• Room 01.023 - Clinical Science B

    United Kingdom

Accepting PhD Students

PhD projects

Mike is keen to hear from prospective PhD or MD students wanting to: - investigate improving the quality and usefulness of trials and reviews; - conduct health services research more generally; or - conduct research relevant to humanitarian emergencies.

19992020

Research output per year

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Personal profile

Research Statement

Prof Clarke has 30 years experience in the rigourous evaluation of the effects of health and social care, including numerous randomised trials, systematic reviews and other prospective studies. He has been actively involved in the design, conduct, monitoring and reporting of dozens of randomised trials, including several that have recruited more than 1000 participants (in breast cancer, maternity care, poisoning and sub-arachnoid haemorrhage). He has provided detailed advice for hundreds of other trials, processed and interpreted the individual participant data (IPD) from more than a thousand trials included in systematic reviews, and assessed reports for tens of thousands more as part of initiatives to improve access to research information. His work on systematic reviews includes the collection of IPD from randomised trials across all treatments for women with breast cancer, leading to internationally-renowned reports that influence the care of millions of women worldwide.

Prof Clarke's research, coupled with more than two decades of teaching about randomised trials and systematic reviews (including establishing the relevant modules on the University of Oxford's MSc in Evidence Based Health Care) have provided him with unique insights into the evaluation of health and social care. He is building on this experience when designing and conducting research into research methodoogly, and established the SWAT and SWAR (Studies Within A Trial / Review) initiatives to facilitate this.

Prof Clarke is the Director of the Northern Ireland Clinical Trials Unit and the Northern Ireland Methodology Hub, and Co-ordinating Editor of the Cochrane Methodology Review Group. He has been a leading proponent of the importance of using systematic reviews in the design and reporting of clinical trials for some time, and his work on core outcome sets (as part of the COMET Initiative) also serves to improve the quality and usefulness of trials and reviews. His research reflects his strong interest in increasing the capacity for reviews and trials, and in improving their accessibility, in particular in low- and middle-income countries. He is Podcast Editor for the Cochrane Library and a founder of Evidence Aid, seeking to make it easier to use evidence from reviews in natural disasters and other humanitarian emergencies, and is the charity's Research Director and Chair of the Board of Trustees.

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Projects

Research Output

Anticipatory care planning intervention for older adults at risk of functional decline: study protocol for a primary care cluster feasibility randomised trial

Brazil, K., Scott, D., Wallace, E., Clarke, M., Fahey, T., Gillespie, P., O'Halloran, P., Cardwell, C., Carter, G., McGlade, K. & Doyle, F., 11 Feb 2020, In : Trials. 21, 1, 10 p., 168.

Research output: Contribution to journalArticle

Open Access
File
  • 16 Downloads (Pure)

    Fool’s gold? Why blinded trials are not always best

    Anand, R., Bradley, J., Clarke, M., McAuley, D. & Norrie, J., 21 Jan 2020, In : The BMJ. 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 106 Downloads (Pure)

    Modifiable lifestyle and medical risk factors associated with myeloproliferative neoplasms

    Duncombe, A. S., Anderson, L., James, G., De Vocht, F., Fritschi, L., Mesa, R., Clarke, M. & McMullin, M., 01 Feb 2020, In : HemaSphere. 4, 1, 6 p., 0327.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 16 Downloads (Pure)

    Resilience, burnout and coping mechanisms in UK doctors: a cross-sectional study

    McKinley, N., McCain, R. S., Convie, L., Clarke, M., Dempster, M., Campbell, W. J. & Kirk, S., 27 Jan 2020, In : BMJ Open. 10, 1, 8 p., e031765.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 20 Downloads (Pure)
    Open Access
    File
  • 27 Downloads (Pure)

    Activities

    • 6 Research and Teaching at External Organisation
    • 1 Participation in conference
    • 1 Participation in workshop, seminar, course
    • 1 Invited or keynote talk at national or international conference

    Supporting advance care planning in dementia palliative care; Evaluation of the family carer decision support intervention

    Kevin Brazil (Presenter), Gillian Carter (Advisor), Christopher Cardwell (Advisor), Michael Clarke (Advisor), Peter Hudson (Advisor), K Froggatt (Contributor), Anthony Passmore (Advisor), G Kernohan (Contributor)
    02 Oct 201805 Oct 2018

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    COMET workshop, at UK and Ireland Cochrane Contributors' meeting

    Mike Clarke (Keynote/plenary speaker)
    23 Apr 2015

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    Stellenbosch University

    Mike Clarke (Visitor)
    2015 → …

    Activity: Visiting an external institution typesResearch and Teaching at External Organisation

    3rd International Clinical Trials Methodology Conference

    Mike Clarke (Chair)
    2014 → …

    Activity: Participating in or organising an event typesParticipation in conference

    National University of Ireland, Galway

    Mike Clarke (Visitor)
    Oct 2010 → …

    Activity: Visiting an external institution typesResearch and Teaching at External Organisation