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  • Room 02.031 - Whitla Medical Building

    United Kingdom

19942019

Research output per year

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Research Output

2019
Open Access
File
16 Downloads (Pure)

Prompting Medical Students to Self-Assess their Learning Needs during the Ageing and Health Module: A Mixed Methods Study

Kennedy, G., Rea, J. N. M. & Rea, I. M., 02 May 2019, In : Medical Education Online. 24, 1, 12 p., 1579558.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
95 Downloads (Pure)
2018

Age and Age-related Diseases: Role of Inflammation Triggers and Cytokines

Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E. & Alexander, H. D., 09 Apr 2018, In : Frontiers in immunology. p. 1-28 586.

Research output: Contribution to journalReview article

Open Access
File
123 Citations (Scopus)
347 Downloads (Pure)

Cytokine Expression and Production Changes in Very Old Age

McNerlan, S., Ross, O. & Rea, I. M., 01 Jan 2018, In: Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec (Eds.), Handbook of Immunosenescence, 1-24, 2018. Springer, p. https://doi.org/10.1007/978-3-319-64597-1_40-1

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Living Long and Aging Well: Are Lifestyle Factors the Epigenetic Link in the Longevity Phenotype

Rea, I. M. & Mills, K., 17 Nov 2017, Epigenetics of Aging and Longevity. Moskalev, A. & Vaiserman, A. M. (eds.). Academic Press Inc., Vol. 4. p. 137-152 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Towards ageing well: Use it or lose it: Exercise, epigenetics and cognition

Rea, I. M., Aug 2017, In : Biogerontology. 18, 4, p. 679-691 13 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
138 Downloads (Pure)
2016

Living long and ageing well: is epigenomics the missing link between nature and nurture?

Rea, I. M., Dellett, M., Mills, K. I. & ACUME2 Project, Feb 2016, In : Biogerontology. 17, 1, p. 33-54 22 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2015

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

Rea, J. N. M., Carvalho, A., McNerlan, S. E., Alexander, H. D. & Rea, I. M., Oct 2015, In : Biogerontology. 16, 5, p. 587-97 11 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
168 Downloads (Pure)
2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J., Beekman, M., Uh, H-W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guðbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., Böhringer, S. & 67 others, Helmer, Q., Nelson, C. P., Saunders, G. I., Alver, M., Anderson-Ranberg, K., Breen, M. E., van der Breggen, R., Caliebe, A., Capri, M., Cevenini, E., Collerton, J. C., Dato, S., Davies, K., Ford, I., Gampe, J., Garagnani, P., de Geus, E. J. C., Harrow, J., van Heemst, D., Heijmans, B. T., Heinsen, F-A., Hottenga, J-J., Hofman, A., Juene, B., Jonsson, P. V., Lathrop, M., Lechner, D., Martin-Ruiz, C., Mcnerlan, S. E., Mihailov, E., Montesanto, A., Mooijaart, S. P., Murphy, A., Nohr, E. A., Paternoster, L., Postmus, I., Rivadeneira, F., Ross, O. A., Salvioli, S., Sattar, N., Schreiber, S., Stefánsson, H., Stott, D. J., Tiemeier, H., Uitterlinden, A. G., Westendorp, R. G. J., Willemsen, G., Samani, N. J., Galan, P., Sørensen, T. I. A., Boomsma, D. I., Jukema, J. W., Rea, I. M., Passarino, G., de Craen, A. J. M., Christensen, K., Nebel, A., Stefánsson, K., Metspalu, A., Magnusson, P., Blanché, H., Christiansen, L., Kirkwood, T. B. L., van Duijn, C. M., Franceschi, C., Houwing-Duistermaat, J. J. & Slagboom, P. E., 15 Aug 2014, In : Human Molecular Genetics. 23, 6, p. 4420-4432 13 p.

