Research output per year
Research output per year
- 1 - 50 out of 164 results
Search results
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2024
ALDH1A1 gene therapy attenuates acrolein-induced Müller cell dysfunction in diabetic retinopathy
Karan, B. M., Augustine, J., Barabas, P., Chen, M., Stitt, A. W. & Curtis, T. M., 01 Jun 2024, In: Investigative Opthalmology and Visual Science. 65, 7, 872.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access -
Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice
Dong, X., Song, Y., Liu, Y., Kou, X., Yang, T., Shi, S. X., He, K., Li, Y., Li, Z., Yao, X., Guo, J., Cui, B., Wu, Z., Lei, Y., Du, M., Chen, M., Xu, H., Liu, Q., Shi, F.-D. & Wang, X. & 1 others, , 14 Aug 2024, In: Science Translational Medicine. 16, 760, 15 p., eadi6626.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy
Lei, Y., Liu, Q., Chen, B., Wu, F., Li, Y., Dong, X., Ma, N., Wu, Z., Zhu, Y., Wang, L., Fu, Y., Liu, Y., Song, Y., Du, M., Zhang, H., Zhu, J., Lyons, T. J., Wang, T., Hu, J. & Xu, H. & 3 others, , 29 Oct 2024, In: Nature Communications. 15, 9334.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
Single-cell sequencing analysis revealed rod photoreceptors are most sensitive to age-induced degeneration
Chen, M., Tang, M., Zhou, B. & Xu, H., Jun 2024, In: Investigative Opthalmology and Visual Science. 65, 7, 1 p., 563.Research output: Contribution to journal › Meeting abstract › peer-review
Open AccessFile -
SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages
Wang, T., Kaneko, S., Kriukov, E., Alvarez, D., Lam, E., Wang, Y., La Manna, S., Marasco, D., Fernandez-Gonzalez, A., Mitsialis, S. A., Kourembanas, S., Stahl, A., Chen, M., Xu, H., Baranov, P., Cai, G., von Andrian, U. H. & Sun, Y., 01 May 2024, In: Molecular Therapy . 32, 5, p. 1425-1444Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)42 Downloads (Pure) -
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis
Xu, H., Yi, C. & Chen, M., Jun 2024, In: Current Opinion in Pharmacology. 76, 8 p., 102448.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)65 Downloads (Pure) -
2023
Dissection of cellular disruptions in autism spectrum disorder comorbidities
Griffin, A., Chen, M. & Tiwari, V. K., 08 Oct 2023, (Early online date) In: European Journal of Neuroscience. 11 p., e16155.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)20 Downloads (Pure) -
IL-33 regulates Müller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy
Augustine, J., Pavlou, S., Harkin, K., Stitt, A. W., Xu, H. & Chen, M., Sept 2023, In: Disease Models and Mechanisms. 16, 9, 14 p., dmm050174.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)41 Downloads (Pure) -
Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages
Yi, C., Liu, J., Deng, W., Luo, C., Qi, J., Chen, M. & Xu, H., 23 Feb 2023, In: Journal of Neuroinflammation. 20, 15 p., 45.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)29 Downloads (Pure) -
Peripheral blood mononuclear cells from patients with type 1 diabetes and diabetic retinopathy produce higher levels of IL-17A, IL-10 and IL-6 and lower levels of IFN-γ-a pilot study
Obasanmi, G., Lois, N., Armstrong, D., Hombrebueno, J. M. R., Lynch, A., Chen, M. & Xu, H., 01 Feb 2023, In: Cells. 12, 3, 467.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)59 Downloads (Pure) -
Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection
Paskeviciute, E., Chen, M., Xu, H., Honoré, B., Vorum, H., Sørensen, T. L., Christensen, J. P., Thomsen, A. R., Nissen, M. H. & Steffensen, M. A., 18 Aug 2023, In: Frontiers in Immunology. 14, 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
2022
CCR2+ monocytes critically contribute to subretinal fibrosis at the chronic stage of the disease
Szczepan, M., Llorian Salvador, M., Mack, M., Chen, M. & Xu, H., 01 Jun 2022, In: Investigative Opthalmology and Visual Science. 63, 7Research output: Contribution to journal › Meeting abstract › peer-review
Open Access -
Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells
Llorián-Salvador, M., Byrne, E. M., Szczepan, M., Little, K., Chen, M. & Xu, H., 14 Jul 2022, In: Journal of Neuroinflammation. 19, 17 p., 182.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)82 Downloads (Pure) -
Editorial: Omics biomarkers in inflammatory ocular diseases
Ttakeuchi, M. & Chen, M., 12 Aug 2022, In: Frontiers in Medicine. 9, 1000706.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile1 Citation (Scopus)66 Downloads (Pure) -
Gene therapeutic enhancement of acrolein detoxification mechanisms for the treatment of diabetic retinopathy (DR)
Karan, B. M., Augustine, J., Barabas, P., Chen, M., Stitt, A. W. & Curtis, T. M., 28 May 2022, In: European Journal of Ophthalmology. 32, 1_suppl, p. 23 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
Tabel, M., Wolf, A., Szczepan, M., Xu, H., Jägle, H., Moehle, C., Chen, M. & Langmann, T., 17 Sept 2022, In: Journal of Neuroinflammation. 19, 229.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)49 Downloads (Pure) -
Hyaluronic Acid-PEG-Based Diels–Alder In Situ Forming Hydrogels for Sustained Intraocular Delivery of Bevacizumab
Ilochonwu, B. C., Mihajlovic, M., Maas-Bakker, R. F., Rousou, C., Tang, M., Chen, M., Hennink, W. E. & Vermonden, T., 11 Jul 2022, In: Biomacromolecules. 23, 7, p. 2914–2929Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)111 Downloads (Pure) -
Immune cells in subretinal wound healing and fibrosis
Szczepan, M., Llorián-Salvador, M., Chen, M. & Xu, H., 10 Jun 2022, In: Frontiers in Cellular Neuroscience. 16, 916719.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)42 Downloads (Pure) -
Immune response in retinal degenerative diseases - Time to rethink?
Xu, H. & Chen, M., Dec 2022, In: Progress in neurobiology. 219, 10 p., 102350.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)79 Downloads (Pure) -
Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
Yi, C., Liu, J., Deng, W., Luo, C., Qi, J., Chen, M. & Xu, H., 05 Apr 2022, In: Journal of Neuroinflammation. 19, 78.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)115 Downloads (Pure) -
Mammalian Target of Rapamycin Inhibitor Rapamycin Alleviates 7-Ketocholesterol Induced Inflammatory Responses and Vascular Endothelial Growth Factor Elevation by Regulating MAPK Pathway in Human Retinal Pigment Epithelium Cells
Yang, L., Yu, P., Chen, M. & Lei, B., 01 Mar 2022, In: Journal of Ocular Pharmacology and Therapeutics. 38, 2, p. 189–200Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Minocycline inhibits microglial activation and improves visual function in a chronic model of age-related retinal degeneration
Du, X., Byrne, E. M., Chen, M. & Xu, H., 12 Dec 2022, In: Biomedicines. 10, 12, 16 p., 3222.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)54 Downloads (Pure) -
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway
Harkin, K., Augustine, J., Stitt, A. W., Xu, H. & Chen, M., Feb 2022, In: Biomedicines. 10, 2, 12 p., 311.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)107 Downloads (Pure) -
2021
Cowpea chlorotic mottle virus‐like particles as potential platform for antisense oligonucleotide delivery in posterior segment ocular diseases
Pretto, C., Tang, M., Chen, M., Xu, H., Subrizi, A., Urtti, A. & Hest, J. C. M., 17 Aug 2021, In: Macromolecular Bioscience. 21, 8, 2100095.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)89 Downloads (Pure) -
Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy
Du, X., Penalva, R., Little, K., Kissenpfennig, A., Chen, M. & Xu, H., 18 Feb 2021, In: Molecular Neurodegeneration. 16, 17 p., 9.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)85 Downloads (Pure) -
Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
Blasiak, J., Koskela, A., Pawlowska, E., Liukkonen, M., Ruuth, J., Toropainen, E., Hyttinen, J. M. T., Viiri, J., Eriksson, J. E., Xu, H., Chen, M., Felszeghy, S. & Kaarniranta, K., 08 Feb 2021, In: International journal of molecular sciences. 22, 4, 17 p., 1684.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)121 Downloads (Pure) -
