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  • Room 02.031 - Whitla Medical Building

    United Kingdom

19942019

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2019
Open Access
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7 Downloads (Pure)

Prompting Medical Students to Self-Assess their Learning Needs during the Ageing and Health Module: A Mixed Methods Study

Kennedy, G., Rea, J. N. M. & Rea, I. M., 02 May 2019, In : Medical Education Online. 24, 1, 12 p., 1579558.

Research output: Contribution to journalArticle

Open Access
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84 Downloads (Pure)
2017

Towards ageing well: Use it or lose it: Exercise, epigenetics and cognition

Rea, I. M., Aug 2017, In : Biogerontology. 18, 4, p. 679-691 13 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
124 Downloads (Pure)
2016

Living long and ageing well: is epigenomics the missing link between nature and nurture?

Rea, I. M., Dellett, M., Mills, K. I. & ACUME2 Project, Feb 2016, In : Biogerontology. 17, 1, p. 33-54 22 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J., Beekman, M., Uh, H-W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guðbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., Böhringer, S. & 67 others, Helmer, Q., Nelson, C. P., Saunders, G. I., Alver, M., Anderson-Ranberg, K., Breen, M. E., van der Breggen, R., Caliebe, A., Capri, M., Cevenini, E., Collerton, J. C., Dato, S., Davies, K., Ford, I., Gampe, J., Garagnani, P., de Geus, E. J. C., Harrow, J., van Heemst, D., Heijmans, B. T., Heinsen, F-A., Hottenga, J-J., Hofman, A., Juene, B., Jonsson, P. V., Lathrop, M., Lechner, D., Martin-Ruiz, C., Mcnerlan, S. E., Mihailov, E., Montesanto, A., Mooijaart, S. P., Murphy, A., Nohr, E. A., Paternoster, L., Postmus, I., Rivadeneira, F., Ross, O. A., Salvioli, S., Sattar, N., Schreiber, S., Stefánsson, H., Stott, D. J., Tiemeier, H., Uitterlinden, A. G., Westendorp, R. G. J., Willemsen, G., Samani, N. J., Galan, P., Sørensen, T. I. A., Boomsma, D. I., Jukema, J. W., Rea, I. M., Passarino, G., de Craen, A. J. M., Christensen, K., Nebel, A., Stefánsson, K., Metspalu, A., Magnusson, P., Blanché, H., Christiansen, L., Kirkwood, T. B. L., van Duijn, C. M., Franceschi, C., Houwing-Duistermaat, J. J. & Slagboom, P. E., 15 Aug 2014, In : Human Molecular Genetics. 23, 6, p. 4420-4432 13 p.

Research output: Contribution to journalArticle

Open Access
File
129 Citations (Scopus)
224 Downloads (Pure)

Physical Activity and Cognitive Function in the Elderly: a Systematic Review

Carvalho, A., Rea, M., Parimon, T. & Cusack, B. J., 14 Mar 2014, In : Clinical Interventions in Ageing . 2014:9, p. 661 - 682

Research output: Contribution to journalArticle

Open Access
File
109 Citations (Scopus)
1262 Downloads (Pure)

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V., Blanché, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E. S., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Poulain, M. & 18 others, Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Eline Slagboom, P., Spazzafumo, L., Antonietta Stazi, M., Toussaint, O., Vaupel, J. W., Rose, G., Majamaa, K., Perola, M., Johnson, T. E., Bolund, L., Yang, H., Passarino, G. & Franceschi, C., Jun 2014, In : Aging cell. 13, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
254 Downloads (Pure)
2013

Altered methylation levels in elderly acute myeloid leukaemia patients compared to elderly well individuals

Dellett, M., Colyer, H. A. A., Pettigrew, K. A., McMullin, M. F., Rea, I. M. & Mills, K. I., Apr 2013, In : British Journal of Haematology. 161, 2, p. 294-296

Research output: Contribution to journalArticle

2 Citations (Scopus)

Blood pressure and TNF-α act synergistically to increase leucocyte CD11b adhesion molecule expression in the BELFAST study: implications for better blood pressure control in ageing

Rea, I. M., McNerlan, S. E., Alexander, D. H. & Armstrong, M. E., Feb 2013, In : AGE. 35, 1, p. 197-205 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
164 Downloads (Pure)

