Mary McGahon

Dr

  • Room 01.014 - Whitla Medical Building

    United Kingdom

19972019
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Research Output 1997 2019

2019
1 Citation (Scopus)
144 Downloads (Pure)

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309

Research output: Contribution to journalArticle

Open Access
File
Endothelial Cells
Ligation
Retina
Retinal Neovascularization
Staining and Labeling
Open Access
Drama
Medical Students
Students
Curriculum
Premature Menopause
2018
20 Downloads (Pure)

A Widening Participation and Outreach Pilot Project

Quinn, J. & McGahon, M., 01 Jun 2018, Queens University Belfast Reflections , 26, p. 5 2 p.

Research output: Contribution to specialist publicationArticle

Open Access
File
video
learning
experience
student
physiology

Involvement of TRPV1 and TRPV4 Channels in Pathological Retinal Angiogenesis: Oral presentation

Curtis, T., O'leary, C., McGahon, M., Ashraf, S., McNaughten, J., Fernandez, J., Stitt, A. & McGeown, G., 2018, p. 150. 1 p.

Research output: Contribution to conferenceOther

Pathologic Neovascularization
Retinal Neovascularization
Retina
Ischemia
Retinal Diseases
43 Downloads (Pure)

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Curtis, T. M., McLaughlin, D., O'Hare, M., Kur, J., Barabas, P., Revolta, G., Scholfield, C. N., McGeown, G. & McGahon, M. K., 14 Jul 2018, In : Journal of visualized experiments : JoVE. 137, 19 p., e57944.

Research output: Contribution to journalArticle

Open Access
File
Cell Physiological Phenomena
Physiology
Arterioles
Retina
Blood

TRPV2 and Diabetic Retinopathy: Oral presentation

O'Hare, M., Barabas, P., Esquiva Sobrino, G., McGahon, M., Henry, J., Knell, R., Grieve, D. & Curtis, T., 2018, (Accepted) p. 145. 1 p.

Research output: Contribution to conferenceOther

Diabetic Retinopathy
Electroretinography
Retina
Pathology
Neuroglia
2017
9 Citations (Scopus)
170 Downloads (Pure)

Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents

Owolabi, B. O., Musale, V., Ojo, O. O., Moffett, R. C., McGahon, M. K., Curtis, T. M., Conlon, J. M., Flatt, P. R. & Abdel-Wahab, Y. H. A., Jul 2017, In : Biochimie. 138, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
Pipidae
Insulin
Peptides
Anura
Therapeutics
10 Citations (Scopus)
173 Downloads (Pure)

Esculentin-2CHa(1–30) and its analogues: stability and mechanisms of insulinotropic action

Vasu, S., McGahon, M. K., Moffett, R. C., Curtis, T. M., Conlon, J. M., Abdel-Wahab, Y. H. A. & Flatt, P. R., Mar 2017, In : The Journal of endocrinology. 232, p. 423-435 13 p.

Research output: Contribution to journalArticle

Open Access
File
Insulin
Cell Membrane
Diazoxide
Glucose
Sincalide
2016
8 Citations (Scopus)
270 Downloads (Pure)

Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells

El Karim, I. A., McCrudden, M. T. C., McGahon, M. K., Curtis, T. M., Jeanneau, C., Giraud, T., Irwin, C. R., Linden, G. J., Lundy, F. T. & About, I., Apr 2016, In : Journal of Endodontics. 42, 4, p. 589-595 7 p.

Research output: Contribution to journalArticle

File
Odontoblasts
Tumor Necrosis Factor-alpha
Transient Receptor Potential Channels
Tooth
Neurogenic Inflammation
7 Citations (Scopus)
252 Downloads (Pure)

Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina

McDowell, R. E., McGahon, M. K., Augustine, J., Chen, M., McGeown, G. & Curtis, T. M., 01 Sep 2016, In : Investigative ophthalmology & visual science. 57, 11, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Open Access
File
Aldehydes
Aldehyde Dehydrogenase
Retina
Neuroglia
Lysine
13 Citations (Scopus)

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

Ojo, O. O., Srinivasan, D. K., Owolabi, B. O., McGahon, M. K., Moffett, R. C., Curtis, T. M., Conlon, J. M., Flatt, P. R. & Abdel-Wahab, Y. H. A., Aug 2016, In : Biological Chemistry. 397, 8, p. 753-764 12 p.

