• Room 01.008 - CCRCB

    United Kingdom

20082018
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Research Output 2008 2018

2018
3 Citations (Scopus)
152 Downloads (Pure)

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

McCann, C., Crawford, N., Majkut, J., Holohan, C., Armstrong, C., Maxwell, P., Ong, C. W., LaBonte Wilson, M., McDade, S., Waugh, D. & Longley, D., 22 Oct 2018, In : Cell, Death & Disease. 9, 1081, 13 p., 1081.

Research output: Contribution to journalArticle

Open Access
File
CASP8 and FADD-Like Apoptosis Regulating Protein
Inhibitor of Apoptosis Proteins
Prostatic Neoplasms
Apoptosis
Caspase 8
3 Citations (Scopus)
234 Downloads (Pure)

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

Forsythe, N., Refaat, A., Javadi, A., Khawaja, H., Weir, J-A., Emam, H., Allen, W. L., Burkamp, F., Popovici, V., Jithesh, P. V., Isella, C., Labonte, M. J., Mills, I. G., Johnston, P. G. & Van Schaeybroeck, S., 26 Feb 2018, In : Molecular Cancer Therapeutics.

Research output: Contribution to journalArticle

Open Access
File
Unfolded Protein Response
Endoplasmic Reticulum Stress
Colorectal Neoplasms
Mitogen-Activated Protein Kinase Kinases
Apoptosis
2017

Enhanced radio-sensitivity of PTEN-deficient prostate tumours mediated by inhibition of intrinsic and treatment-potentiated CXC-chemokine signaling

Armstrong, C., Coulter, J., Ong, C. W., Maxwell, P., LaBonte Wilson, M., Butterworth, K., Lyubomska, O., Berlingeri, S., Gallagher, R., Walker, S., O'Sullivan, J., Mills, I., Salto-Tellez, M., Illidge, T., Bristow, R. G., Kennedy, R., Prise, K. & Waugh, D., 2017.

Research output: Contribution to conferencePoster

Enzalutamide-induced hypoxia attenuates response and promotes resistance in pre-clinical models of prostate cancer.

Maxwell, P., McKechnie, M., Armstrong, C., Ong, C. W., Waugh, D. & LaBonte Wilson, M., 2017.

Research output: Contribution to conferencePoster

Imbalanced nucleotide metabolism sensitises breast cancer cells to anthracyclines

Davison, C., Chevallier, O., McKechnie, M., Carson, R., Oliver Esteve, J. A., Stachtea, X., Wilson, R., Ladner, R. & LaBonte Wilson, M., Nov 2017.

Research output: Contribution to conferencePoster

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

Van Schaeybroeck, S., Forsythe, N., Refaat, A., Javadi, A., Khawaja, H., Weir, J-A., Emam, H., Moore, W., Burkamp, F., Popovici, V., Jithesh, P., Isella, C., LaBonte Wilson, M., Mills, I. & Johnston, P., 2017, The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer. National Cancer Research Insitute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Unfolded Protein Response
Endoplasmic Reticulum Stress
Colorectal Neoplasms
Mitogen-Activated Protein Kinase Kinases
Apoptosis
Prostatic Neoplasms
Neoplasms
Interleukin-8
Vascular Endothelial Growth Factor A
Androgens

Treatment-induced hypoxia attenuates Enzalutamide response and promotes resistance in pre-clinical models of prostate cancer

Maxwell, P., LaBonte Wilson, M., McKechnie, M., Armstrong, C., Ong, C. W., Worthington, J. & Waugh, D., 2017.

Research output: Contribution to conferencePoster

2016
2 Citations (Scopus)
199 Downloads (Pure)

A Phase II Biomarker-Embedded Study of Lapatinib plus Capecitabine as First-line Therapy in Patients with Advanced or Metastatic Gastric Cancer

LaBonte Wilson, M., Yang, D., Wilson, P., Zhang, W., Nagarwala, Y., Koch, K., Briner, C., Kaneko, T., Rha, S-Y., Gladkov, O., Urba, S., Sakaeva, D., Pishvaian, M., Hsieh, R-K., Lee, W-P. & Lenz, H-J., 01 Sep 2016, In : Molecular Cancer Therapeutics. 15, 9

Research output: Contribution to journalArticle

Open Access
File
Stomach Neoplasms
Biomarkers
Disease-Free Survival
Esophagogastric Junction
Therapeutics
12 Citations (Scopus)
356 Downloads (Pure)

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

Armstrong, C. W. D., Maxwell, P. J., Ong, C. W., Redmond, K. M., McCann, C., Neisen, J., Ward, G. A., Chessari, G., Johnson, C., Crawford, N. T., LaBonte, M. J., Prise, K. M., Robson, T., Salto-Tellez, M., Longley, D. B. & Waugh, D. J. J., 20 Jan 2016, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Hypersensitivity
Radiotherapy
Macrophages
Inhibitor of Apoptosis Proteins
2015

Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer

Benhaim, L., Zhang, W., Wakatsuki, T., Yang, D., Gerger, A., Bohanes, P., Paez, D., Loupakis, F., LaBonte, M. J., Ning, Y., El-Khoueiry, R., Ladner, R., Wilson, P., Zhang, H., Giamas, G., Stebbing, J. & Lenz, H. J., Jun 2015, In : The pharmacogenomics journal. 15, 3, p. 235-40 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Survival
Disease-Free Survival
Genotype
11 Citations (Scopus)

Integrin genetic variants and stage-specific tumor recurrence in patients with stage II and III colon cancer

Bohanes, P., Yang, D., Loupakis, F., LaBonte, M. J., Gerger, A., Ning, Y., Lenz, C., Lenz, F., Wakatsuki, T., Zhang, W., Benhaim, L., El-Khoueiry, A., El-Khoueiry, R. & Lenz, H-J., Jun 2015, In : The pharmacogenomics journal. 15, 3, p. 226-34 9 p.

Research output: Contribution to journalArticle

Integrins
Colonic Neoplasms
Recurrence
Neoplasms
Single Nucleotide Polymorphism
2014
23 Citations (Scopus)

Association of common gene variants in the WNT/β-catenin pathway with colon cancer recurrence

Páez, D., Gerger, A., Zhang, W., Yang, D., LaBonte, M. J., Benhanim, L., Kahn, M., Lenz, F., Lenz, C., Ning, Y., Wakatsuki, T., Loupakis, F. & Lenz, H-J., 01 Apr 2014, In : The pharmacogenomics journal. 14, 2, p. 142-50 9 p.

Research output: Contribution to journalArticle

Catenins
Colonic Neoplasms
Recurrence
Wnt Signaling Pathway
Fluorouracil
7 Citations (Scopus)

Gender-specific profiling in SCN1A polymorphisms and time-to-recurrence in patients with stage II/III colorectal cancer treated with adjuvant 5-fluoruracil chemotherapy

Benhaim, L., Gerger, A., Bohanes, P., Paez, D., Wakatsuki, T., Yang, D., LaBonte, M. J., Ning, Y., El-Khoueiry, R., Loupakis, F., Zhang, W., Laurent-Puig, P. & Lenz, H. J., Apr 2014, In : The pharmacogenomics journal. 14, 2, p. 135-41 7 p.

Research output: Contribution to journalArticle

Fluorouracil
Colorectal Neoplasms
Recurrence
Drug Therapy
Genotype
18 Citations (Scopus)

Plastin Polymorphisms Predict Gender- and Stage-Specific Colon Cancer Recurrence after Adjuvant Chemotherapy

Ning, Y., Gerger, A., Zhang, W., Hanna, D. L., Yang, D., Winder, T., Wakatsuki, T., LaBonte, M. J., Stintzing, S., Volz, N., Sunakawa, Y., Stremitzer, S., El-Khoueiry, R. & Lenz, H-J., Feb 2014, In : Molecular Cancer Therapeutics. 13, 2, p. 528-39 12 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Colonic Neoplasms
Recurrence
Colorectal Neoplasms
Neoplasms
12 Citations (Scopus)

The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy

Absenger, G., Benhaim, L., Szkandera, J., Zhang, W., Yang, D., LaBonte, M. J., Pichler, M., Stotz, M., Samonigg, H., Renner, W., Gerger, A. & Lenz, H-J., Apr 2014, In : The pharmacogenomics journal. 14, 2, p. 130-4 5 p.

Research output: Contribution to journalArticle

Cyclin D1
Fluorouracil
Colonic Neoplasms
Drug Therapy
Recurrence
2013
17 Citations (Scopus)

Assessing the in vivo efficacy of biologic antiangiogenic therapies

Wilson, P. M., LaBonte, M. J., Lenz, H-J. & LaBonte Wilson, M., Jan 2013, In : Cancer Chemotherapy and Pharmacology. 71, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Biological Therapy
Vascular Endothelial Growth Factor A
Tumors
Vascular Endothelial Growth Factor B
Therapeutics
10 Citations (Scopus)

Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States

Wakatsuki, T., LaBonte, M. J., Bohanes, P. O., Zhang, W., Yang, D., Azuma, M., Barzi, A., Ning, Y., Loupakis, F., Saadat, S., Volz, N., Stintzing, S., El-Khoueiry, R., Koizumi, W., Watanabe, M., Shah, M., Stebbing, J., Giamas, G., Lenz, H-J. & LaBonte Wilson, M., Oct 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2261-72 12 p.

