawford, L. & Irvine, A., Apr 2007, In: British Journal of Haematology. 137, p. 20-20 1 p.
Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)
2006

Adiponectin produced by lymphocytes inhibits granulopoiesis.
Crawford, L., Peake, R. W., Price, S., Morris, T. & Irvine, A., Dec 2006, In: Blood. 108, p. 374A-374A
Research output: Contribution to journal › Article › peer-review
Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.
Walker, B., Ovaa, H., Chauhan, D., Crawford, L., Anderson, K. C., Morris, T. C. M. & Irvine, A. E., 15 Jun 2006, In: Cancer Research. 66(12), 12, p. 6379-6386 8 p.
Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)
2005

Evaluation of the specificity and cytotoxicity of three proteasome inhibitors
Crawford, L., Ovaa, H., Walker, B., Chauhan, D., Anderson, K. C., Morris, T. & Irvine, A., Dec 2005, In: Blood. 106, p. 941A-941A
Research output: Contribution to journal › Article › peer-review
The novel proteasome inhibitor BzLLL-COCHO is a specific inhibitor of proteasome activity
Crawford, L., Morris, T., Chauhan, D., Anderson, K. C., Walker, B. & Irvine, A., Apr 2005, In: British Journal of Haematology. 129, p. 8-8 1 p.
Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)
2004

Profiling proteasome activity in multiple myeloma and lymphoma
Crawford, L., Morris, T., Chauhan, D., Anderson, K. C., Walker, B. & Irvine, A., Apr 2004, In: British Journal of Haematology. 125, p. 37-37 1 p.
Research output: Contribution to journal › Article › peer-review
2003

Proteasome activity is cell-type dependent.
Crawford, L., Morris, T., Chauhan, D., Anderson, K. C., Walker, B. & Irvine, A., Dec 2003, In: Blood. 102, p. 933A-933A
Research output: Contribution to journal › Article › peer-review

Lisa Crawford

Research output

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