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Professor Manuel Salto-Tellez (MD-LMS, FRCPath, FRCPI) is the Chair of Molecular Pathology at Queen’s University Belfast, Clinical Consultant Pathologist at the Belfast Health and Social Care Trust and Deputy Director of the Centre for Cancer Research and Cell Biology.
PERSONAL INFORMATION (degrees)
August 1991 |
Degree (LMS, MD equivalent): Título de Licenciado en Medicina y Cirugía, |
October 1998 |
MRCPath: |
February 2006 |
FRCPath |
December 2013 |
FRCPI – 48435 |
December 2001 |
Mol Path Fellowship: |
April 1999 |
Certificate of Completion of Specialist Training (UK) |
1992 |
General Medical Council Registration Number (UK): 3624504 |
1999 |
Singapore Medical Council Registration Number: 08697E |
|
Member of the Royal College of Pathologists: 070761X/ME |
EDUCATION - Medical Schools (in the context of the ERASMUS Programme)
1984-88 |
University of Oviedo, Spain; |
1988-90 |
R-W Technischen Hochschule Aachen, Germany; |
1990-91 |
The Royal University of Leiden, The Netherlands. |
PREVIOUS POSTS (in brief chronological order)
1992 to 2002 – |
Trainee in Pathology at the University of Edinburgh (Royal Infirmary) and the Northwick Park & St. Mark’s Hospitals in London; Fellow in Diagnostic Molecular Pathology at UPENN (USA) |
1999 - 2011: |
Assistant and Associate Professor, National University of Singapore (NUS). From 2004 - Sr. Research Scientist at the NUS Cancer Science Institute |
1999 - 2011: |
Consultant and Senior Consultant, Department of Pathology, National University Hospital (NUH), Singapore. Director, Diagnostic Molecular Oncology Centre, NUH |
2007 - 2010: |
Assist. Dean & Vice-dean for Research, NUS. Head of Clinical Science Research at the National University Health System (NUHS) |
2011 to 2014: |
Visiting Professor, Department of Pathology & Cancer Science Institute, NUS |
March 2011 to date: |
Chair and Professor of Molecular Pathology, Centre for Cancer Research and Cell Biology (CCRCB); School of Medicine, Dentistry and Biomedical Sciences (SMDBS), Queen’s University Belfast (QUB), United Kingdom |
March 2011 to date: |
Clinical Consultant, Belfast Health and Social Care Trust, UK |
July 2012 to date: |
Deputy Director, CCRCB; SMDBS, QUB, UK |
May 2014 to date: |
Associate member of the Cancer Science Institute, NUS |
July 2016 to date: |
Clinical Director, Molecular Diagnostics, Northern Ireland remit |
COMMITTEE MEMBERSHIP (selection)
August 2011-14: |
Member of the Interspecialty Committee on Molecular Pathology in the Royal College of Pathologists of Great Britain and Ireland |
Since March 2012: |
Member of the Colorectal Group of the National Cancer Research Institute |
Novem 2012-17: |
Member of the Molecular Pathology Committee of the Association of Clinical Pathology |
March 2013-16: |
Member of the Ex. Group of the Confederation of Cancer Biobanks, National Cancer Research Institute |
Since June 2013: |
Member of the Cancer Research UK Biomarker Expert Review Panel. |
Since April 2014: |
ECMC Cellular and Molecular Pathology (CM-Path) Network Group |
Since Decem 2014: |
Member of the UKNEQAS Committee for DNA Quality |
Since Novem 2014: |
Member of the Molecular Pathology Committee of Genomics England |
Since Decem 2014: |
Member of the Genomics England GCIPs on CRC and data interpretation |
Since August 2015: |
Member of the Wales Cancer Research Centre’s External Advisory Board |
Since July 2016: |
Member of the Main Committee of the Pathological Society of GB & Ireland |
Since 2016: |
Member of the Cancer Research UK New Agents Committee |
July 2016: |
Member of the Independent Selection Panel for applications for NIHR funding and designation for Clinical Research Facilities for early translational research (Department of Health) |
January 2017 |
Member of the NIHR Senior Investigators Appointment Panel (Department of Health) |
RESEARCH GRANTS (selection) – From a total lifetime to date of £7.9M
