Projects per year
Personal profile
Research Statement
Lorcan McGarvey MD FRCP graduated with Honours in Medicine and trained in General Internal and Respiratory Medicine. He is a Consultant Respiratory Physician and Clinical Professor in QUB. He is internationally known for his research in cough reflected in his highly cited publication output. He has a sustained track record of leadership in cough guideline development as Co-Chair of the British Thoracic Society (BTS) Cough Taskforce and currently serves on the European Respiratory Society (ERS) Cough Task Force and as an Expert Member on the American College Chest Physicians (ACCP) Cough Guideline Committee. He has undertaken a range of research studies in cough ranging from evaluation of diagnostic protocols relevant to clinical practice to mechanistic studies designed to elucidate the pathogenesis of chronic cough. Currently his work is focused on the expression and functional characteristics of ion channels located in the airways. In collaboration with colleagues in QUB he is exploring the potential of human dental pulp stem cells (hDPSCs) and induced pluripotent stem cell (iPSC) derived sensory neuronal models to study neuro-inflammatory mechanisms associated with acute and chronic cough. Professor McGarvey established and leads the Northern Ireland Specialist Cough Clinic which receives a high volume of referrals from throughout Ireland for management of complex cough syndromes. This specialist clinic has provided the opportunity for patients to participate in a number of pivotal Phase II national and International clinical trials of novel therapies for cough.
Professor McGarvey has also worked extensively in the area of chronic obstructive pulmonary disease (COPD). In collaboration with Wise (Johns Hopkins Hospital, Baltimore, USA) and John (Charite Hospital, Berlin, Germany) he developed a new methodological approach to the reliable adjudication of cause-specific mortality in COPD clinical trials. This methodology has now been widely adopted and was utilised in three of the largest global COPD trials to date (TORCH, UPLIFT and TIOSPIR). Currently, he is Co-Principal Investigator on the Border REgions And Training Hub (BREATH) a €7.7M funded EU INTERREG 5-year program (2017-2022) and provides clinical leadership across the 3 participating Institutions (QUB, Dundalk Institute of Technology, & University of West of Scotland). Professor McGarvey’s work has been funded from peer-reviewed national and International funding bodies including European Union, Medical Research Council and Higher Education Authority. He is Joint Clinical Lead for the Northern Ireland Clinical Research Network for Respiratory Health.
Professor McGarvey is a Fellow of the Royal College of Physicians and was elected in 2011 to the Association of Physicians of Great Britain and Ireland.
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Network
Projects
- 2 Active
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R1525CII: United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L., Coyle, P. & McGarvey, L.
01/05/2015 → …
Project: Research
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R1553CII: A GMP cell therapy facility to test cell based therapies
McAuley, D., Elborn, S., Johnston, P., Lois, N. & McGarvey, L.
17/08/2014 → …
Project: Research
Research Output
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Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)
Short, B., Carson, S., Devlin, A-C., Reihill, J., Crilly, A., MacKay, W., Ramage, G., Williams, C., Lundy, F., McGarvey, L., Thornbury, K. & Martin, L., 18 Jan 2021, In : Critical Reviews in Microbiology.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD
Andreas, S., McGarvey, L., Bothner, U., Trampisch, M., de la Hoz, A., Fležar, M., Buhl, R. & Alter, P., 10 Aug 2020, In : International journal of chronic obstructive pulmonary disease. 15, p. 1935-1944Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)25 Downloads (Pure) -
ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial
ACCORD Collaborators, 31 Jul 2020, In : Trials. 21, 1, 3 p., 691.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)28 Downloads (Pure) -
ERS guidelines on the diagnosis and treatment of chronic cough in adults and children
Morice, A. H., Millqvist, E., Bieksiene, K., Birring, S. S., Dicpinigaitis, P., Domingo Ribas, C., Hilton Boon, M., Kantar, A., Lai, K., McGarvey, L., Rigau, D., Satia, I., Smith, J., Song, W-J., Tonia, T., van den Berg, J. W. K., van Manen, M. J. G. & Zacharasiewicz, A., 02 Jan 2020, In : European Respiratory Journal. 55, 1Research output: Contribution to journal › Article › peer-review
57 Citations (Scopus) -
Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial
Protocol 012 Investigators, 25 Feb 2020, In : The Lancet Respiratory Medicine.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)220 Downloads (Pure)
Prizes
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Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards
Martin, Lorraine (Recipient), McGarvey, Lorcan (Recipient), Lundy, Fionnuala (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient), John Lockhart (Recipient), Gary Litherland (Recipient) & Anne Crilly (Recipient), 22 Feb 2018
Prize: Prize (including medals and awards)
File -
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Vice-Chancellor's Research Culture Prize 2020
Martin, Lorraine (Recipient), Lundy, Fionnuala (Recipient) & McGarvey, Lorcan (Recipient), 17 Dec 2020
Prize: Prize (including medals and awards)
Activities
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Clinical Phytoscience (Journal)
Lorcan McGarvey (Associate editor)
2016 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Advanced Grant Reviewer
Lorcan McGarvey (Reviewer)
2015Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Committee member on UKCRN/NIHR Respiratory Specialty Group
Lorcan McGarvey (Member)
2014Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Data Safety Monitoring Committee for UK NIHR funded project (External organisation)
Lorcan McGarvey (Chair)
2014 → 2017Activity: Membership types › Membership of peer review panel or committee
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Chest (Journal)
Lorcan McGarvey (Editorial board member)
2014 → …Activity: Publication peer-review and editorial work types › Editorial activity
Impact
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact