Projects per year
Personal profile
Research Statement
Dr Niamh Buckley graduated from Trinity College, Dublin in 2002 with a First Class Honours Degree in Biochemistry. She then carried out her Ph.D. training in the Department of Oncology (Queen’s University Belfast) under the supervision of Prof. Paul Harkin. Following this, she then worked as a post-doctoral researcher with Dr Paul Mullan in the Centre for Cancer Research and Cell Biology (Queen’s University Belfast). During this time, she investigated the role of the breast and ovarian tumour suppressor gene, BRCA1, in stem cell regulation and mammary gland differentiation.
Dr Buckley was awarded the prestigious Breast Cancer Now fellowship in 2013 to develop novel biomarkers and therapeutic strategies in BRCA1-mutant and/or triple negative breast cancer. In 2016 she was appointed as a Lecturer in Personalised Medicine and Pharmacogenomics in the School of Pharmacy (Queen’s University Belfast). She was then promoted to Senior Lecturer in 2020 and is an active member of the Nanomedicine and Biotherapeutics Cluster. Dr Buckley is also an associate member of the Patrick G Johnson Centre for Cancer Research (PGJCCR) at QUB. Her research focuses on the integration of in vitro, in vivo, bioinformatics and pathology approaches to identify key pathways underpinning poor outcome breast cancer and use detailed knowledge of this biology to identify appropriate targeted treatment options, personalising therapy in an area of unmet clinical need.
Achievements
Dr Buckley has secured ~£5 million in competitive grant income from national and international funding boards in the last 2 years with >£750,000 as PIand has published in over 30 articles in leading Q1 journals with over 1100 citations. Her knowledge and expertise have been recognised by invitations to speak at national and international conferences and membership of the Breast Cancer Now Grant Review Committee and Tissue Access Committee. She has also been the recipient of several prestigious awards including European Association of Cancer Research (EACR) Young Scientist Award (2012), Roche Gold Medal Award (2011) and School of Medicine, Dentistry and Biomedical Sciences Post-Doctoral Researcher of the Year (2012).
Research Interests
Breast Cancer
Triple Negative Breast Cancer
BRCA1
Ovarian Cancer
Personalised Medicine
Targeted Treatments
Biomarkers
Teaching
Contributes to the following modules:
MPharm Degree
PMY3176 Advanced Delivery Systems for Large and Small Molecules (Module Co-ordinator)
PMY4005 Research Project
PMY4107 Advanced Pharmaceutical Care
BSc Pharmaceutical Sciences
PMY2021 Principles of Drug Action
PMY3176 Advanced Delivery Systems for Large and Small Molecules (Module Co-ordinator)
BSc Pharmaceutical Biotechnology
PMY2021 Principles fo Drug Action
PMY2026 Biochemistry and Molecular Biology
PMY3027 Applied Biotechnology and Regulatory Affairs (Module Co-ordinator)
PMY3028 Biological Approaches to Disease Prevention and Treatment
Distance Learning Supervisor
PG Diploma in Clinical Pharmacy
MSc Clinical Pharmacy
Postgraduate Courses within SMDBS
MSc(Res) Cancer Medicine
MSc Molecular Pathology of Cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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R2652CNR: High Parameter Flow Cytometry in Health and Disease - Full application
Small, D. (PI), Buckley, N. (CoI), Fitzgerald, D. (CoI), Guzman de la Fuente, A. (CoI), Ingram, B. (CoI), Kerr, E. (CoI) & Longley, D. (CoI)
28/10/2019 → …
Project: Research
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A SRC-slug-TGFβ2 signaling axis drives poor outcomes in triple-negative breast cancers
Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S., McIntyre, A. J., Haddock, P., Sharifova, M., Branco, C. M. & Mullan, P. B., 26 Sept 2024, In: Cell communication and signaling : CCS. 22, 16 p., 454.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
Development and characterization of a peptide-bisphosphonate nanoparticle for the treatment of breast cancer
Glass, K., Fines, C., Coulter, P., Jena, L., McCarthy, H. O. & Buckley, N., 07 Oct 2024, In: Molecular Pharmaceutics. 21, 10, p. 4970-4982 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Embryo movement is required for limb tendon maturation
Rolfe , R. A., Busturkmen , E. T., Sliney, L., Hayden, G., Dunne, N., Buckley, N., McCarthy, H., Szczesny, S. E. & Murphy, P., 05 Nov 2024, In: Frontiers in Cell and Developmental Biology. 12, 16 p., 1466872.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Downloads (Pure) -
Exploring retrograde trafficking: mechanisms and consequences in cancer and disease
Bingham, R., McCarthy, H. & Buckley, N., Feb 2024, In: Traffic. 25, 2, 15 p., e12931.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)36 Downloads (Pure) -
Structural determinants of tendon multiscale mechanics and their sensitivity to mechanical stimulation during development in an embryonic chick model
Peterson, B. E., Canonicco Castro, M. L., McCarthy, H. O., Buckley, N., Dunne, N., Rolfe, R. A., Murphy, P. & Szczesny, S. E., 10 Oct 2024, (Early online date) In: Acta Biomaterialia.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Prizes
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All Ireland Researcher of the Year
Buckley, N. (Recipient), 2012
Prize: Prize (including medals and awards)
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JD Williamson Prize for Research
Buckley, N. (Recipient), 2011
Prize: Prize (including medals and awards)
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Activities
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The clinical and molecular significance of STING in breast cancer
Buckley, N. (Advisor)
16 Feb 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Nanomedicine based delivery of Bisphosphonates for the treatment of early and advanced Breast Cancer
Buckley, N. (Advisor)
24 Jun 2021Activity: Talk or presentation types › Invited talk
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Frontiers in Oncology (Journal)
Buckley, N. (Reviews editor)
Apr 2021 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Cancers (Journal)
Buckley, N. (Reviews editor)
Apr 2021 → …Activity: Publication peer-review and editorial work types › Editorial activity
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57th Irish Association for Cancer Research Conference 2021
Buckley, N. (Organiser)
24 Mar 2021 → 26 Mar 2021Activity: Participating in or organising an event types › Participation in conference
Press/Media
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Facebook Live Event: Triple Negative Breast Cancer
24/05/2021
1 Media contribution
Press/Media: Public Engagement Activities
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Breakthrough' for triple negative breast cancer patients
10/04/2019
1 item of Media coverage
Press/Media: Public Engagement Activities
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Queen's University breast cancer discovery paves way for improved treatment
10/04/2019
1 item of Media coverage
Press/Media: Public Engagement Activities
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Thousands of women with deadliest form of breast cancer could be saved by a simple test that could tell doctors in 24 hours how well they will respond to chemotherapy
10/04/2019
1 item of Media coverage
Press/Media: Public Engagement Activities