In Singapore (selection, from a total of S$5.17M - 1£ = 2.2 Singapore $)
Singapore Cancer Syndicate April 2004 – March 2005: S$275,000
April 2005 – March 2008: S$1,890,000
April 2006 – March 2009: S$1,200,000
July 2008 – July 2011: S$1,005,000
In Queen’s University Belfast (from £4.9M of active funding, selection) Project Title
R1089CNR - Medical Research Council - £163,015 |
Central Importance of CXCL8 to Inflammation - Promoted Prostate Cancer Progression |
R2116CNR - Prostate Cancer UK - £273,017 |
Movember Centre of Excellence |
R3511CNR - Invest NI - £359,272 |
Establishment of an Intergrated Almac-QUB Drug Discovery Unit at QUB |
CRUK - £3,900,000 £ |
CR-UK Accelerator Award |
Pending final confirmation: |
Centre of Excellence in Mol Pathology £10,000,000 |
AWARDS AND INTERNATIONAL LEADERSHIP (strict selection)
Awards (selection)
November 1990, |
Erasmus Prize of the European Community; |
2003 |
Courage Star by the Courage Fund. This was in recognition to the work developed during the Severe Acute Respiratory Syndrome (SARS) crisis that affected (primarily) the South-east of Asia in 2003; |
2005 |
World Scientists Forum International Award in the field of Onco-Cytology by the International Research Promotion Council (IRPC); |
28-29 March 2008 |
Silver frame in recognition to research in the area of gastrointestinal diseases, presented at the 13th Annual Helenic Helicobacter Pylori Congress, Athens |
March 10-11 2010 |
Keynote Speaker at the 6th Annual Tucson Symposium: Targeted Therapeutics: Leading the Global Paradigm Shift for Pathology, Arizona |
7-10 October 2011 |
Keynote Speaker at the 41st annual Scientific Meeting of the Australian Society of Cytology. Molecular Biology for the Cytologists, Perth |
14 February 2014 |
Key note speaker at the 32nd Annual Symposium of the Faculty of Pathology of the Royal College of Physicians of Ireland. Integrated Molecular Tissue Pathology. |
14-15 March 2016 |
Leading member of the Advisory Panel to the Division of Cancer Epidemiology and Genomics on Molecular Pathology, NCI/NIH, (Drs. Stephen Chanok and Montserrat Garcia-Closas) |
March-April 2016 |
Reviewer to the Molecular Pathology Programme at the Ontario Institute of Cancer Research, Canada, (Dr. Thomas J Hudson, President and Scientific Director) |
Invitations to meetings (strict selection, only since 2010)
2010
24-25 April 2010 |
Speaker at the “2010 AstraZeneca Asia Pacific Oncology Summit” - EGFR Mutation Testing, in Taipei, Taiwan. |
16-20 May 2010 |
Invited speaker at the 17th International Congress of Cytology (International Academy of Cytology) to deliver the lecture “Molecular Cytopathology and Personalised Medicine” at the International Conference Centre in Edinburgh, UK, – ACTA CYTOLOGICA 54,3:385-85 2010 |
June 9-10 2010 |
Invited Speaker at the 3rd InterAcademy Medical Panel (IAMP) and General Assembly meeting - “Molecular Diagnostics in Cancer and Implications for the Developing World”, in Kuala Lumpur, Malaysia, |
4-5 Septem 2010 |
Invited Speaker and Guest of Honour at the 2010 Annual Meeting of the Sri Lankan Society of Pathology to deliver several lectures, workshops and speeches, at Kandy, Sri Lanka, |
October 1-3 2010 |
Invited speaker (Plenary Speaker, inaugural session) at the 2010 Annual Scientific Congress of the Malaysian Oncological Society - Role of Pathologist in Personalized Cancer Treatment, at Kota Bharu, Kelantan, Malaysia, |
23 October 2010 |
Invited Speaker at the 8th Meeting of the Association of Directors of Pathology of China - Molecular Pathology, Targeted Therapeutics and the Future of Pathology, Shanghai Everbright Convention & Exhibition Center, China, |
Novem 9–11 2010 |
Invited speaker at the International Conference in Laboratory Medicine at the Sultan Qaboos University, Muscat (Oman): “Molecular Pathology – A hospital based platform for Translational Research”. |
2011
May 9-10 2011 |