IL-17A damages the blood–retinal barrier through activating the Janus kinase 1 pathway
Byrne, E. M., Llorián-Salvador, M., Tang, M., Margariti, A., Chen, M. & Xu, H., 16 Jul 2021, In: Biomedicines. 9, 7, 18 p., 831.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)153 Downloads (Pure) -
Microglia increase tight-junction permeability in coordination with Müller cells under hypoxic condition in an in vitro model of inner blood-retinal barrier
Inada, M., Xu, H., Takeuchi, M., Ito, M. & Chen, M., 16 Feb 2021, (Early online date) In: Experimental Eye Research. p. 108490 35 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)381 Downloads (Pure) -
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α -/- Mouse Model Evoke Complement Component C5a Independent of C3
Sridevi Gurubaran, I., Heloterä, H., Marry, S., Koskela, A., Hyttinen, J. M. T., Paterno, J. J., Urtti, A., Chen, M., Xu, H., Kauppinen, A. & Kaarniranta, K., 04 Jul 2021, In: Biology. 10, 7, 14 p., 622.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)82 Downloads (Pure) -
Retinal pigment epithelial cells express antimicrobial peptide lysozyme - a novel mechanism of innate immune defense of the blood-retina barrier
Liu, J., Yi, C., Ming, W., Tang, M., Tang, X., Luo, C., Lei, B., Chen, M. & Xu, H., 18 Jun 2021, In: Investigative Ophthalmology and Visual Science. 62, 7, 10 p., 21.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)114 Downloads (Pure) -
Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular applications
Balasso, A., Subriz, A., Salmaso, S., Mastrotto, F., Garofalo, M., Tang, M., Chen, M., Xu, H., Urtti, A. & Caliceti, P., 01 Jun 2021, In: European Journal of Pharmaceutical Sciences. 161, 15 p., 105785.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)164 Downloads (Pure) -
Tofacitinib Ameliorates Retinal Vascular Leakage in a Murine Model of Diabetic Retinopathy with Type 2 Diabetes
Byrne, E. M., Llorián-Salvador, M., Lyons, T. J., Chen, M. & Xu, H., 02 Nov 2021, (Early online date) In: International Journal of Molecular Sciences. 22, 21, 11876.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)69 Downloads (Pure) -
2020
A two-stage laser–induced mouse model of subretinal fibrosis secondary to choroidal neovascularization
Little, K., Llorian Salvador, M., Tang, M., O'Shaughnessy, O., Du, X., McIlwaine, G., Chen, M. & Xu, H., 01 Mar 2020, In: Translational Vision Science & Technology. 9, 4, 11 p., 3.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)340 Downloads (Pure) -
Circulating Leukocyte Alterations and the Development/Progression of Diabetic Retinopathy in Type 1 Diabetic Patients – A Pilot Study
Obasanmi, G., Lois, N., Armstrong, D., Lavery, N. J., Romero Hombrebueno, J. M., Lynch, A., Wright, D., Chen, M. & Xu, H., 30 Jan 2020, (Early online date) In: Current eye research. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)338 Downloads (Pure) -
Effect of precursor pH on AuNP/MWCNT nanocomposites synthesized by plasma-induced non-equilibrium electrochemistry
Sun, D., Maddi , C., Rafferty, C., Tang, M., Chen, M., Falzon, B., Sarri, G., Mariotti, D., Maguire, P. & Sun, D., 14 Oct 2020, In: Journal of Physics D: Applied Physics. 53, 42, 10 p., 425207.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)78 Downloads (Pure) -
Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy
Hombrebueno, J. R., Lynch, A., Byrne, E. M., Obasanmi, G., Kissenpfennig, A., Chen, M. & Xu, H., Dec 2020, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 12, p. e367-e379 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)97 Downloads (Pure) -
Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration
Little, K., Llorián-Salvador, M., Tang, M., Du, X., Marry, S., Chen, M. & Xu, H., 25 Nov 2020, In: Journal of Neuroinflammation. 17, 12 p., 355.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)114 Downloads (Pure) -
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis
Chen, M., Yang, N., Lechner, J., Toth, L., Hogg, R., Silvestri, G., Chakravarthy, U. & Xu, H., 14 Nov 2020, In: Immunity & ageing. 17, 9 p., 35.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)479 Downloads (Pure) -
Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors - implications in subretinal immune regulation
Liu, J., Tang, M., Harkin, K., Du, X., Luo, C., Chen, M. & Xu, H., 01 Jul 2020, In: Journal of Neuroscience Research. 98, 7, p. 1458-1513Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)591 Downloads (Pure) -
The IL-1 receptor signalling pathway as a potential target for the management of diabetic retinopathy
Chen, M., Mar 2020.Research output: Contribution to conference › Abstract › peer-review
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VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions
Llorián-Salvador, M., Barabas, P., Byrne, E. M., Lechner, J., Augustine, J., Curtis, T. M., Chen, M. & Xu, H., 18 Sept 2020, In: Investigative ophthalmology & visual science. 61, 11, 1 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)96 Downloads (Pure) -
2019
Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7
Pavlou, S., Augustine, J., Cunning, R., Harkin, K., Stitt, A. W., Xu, H. & Chen, M., 29 Apr 2019, In: International journal of molecular sciences. 20, 9, 12 p., 2101.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)197 Downloads (Pure) -
CHAPTER 2 : Immune response of the retina
Chen, M. & Xu, H., 01 Jan 2019, Royal Society of Chemistry. Cotter, T. & de la Rosa, E. J. (eds.). 66 ed. Royal Society of Chemistry, Vol. 2019-January. p. 31-47 17 p. (RSC Drug Discovery Series).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Glucose transporter 1 critically controls microglial activation through facilitating glycolysis
Wang, L., Pavlou, S., Du, X., Bhuckory, M., Xu, H. & Chen, M., 11 Jan 2019, In: Molecular Neurodegeneration. 14, 2, 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile185 Citations (Scopus)327 Downloads (Pure) -
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
Augustine, J., Pavlou, S., Ali, I., Harkin, K., Ozaki, E., Campbell, M., Stitt, A. W., Xu, H. & Chen, M., 03 Dec 2019, In: Journal of Neuroinflammation. 16, 15 p., 251.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)157 Downloads (Pure) -
Immune regulation in the aging retina
Chen, M., Luo, C., Zhao, J., Devarajan, G. & Xu, H., Mar 2019, In: Progress in Retinal and Eye Research. 69, p. 159-172 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile180 Citations (Scopus)1274 Downloads (Pure) -
Investigating the role of Gli1 in the development of choroidal neovascularisation
Marry, S., Chen, M. & Xu, H., 2019.Research output: Contribution to conference › Abstract
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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S., Viiri, J., Paterno, J. J., Hyttinen, J. M. T., Koskela, A., Chen, M., Leinonen, H., Tanila, H., Kivinen, N., Koistinen, A., Toropainen, E., Amadio, M., Smedowski, A., Reinisalo, M., Winiarczyk, M., Mackiewicz, J., Mutikainen, M., Ruotsalainen, A. K., Kettunen, M. & Jokivarsi, K. & 16 others, , 01 Jan 2019, In: Redox Biology. 20, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile127 Citations (Scopus)229 Downloads (Pure) -
Microplasma assisted synthesis of gold nanoparticle/graphene oxide nanocomposites and their potential application in SERS sensing
Sun, D., Tang, M., Zhang, L., Falzon, B. G., Padmanaban, D. B., Mariotti , D., Maguire , P., Xu, H., Chen, M. & Sun, D., 27 Aug 2019, In: Nanotechnology. 30, 11 p., 455603.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)184 Downloads (Pure) -
Poster abstract: AIM2-mediated inflammasome activation contributes to N-methyl-N-nitrosourea induced photoreceptor death
Chen, M., Harkin, K., Dombrowski, Y. & Xu, H., 2019.Research output: Contribution to conference › Abstract › peer-review