Research output: Contribution to journalArticle

Open Access
File
133 Citations (Scopus)
238 Downloads (Pure)

Physical Activity and Cognitive Function in the Elderly: a Systematic Review

Carvalho, A., Rea, M., Parimon, T. & Cusack, B. J., 14 Mar 2014, In : Clinical Interventions in Ageing . 2014:9, p. 661 - 682

Research output: Contribution to journalArticle

Open Access
File
111 Citations (Scopus)
1307 Downloads (Pure)

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V., Blanché, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E. S., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Poulain, M. & 18 others, Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Eline Slagboom, P., Spazzafumo, L., Antonietta Stazi, M., Toussaint, O., Vaupel, J. W., Rose, G., Majamaa, K., Perola, M., Johnson, T. E., Bolund, L., Yang, H., Passarino, G. & Franceschi, C., Jun 2014, In : Aging cell. 13, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

Open Access
File
56 Citations (Scopus)
264 Downloads (Pure)
2013

Altered methylation levels in elderly acute myeloid leukaemia patients compared to elderly well individuals

Dellett, M., Colyer, H. A. A., Pettigrew, K. A., McMullin, M. F., Rea, I. M. & Mills, K. I., Apr 2013, In : British Journal of Haematology. 161, 2, p. 294-296

Research output: Contribution to journalArticle

2 Citations (Scopus)

Blood pressure and TNF-α act synergistically to increase leucocyte CD11b adhesion molecule expression in the BELFAST study: implications for better blood pressure control in ageing

Rea, I. M., McNerlan, S. E., Alexander, D. H. & Armstrong, M. E., Feb 2013, In : AGE. 35, 1, p. 197-205 9 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
179 Downloads (Pure)

Depression associates with Mini Nutritional Assessment (MNA), Vitamin B12 and Folate status: Findings from Belfast Elderly Longitudinal Free-Living Ageing STudy (BELFAST)

Bowman, M. A., Rea, J. N. M., Murphy, A. & Rea, M., 01 Mar 2013, Age and Ageing. Francis, R. (ed.). Oxford University Press, Vol. 42 Supp (2) ii1. (Age and Ageing; vol. 42, no. 2;ii1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Genome-wide linkage analysis for human longevity: Genetics of healthy aging study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., Rea, . I. M., Poulain, M., Robine, J-M., Valensin, S., Stazi, M. A., Passarino, G., Deiana, L., Gonos, E. S., Paternoster, L., Sørensen, T. I. A. & 20 others, Tan, Q., Helmer, Q., Van den Akker, E. B., Deelen, J., Martella, F., Cordell, H. J., Ayers, K., Vaupel, J. W., Törnwall, O., Johnson, T. E., Schreiber, S., Lathrop, M., Skytthe, A., Westendorp, R. G. J., Christensen, K., Gampe, J., Nebel, A., Houwing-Duistermaat, J. J., Slagboom, P. E. & Franceschi, C., Apr 2013, In : Aging cell. 12, 2, p. 184-193 10 p.

Research output: Contribution to journalArticle

Open Access
File
113 Citations (Scopus)
289 Downloads (Pure)
7 Citations (Scopus)

Killer immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)

Rea, I. M., Maxwell, L. D., McNerlan, S. E., Alexander, H. D., Curran, M. D., Middleton, D. & Ross, O. A., Aug 2013, In : Immunity & ageing. 10, 12 p., 35.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
243 Downloads (Pure)

Living long and ageing well: insights from nonagenarians

Rea, M., 11 Mar 2013, Improving later life: Understanding the oldest old. Davidson, D. S., Goodwin, P. J. & Rossall, P. (eds.). AgeUK, p. 74-78 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study

Rea, I. M., McNerlan, S. E., Archbold, G. P., Middleton, D., Curran, M. D., Young, I. S. & Ross, O. A., Aug 2013, In : Age (Dordrecht, Netherlands). 35, 4, p. 1445-1456 12 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
242 Downloads (Pure)

Nature or Nurture Nonagenarians tell us how they understand their Ageing Long and Ageing Well

Rea, M., 14 Jun 2013, (In preparation).

Research output: Contribution to conferenceOther

USING ‘NUTRITIONAL NARRATIVE’ AND FOCUS GROUPS TO UNDERSTAND HOW NUTRITIONAL CARE CAN BETTER PRIORITISED FOR OLDER PEOPLE IN HOSPITAL SETTINGS

Morrison, S., Machniewski, S., Purdy, J., Carlisle, K., Coleman, D., Rea, M. & O'Donnell, C., 23 Aug 2013, Age Ageing : British Geriatrics Society;British Geriatrics Society Communications to the Spring Meeting 17th-19th April 2013 Belfast . Francis, R. (ed.). iii22-iii24. ed. UK: Oxford University Press, Vol. 2013, 42(Suppl 3). p. 22-24

