• Room 03.062 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Chen is open to wide-range PhD applications, her fields of interest include: immunopathogenesis of age-related retinal degeneration, ocular drug delivery.

20072020

Research output per year

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Research Output

2020

A two-stage laser–induced mouse model of sub-retinal fibrosis secondary to choroidal neovascularization

Little, K., Llorian Salvador, M., Tang, M., O'Shaughnessy, O., Du, X., McIlwaine, G., Chen, M. & Xu, H., Mar 2020, In : Translational Vision Science & Technology. 9, 3, 11 p., 3.

Research output: Contribution to journalArticle

Open Access
File
47 Downloads (Pure)

Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients – A Pilot Study

Obasanmi, G., Lois, N., Armstrong, D., Lavery, N. J., Romero Hombrebueno, J. M., Lynch, A., Wright, D., Chen, M. & Xu, H., 30 Jan 2020, In : Current eye research. 11 p.

Research output: Contribution to journalArticle

Open Access
File
12 Downloads (Pure)

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7

Pavlou, S., Augustine, J., Cunning, R., Harkin, K., Stitt, A. W., Xu, H. & Chen, M., 29 Apr 2019, In : International journal of molecular sciences. 20, 9, 12 p., 2101.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
120 Downloads (Pure)

CHAPTER 2 : Immune response of the retina

Chen, M. & Xu, H., 01 Jan 2019, Royal Society of Chemistry. Cotter, T. & de la Rosa, E. J. (eds.). 66 ed. Royal Society of Chemistry, Vol. 2019-January. p. 31-47 17 p. (RSC Drug Discovery Series).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

DC atmospheric pressure microplasma for the synthesis of gold nanoparticle/graphene oxide nanocomposites

Sun, D., Tang, M., Zhang, L., Falzon, B., Babu, D., Mariotti, D., Maguire, P., Chen, M. & Sun, D., 2019.

Research output: Contribution to conferencePoster

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

Wang, L., Pavlou, S., Du, X., Bhuckory, M., Xu, H. & Chen, M., 11 Jan 2019, In : Molecular Neurodegeneration. 14, 2, 15 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
169 Downloads (Pure)

IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment

Augustine, J., Pavlou, S., Ali, I., Harkin, K., Ozaki, E., Campbell, M., Stitt, A. W., Xu, H. & Chen, M., 03 Dec 2019, In : Journal of neuroinflammation. 16, 15 p., 251.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
58 Downloads (Pure)

Immune regulation in the aging retina

Chen, M., Luo, C., Zhao, J., Devarajan, G. & Xu, H., Mar 2019, In : Progress in Retinal and Eye Research. 69, p. 159-172 14 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
330 Downloads (Pure)

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S., Viiri, J., Paterno, J. J., Hyttinen, J. M. T., Koskela, A., Chen, M., Leinonen, H., Tanila, H., Kivinen, N., Koistinen, A., Toropainen, E., Amadio, M., Smedowski, A., Reinisalo, M., Winiarczyk, M., Mackiewicz, J., Mutikainen, M., Ruotsalainen, A. K., Kettunen, M., Jokivarsi, K. & 16 others, Sinha, D., Kinnunen, K., Petrovski, G., Blasiak, J., Bjørkøy, G., Koskelainen, A., Skottman, H., Urtti, A., Salminen, A., Kannan, R., Ferrington, D. A., Xu, H., Levonen, A. L., Tavi, P., Kauppinen, A. & Kaarniranta, K., 01 Jan 2019, In : Redox Biology. 20, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
145 Downloads (Pure)

Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing

Sun, D., Tang, M., Zhang, L., Falzon, B. G., Padmanaban, D. B., Mariotti, D., Maguire, P., Xu, H., Chen, M. & Sun, D., 2019, In : Nanotechnology. 30, 11 p., 455603.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
31 Downloads (Pure)

STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes

Chen, M., Obasanmi, G., Armstrong, D., Lavery, N-J., Kissenpfennig, A., Lois, N. & Xu, H., 08 Jul 2019, In : Journal of neuroinflammation. 16, 1, p. 138

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
81 Downloads (Pure)

Status of the Horizon 2020 EuPRAXIA conceptual design study

Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I. A., Aschikhin, A., Assmann, R. W., Audet, T., Bacci, A., Barna, I. F., Beaton, A., Beck, A., Beluze, A., Bernhard, A., Bielawski, S., Bisesto, F. G., Brandi, F., Brinkmann, R. & 146 others, Bruendermann, E., Büscher, M., Bussmann, M. H., Bussolino, G., Chance, A., Chen, M., Chiadroni, E., Cianchi, A., Clarke, J. A., Cole, J., Couprie, M. E., Croia, M., Cros, B., Crump, P. A., Dattoli, G., Del Dotto, A., Delerue, N., De Nicola, S., Dias, J. M., Dorda, U., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fiore, G., Fonseca, R. A., Galimberti, M., Gallo, A., Ghaith, A., Giove, D., Giribono, A., Gizzi, L. A., Grüner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Huebner, M., Irman, A., Jafarinia, F. J., Jaroszynski, D. A., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Blanc, C. L., Lechner, C., Leemans, W., Lehrach, A., Li, X., Libov, V., Lifschitz, A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marchetti, B., Martinez De La Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Molodozhentsev, A. Y., Mostacci, A., Mueller, A. S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Osterhoff, J., Oumbarek Espinos, D., Papadopoulos, D. N., Patrizi, B., Petrillo, V., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Rajeev, P. P., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Roussel, E., Sahai, A. A., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sheng, Z. M., Siders, C., Silva, L. O., Silva, T., Simon, C., Sinha, U., Specka, A., Streeter, M. J. V., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Thompson, N., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Vannini, M., Vieira, J. M., Villa, F., Wahlstrom, C. G., Walczak, R., Walker, P. A., Wang, K., Welsch, C. P., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhu, J. & Zigler, A., 02 Dec 2019, In : Journal of Physics: Conference Series. 1350, 1, 012059.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
24 Downloads (Pure)
1 Citation (Scopus)

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic

O'Leary, O. E., Canning, P., Reid, E., Bertelli, P. M., McKeown, S., Brines, M., Cerami, A., Du, X., Xu, H., Chen, M., Dutton, L., Brazil, D. P., Medina, R. J. & Stitt, A. W., 01 May 2019, In : Experimental Eye Research. 182, p. 144-155 12 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes

Hombrebueno, J. R., Ali, I. H. A., Ma, J-X., Chen, M. & Xu, H., Nov 2018, In : Diabetologia. 61, 11, p. 2433-2446 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
191 Downloads (Pure)

Characterization of a spontaneously immortalized murine Müller glial cell line QMMuC-1

Augustine, J., Pavlou, S., O'Hare, M., Harkin, K., Stitt, A., Curtis, T., Xu, H. & Chen, M., 01 Mar 2018, In : Investigative Opthalmology and Visual Science. 59, 3, p. 1666-1674

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
279 Downloads (Pure)

Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

Chen, M., Chan, C-C. & Xu, H., Nov 2018, In : Annals of Translational Medicine. 6 , Supplement 1, 5 p.

Research output: Contribution to journalArticle

Open Access
File
134 Downloads (Pure)

Innate immune dysregulation and diabetic retinopathy

Chen, M., Sep 2018.

Research output: Contribution to conferenceAbstract

Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment

Chen, M., Augustine, J., Pavlou, S., Ali, I., Doyle, S. L., Stitt, A., Campbell, M. & Xu, H., May 2018.

Research output: Contribution to conferenceAbstract

Open Access
File
4 Citations (Scopus)
267 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
147 Downloads (Pure)

Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology

Cao, L., Liu, J., Pu, J., Milne, G., Chen, M., Xu, H., Shipley, A., Forrester, J. V., McCaig, C. D. & Lois, N., Nov 2018, In : Journal of Cellular and Molecular Medicine. 22, 11, p. 5552-5564 13 p.

Research output: Contribution to journalArticle

Open Access
File
164 Downloads (Pure)
Open Access
File
12 Citations (Scopus)
180 Downloads (Pure)
Open Access
File
21 Citations (Scopus)
183 Downloads (Pure)
Open Access
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4 Citations (Scopus)
225 Downloads (Pure)

Topical delivery of anti-VEGF therapeutics to the posterior segment and their efficacy in animal models of choroidal neovascularization.

de Cogan, F., Lynch, A., Berwick, M. R., Peacock, A. F. A., Chen, M. & Xu, H., 2018.

Research output: Contribution to conferenceAbstract

Wedelolactone protects DNA-induced photoreceptor death

Harkin, K., Pavlou, S., Stitt, A., Xu, H. & Chen, M., 2018.

Research output: Contribution to conferenceAbstract

2017

Diabetic retinopathy and dysregulated innate immunity

Xu, H. & Chen, M., Oct 2017, In : Vision Research. 139, p. 39-46 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
Open Access
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21 Citations (Scopus)
276 Downloads (Pure)
Open Access
File
17 Citations (Scopus)
221 Downloads (Pure)

PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

Rajapakse, D., Chen, M., Curtis, T. & Xu, H., 09 Oct 2017, In : Aging. 9, 10, p. 2052-2068

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
198 Downloads (Pure)

Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides

de Cogan, F., Hill, L. J., Lynch, A., Morgan-Warren, P. J., Lechner, J., Berwick, M. R., Peacock, A. F. A., Chen, M., Scott, R. A. H., Xu, H. & Logan, A., 01 May 2017, In : Investigative ophthalmology & visual science. 58, 5, p. 2578-2590 13 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
380 Downloads (Pure)
Open Access
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10 Citations (Scopus)
175 Downloads (Pure)
2016

Animal models of diabetic retinopathy

Chen, M. & Stitt, A., 2016, Animal models of ophthalmic diseases. Chan, C-C. (ed.). Springer, p. 67-83 Chapter 5. (Essentials in Ophthalmology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

16 Citations (Scopus)

Attenuating diabetic vascular degeneration by targeting the P2X7 receptor

Chen, M., Pavlou, S., Cunning, R. & Xu, H., May 2016.

Research output: Contribution to conferenceAbstract

Control microglial activation by targeting the glucose transporter 1

Wang, L., Chen, M. & Xu, H., May 2016.

Research output: Contribution to conferenceAbstract

Degeneration of postsynaptic terminals, but not second-order neurons following light-induced photoreceptor degeneration

Bhuckory, M., Lynch, A., Chen, M. & Xu, H., May 2016.

Research output: Contribution to conferenceAbstract

Deletion of interleukin-33 (IL33) results in persistent Müller cell activation in retinal detachment

Pavlou, S., Augustine, J., Doyle, S., Stitt, A., Campbell, M., Xu, H. & Chen, M., May 2016.

Research output: Contribution to conferenceAbstract

Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina

McDowell, R. E., McGahon, M. K., Augustine, J., Chen, M., McGeown, G. & Curtis, T. M., 01 Sep 2016, In : Investigative ophthalmology & visual science. 57, 11, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
299 Downloads (Pure)
Open Access
File
45 Citations (Scopus)
351 Downloads (Pure)

Inflammasome activation in Photoreceptor cells

Chen, M., Sep 2016.

Research output: Contribution to conferenceAbstract

Inflammasome activation in the photoreceptor cells

Cunning, R., Pavlou, S., Stitt, A., Xu, H. & Chen, M., May 2016.

Research output: Contribution to conferenceAbstract

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis

Chen, M., Rajapakse, D., Fraczek, M., Luo, C., Forrester, J. V. & Xu, H., 15 Feb 2016, In : Aging cell. 10 p.

Research output: Contribution to journalArticle

Open Access
File
40 Citations (Scopus)
386 Downloads (Pure)