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Murali Shyamsundar

Dr

 https://orcid.org/0000-0003-3797-8080

  • Room 02.019 - CEM

    United Kingdom

20082019

Research output per year

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Personal profile

Research Interests

I am a clinical researcher working as a Consultant in Intensive Care Medicine in the Royal Victoria Hospital Belfast and Senior Lecturer in Queen's University Belfast.

 

My research programme has two themes; Discovery science and critical care big data.

 

1. The discovery science theme is focussed on using human in vivo models of infection and inflammation in the pulmonary compartment. I use the inhaled lipopolysaccharide model of pulmonary inflammation and surgical one lung model of inflammation. My current reserach projects in these lines include

a. Prevention HARP 2 study - UK multicentre trial aimed at reducing post-operative pulmonary and cardiac complications

b. SELECT - Understanding the in vivo effects of e-cigarettes

c. Role of T regulatory cells in acute respiratory distress syndrome

Current study in set up is "Hyperoxia mediated lung injury" to study the effect of liberal oxygen on pulmonary inflammation.

I have other grants in submission with a similar focus including the role of lung microbiome in increasing the risk of post-operative pulmonary infections.

I collaborate with the Centre for Experimental Medicine and externally with University of California San Francisco for these projects.

2. The critical care big data theme is focussed on supporting clinicians using real time data analytics. There is also a significant component of behavioural sciences in this theme. I collaborate with ECIT, School for Mathematics and Physics and Centre for Public Health in this theme.

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Projects

R1608CII: MRC P2D 2015 - Accelerating the discovery and development of new medicines for the treatment of Acute Respiratory Distress Syndrome (ARDS) through knowledge exchange

McAuley, D. & Shyamsundar, M.

02/03/2016 → 30/11/2016

Project: Research

Research Output

The weekend effect in status epilepticus: a national cohort study

Goulden, R., Whitehouse, T., Murphy, N., Hayton, T., Khan, Z., Shyamsundar, M., Gao-Smith, F., Snelson, C., Bion, J. & Veenith, T., 03 Jan 2019, In : Anaesthesia.

Research output: Contribution to journal › Article

Open Access
File
    • 1 Citation (Scopus)
    38 Downloads (Pure)

    Expediting assessments of database performance for streams of respiratory parameters

    Gillan, C. J., Novakovic, A., Marshall, A. H., Shyamsundar, M. & Nikolopoulos, D. S., 01 Sep 2018, In : Computers in Biology and Medicine. 100, p. 186-195 10 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 1 Citation (Scopus)
    107 Downloads (Pure)

    Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial

    Shyamsundar, M., O'Kane, C., Perkins, G. D., Kennedy, G., Campbell, C., Agus, A., Phair, G. & McAuley, D., 18 Dec 2018, In : Trials. 19, 1, p. 690

    Research output: Contribution to journal › Article

    Open Access
    File
    • 1 Citation (Scopus)
    163 Downloads (Pure)

    The effects of E-cigarettes on pulmonary inflammation and inflammasome activation  

    Bell, R., O'Kane, C., Shyamsundar, M. & Dombrowski, Y., 2018.

    Research output: Contribution to conference › Poster

    The effects of E-cigarettes on pulmonary inflammation and inflammasome activation  

    Bell, R., O'Kane, C., Shyamsundar, M. & Dombrowski, Y., 2018.

    Research output: Contribution to conference › Poster

    Datasets

    Mucoactive agent use in adult UK Critical Care Units: a survey of health care professionals perception, pharmacists’ description of practice, and point prevalence of mucoactive use in invasively mechanically ventilated patients

    Shyamsundar, M. (Creator), Queen's University Belfast, 30 Aug 2019

    DOI: 10.17034/de3d8d3c-9c4b-459e-8b16-8fb9bb50e1d7

    Dataset

    File

    Activities

    • 1 Participation in conference

    UK Critical Care Research Forum

    Cecilia O'Kane (Organiser), Murali Shyamsundar (Organiser), Bronagh Blackwood (Organiser), Danny McAuley (Organiser)
    07 Jun 2018 → 08 Jun 2018

    Activity: Participating in or organising an event types › Participation in conference