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2012

Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death

Pettigrew, K. A., Armstrong, R. N., Colyer, H. A. A., Zhang, S-D., Rea, I. M., Jones, R. E., Baird, D. M. & Mills, K. I., Aug 2012, In : GENES CHROMOSOMES & CANCER. 51, 8, p. 768-80 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Do Nonagenarians siblings provide mutual support? Insights from the EU GeHA project

Cevenni, E., Celani, L., Rea, J. NM., Numminen, A., Virras, O., Broczeke, K., Sikora, E., Franceschi, C. & Rea, M., 2012, In : European Geriatric Medicine. 3S (2012) S33–S143, p. S79-S80 1 p., p157.

Research output: Contribution to journalMeeting abstract

The European Axis: How nonagenarians view their Survivorship

Rea, M., Mar 2012, The Global Dynamics of Aging. Powell, J. L. & Chen, S. (eds.). Nova Publishers, p. 200-224 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

Skytthe, A., Valensin, S., Jeune, B., Cevenini, E., Balard, F., Beekman, M., Bezrukov, V., Blanche, H., Bolund, L., Broczek, K., Carru, C., Christensen, K., Christiansen, L., Collerton, J. C., Cotichini, R., de Craen, A. J. M., Dato, S., Davies, K., De Benedictis, G., Deiana, L. & 31 others, Flachsbart, F., Gampe, J., Gilbault, C., Gonos, E. S., Haimes, E., Hervonen, A., Hurme, M. A., Janiszewska, D., Jylhä, M., Kirkwood, T. B. L., Kristensen, P., Laiho, P., Leon, A., Marchisio, A., Masciulli, R., Nebel, A., Passarino, G., Pelicci, G., Peltonen, L., Perola, M., Poulain, M., Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Scurti, M., Sevini, F., Sikora, E., Skouteri, A., Slagboom, P. E. & GEHA consortium, Nov 2011, In : Experimental Gerontology. 46, 11, p. 934-45 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

European Geriatric Medicine

Rea, M., Drysdale, C., Dellet, M. & Mills, K. I., Sep 2011, p. 225-225. 1 p.

Research output: Contribution to conferencePaper

Irish Journal of Medical Science

Drysdale, C., Dallet, M., Murphy, A., Mills, K. & Rea, M., Sep 2011, p. 344-344. 1 p.

Research output: Contribution to conferencePaper

Nutrition and epigenetic change in belfast elderly longitudinal free-living ageing study (BELFAST)

Drysdale, C., Dellett, M., Murphy, A., Mills, K. & Rea, M., Sep 2011, In : Irish journal of medical science. 180, p. S344-S344 1 p.

Research output: Contribution to journalMeeting abstract

Super Vivere

Rea, S. & Rea, M., Jan 2011

Research output: Non-textual formExhibition

Super Vivere: Reflections on long life and ageing well

Rea, M. & Susie, R., Mar 2011, Blackstaff Press. 176 p.

Research output: Book/ReportBook

2010

Age and Ageing

Rea, M. & Roberts, M. V., Nov 2010, p. i8-i8. 1 p.

Research output: Contribution to conferencePaper

10 Citations (Scopus)

BELFAST centenarians: a case of optimised cardiovascular risk?

Bennati, E., Murphy, A., Cambien, F., Whitehead, A. S., Archbold, G. P. R., Young, I. S. & Rea, I. M., 2010, In : Current Pharmaceutical Design. 16, 7, p. 789-95 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

BELFAST centenarians: A Case of Optimal Cardiovascular Risk?

Bennati, E., Murphy, A., Cambien, F., Whitehead, A. S., Archbold, G. P. R., Young, I. S. & Rea, M., Mar 2010, In : Current Pharmaceutical Design. 16, 7, p. 789-795 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

BELFAST nonagenarians; Nature or Nurture? Immunological, cardiovascular and genetic factors

Rea, M., 27 May 2010, In : Immunity and Ageing. 7, p. 1-12 12 p., 6.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Beyond 90 Together: Telling our Stories

Rea, M., May 2010, Unknown Publisher.

Research output: Book/ReportOther report

Eur Ger Med

Rea, M., Rea, S. & Murphy, A., Sep 2010, p. 16-16. 1 p.