Research output: Contribution to journalArticle

Lemur
Protein-Tyrosine Kinases
Stomach Neoplasms
Japan
Confidence Intervals
1 Citation (Scopus)

Role of cyclin polymorphisms in predicting outcome of 5-fluorouracil-based chemotherapy in colorectal cancer: one piece in a complex puzzle

LaBonte, M. J., Lenz, H-J. & LaBonte Wilson, M., Nov 2013, In : Pharmacogenomics. 14, 14, p. 1671-4 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer

Wilson, P. M., Labonte, M. J., Martin, S. C., Kuwahara, S. T., El-Khoueiry, A., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., Aug 2013, In : INVESTIGATIONAL NEW DRUGS. 31, 4, p. 845-57 13 p.

Research output: Contribution to journalArticle

Histones
Colorectal Neoplasms
Pharmaceutical Preparations
Thymidylate Synthase
Growth
2012
110 Citations (Scopus)

Cancer dormancy: a model of early dissemination and late cancer recurrence

Páez, D., Labonte, M. J., Bohanes, P., Zhang, W., Benhanim, L., Ning, Y., Wakatsuki, T., Loupakis, F., Lenz, H-J. & LaBonte Wilson, M., 01 Feb 2012, In : Clinical Cancer Research. 18, 3, p. 645-53 9 p.

Research output: Contribution to journalArticle

Recurrence
Neoplasms
Neoplasm Micrometastasis
Residual Neoplasm
Tumor Biomarkers
2 Citations (Scopus)

"HER majesty's a pretty nice girl but she changes from day to day"

Bohanes, P., Loupakis, F., Labonte, M. J., Wakatsuki, T., Lenz, H-J. & LaBonte Wilson, M., 01 Feb 2012, In : Journal of Clinical Oncology. 30, 4, p. 465-6; author reply 466-7

Research output: Contribution to journalArticle

64 Citations (Scopus)

Influence of sex on the survival of patients with esophageal cancer

Bohanes, P., Yang, D., Chhibar, R. S., Labonte, M. J., Winder, T., Ning, Y., Gerger, A., Benhaim, L., Paez, D., Wakatsuki, T., Loupakis, F., El-Khoueiry, R., Zhang, W., Lenz, H-J. & LaBonte Wilson, M., 20 Jun 2012, In : Journal of Clinical Oncology. 30, 18, p. 2265-72 8 p.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Survival
Epithelial Cells
Histology
Proportional Hazards Models
35 Citations (Scopus)

Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer

Wilson, P. M., LaBonte, M. J., Lenz, H-J., Mack, P. C., Ladner, R. D. & LaBonte Wilson, M., Mar 2012, In : Molecular Cancer Therapeutics. 11, 3, p. 616-28 13 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Non-Small Cell Lung Carcinoma
Pemetrexed
Floxuridine
Uracil
145 Citations (Scopus)

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

Lee, Y. S., Choi, I., Ning, Y., Kim, N. Y., Khatchadourian, V., Yang, D., Chung, H. K., Choi, D., LaBonte, M. J., Ladner, R. D., Nagulapalli Venkata, K. C., Rosenberg, D. O., Petasis, N. A., Lenz, H-J., Hong, Y-K. & LaBonte Wilson, M., 22 May 2012, In : British Journal of Cancer. 106, 11, p. 1833-41 9 p.

Research output: Contribution to journalArticle

Interleukin-8 Receptors
Tumor Microenvironment
Colonic Neoplasms
Interleukin-8
Neoplasm Metastasis
26 Citations (Scopus)

Pancreatic cancer: medical management (novel chemotherapeutics)

Páez, D., Labonte, M. J., Lenz, H-J. & LaBonte Wilson, M., Mar 2012, In : Gastroenterology clinics of North America. 41, 1, p. 189-209 21 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Neoplasms
Recurrence
Survival
8 Citations (Scopus)

Pharmacogenomics and metastatic colorectal cancer: current knowledge and perspectives

Benhaim, L., Labonte, M. J., Lenz, H-J. & LaBonte Wilson, M., Mar 2012, In : Scandinavian Journal of Gastroenterology. 47, 3, p. 325-39 15 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Colorectal Neoplasms
Drug Therapy
Metabolic Networks and Pathways
Pharmaceutical Preparations
2 Citations (Scopus)

Selecting the best targeted agent in first-line treatment of unresectable liver metastases from colorectal cancer: does the bench have the answers?

