Projects per year
Personal profile
Research Interests
I am a clinical researcher working as a Consultant in Intensive Care Medicine in the Royal Victoria Hospital Belfast and Senior Lecturer in Queen's University Belfast.
My research programme has two themes; Discovery science and critical care big data.
1. The discovery science theme is focussed on using human in vivo models of infection and inflammation in the pulmonary compartment. I use the inhaled lipopolysaccharide model of pulmonary inflammation and surgical one lung model of inflammation. My current reserach projects in these lines include
a. Prevention HARP 2 study - UK multicentre trial aimed at reducing post-operative pulmonary and cardiac complications
b. SELECT - Understanding the in vivo effects of e-cigarettes
c. Role of T regulatory cells in acute respiratory distress syndrome
Current study in set up is "Hyperoxia mediated lung injury" to study the effect of liberal oxygen on pulmonary inflammation.
I have other grants in submission with a similar focus including the role of lung microbiome in increasing the risk of post-operative pulmonary infections.
I collaborate with the Centre for Experimental Medicine and externally with University of California San Francisco for these projects.
2. The critical care big data theme is focussed on supporting clinicians using real time data analytics. There is also a significant component of behavioural sciences in this theme. I collaborate with ECIT, School for Mathematics and Physics and Centre for Public Health in this theme.
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Network
Projects
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R4903CEM: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
Connolly, B., Blackwood, B., Bradley, J., Clarke, M., McAuley, D. & Shyamsundar, M.
24/07/2020 → …
Project: Research
Research output
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Applying AI to manage acute and chronic clinical conditions
Gillan, C., Hagan, R. & Shyamsundar, M., 25 Jan 2021, (Accepted) Technologies and Applications for Big Data Value. SpringerResearch output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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High-flow nasal cannula therapy for initial oxygen administration in acute hypercapnic respiratory failure: study protocol of randomised controlled unblinded trial
Alnajada, A., Blackwood, B., Mobrad, A., Akhtar, A. & Shyamsundar, M., 08 Jan 2021, In: BMJ Open Respiratory Research. 8, 1, 8 p., e000853.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Airway clearance techniques and use of mucoactive agents for adult critically ill patients with acute respiratory failure: a qualitative study exploring UK physiotherapy practice
Connolly, B., Barclay, M., Blackwood, B., Bradley, J., Anand, R., Borthwick, M., Chikhani, M., Dark, P., Shyamsundar, M., Warburton, J., McAuley, D. F. & O'Neill, B., 01 Sep 2020, In: Physiotherapy (United Kingdom). 108, p. 78-87 10 p.Research output: Contribution to journal › Article › peer-review
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Comparing regression and neural network techniques for personalized predictive analytics to promote lung protective ventilation in Intensive Care Units
Hagan, R., Gillan, C., Spence, I., McAuley, D. & Shyamsundar, M., 01 Nov 2020, In: Computers in Biology and Medicine. 126Research output: Contribution to journal › Article › peer-review
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Mucoactive agents for acute respiratory failure in the critically ill a systematic review and meta-analysis
Anand, R., McAuley, D. F., Blackwood, B., Yap, C., ONeill, B., Connolly, B., Borthwick, M., Shyamsundar, M., Warburton, J., Meenen, D. V., Paulus, F., Schultz, M. J., Dark, P. & Bradley, J. M., 08 Jun 2020, In: Thorax.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Mucoactive agent use in adult UK Critical Care Units: a survey of health care professionals perception, pharmacists’ description of practice, and point prevalence of mucoactive use in invasively mechanically ventilated patients
Shyamsundar, M. (Creator), Queen's University Belfast, 30 Aug 2019
DOI: 10.17034/de3d8d3c-9c4b-459e-8b16-8fb9bb50e1d7
Dataset
File
Activities
- 1 Participation in conference
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UK Critical Care Research Forum
Cecilia O'Kane (Organiser), Murali Shyamsundar (Organiser), Bronagh Blackwood (Organiser) & Danny McAuley (Organiser)
07 Jun 2018 → 08 Jun 2018Activity: Participating in or organising an event types › Participation in conference