Research output: Contribution to conferencePaper

Exploring the nutritional needs of older people in a hospital environment

Morison, S., Machniewski, S., Purdy, J., Carlisle, K., Rea, M. & Coleman, D., Apr 2010, Changing Ageing Partnership. 111 p.

Research output: Book/ReportOther report

No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis

Caliebe, A., Kleindorp, R., Blanché, H., Christiansen, L., Puca, A. A., Rea, I. M., Slagboom, E., Flachsbart, F., Christensen, K., Rimbach, G., Schreiber, S. & Nebel, A., Jul 2010, In : Ageing research reviews. 9, 3, p. 238-44 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA stud

Rose, G., Romeo, G., Dato, S., Crocco, P., Bruni, A. C., Hervonen, A., Majamaa, K., Sevini, F., Franceschi, C., Bezrukov, V., Blanché, H., Bolund, L., Christensen, K., Deiana, L., Gonos, E., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Perola, M. & 11 others, Poulain, M., Rea, M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Slagboom, P. E., Spazzafumo, L., Stazi, M. A., Toussaint, O. & Vaupel, J. W., Oct 2010, In : PLoS ONE. 5, 10, p. 1-10 10 p., e13395.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2009

ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma

Drain, S., Catherwood, M. A., Orr, N., Galligan, L., Rea, M., Hodkinson, C., Drake, M. B., Kettle, P. J., Morris, T. C. & Alexander, H. D., Apr 2009, In : Leukemia and Lymphoma. 50, 4, p. 566-570 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Age Ageing: Effect on Attitudes and Specialty Popularity of Undergraduate Geriatric Medicine Programmes in Scotland and Northern Ireland

Soiza, R. L., Rea, M., Shaw, J., MacLullich, A. M. J., Hoyle, G. E., Fraser, M. A., Hughes, N. J., Chua, M. P. W., MacDonald, A., McKenzie, H., Young, A., McMurdo, M. E. T. & Seymour, D. G., Oct 2009, In : Age and Ageing. Suppl 1, p. i41-i41 1 p.

Research output: Contribution to journalArticle

Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis

Di Bona, D., Vasto, S., Capurso, C., Christiansen, L., Deiana, L., Franceschi, C., Hurme, M., Mocchegiani, E., Rea, M., Lio, D., Candore, G. & Caruso, C., Jan 2009, In : Ageing research reviews. 8, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis

Di Bona, D., Vasto, S., Capurso, C., Christiansen, L., Deiana, L., Franceschi, C., Hurme, M., Mocchegiani, E., Rea, M., Lio, D., Candore, G. & Caruso, C., Jan 2009, In : Ageing research reviews. 8, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Irish Journal Medical Science

Myint, P., Mueller, H., Murphy, A., McNulty, H., Patterson, C., Archbold, P. & Rea, M., Sep 2009, p. S294-S294. 1 p.

Research output: Contribution to conferencePaper

journal Nutrition Health and Ageing

Rea, M., Dallet, M., McNerlan, S. E., Murphy, A. & Mills, K., Jun 2009, p. 551-552. 2 p.

Research output: Contribution to conferencePaper

Journal Nutrition Health and Ageing

Rea, M., Armstrong, M., McNerlan, S. E., McMillen, S. & Alexander, H. D., Jun 2009, p. 174-174. 1 p.

Research output: Contribution to conferencePaper

Medical Students' views of a career in Geriatric Medicine; Multi-Centre Qualitative Analysis

Rea, M., Sep 2009, In : Age and Ageing. 38, p. i42-i42 1 p.

Research output: Contribution to journalArticle

MEDICAL STUDENTS’ VIEWS OF A CAREER IN GERIATRIC MEDICINE: MULTI-CENTRE QUALITATIVE ANALYSIS

Hoyle, G. E., Rea, M., Soiza, R. L., Shaw, J., MacLullich, A. M. J., Fraser, M. A., Hughes, N. J., Chua, M. P. W., MacDonald, A., McKenzie, H., Young, A., McMurdo, M. E. T. & Seymour, D. J., Sep 2009, In : Age and Ageing. Suppl, p. i42-i42 1 p.

Research output: Contribution to journalArticle

2008

Cytokine Expression and Production Changes in Very Old Age

McNerlan, S. E., Armstrong, M. A., Ross, O. A. & Rea, M., Nov 2008, Handbook of Immunosenesence. Fulop, F., Hirokawa & Pawelec (eds.). Springer, p. 771-785 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter