• Room 01.023 - Clinical Science B Block 6 R.V.H. Site

    United Kingdom

Accepting PhD Students

19992019
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Personal profile

Research Statement

Prof Clarke has 30 years experience in the rigourous evaluation of the effects of health and social care, including numerous randomised trials, systematic reviews and other prospective studies. He has been actively involved in the design, conduct, monitoring and reporting of dozens of randomised trials, including several that have recruited more than 1000 participants (in breast cancer, maternity care, poisoning and sub-arachnoid haemorrhage). He has provided detailed advice for hundreds of other trials, processed and interpreted the individual participant data (IPD) from more than a thousand trials included in systematic reviews, and assessed reports for tens of thousands more as part of initiatives to improve access to research information. His work on systematic reviews includes the collection of IPD from randomised trials across all treatments for women with breast cancer, leading to internationally-renowned reports that influence the care of millions of women worldwide.

Prof Clarke's research, coupled with more than two decades of teaching about randomised trials and systematic reviews (including establishing the relevant modules on the University of Oxford's MSc in Evidence Based Health Care) have provided him with unique insights into the evaluation of health and social care. He is building on this experience when designing and conducting research into research methodoogly, and established the SWAT and SWAR (Studies Within A Trial / Review) initiatives to facilitate this.

Prof Clarke is the Director of the Northern Ireland Clinical Trials Unit and the Northern Ireland Methodology Hub, and Co-ordinating Editor of the Cochrane Methodology Review Group. He has been a leading proponent of the importance of using systematic reviews in the design and reporting of clinical trials for some time, and his work on core outcome sets (as part of the COMET Initiative) also serves to improve the quality and usefulness of trials and reviews. His research reflects his strong interest in increasing the capacity for reviews and trials, and in improving their accessibility, in particular in low- and middle-income countries. He is Podcast Editor for the Cochrane Library and a founder of Evidence Aid, seeking to make it easier to use evidence from reviews in natural disasters and other humanitarian emergencies, and is the charity's Research Director and Chair of the Board of Trustees.

Fingerprint Dive into the research topics where Mike Clarke is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Meta-Analysis Medicine & Life Sciences
Research Medicine & Life Sciences
Randomized Controlled Trials Medicine & Life Sciences
Clinical Trials Medicine & Life Sciences
Health Medicine & Life Sciences
Feasibility Studies Medicine & Life Sciences
Research Personnel Medicine & Life Sciences
Databases Medicine & Life Sciences

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Research Output 1999 2019

A Core Outcome Set for Critical Care Ventilation Trials

Blackwood, B., Ringrow, S., Clarke, M., Marshall, J. C., Connolly, B., Rose, L. & McAuley, D. F., 25 Jul 2019, In : Critical Care Medicine.

Research output: Contribution to journalArticle

Open Access
File
Delphi Technique
Ventilation
Clinical Trials
Critical Care
Artificial Respiration

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks-results from the Lassa fever pilot

Sigfrid, L., Moore, C., Salam, A. P., Maayan, N., Hamel, C., Garritty, C., Lutje, V., Buckley, B., Soares-Weiser, K., Marshall, R., Clarke, M. & Horby, P., 11 Jun 2019, In : BMC Medicine. 17, 1, p. 107

Research output: Contribution to journalArticle

Open Access
File
Lassa Fever
Disease Outbreaks
Research
Software
Philippines

A systematic review of feasibility studies promoting the use of mobile technologies in clinical research

Bakker, J. P., Goldsack, J. C., Clarke, M., Coravos, A., Geoghegan, C., Godfrey, A., Heasley, M. G., Karlin, D. R., Manta, C., Peterson, B., Ramirez, E., Sheth, N., Bruno, A., Bullis, E., Wareham, K., Zimmerman, N., Forrest, A. & Wood, W. A., 06 Dec 2019, In : NPJ digital medicine. 2, p. 47

Research output: Contribution to journalArticle

Open Access
File
Feasibility Studies
Technology
Research
Databases
Clinical Trials

Core Outcome Set-STAndardised Protocol Items: the COS-STAP Statement

COS-STAP Group, 11 Feb 2019, In : Trials. 20, p. 116 7 p.

Research output: Contribution to journalArticle

Open Access
File
Consensus
Research Personnel
Politics
Checklist
Research

Correspondence

Convie, L., McCain, R. S., McKinley, N., Kirk, S. J., Campbell, W. J. & Clarke, M., 27 Feb 2019, In : British Journal of Surgery. 106, 4, p. 508-508 1 p.

Research output: Contribution to journalLetter

Activities 2004 2015

  • 6 Research and Teaching at External Organisation
  • 1 Participation in conference
  • 1 Participation in workshop, seminar, course

COMET workshop, at UK and Ireland Cochrane Contributors' meeting

Mike Clarke (Keynote/plenary speaker)
23 Apr 2015

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

Stellenbosch University

Mike Clarke (Visitor)
2015 → …

Activity: Visiting an external institution typesResearch and Teaching at External Organisation

3rd International Clinical Trials Methodology Conference

Mike Clarke (Chair)
2014 → …

Activity: Participating in or organising an event typesParticipation in conference

National University of Ireland, Galway

Mike Clarke (Visitor)
Oct 2010 → …

Activity: Visiting an external institution typesResearch and Teaching at External Organisation

Trinity College Dublin

Mike Clarke (Chair)
Jul 2010 → …

Activity: Visiting an external institution typesResearch and Teaching at External Organisation