Research output: Contribution to journalArticle

Nutrition
Insulin Resistance
Obesity
Insulin
Diet

TRPV2 channels are critical in retinal arteriolar myogenic signalling.

McGahon, M., Fernandez, J., McKee, J., Dash, D., Simpson, D., Zholos, A., McGeown, G. & Curtis, T., 2016, p. 409P. 1 p.

Research output: Contribution to conferencePoster

Arterioles
Smooth Muscle Myocytes
Economic Inflation
Pressure
Cations
12 Citations (Scopus)
318 Downloads (Pure)

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

McGahon, M. K., Fernández, J. A., Dash, D. P., McKee, J., Simpson, D. A., Zholos, A. V., McGeown, J. G. & Curtis, T. M., 01 Oct 2016, In : Investigative ophthalmology & visual science. 57, 13, p. 5637-5647 11 p.

Research output: Contribution to journalArticle

Open Access
File
Retinal Vessels
Arterioles
Vascular Smooth Muscle
Constriction
Smooth Muscle Myocytes
2015
8 Citations (Scopus)
202 Downloads (Pure)

CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signalling in Rat Retinal Arterioles

Fernandez, J. A., McGahon, M. K., McGeown, J. G. & Curtis, T. M., Aug 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, p. 5125-5132 8 p.

Research output: Contribution to journalArticle

Open Access
File
Arterioles
Smooth Muscle Myocytes
Myography
Retinal Vessels
Eye Diseases

Evidence of a role for TRPV2 channels in retinal arteriolar myogenic signalling. Oral presentation

McGahon, M., Fernandez, J., McKee, J., Dash, D., Zholos, A., McGeown, G. & Curtis, T., 17 Apr 2015, p. 753-781. 1 p.

Research output: Contribution to conferenceAbstract

Arterioles
Cytophotometry
Amiloride
Vasoconstriction
Cytosol
37 Citations (Scopus)
219 Downloads (Pure)

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

Robinson, E., Cassidy, R. S., Tate, M., Zhao, Y., Lockhart, S., Calderwood, D., Church, R., McGahon, M. K., Brazil, D. P., McDermott, B. J., Green, B. D. & Grieve, D. J., 01 Mar 2015, In : Basic Research in Cardiology. 110, 20, p. 20 15 p.

Research output: Contribution to journalArticle

Open Access
File
Extracellular Matrix
Myocardial Infarction
Inflammation
Glucagon-Like Peptide 1
Heart Failure
26 Citations (Scopus)
283 Downloads (Pure)

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium

Monaghan, K., McNaughten, J., McGahon, M. K., Kelly, C., Kyle, D., Yong, P. H., McGeown, G. & Curtis, T. M., 05 Jun 2015, In : PloS one. 10, 6, 16 p., e0128359.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
hyperglycemia
Medical problems
endothelium
Hyperglycemia
Astrocytes
Homeostasis
Small Interfering RNA
Blood-Retinal Barrier
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
26 Citations (Scopus)

TNF alpha-Induced p38MAPK Activation Regulates TRPA1 and TRPV4 Activity in Odontoblast-Like Cells

El Karim, I., McCrudden, M. T. C., Linden, G. J., Abdullah, H., Curtis, T. M., McGahon, M., About, I., Irwin, C. & Lundy, F. T., Nov 2015, In : American Journal of Pathology. 185, 11, p. 2994-3002 9 p.

Research output: Contribution to journalArticle

Odontoblasts
Tumor Necrosis Factor-alpha
p38 Mitogen-Activated Protein Kinases
Transient Receptor Potential Channels
Cytophotometry

TNFα-induced p38 MAPK activation regulates TRPA1 and TRPV4 activity in human odontoblast-like cells

El Karim, I., McCrudden, M., Linden, G., Curtis, T., McGahon, M., Abdullah, H., About, I., Irwin, C. & Lundy, F., 2015, In : Journal of Dental Research.

