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Michelle Greene

Dr

20142020

Research output per year

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Personal profile

Interests

Dr. Greene completed her PhD within the School of Pharmacy at Queen’s University Belfast, which focused on the therapeutic evaluation of a novel immunomodulatory nanoparticle in models of Acute Respiratory Distress Syndrome. Within her present role as a postdoctoral researcher, Dr. Greene has continued to apply her expertise in nanomedicine, particularly in the field of oncology. She is currently engaged in a US-Ireland R&D Partnership Programme that aims to develop more effective therapies for pancreatic cancer, by combining nanomedicines with agents that can overcome the drug delivery barriers posed by the tumour microenvironment. 

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Research Output

Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells

Greene, M., Nogueira, J., Tracey, S., Richards, D., McDaid, W., Burrows, J., Campbell, K., Longley, D., Chudasama, V. & Scott, C., 14 May 2020, In : Nanoscale.

Research output: Contribution to journal › Article

Open Access
File
    • 5 Downloads (Pure)

    Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

    Nogueira, J. C. F., Greene, M. K., Richards, D. A., Furby, A. O., Steven, J., Porter, A., Barelle, C., Scott, C. J. & Chudasama, V., 27 Jun 2019, In : Chemical Communications. 55, 53, p. 7671-7674

    Research output: Contribution to journal › Article

    Open Access
    File
    • 4 Citations (Scopus)
    82 Downloads (Pure)

    Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

    McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, In : Nanoscale. 13 p.

    Research output: Contribution to journal › Article

    • 2 Citations (Scopus)

    Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles

    Jiang, L., Greene, M. K., Insua, J. L., Sa-Pessoa, J., Small, D. M., Smyth, P., McCann, A., Cogo, F., Bengoechea, J. A., Taggart, C. C. & Scott, C. J., 25 Apr 2018, In : Journal of Controlled Release.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 7 Citations (Scopus)
    235 Downloads (Pure)

    Generating Next-Generation Antibody-Nanoparticle Conjugates through the Oriented Installation of Non-Engineered Antibody Fragments

    Greene, M. K., Richards, D. A., Nogueira, J. C. F., Campbell, K., Smyth, P., Fernańdez, M., Scott, C. J. & Chudasama, V., 14 Aug 2017, In : Chemical Science. 1, p. 79-87 9 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 30 Citations (Scopus)
    272 Downloads (Pure)