Genome-wide linkage analysis for human longevity: Genetics of healthy aging study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., Rea, . I. M., Poulain, M., Robine, J-M., Valensin, S., Stazi, M. A., Passarino, G., Deiana, L., Gonos, E. S., Paternoster, L., Sørensen, T. I. A. & 20 others, Tan, Q., Helmer, Q., Van den Akker, E. B., Deelen, J., Martella, F., Cordell, H. J., Ayers, K., Vaupel, J. W., Törnwall, O., Johnson, T. E., Schreiber, S., Lathrop, M., Skytthe, A., Westendorp, R. G. J., Christensen, K., Gampe, J., Nebel, A., Houwing-Duistermaat, J. J., Slagboom, P. E. & Franceschi, C., Apr 2013, In : Aging cell. 12, 2, p. 184-193 10 p.

Research output: Contribution to journalArticle

Open Access
File
113 Citations (Scopus)
269 Downloads (Pure)
7 Citations (Scopus)

Killer immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)

Rea, I. M., Maxwell, L. D., McNerlan, S. E., Alexander, H. D., Curran, M. D., Middleton, D. & Ross, O. A., Aug 2013, In : Immunity & ageing. 10, 12 p., 35.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
232 Downloads (Pure)

Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study

Rea, I. M., McNerlan, S. E., Archbold, G. P., Middleton, D., Curran, M. D., Young, I. S. & Ross, O. A., Aug 2013, In : Age (Dordrecht, Netherlands). 35, 4, p. 1445-1456 12 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
235 Downloads (Pure)
2012

Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death

Pettigrew, K. A., Armstrong, R. N., Colyer, H. A. A., Zhang, S-D., Rea, I. M., Jones, R. E., Baird, D. M. & Mills, K. I., Aug 2012, In : GENES CHROMOSOMES & CANCER. 51, 8, p. 768-80 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

Skytthe, A., Valensin, S., Jeune, B., Cevenini, E., Balard, F., Beekman, M., Bezrukov, V., Blanche, H., Bolund, L., Broczek, K., Carru, C., Christensen, K., Christiansen, L., Collerton, J. C., Cotichini, R., de Craen, A. J. M., Dato, S., Davies, K., De Benedictis, G., Deiana, L. & 31 others, Flachsbart, F., Gampe, J., Gilbault, C., Gonos, E. S., Haimes, E., Hervonen, A., Hurme, M. A., Janiszewska, D., Jylhä, M., Kirkwood, T. B. L., Kristensen, P., Laiho, P., Leon, A., Marchisio, A., Masciulli, R., Nebel, A., Passarino, G., Pelicci, G., Peltonen, L., Perola, M., Poulain, M., Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Scurti, M., Sevini, F., Sikora, E., Skouteri, A., Slagboom, P. E. & GEHA consortium, Nov 2011, In : Experimental Gerontology. 46, 11, p. 934-45 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2010

BELFAST centenarians: a case of optimised cardiovascular risk?

Bennati, E., Murphy, A., Cambien, F., Whitehead, A. S., Archbold, G. P. R., Young, I. S. & Rea, I. M., 2010, In : Current Pharmaceutical Design. 16, 7, p. 789-95 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

BELFAST centenarians: A Case of Optimal Cardiovascular Risk?

Bennati, E., Murphy, A., Cambien, F., Whitehead, A. S., Archbold, G. P. R., Young, I. S. & Rea, M., Mar 2010, In : Current Pharmaceutical Design. 16, 7, p. 789-795 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

BELFAST nonagenarians; Nature or Nurture? Immunological, cardiovascular and genetic factors

Rea, M., 27 May 2010, In : Immunity and Ageing. 7, p. 1-12 12 p., 6.

Research output: Contribution to journalArticle

5 Citations (Scopus)

No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis

Caliebe, A., Kleindorp, R., Blanché, H., Christiansen, L., Puca, A. A., Rea, I. M., Slagboom, E., Flachsbart, F., Christensen, K., Rimbach, G., Schreiber, S. & Nebel, A., Jul 2010, In : Ageing research reviews. 9, 3, p. 238-44 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA stud

Rose, G., Romeo, G., Dato, S., Crocco, P., Bruni, A. C., Hervonen, A., Majamaa, K., Sevini, F., Franceschi, C., Bezrukov, V., Blanché, H., Bolund, L., Christensen, K., Deiana, L., Gonos, E., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Perola, M. & 11 others, Poulain, M., Rea, M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Slagboom, P. E., Spazzafumo, L., Stazi, M. A., Toussaint, O. & Vaupel, J. W., Oct 2010, In : PLoS ONE. 5, 10, p. 1-10 10 p., e13395.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2009

ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma

Drain, S., Catherwood, M. A., Orr, N., Galligan, L., Rea, M., Hodkinson, C., Drake, M. B., Kettle, P. J., Morris, T. C. & Alexander, H. D., Apr 2009, In : Leukemia and Lymphoma. 50, 4, p. 566-570 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Age Ageing: Effect on Attitudes and Specialty Popularity of Undergraduate Geriatric Medicine Programmes in Scotland and Northern Ireland

Soiza, R. L., Rea, M., Shaw, J., MacLullich, A. M. J., Hoyle, G. E., Fraser, M. A., Hughes, N. J., Chua, M. P. W., MacDonald, A., McKenzie, H., Young, A., McMurdo, M. E. T. & Seymour, D. G., Oct 2009, In : Age and Ageing. Suppl 1, p. i41-i41 1 p.

Research output: Contribution to journalArticle

Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis

Di Bona, D., Vasto, S., Capurso, C., Christiansen, L., Deiana, L., Franceschi, C., Hurme, M., Mocchegiani, E., Rea, M., Lio, D., Candore, G. & Caruso, C., Jan 2009, In : Ageing research reviews. 8, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis

Di Bona, D., Vasto, S., Capurso, C., Christiansen, L., Deiana, L., Franceschi, C., Hurme, M., Mocchegiani, E., Rea, M., Lio, D., Candore, G. & Caruso, C., Jan 2009, In : Ageing research reviews. 8, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Medical Students' views of a career in Geriatric Medicine; Multi-Centre Qualitative Analysis

Rea, M., Sep 2009, In : Age and Ageing. 38, p. i42-i42 1 p.

Research output: Contribution to journalArticle

MEDICAL STUDENTS’ VIEWS OF A CAREER IN GERIATRIC MEDICINE: MULTI-CENTRE QUALITATIVE ANALYSIS

Hoyle, G. E., Rea, M., Soiza, R. L., Shaw, J., MacLullich, A. M. J., Fraser, M. A., Hughes, N. J., Chua, M. P. W., MacDonald, A., McKenzie, H., Young, A., McMurdo, M. E. T. & Seymour, D. J., Sep 2009, In : Age and Ageing. Suppl, p. i42-i42 1 p.

Research output: Contribution to journalArticle

2007

Genetics of Healthy Aging in Europe.The EU-Integrated Project GEHA (GEnetics of Healthy Aging)

Franceschi, C., Bezrukov, V., Blanche, H., Bolund, L., Christensen, K., De Benedictus, G., Deiana, L., Gonos, E., Hervonen, A., Yang, H., Jeune, B., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Peltonen, L., Poulain, M., Rea, M., Remacle, J., Robine, J. M. & 7 others, Schreiber, S., Sikora, E., Slagboom, P. E., Spazzafumo, L., Stazi, M. A., Toussaint, O. & Vaupel, J. W., 2007, In : Annals of the New York Academy of Sciences. 1100, p. 21-45 25 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2005

Pro-inflammatory and anti-inflammatory cytokines track with KIR haplotypes A and B in octo/nonagenarian subjects.

Rea, M., Maxwell, L. D., Ross, O., Rea-Lyon, C. A., Alexander, H. D. & Middleton, D., May 2005, In : Clinical Immunology. 115, p. S202-S203 2 p.

Research output: Contribution to journalArticle

Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish.

Ross, O. A., O'Neill, C., Rea, M., Lynch, T., Gosal, D., Wallace, A., Curran, M. D., Middleton, D. & Gibson, J. M., Apr 2004, In : Human Immunology. 65(4), 4, p. 340-346 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish.

Ross, O. A., Maxwell, L. D., Rea, M. & Curran, M. D., May 2004, In : Experimental Gerontology. 39(5), 5, p. 801-805 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Investigation of KIR diversity in immunosenescence and longevity within the Irish population.

Maxwell, L. D., Ross, O. A., Curran, M. D., Rea, M. & Middleton, D., Aug 2004, In : Experimental Gerontology. 39(8), 8, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Malondialdehyde and measures of antioxidant activity in subjects from the Belfast Elderly Longitudinal Free-living Aging Study.

Rea, M., McMaster, D., Donnelly, J., McGrath, L. T. & Young, I., Jun 2004, In : Annals of the New York Academy of Sciences. 1019, p. 392-395 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Paraoxanase polymorphisms PON1 192 and 55 in italian centenarians and irish nonagenarians: a pooled analysis

Rea, M., McKeown, P., McMaster, D., Young, I., Patterson, C., Savage, M., Belton, C., Marchegiani, F., Olivieri, F., Bonafe, M. & Franceschi, C., 2004, In : Experimental Gerontology. 39, p. 629-635 7 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2003

Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population.

Ross, O. A., Curran, M. D., Crum, K. A., Rea, M., Barnett, Y. A. & Middleton, D., 01 May 2003, In : Experimental Gerontology. 38(5), 5, p. 561-565 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants.

Rea, M., Ross, O. A., McNerlan, S. E., Curran, M. D., Middleton, D. & Armstrong, M., 01 Apr 2003, In : Mechanisms of Ageing and Development. 124(4), 4, p. 555-561 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish.

Ross, O. A., McCormack, R., Maxwell, L. D., Duguid, R. A., Quinn, D. J., Barnett, Y. A., Rea, M., El-Agnaf, O. M., Gibson, J. M., Wallace, A., Middleton, D. & Curran, M. D., 2003, In : Experimental Gerontology. 38(4), p. 397-405 9 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Study of age-association with cytokine gene polymorphisms in an aged Irish population.

Ross, O. A., Curran, M. D., Meenagh, A., Williams, F., Barnett, Y. A., Middleton, D. & Rea, M., 01 Feb 2003, In : Mechanisms of Ageing and Development. 124(2), 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2002

A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish.

Ross, O. A., Mcwhinney, D., Awayn, N. H., Maxwell, L. D., El-Agnal, O. M., Barnett, Y. A., Rea, M., Middleton, D., Wallace, A., Gibson, J. M. & Curran, M. D., 2002, In : Neuroreport. 13(13), p. 1621-1625 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
48 Citations (Scopus)
2001
6 Citations (Scopus)
42 Citations (Scopus)

Mitochondrial DNA polymorphism: its role in longevity of the Irish population.

Rea, M., 2001, In : Experimental Gerontology. 36(7), 7, p. 1161-1178 18 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Serum heat shock protein and anti-heat shock protein antibody levels in aging.

Rea, M., McNerlan, S. E. & Pockley, G., Feb 2001, In : Experimental Gerontology. 36(2), 2, p. 341-352 12 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)
2000

Community-living nonagenarians in northern ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70-89-year-old subjects

Rea, I. M., McMaster, D., Woodside, J. V., Young, I. S., Archbold, G. P., Linton, T., Lennox, S., McNulty, H., Harmon, D. L. & Whitehead, A. S., Mar 2000, In : Atherosclerosis. 149, 1, p. 207-14 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Community-living nonagenarians in northern ireland have lower plasma homocysteine but similar methylenetrahydrofolate reductase thermolabile genotype prevalence compared to 70 -89 year old subjects.

Rea, M., McMaster, D., Woodside, J., Young, I., Archbold, G. P. R., Linton, T., Lennox, S., McNulty, H., Harmon, D. L. & Whitehead, A. S., 2000, In : Atherosclerosis. 149, p. 207-214 8 p.

Research output: Contribution to journalArticle

Flow cytometry analysis of platelet P-selectin expression in whole blood--methodological considerations.

Rea, M., McNerlan, S. E. & Alexander, H. D., 2000, In : Clinical and Laboratory Haematology. 22(6), 6, p. 359-363 5 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsets

Rea, I. M., McNerlan, S. E. & Alexander, H. D., Feb 2000, In : Cytokine. 12, 2, p. 156-9 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)