Benhaim, L., Loupakis, F., Labonte, M. J., Lenz, H. J. & LaBonte Wilson, M., Sep 2012, In : Journal of hepato-biliary-pancreatic sciences. 19, 5, p. 528-35 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasm Metastasis
Liver
Vascular Endothelial Growth Factor A
Therapeutics
65 Citations (Scopus)

The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models

Ning, Y., Labonte, M. J., Zhang, W., Bohanes, P. O., Gerger, A., Yang, D., Benhaim, L., Paez, D., Rosenberg, D. O., Nagulapalli Venkata, K. C., Louie, S. G., Petasis, N. A., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., Jun 2012, In : Molecular Cancer Therapeutics. 11, 6, p. 1353-64 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Colonic Neoplasms
Colorectal Neoplasms
Neoplasms
Interleukin-8
8 Citations (Scopus)

The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer

Labonte, M. J., Wilson, P. M., Yang, D., Zhang, W., Ladner, R. D., Ning, Y., Gerger, A., Bohanes, P. O., Benhaim, L., El-Khoueiry, R., El-Khoueiry, A., Lenz, H-J. & LaBonte Wilson, M., Jun 2012, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 23, 6, p. 1455-64 10 p.

Research output: Contribution to journalArticle

Cyclin D1
Breast Neoplasms
Single Nucleotide Polymorphism
Alleles
Capecitabine
2011
50 Citations (Scopus)

A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression

Ou, C-Y., LaBonte, M. J., Manegold, P. C., So, A. Y-L., Ianculescu, I., Gerke, D. S., Yamamoto, K. R., Ladner, R. D., Kahn, M., Kim, J. H., Stallcup, M. R. & LaBonte Wilson, M., May 2011, In : Molecular cancer research : MCR. 9, 5, p. 660-70 11 p.

Research output: Contribution to journalArticle

Catenins
Colorectal Neoplasms
Gene Expression
Growth
Genes
115 Citations (Scopus)

A let-7 microRNA-binding site polymorphism in 3'-untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy

Zhang, W., Winder, T., Ning, Y., Pohl, A., Yang, D., Kahn, M., Lurje, G., Labonte, M. J., Wilson, P. M., Gordon, M. A., Hu-Lieskovan, S., Mauro, D. J., Langer, C., Rowinsky, E. K., Lenz, H-J. & LaBonte Wilson, M., Jan 2011, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 22, 1, p. 104-9 6 p.

Research output: Contribution to journalArticle

3' Untranslated Regions
MicroRNAs
Colorectal Neoplasms
Binding Sites
Genes
38 Citations (Scopus)

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates

Wilson, P. M., Labonte, M. J., Russell, J., Louie, S., Ghobrial, A. A., Ladner, R. D. & LaBonte Wilson, M., 01 Sep 2011, In : Nucleic Acids Research. 39, 17, p. e112

Research output: Contribution to journalArticle

Deoxyribonucleosides
Fluorescence
triphosphoric acid
Taq Polymerase
Exonucleases
30 Citations (Scopus)

A review of excision repair cross-complementation group 1 in colorectal cancer

Bohanes, P., Labonte, M. J., Lenz, H-J. & LaBonte Wilson, M., Sep 2011, In : Clinical colorectal cancer. 10, 3, p. 157-64 8 p.

Research output: Contribution to journalArticle

oxaliplatin
DNA Repair
Colorectal Neoplasms
Biomarkers
Platinum Compounds
70 Citations (Scopus)

Common cancer stem cell gene variants predict colon cancer recurrence

Gerger, A., Zhang, W., Yang, D., Bohanes, P., Ning, Y., Winder, T., LaBonte, M. J., Wilson, P. M., Benhaim, L., Paez, D., El-Khoueiry, R., El-Khoueiry, A., Kahn, M., Lenz, H-J. & LaBonte Wilson, M., 01 Nov 2011, In : Clinical Cancer Research. 17, 21, p. 6934-43 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Colonic Neoplasms
Recurrence
Activated-Leukocyte Cell Adhesion Molecule
Genes
35 Citations (Scopus)

EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients

Hu-Lieskovan, S., Vallbohmer, D., Zhang, W., Yang, D., Pohl, A., Labonte, M. J., Grimminger, P. P., Hölscher, A. H., Semrau, R., Arnold, D., Dellas, K., Debucquoy, A., Haustermans, K., Machiels, J-P. H., Sempoux, C., Rödel, C., Bracko, M., Velenik, V., Lenz, H-J. & LaBonte Wilson, M., 01 Aug 2011, In : Clinical Cancer Research. 17, 15, p. 5161-9 9 p.

