Projects per year
Personal profile
Particulars
Dr Meilan Huang joined Queen’s University Belfast in 2007 as a lecturer. She worked with Prof Fengling Qing's in the Key Laboratory of Organoflorine Chemistry at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences in 1998-1999. After awarded a PhD degree in Computational Chemistry at Zhejiang University in Feb 2003, she was a postdoc working with Prof Arvi Rauk in the Department of Chemistry at University of Calgary Canada. She was a Welcome Trust research fellow in the Laboratory of Physical and Theoretical Chemistry at University of Oxford working with Prof W. Graham Richards, FRS in 2004-2006 and a research fellow working with Prof Artem Cherkasov in Department of Medicine, University of British Columbia, Canada in 2006-2007. She is a Fellow of Royal Society of Chemistry (FRSC) and a Fellow of Royal Society of Biology (FRSB).
Her main research area is developing and applying Computational methods for biocatalysis. She studies the interactions and catalytic mechanism of various enzymes to direct the rational design of novel biocatalysts for chemical transformations. She published over 60 full research articles in high-impact peer-reviewed journals. She is the corresponding author of many publications in top chemistry journals including ACS Catalysis, (2022, 12: 4037), Chem Comm (2020, 56: 9356 & 2019, 55: 2198), J Am Chem Soc (2019, 141: 19, 7934), Nature Communications (2019, 10: 3198), ACS Catalysis (2016, 6: 11, 7749).
She has led the Computational team in several interdisciplinary reserach projects. She was the PI of Chemistry in the interdisciplinary biotechnological project “Development of a computational and molecular biology platform between QUB and Almac” (2015-2019). She is the PI of chemistry in a new 3-year project (2021-2024) INSIGHT@ "IN Silico-Informed metaGenomic Harvesting Technology", in close collaboration with experimentalists and industry. So far, she has secured over £2m research income with a share of £688k. As the principle supervisor, she has supervised 2 computational postdocs and currently is supervising another computational postdoc.
Research Interests
Computational Chemistry and Biology;
Enzyme Engineering;
Biocatalysis;
Rational Drug Design;
Photocatalytis;
Statistical algorithm and Machine Learning
Teaching
PGCHET
CHM1015: Skills for Physical Chemistry (Module Coordinator) (2011-2021)
CHE1006/CHE1104: Maths for Chemists and Engineers (2021-present)
CCE1102: Physical Theory
CHM3005C: Computational Chemistry in Drug Discovery (2019-present) (Module Coordinator)
CHM4007: Frontier in Medicinal Chemistry (2013-2019) (Module coordinator)
CHM3010: Practical Skills in Chemistry (Module Coordinator)
CHM3016: Drug Development
CHM4001: Chemistry Research Project
CHM7004: Research Project
CCE Summer School programme (Programme Lead)
Achievements
2017: Queen's Student Union "Education Excellence Award"
2021: Newton Fund Research Links Workshop grant-2020-RLWK12-10149 "Catalytic Chemistry and Chemical Technology of C1 process" British Council. PI
2021-2023: Royal Society: IEC\NSFC\201177 - International Exchanges 2020 “Machine Learning-assisted Directed Evolution of Enzymes”. PI
2021-2024: "INSIGHT: IN Silico Informed metaGenomic Harvesting Technology platform - Development of an advanced and secure enzyme discovery platform for Almac and QUB" Invest NI, RD11181114, £1,299,329. PI of Chemistry
2015-2019: "New Biotechnology: Development of Computational and Molecular Biology Platforms for Almac and QUB" Invest NI, RD3014092, £981,360. PI of Chemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
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R3253GFS: IN Silico Informed metaGenomic Harvesting Technology platform (INSIGHT)
Allen, C. C. R., Gilmore, B., Huang, M. & Law, C.
06/01/2021 → …
Project: Research
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R3671BSC: Development of computational and molecular biology platforms for Almac and QUB
Allen, C. C. R., Huang, M. & Kulakov, L.
21/11/2014 → 30/03/2019
Project: Research
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2D/3D heterostructured CsPbI2Br solar cells: a choice for a monolithic all-perovskite tandem device
Yan, L., Li, Y., Li, S., Sun, X., Li, Y., Han, X., Huang, M. & Tao, X., 15 Jun 2022, (Early online date) In: Journal of Materials Chemistry A.Research output: Contribution to journal › Article › peer-review
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An autonomously self-gel-breaking, highly reservoir protective completion fluid tailored for gel-free processing in multi-lateral well construction
Xu, L., Xu, M., Wei, Y., Jie, F., Huang, M., Huang, Y., Xu, J., Wang, L. & Xu, L., Apr 2022, In: Journal of Petroleum Science and Engineering. 211, 110136.Research output: Contribution to journal › Article › peer-review
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Computer-Informed Engineering: A New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of an Unusual C10-(S)-Bicyclogermacrene
Yan, X., Zhou, J., Ge, J., Li, W., Liang, D., Singh, W., Black, G., Nie, S., Liu, J., Sun, M., Qiao, J. & Huang, M., 01 Apr 2022, In: ACS Catalysis. 12, 7, p. 4037-4045 9 p.Research output: Contribution to journal › Article › peer-review
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NH4Br-Assisted Two-Step-Processing of Guanidinium-Rich Perovskite Films for Extremely Stable Carbon-Based Perovskite Solar Cells in Ambient Air
Li, Y., Li, S., Li, Y., Sun, X., Lv, X., Zheng, Y. Z., Huang, M. & Tao, X., 22 Mar 2022, (Early online date) In: Solar RRL.Research output: Contribution to journal › Article › peer-review
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NH4Br-Assisted Two-Step-Processing Rich Guanidinium Perovskite Films for Extremely Stable Carbon-Based Perovskite Solar Cells in Ambient Air
Li, Y., Li, S., Li, Y., Sun, X., Lv, X., Zheng, Y-Z., Huang, M. & Tao, X., 15 Mar 2022, (Early online date) In: SOLAR RRL.Research output: Contribution to journal › Article › peer-review
Prizes
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Education Excellence Award
Huang, Meilan (Recipient), 10 May 2017
Prize: Prize (including medals and awards)
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Fellow of Royal Society of Biology (FRSB)
Huang, Meilan (Recipient), Jan 2022
Prize: Election to learned society
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Fellow of Royal Society of Chemistry (FRSC)
Huang, Meilan (Recipient), May 2021
Prize: Election to learned society
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Guest Research Fellowship awarded by Shanghai Jiaotong University (06/12-06/15)
Huang, Meilan (Recipient), Jun 2012
Prize: National/international honour
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Activities
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BBSRC standard grant review
Meilan Huang (Advisor)
Feb 2022 → Mar 2022Activity: Consultancy types › Contribution to the work of national or international committees and working groups
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Online joint programme promotional event to Chinese partner
Meilan Huang (Participant)
31 May 2022 → …Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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Computer-directed biocatalyst design
Meilan Huang (Invited speaker)
03 Jul 2022 → 08 Jul 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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CCE 2022 Virtual Summer School
Meilan Huang (Organiser)
2022 → …Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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External examiner of PhD viva
Meilan Huang (Examiner)
Mar 2022 → …Activity: Examination types › PhD external examination
Press / Media
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Queen’s scientists awarded significant funding to develop the enzymes of tomorrow
22/03/2021
1 Media contribution
Press/Media: Research
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New Biotechnology: Development of Computational and Molecular Biology Platforms for Almac and QUB
02/02/2015
1 Media contribution
Press/Media: Research