Projects per year
Personal profile
Research Statement
Lorcan McGarvey MD FRCP graduated with Honours in Medicine and trained in General Internal and Respiratory Medicine. He is a Consultant Respiratory Physician and Clinical Professor in QUB. He is internationally known for his research in cough reflected in his highly cited publication output. He has a sustained track record of leadership in cough guideline development as Co-Chair of the British Thoracic Society (BTS) Cough Taskforce and currently serves on the European Respiratory Society (ERS) Cough Task Force and as an Expert Member on the American College Chest Physicians (ACCP) Cough Guideline Committee. He has undertaken a range of research studies in cough ranging from evaluation of diagnostic protocols relevant to clinical practice to mechanistic studies designed to elucidate the pathogenesis of chronic cough. Currently his work is focused on the expression and functional characteristics of ion channels located in the airways. In collaboration with colleagues in QUB he is exploring the potential of human dental pulp stem cells (hDPSCs) and induced pluripotent stem cell (iPSC) derived sensory neuronal models to study neuro-inflammatory mechanisms associated with acute and chronic cough. Professor McGarvey established and leads the Northern Ireland Specialist Cough Clinic which receives a high volume of referrals from throughout Ireland for management of complex cough syndromes. This specialist clinic has provided the opportunity for patients to participate in a number of pivotal Phase II national and International clinical trials of novel therapies for cough.
Professor McGarvey has also worked extensively in the area of chronic obstructive pulmonary disease (COPD). In collaboration with Wise (Johns Hopkins Hospital, Baltimore, USA) and John (Charite Hospital, Berlin, Germany) he developed a new methodological approach to the reliable adjudication of cause-specific mortality in COPD clinical trials. This methodology has now been widely adopted and was utilised in three of the largest global COPD trials to date (TORCH, UPLIFT and TIOSPIR). Currently, he is Co-Principal Investigator on the Border REgions And Training Hub (BREATH) a €7.7M funded EU INTERREG 5-year program (2017-2022) and provides clinical leadership across the 3 participating Institutions (QUB, Dundalk Institute of Technology, & University of West of Scotland). Professor McGarvey’s work has been funded from peer-reviewed national and International funding bodies including European Union, Medical Research Council and Higher Education Authority. He is Joint Clinical Lead for the Northern Ireland Clinical Research Network for Respiratory Health.
Professor McGarvey is a Fellow of the Royal College of Physicians and was elected in 2011 to the Association of Physicians of Great Britain and Ireland.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R6964PMY: Interreg VA: BREATH - Border and REgions Airways Training Hub (Full Proposal)
Martin, L., Lundy, F., McGarvey, L. & Tikhonova, I.
02/05/2017 → …
Project: Research
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R1553CII: A GMP cell therapy facility to test cell based therapies
McAuley, D., Elborn, S., Johnston, P., Lois, N. & McGarvey, L.
17/08/2014 → …
Project: Research
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R2327CEM: Epithelial Exosomes Key modulators of neural function in human trigeminal nerve
Lundy, F., Curtis, T., El Karim, I., McGarvey, L. & Simpson, D.
28/07/2016 → 30/09/2018
Project: Research
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R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L., Coyle, P. & McGarvey, L.
01/05/2015 → 09/10/2021
Project: Research
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Adverse perception of cough in patients with severe asthma: a discrete choice experiment
Holmes, J., O'Neill, V., McGarvey, L. P. & Heaney, L. G., 01 Jan 2023, In: ERJ Open Research. 9, 1, 10 p., 00442-2022.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure) -
Burden of chronic cough in the UK: results from the 2018 National Health and Wellness Survey
McGarvey, L., Morice, A. H., Martin, A., Li, V. W., Doane, M. J., Urdaneta, E., Schelfhout, J., Ding, H. & Fonseca, E., 17 Jul 2023, In: ERJ Open Research. 9, 4, 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough
Dicpinigaitis, P. V., Birring, S. S., Blaiss, M., McGarvey, L. P., Morice, A. H., Pavord, I. D., Satia, I., Smith, J. A., La Rosa, C., Li, Q., Nguyen, A. M., Schelfhout, J., Tzontcheva, A. & Muccino, D., 02 Jan 2023, In: Annals of Allergy, Asthma and Immunology. 130, 1, p. 60-66Research output: Contribution to journal › Article › peer-review
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Efficacy and safety of eliapixant in refractory chronic cough: the randomized, placebo-controlled phase 2b PAGANINI study
Dicpinigaitis, P. V., Morice, A. H., Smith, J. A., Sher, M. R., Vaezi, M., Guilleminault, L., Niimi, A., Gude, K., Krahn, U., Saarinen, R., Pires, P. V., Wosnitza, M. & McGarvey, L., 01 Jun 2023, In: Lung. 12 p.Research output: Contribution to journal › Article › peer-review
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Efficacy and safety of gefapixant for refractory or unexplained chronic cough over 52 weeks
Birring, S. S., Dicpinigaitis, P. V., Smith, J. A., Morice, A. H., McGarvey, L. P., Pavord, I. D., Martin Nguyen, A., Schelfhout, J., Li, Q., Iskold, B., Green, S. A., Philip, G., Muccino, D. R. & La Rosa, C., 30 Mar 2023, (Early online date) In: American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Article › peer-review
Prizes
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Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards
Martin, Lorraine (Recipient), McGarvey, Lorcan (Recipient), Lundy, Fionnuala (Recipient), Thornbury, Keith (Recipient), Hollywood, Mark (Recipient), Sergeant, Gerard (Recipient), Lockhart, John (Recipient), Litherland, Gary (Recipient) & Crilly, Anne (Recipient), 22 Feb 2018
Prize: Prize (including medals and awards)
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Vice-Chancellor's Research Culture Prize 2020
Martin, Lorraine (Recipient), Lundy, Fionnuala (Recipient) & McGarvey, Lorcan (Recipient), 17 Dec 2020
Prize: Prize (including medals and awards)
Activities
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Clinical Phytoscience (Journal)
Lorcan McGarvey (Associate editor)
2016 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Advanced Grant Reviewer
Lorcan McGarvey (Reviewer)
2015Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Committee member on UKCRN/NIHR Respiratory Specialty Group
Lorcan McGarvey (Member)
2014Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Data Safety Monitoring Committee for UK NIHR funded project (External organisation)
Lorcan McGarvey (Chair)
2014 → 2017Activity: Membership types › Membership of peer review panel or committee
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Chest (Journal)
Lorcan McGarvey (Editorial board member)
2014 → …Activity: Publication peer-review and editorial work types › Editorial activity
Press/Media
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QUEEN’S COLLABORATIVE PROJECT WINS ASTHMA / COPD PROJECT OF THE YEAR
Lorraine Martin, Lorcan McGarvey & Fionnuala Lundy
28/02/2018
1 item of Media coverage
Press/Media: Research
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Urgent Call to Tackle Killer Disease on World COPD Day
Lorraine Martin, Lorcan McGarvey & Fionnuala Lundy
15/11/2017
1 Media contribution
Press/Media: Research
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QUEEN'S SECURES EU FUNDING FOR FIGHT AGAINST LUNG DISEASE
Lorraine Martin, Lorcan McGarvey & Fionnuala Lundy
26/01/2017
1 Media contribution
Press/Media: Research
Impact
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact