Projects per year
Personal profile
Research Statement
Dr Niamh Buckley graduated from Trinity College, Dublin in 2002 with a First Class Honours Degree in Biochemistry. She then carried out her Ph.D. training in the Department of Oncology (Queen’s University Belfast) under the supervision of Prof. Paul Harkin. Following this, she then worked as a post-doctoral researcher with Dr Paul Mullan in the Centre for Cancer Research and Cell Biology (Queen’s University Belfast). During this time, she investigated the role of the breast and ovarian tumour suppressor gene, BRCA1, in stem cell regulation and mammary gland differentiation.
Dr Buckley was awarded the prestigious Breast Cancer Now fellowship in 2013 to develop novel biomarkers and therapeutic strategies in BRCA1-mutant and/or triple negative breast cancer. In 2016 she was appointed as a Lecturer in Personalised Medicine and Pharmacogenomics in the School of Pharmacy (Queen’s University Belfast). She was then promoted to Senior Lecturer in 2020 and is an active member of the Nanomedicine and Biotherapeutics Cluster. Dr Buckley is also an associate member of the Patrick G Johnson Centre for Cancer Research (PGJCCR) at QUB. Her research focuses on the integration of in vitro, in vivo, bioinformatics and pathology approaches to identify key pathways underpinning poor outcome breast cancer and use detailed knowledge of this biology to identify appropriate targeted treatment options, personalising therapy in an area of unmet clinical need.
Achievements
Dr Buckley has secured ~£5 million in competitive grant income from national and international funding boards in the last 2 years with >£750,000 as PIand has published in over 30 articles in leading Q1 journals with over 1100 citations. Her knowledge and expertise have been recognised by invitations to speak at national and international conferences and membership of the Breast Cancer Now Grant Review Committee and Tissue Access Committee. She has also been the recipient of several prestigious awards including European Association of Cancer Research (EACR) Young Scientist Award (2012), Roche Gold Medal Award (2011) and School of Medicine, Dentistry and Biomedical Sciences Post-Doctoral Researcher of the Year (2012).
Research Interests
Breast Cancer
Triple Negative Breast Cancer
BRCA1
Ovarian Cancer
Personalised Medicine
Targeted Treatments
Biomarkers
Teaching
Contributes to the following modules:
MPharm Degree
PMY3176 Advanced Delivery Systems for Large and Small Molecules (Module Co-ordinator)
PMY4005 Research Project
PMY4107 Advanced Pharmaceutical Care
BSc Pharmaceutical Sciences
PMY2021 Principles of Drug Action
PMY3176 Advanced Delivery Systems for Large and Small Molecules (Module Co-ordinator)
BSc Pharmaceutical Biotechnology
PMY2021 Principles fo Drug Action
PMY2026 Biochemistry and Molecular Biology
PMY3027 Applied Biotechnology and Regulatory Affairs (Module Co-ordinator)
PMY3028 Biological Approaches to Disease Prevention and Treatment
Distance Learning Supervisor
PG Diploma in Clinical Pharmacy
MSc Clinical Pharmacy
Postgraduate Courses within SMDBS
MSc(Res) Cancer Medicine
MSc Molecular Pathology of Cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
Projects
- 1 Active
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R2652CNR: High Parameter Flow Cytometry in Health and Disease - Full application
Small, D., Buckley, N., Fitzgerald, D., Guzman de la Fuente, A., Ingram, B., Kerr, E. & Longley, D.
28/10/2019 → …
Project: Research
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Fusobacterium nucleatum: a novel immune modulator in breast cancer?
Little, A., Tangney, M., Tunney, M. M. & Buckley, N. E., 03 Apr 2023, In: Expert Reviews in Molecular Medicine. 25, 10 p., e15.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Downloads (Pure) -
PharmaCast: The International Postgraduate Experience
Corbett, D., Coulter, J., Buckley, N. E., Li, H. & Shambharkar, A., 03 May 2023Research output: Non-textual form › Digital or Visual Products
Open AccessFile4 Downloads (Pure) -
Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer
Parkes, E. E., Savage, K. I., Lioe, T., Boyd, C., Halliday, S., Walker, S. M., Lowry, K., Knight, L., Buckley, N. E., Grogan, A., Logan, G. E., Clayton, A., Hurwitz, J., Kirk, S. J., Xu, J., Sidi, F. A., Humphries, M. P., Bingham, V., Ang, M., Askin, C., & 25 others , 01 Feb 2022, In: British Journal of Cancer. 126, 2, p. 247-258 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile84 Downloads (Pure) -
Nucleic acid vaccination strategies for ovarian cancer
Saha, C., Bojdo, J., Dunne, N. J., Duary, R. K., Buckley, N. E. & McCarthy, H. O., 07 Nov 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 953887.Research output: Contribution to journal › Article › peer-review
Open AccessFile67 Downloads (Pure) -
PDLIM2 is highly expressed in breast cancer tumour-associated macrophages and is required for M2 macrophage polarization
Cox, O. T., O’Sullivan, N., Tresse, E., Ward, S., Buckley, N. & O’Connor, R., 30 Nov 2022, (Early online date) In: Frontiers in Oncology. 12, 1028959.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure)
Prizes
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All Ireland Researcher of the Year
Buckley, Niamh (Recipient), 2012
Prize: Prize (including medals and awards)
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CCRCB Researcher of the Year
Buckley, Niamh (Recipient), 2012
Prize: Prize (including medals and awards)
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JD Williamson Prize for Research
Buckley, Niamh (Recipient), 2011
Prize: Prize (including medals and awards)
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Activities
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The clinical and molecular significance of STING in breast cancer
Niamh Buckley (Advisor)
16 Feb 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Nanomedicine based delivery of Bisphosphonates for the treatment of early and advanced Breast Cancer
Niamh Buckley (Advisor)
24 Jun 2021Activity: Talk or presentation types › Invited talk
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Cancers (Journal)
Niamh Buckley (Reviews editor)
Apr 2021 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Frontiers in Oncology (Journal)
Niamh Buckley (Reviews editor)
Apr 2021 → …Activity: Publication peer-review and editorial work types › Editorial activity
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57th Irish Association for Cancer Research Conference
Niamh Buckley (Organiser)
24 Mar 2021 → 26 Mar 2021Activity: Participating in or organising an event types › Participation in conference
Press/Media
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Facebook Live Event: Triple Negative Breast Cancer
24/05/2021
1 Media contribution
Press/Media: Public Engagement Activities
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Queen's University breast cancer discovery paves way for improved treatment
10/04/2019
1 item of Media coverage
Press/Media: Public Engagement Activities
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Breakthrough' for triple negative breast cancer patients
10/04/2019
1 item of Media coverage
Press/Media: Public Engagement Activities
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Thousands of women with deadliest form of breast cancer could be saved by a simple test that could tell doctors in 24 hours how well they will respond to chemotherapy
10/04/2019
1 item of Media coverage
Press/Media: Public Engagement Activities