Invited Speaker by the The Western Australian Clinical Oncology Group - “The Future of Personalized Medicine from a Diagnostic and Therapeutic Perspective”, “Histopathology, Molecular Diagnostics and Therapeutic Pathology - challenges and opportunities” and “Tissue-based Translational Research”, Perth (Australia) |
Septem 7-8 2011 |
2nd Meeting of the Society for Translational Oncology / 3rd CCRCB International Cancer Symposium: EGFR mutation analysis: a paradigm for the future of therapeutic pathology and personalized medicine. Belfast |
2012
8-10 March 2012 |
Invited Speaker at Coloproctology 2012, 10th annual meeting of the Malaysian Society of Colorectal Surgeons - “Histopathological assessment of rectal cancer resection specimens”, “Introduction to biopsy interpretation” and “Molecular diagnostics of GIT pathology”, as well as the workshop “Colorectal Pathology”, in Kuching, Sarawak |
18 April 2012 |
Invited speaker at the session - The Importance of Molecular Testing in Non-Small Cell Lung Cancer: Practical Advice for Clinicians 3rd European Lung Cancer Conference (ELCC) Geneva, Switzerland - “How should EGFR mutation status be evaluated?” |
May 23 2012 |
Invited Speaker at the Marsden Annual Cancer Meeting, London - Molecular Pathology: Tissue is the issue |
8-12 Septem 2012 |
Invited Speaker at the 24th European Congress of Pathology (Prague) -Predictive biomarkers in NSCLC in the present and the future; challenges and opportunities of a changing landscape |
30-31 Octob 2012 |
Invited speaker at the 50th Anniversary Symposium on Molecular Pathology Symposium organized by the Royal College of Pathologist s of Great Britain and Ireland - Integrating genetics & histopathology, London |
11December 2012 |
Invited Teaching Faculty at the first Molecular Pathology and Diagnosis of Cancer course (9-14 December 2012), organized by the Welcome Trust / Sanger Institute - “Tissue Molecular Diagnostics” and every year onwards |
2013
20 April 2013 |
Lecture “Era of Molecular Targeted Therapy for Lung Cancer: The Role of Pathology” at the Expert Practice in Lung Cancer Annual Meeting in Paris, France |
22 APRIL 2013 |
Lecture “Aspectos Moleculares del cáncer gástrico. Avances en la clasificación del cáncer gástrico” at the FÓRMULA II EN CÁNCER GÁSTRICO meeting in Madrid, Spain, |
26-30 May 2013 |
Chairperson of the Symposium “ECHOENDOSCOPIC FNAC. Toward a more personalized medicine” and lecture “Introduction: cytology and lung cancer – a new paradigm?”, at the 18th International Congress of Cytology, Paris (France) |
2 September 2013 |
Co-chairmanship of the session “Cytology and molecular testing: What is effective?” and lecture “Personalised Medicine and Molecular Cytopathology: a Critical Appraisal ” - 25th European Congress of Pathology in Lisbon (Portugal) |
31.10.–1.11.2013 |
Lecture: Molecular stratification of oesophago-gastric cancer. 2nd Translational Research Meeting of the EORTC GI-Group. University Hospital Carl Gustav Carus, Dresden, Germany. |
November 2013 |
Lecture: What funders are looking for in a project involving tissue. Symposium by the Confederation of Cancer Biobanks, annual NCRI, Liverpool |
2014
6 February 2014 |
Facultade de Medicina da Universidade de São Paulo: The Northern Ireland Molecular Pathology Laboratory – New insights in Hepatocellular Carcinoma and Clinical Sequencing in Molecular Diagnostics. São Paulo, Brazil |
26-28 August 2014 |
Invited speaker at the International Congress of Pathology and Laboratory Medicine (ICPaLM), in Kuala Lumpur, Malaysia, to deliver several lectures |
28 Septemb 2014 |
Invited Speaker: European Society of Medical Oncology satellite symposium on “Understanding the Multidisciplinary Focus for Improving Gastric Cancer Care”, to lecture on The Role of Pathology in Gastric Cancer Care, Madrid (Spain) . |
2015
23 February 2015 |
Invited speaker to the Clínica Universitaria de Navarra: “Morpho-molecular Pathology: an Integrated Model for Diagnosis and Science”, Pamplona, |
16-17 April 2015 |
Invited speaker at the Spanish Multidisciplinary Group for the Study of Cancer of the Digestive System (international meeting) to lecture: Advances in molecular classification of gastric cancer. Valencia, Spain |
24 June 2015 |
Invited speaker: 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, to lecture “Training in Pathology – The Belfast Model”’, Dublin |
6-8 of August 2015 |
Invited Speaker at the “II International Symposium on Personalized Medicine”, the Albert Einstein Research and Education Institute - “Next Generation Sequencing and Oncology“. São Paulo, (Brazil)
|
2016
27 June 2016 |
Invited Speaker at the Universitätsspital Basel to deliver the lecture: “Future perspectives in Molecular Pathology – Changing Pathology Practice, Basel Switzerland |
4 October 2016 |
Keynote Lecture at the 40th European Congress of Cytology - More than a decade of Molecular Diagnostic Cytopathology : How do we Practice it, how do we Teach it?, Liverpool (UK) |
21 October 2016 |
Invited Lecture at the The Gathering Around Cancer, Croke Park - Microsatellite Instability, broad genomic testing and tumour microenvironment in colorectal cancer: Practical aspects in Pathology practice and clinical relevance. Dublin. Ireland |
17 November 2016 |
Keynote Lecture at the Annual Meeting of the International Academy of Pathology - Finnish Division – “Digital workflows in molecular pathology”, Helsinki (Finland) |
2017
2 February 2017 |
Expert speaker at the Arab Health Congress, Dubai International Convention and Exhibition Centre., Dubai, UAE – Session “Leaders in Healthcare- Innovation in healthcare automation and technology”, talk - “Digital pathology workflows to deliver personalised medicine” |
13 March 2017 |
Invited Lecture: Introduction to Molecular Pathology – what do we mean, what do you need to know, and why? British Division of the International Academy of Pathology Molecular Pathology Study Day |
31 March 2017 |
Invited speaker - ‘‘Integrated Molecular Pathology and Translational Medicine’’, at the official launch of the Trinity Translational Medicine Institute – Trinity College Dublin
|
June 2017 |
Organizer – Biannual combines PathSoc/BDIAP meeting, Belfast The Waterfront |
November 2017 |
Invited International Keynote speaker – Natinal Congress of Anantomic Pathology in Chile – Puerto Montt |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1300CNR: Future Medicines Institute
Scott, C. (PI), Bruce, I. (CoI), Burden, R. (CoI), Burrows, J. (CoI), Collins, B. (CoI), Harrison, T. (CoI), James, J. (CoI), Kennedy, R. (CoI), Lawler, M. (CoI), Longley, D. (CoI), Maguire, S. (CoI), Malinova, D. (CoI), Maule, A. (CoI), McCloskey, K. (CoI), McDade, S. (CoI), Salto-Tellez, M. (CoI), Savage, K. (CoI), Stitt, A. (CoI) & Williams, R. (CoI)
15/10/2024 → …
Project: Research
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R1129ECI: Kelvin-2 - The High Performance Computing Centre in Northern Ireland (HPC-NI)
Woods, R. (PI), Chevallier, O. (CoI), Gillan, C. (CoI), Hu, P. (CoI), Rafferty, K. (CoI), Salto-Tellez, M. (CoI), Tikhonova, I. (CoI) & Vandierendonck, H. (CoI)
04/12/2019 → …
Project: Research
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R3005CNR: Establishing a Precision Medicine Catapult Centre of Excellence in Northern Ireland
Salto-Tellez, M. (PI), Gonzalez de Castro, D. (CoI), James, J. (CoI), Kennedy, R. (CoI), McArt, D. (CoI) & Waugh, D. (CoI)
01/12/2017 → …
Project: Research
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R4805CNR: Systems Modeling of Tumor Heterogeneity & Therapy response in Colorectal Cancer
Longley, D. (PI), Dunne, P. (CoI), Lawler, M. (CoI), McArt, D. (CoI) & Salto-Tellez, M. (CoI)
28/06/2017 → …
Project: Research
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R2111CNR: Research Resource – A national digital pathology and image analysis platform for solid tumours, complemented by a comprehensive Clinical Fellowship programme in Molecular Pathology.
Salto-Tellez, M. (PI), James, J. (CoI), Kennedy, R. (CoI), Lawler, M. (CoI) & Waugh, D. (CoI)
09/06/2015 → …
Project: Research
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Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study
Azam, A. S., Tsang, Y. W., Thirlwall, J., Kimani, P. K., Sah, S., Gopalakrishnan, K., Boyd, C., Loughrey, M. B., Kelly, P. J., Boyle, D. P., Salto-Tellez, M., Clark, D., Ellis, I. O., Ilyas, M., Rakha, E., Bickers, A., Roberts, I. S. D., Soares, M. F., Neil, D. A. H. & Takyi, A. & 15 others, , Apr 2024, In: Histopathology. 84, 5, p. 847-862 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)76 Downloads (Pure) -
Encrypted federated learning for secure decentralized collaboration in cancer image analysis
Truhn, D., Arasteh, S. T., Saldanha, O. L., Müller-Franzes, G., Khader, F., Quirke, P., West, N. P., Gray, R., Hutchins, G. G. A., James, J. A., Loughrey, M. B., Salto-Tellez, M., Brenner, H., Brobeil, A., Yuan, T., Chang-Claude, J., Hoffmeister, M., Foersch, S., Han, T. & Keil, S. & 6 others, , Feb 2024, In: Medical Image Analysis. 92, 103059.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)81 Downloads (Pure) -
KRASFormer: a fully vision transformer-based framework for predicting KRAS gene mutations in histopathological images of colorectal cancer
Singh, V. K., Makhlouf, Y., Sarker, M. M. K., Craig, S., Baena, J., Greene, C., Mason, L., James, J. A., Salto-Tellez, M., O’Reilly, P. & Maxwell, P., Sept 2024, In: Biomedical Physics & Engineering Express. 10, 5, 14 p., 055012.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Stratification to neoadjuvant radiotherapy in rectal cancer by regimen and transcriptional signatures
Mahmood, U., Blake, A., Rathee, S., Samuel, L., Murray, G., Sebag-Montefiore, D., Gollins, S., West, N. P., Begum, R., Bach, S. P., Richman, S. D., Quirke, P., Redmond, K. L., Salto-Tellez, M., Koelzer, V. H., Leedham, S. J., Tomlinson, I., Dunne, P. D., Buffa, F. M. & Maughan, T. S. & 2 others, , 01 Jul 2024, In: Cancer Research Communications. 4, 7, p. 1765-1776 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)14 Downloads (Pure) -
Topographic analysis of pancreatic cancer by TMA and digital spatial profiling reveals biological complexity with potential therapeutic implications
Bingham, V., Harewood, L., McQuaid, S., Craig, S. G., Revolta, J. F., Kim, C. S., Srivastava, S., Quezada-Marín, J., Humphries, M. P. & Salto-Tellez, M., 18 May 2024, In: Scientific Reports. 14, 14 p., 11361.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure)
Prizes
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Faculty Research Excellence Award
Salto-Tellez, M. (Recipient), 2006
Prize: Prize (including medals and awards)
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Pathological Society: JSPS Summer Studentship - £1000
Craig, S. (Recipient) & Salto-Tellez, M. (Recipient), 20 Jul 2022
Prize: Other distinction
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World Scientists Forum International Award in the field of Onco-Cytology
Salto-Tellez, M. (Recipient), 2005
Prize: Prize (including medals and awards)
Activities
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Behnoush Abedi-Ardekani
Craig, S. (Host), James, J. (Host), Salto-Tellez, M. (Host), McCombe, K. (Host), Albraikat, M. (Host), Graham, L. (Host), Maxwell, P. (Host), Gonzalez de Castro, D. (Host) & Lewis, C. (Host)
14 Sept 2023 → 15 Sept 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Best poster for PGJCCR SRP 2023
Pruistinne Newton Harijanto, S. S. (Recipient), Craig, S. (Supervisor) & Salto-Tellez, M. (Supervisor)
27 Jul 2023Activity: Other activity types › Other
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Guillermo Garcia Porrero
Craig, S. (Host), James, J. (Host) & Salto-Tellez, M. (Host)
05 Jun 2023 → 18 Aug 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Pruistinne Newton Harijanto
Craig, S. (Host), Salto-Tellez, M. (Host), McCombe, K. (Host) & Reilly, L. (Host)
05 Jun 2023 → 28 Jul 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Hannah James
Craig, S. (Host), Loughrey, P. (Host), McCombe, K. (Host) & Salto-Tellez, M. (Host)
20 Jun 2022 → 29 Jul 2022Activity: Hosting a visitor types › Hosting an academic visitor
Press/Media
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PGJCCR Cancer Digest: Digital Pathology
Branco, C., Loughrey, M., Fisher, N., Craig, S., McGill, K., Dunne, P., Allott, E., Huang, L., Walls, G., Small, D., Morelli, R., Salto-Tellez, M., James, J., Maxwell, P. & Makhlouf, Y.
20/07/2022
1 Media contribution
Press/Media: Public Engagement Activities
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Cancers, Volume 13 Issue 1, Cover Story
Abdullahi Sidi, F., Bingham, V., Craig, S., McQuaid, S., James, J., Humphries, M. & Salto-Tellez, M.
01/01/2021
1 item of Media coverage
Press/Media: Other
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Molecular Oncology Research Article Highlights 2020, Featured Article
Viratham Pulsawatdi, A., Craig, S., Bingham, V., McCombe, K., Humphries, M., Senevirathne, S., Richman, S., Quirke, P., Campo, L., Domingo, E., Maughan, T., James, J. & Salto-Tellez, M.
01/12/2020
1 item of Media coverage
Press/Media: Other
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Molecular Oncology, Volume 14 Number 10, Cover Art
Viratham Pulsawatdi, A., Craig, S., Bingham, V., McCombe, K., Humphries, M., Senevirathne, S., Richman, S., Quirke, P., Campo, L., Domingo, E., Maughan, T., James, J. & Salto-Tellez, M.
02/10/2020
1 item of Media coverage
Press/Media: Other
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Medscape News UK: Immune Status is Prognostic for Poor Survival in Colorectal Cancer
Craig, S., Humphries, M., Alderdice, M., Bingham, V., Richman, S., Loughrey, M., Coleman, H., Viratham Pulsawatdi, A., McCombe, K., Graeme, M., Blake, A., Domingo, E., Robineau, J., Brown, L., Fisher, D., Seymour, M., Quirke, P., Bankhead, P., McQuaid, S., Lawler, M., McArt, D., Maughan, T., James, J. & Salto-Tellez, M.
24/07/2020
1 item of Media coverage
Press/Media: Research
Impacts
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Implementation of HPV-specific testing in addition to assessment of p16 expression in oropharyngeal squamous cell carcinoma
Craig, S. (Participant), Anderson, L. (Participant), Schache, A. (Participant), Moran, M. (Participant), Graham, L. (Participant), Currie, K. (Participant), Rooney, K. (Participant), Robinson, M. (Participant), Upile, N. (Participant), Brooker, R. (Participant), Mesri, M. (Participant), Bingham, V. (Participant), Cuschieri, K. (Participant), McQuaid, S. (Participant), Jones, T. (Participant), McCance, D. (Participant), Salto-Tellez, M. (Participant), McDade, S. (Participant) & James, J. (Participant)
Impact: Health Impact, Quality of Life Impact