Research output: Contribution to journalArticle

Rectal Neoplasms
Epidermal Growth Factor
Alleles
Antibody-Dependent Cell Cytotoxicity
Neoplasms
16 Citations (Scopus)

Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin

Gordon, M. A., Zhang, W., Yang, D., Iqbal, S., El-Khouiery, A., Nagashima, F., Lurje, G., Labonte, M., Wilson, P., Sherrod, A., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., Jan 2011, In : Pharmacogenomics. 12, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

oxaliplatin
Fluorouracil
Colorectal Neoplasms
Disease-Free Survival
Regression Analysis
245 Citations (Scopus)

Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models

Ning, Y., Manegold, P. C., Hong, Y. K., Zhang, W., Pohl, A., Lurje, G., Winder, T., Yang, D., LaBonte, M. J., Wilson, P. M., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., 01 May 2011, In : International journal of cancer. Journal international du cancer. 128, 9, p. 2038-49 12 p.

Research output: Contribution to journalArticle

Interleukin-8
Colonic Neoplasms
Cell Line
oxaliplatin
Colorectal Neoplasms
42 Citations (Scopus)

Molecular predictors of response to antiangiogenesis therapies

Gerger, A., LaBonte, M., Lenz, H-J. & LaBonte Wilson, M., 24 Mar 2011, In : The Cancer Journal. 17, 2, p. 134-41 8 p.

Research output: Contribution to journalArticle

Biomarkers
Therapeutics
Translational Medical Research
United States Food and Drug Administration
Vascular Endothelial Growth Factor A
51 Citations (Scopus)

Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

Gerger, A., El-Khoueiry, A., Zhang, W., Yang, D., Singh, H., Bohanes, P., Ning, Y., Winder, T., Labonte, M. J., Wilson, P. M., Benhaim, L., Paez, D., El-Khoueiry, R., Absenger, G., Lenz, H-J. & LaBonte Wilson, M., 01 Sep 2011, In : Clinical Cancer Research. 17, 17, p. 5783-92 10 p.

Research output: Contribution to journalArticle

oxaliplatin
Pharmacogenetics
Colorectal Neoplasms
Drug Therapy
Vascular Endothelial Growth Factor A
20 Citations (Scopus)

Predictive molecular classifiers in colorectal cancer

Bohanes, P., LaBonte, M. J., Winder, T., Lenz, H-J. & LaBonte Wilson, M., Aug 2011, In : Seminars in Oncology. 38, 4, p. 576-87 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epidermal Growth Factor Receptor
Mutation
Cytotoxins
Antibodies
64 Citations (Scopus)

The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models

LaBonte, M. J., Wilson, P. M., Fazzone, W., Russell, J., Louie, S. G., El-Khoueiry, A., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., 15 May 2011, In : Cancer Research. 71, 10, p. 3635-48 14 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Epidermal Growth Factor Receptor
Colorectal Neoplasms
1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase Kinases
2010
35 Citations (Scopus)

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy

Wilson, P. M., El-Khoueiry, A., Iqbal, S., Fazzone, W., LaBonte, M. J., Groshen, S., Yang, D., Danenberg, K. D., Cole, S., Kornacki, M., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., Apr 2010, In : Cancer Chemotherapy and Pharmacology. 65, 5, p. 979-88 10 p.

Research output: Contribution to journalArticle

Chemotherapy
Thymidylate Synthase
Fluorouracil
Colorectal Neoplasms
Drug Therapy
49 Citations (Scopus)

Molecular markers in the treatment of metastatic colorectal cancer

Wilson, P. M., Labonte, M. J., Lenz, H-J. & LaBonte Wilson, M., 09 Jun 2010, In : The Cancer Journal. 16, 3, p. 262-72 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Biomarkers
Therapeutics
Drug Therapy
Precision Medicine
2009
66 Citations (Scopus)

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines

LaBonte, M. J., Wilson, P. M., Fazzone, W., Groshen, S., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., 2009, In : BMC Medical Genomics. 2, p. 67

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
DNA Fingerprinting
Oligonucleotide Array Sequence Analysis
Colonic Neoplasms
Cell Line
56 Citations (Scopus)
Thymidylate Synthase
Histone Deacetylase Inhibitors
Colonic Neoplasms
Gene Expression
Fluorouracil