Research output: Contribution to journalMeeting abstract

2014
68 Citations (Scopus)
376 Downloads (Pure)

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in severe asthma

McGarvey, L. P., Butler, C. A., Stokesberry, S., Polley, L., McQuaid, S., Abdullah, H., Ashraf, S., McGahon, M. K., Curtis, T. M., Arron, J., Choy, D., Warke, T. J., Bradding, P., Ennis, M., Zholos, A., Costello, R. W. & Heaney, L. G., Mar 2014, In : Journal of Allergy and Clinical Immunology. 133, 3, p. 704-712 9 p.

Research output: Contribution to journalArticle

Open Access
File
Asthma
Transient Receptor Potential Channels
Healthy Volunteers
Epithelium
Epithelial Cells
6 Citations (Scopus)
145 Downloads (Pure)

Role of ion channels and subcellular Ca2+ signalling in arachidonic acid induced dilation of pressurised retinal arterioles

Kur, J., McGahon, M., Fernández, J. A., Scholfield, N., McGeown, G. & Curtis, T., 02 May 2014, In : Investigative ophthalmology & visual science. 55, 5, p. 2893-2902

Research output: Contribution to journalArticle

Open Access
File
Arterioles
Ion Channels
Arachidonic Acid
Dilatation
Vasodilator Agents
6 Citations (Scopus)

The Role of K+ and Cl- Channels in the Regulation of Retinal Arteriolar Tone and Blood Flow

Needham, M., McGahon, M. K., Bankhead, P., Gardiner, T. A., Scholfield, C. N., Curtis, T. M. & McGeown, J. G., 07 Apr 2014, In : Investigative ophthalmology & visual science. 55, 4, p. 2157-2165 9 p.

Research output: Contribution to journalArticle

Endothelin-1
Smooth Muscle
Intravitreal Injections
Ion Channels
Photofluorography
2013
19 Citations (Scopus)
238 Downloads (Pure)

Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle

McGahon, M. K., Yarham, J. M., Daly, A., Guduric-Fuchs, J., Ferguson, L. J., Simpson, D. A. & Collins, A., 14 Jun 2013, In : PLoS ONE. 8, 6, 17 p., e65809.

Research output: Contribution to journalArticle

Open Access
File
MicroRNAs
microRNA
Heart Ventricles
Rats
heart
2012
13 Citations (Scopus)
Inwardly Rectifying Potassium Channel
Untranslated Regions
3' Untranslated Regions
MicroRNAs
Fluorescence
2 Citations (Scopus)

Pharmacological profiling of store-operated Ca(2+) entry in retinal arteriolar smooth muscle

McGahon, M. K., McKee, J., Dash, D. P., Brown, E., Simpson, D. A., Curtis, T. M., McGeown, J. G. & Scholfield, C. N., Oct 2012, In : Microcirculation (New York, N.Y. : 1994). 19, 7, p. 586-597 12 p.

Research output: Contribution to journalArticle

Smooth Muscle
Borates
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Pharmacology
Cytophotometry
2011
28 Citations (Scopus)
Transient Receptor Potential Channels
Dental Pulp
Fibroblasts
Cytophotometry
Tooth
28 Citations (Scopus)

Human Dental Pulp Fibroblasts Express the “Cold-sensing” Transient Receptor Potential Channels TRPA1 and TRPM8

El Karim, I., Linden, G., Curtis, T., About, I., McGahon, M., Irwin, C., Killough, S. & Lundy, F., Apr 2011, In : Journal of Endodontics. 37, 4, p. 473-478 6 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Dental Pulp
Fibroblasts
Cytophotometry
Tooth
68 Citations (Scopus)

Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity

El Karim, I., Linden, G., Curtis, T., About, I., McGahon, M., Irwin, C. & Lundy, F., Oct 2011, In : Pain. 152, 10, p. 2211-2223 13 p.

Research output: Contribution to journalArticle

Dentin Sensitivity
Transient Receptor Potential Channels
Odontoblasts
Population Groups
Tooth
2010
7 Citations (Scopus)

cAMP/PKA-dependent increases in Ca Sparks, oscillations and SR Ca stores in retinal arteriolar myocytes after exposure to vasopressin.

Jeffries, O., McGahon, M., Bankhead, P., Lozano, M. M., Scholfield, N., Curtis, T. & McGeown, G., Mar 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

Arginine Vasopressin
Sarcoplasmic Reticulum
Vasopressins
Muscle Cells
Caffeine
8 Citations (Scopus)

PAR-2 Regulates Dental Pulp Inflammation Associated with Caries

Lundy, F., About, I., Curtis, T., McGahon, M., Linden, G., Irwin, C. & El Karim, I., Jul 2010, In : Journal of Dental Research. 89, 7, p. 684-688 5 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Dental Pulp
Inflammation
Proteinase-Activated Receptors
Tooth
2009
13 Citations (Scopus)

Ca2+-activated Cl- current in retinal arteriolar smooth muscle.

McGahon, M., Needham, M. A., Scholfield, C. N., McGeown, G. & Curtis, T., Jan 2009, In : Investigative Ophthalmology and Visual Science. 50(1), 1, p. 364-371 8 p.

Research output: Contribution to journalArticle

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Smooth Muscle
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
Muscle Cells
Vasoconstriction
2008
9 Citations (Scopus)

Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation.

Curtis, T., Tumelty, J., Stewart, M., Arora, A., Lai, F. A., McGahon, M., Scholfield, N. & McGeown, G., Feb 2008, In : Cell Calcium. 43(2), 2, p. 142-154 13 p.

Research output: Contribution to journalArticle

Tetracaine
Smooth Muscle
Arterioles
Muscle Cells
Ryanodine
2007
107 Citations (Scopus)

Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle

McGahon, M. K., Dash, D. P., Arora, A., Wall, N., Dawicki, J., Simpson, D. A., Scholfield, C. N., McGeown, G. & Curtis, T., Mar 2007, In : Circulation Research. 100, 5, p. 703-11 9 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Smooth Muscle
Potassium
Down-Regulation
Arterioles
29 Citations (Scopus)

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

McGahon, M., Dawicki, J., Arora, A., Simpson, D., Gardiner, T., Stitt, A., Scholfield, N., McGeown, G. & Curtis, T., Oct 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 2, p. H1001-H1008 8 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Smooth Muscle
Potassium
Arterioles
Muscle Cells

New Developments in Diabetic Retinopathy

Curtis, T., Stitt, A., McGahon, M., Scholfield, N. & McGeown, G., 2007, In : Expert Review of Ophthalmology. 2, p. 947-956 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Selective downregulation of the BKbeta1 subunit in diabetic arteriolar myocytes

McGahon, M., Zhang, X., Scholfield, N., Curtis, T. & McGeown, G., May 2007, In : Channels (Austin, Tex.). 1 (3), 3, p. e1-e3 3 p.

Research output: Contribution to journalArticle

2005
22 Citations (Scopus)

A-type K+ current in retinal arteriolar smooth muscle.

McGahon, M., Dawicki, J., Scholfield, N., Gardiner, T., McGeown, G. & Curtis, T., 2005, In : Investigative Ophthalmology and Visual Science. 46, p. 3281-3287 7 p.

Research output: Contribution to journalArticle

2003
15 Citations (Scopus)
Electrophysiology
Cardiac
Potassium
Cell
Vertex of a graph
2000
25 Citations (Scopus)

Effects of BDF 9198 on action potentials and ionic currents from guinea-pig isolated ventricular myocytes.

Yuill, K., McGahon, M., Dooley, P., Doggrell, S. & Hancox, J., 2000, In : British Journal of Pharmacology. 130, 8, p. 1753-1766 14 p.

Research output: Contribution to journalArticle

Muscle Cells
Action Potentials
Guinea Pigs
BDF 9148
Pharmaceutical Preparations
15 Citations (Scopus)
Architectural Accessibility
Muscle Cells
Action Potentials
Rabbits
Atrioventricular Node
1999
33 Citations (Scopus)
Architectural Accessibility
Muscle Cells
Rabbits
Clamping devices
Electric potential
1998
14 Citations (Scopus)
Muscle Cells
Rabbits
Calcium
Potassium
Chemical activation