Niamh Buckley

2024

A SRC-slug-TGFβ2 signaling axis drives poor outcomes in triple-negative breast cancers

Angel, C. Z., Beattie, S., Hanif, E. A. M., Ryan, M. P., Guerra Liberal, F. D. C., Zhang, S.-D., Monteith, S., Buckley, N. E., Parker, E., Haynes, S., McIntyre, A. J., Haddock, P., Sharifova, M., Branco, C. M. & Mullan, P. B., 26 Sept 2024, In: Cell communication and signaling : CCS. 22, 16 p., 454.

Research output: Contribution to journal › Article › peer-review

Open Access

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30 Downloads (Pure)

Development and characterization of a peptide-bisphosphonate nanoparticle for the treatment of breast cancer

Glass, K., Fines, C., Coulter, P., Jena, L., McCarthy, H. O. & Buckley, N., 07 Oct 2024, In: Molecular Pharmaceutics. 21, 10, p. 4970-4982 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

6 Downloads (Pure)

Embryo movement is required for limb tendon maturation

Rolfe , R. A., Busturkmen , E. T., Sliney, L., Hayden, G., Dunne, N., Buckley, N., McCarthy, H., Szczesny, S. E. & Murphy, P., 05 Nov 2024, In: Frontiers in Cell and Developmental Biology. 12, 16 p., 1466872.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

69 Downloads (Pure)

Exploring retrograde trafficking: mechanisms and consequences in cancer and disease

Bingham, R., McCarthy, H. & Buckley, N., Feb 2024, In: Traffic. 25, 2, 15 p., e12931.

Research output: Contribution to journal › Review article › peer-review

Open Access

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2 Citations (Scopus)

46 Downloads (Pure)

Identification and characterisation of nucleotide vaccine targets for HPV negative head and neck squamous cell carcinoma

Jiang, B., Buckley, N. E., Coulter, J., Dunne, N. J. & McCarthy, H., 27 Jan 2024.

Research output: Contribution to conference › Paper › peer-review

Structural determinants of tendon multiscale mechanics and their sensitivity to mechanical stimulation during development in an embryonic chick model

Peterson, B. E., Canonicco Castro, M. L., McCarthy, H. O., Buckley, N., Dunne, N., Rolfe, R. A., Murphy, P. & Szczesny, S. E., 10 Oct 2024, (Early online date) In: Acta Biomaterialia.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Synthesis and characterisation of a nucleotide based pro-drug formulated with a peptide into a nano-chemotherapy for colorectal cancer

Wilson, J. J., Bennie, L., Eguaogie, O., Elkashif, A., Conlon, P. F., Jena, L., McErlean, E., Buckley, N., Englert, K., Dunne, N. J., Tucker, J. H. R., Vyle, J. S. & McCarthy, H. O., May 2024, In: Journal of Controlled Release. 369, p. 63-74 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

32 Downloads (Pure)

2023

4D printed multipurpose smart implants for breast cancer management

Moroni, S., Bingham, R., Buckley, N., Casettari, L. & Lamprou, D. A., 25 Jul 2023, In: International Journal of Pharmaceutics. 642, 11 p., 123154.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

52 Downloads (Pure)

Development of a DNA vaccine for ovarian cancer

Saha, C., Elkashif, A., Buckley, N. E., Druary , R., Dunne, N. J. & McCarthy, H., 10 Jun 2023.

Research output: Contribution to conference › Poster › peer-review

Fusobacterium nucleatum: a novel immune modulator in breast cancer?

Little, A., Tangney, M., Tunney, M. M. & Buckley, N. E., 03 Apr 2023, In: Expert Reviews in Molecular Medicine. 25, 10 p., e15.

Research output: Contribution to journal › Review article › peer-review

Open Access

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16 Citations (Scopus)

407 Downloads (Pure)

Peptide delivery of a multivalent mRNA SARS-CoV-2 vaccine

McCrudden, C. M., Bennie, L., Chambers, P., Wilson, J., Kerr, M., Ziminska, M., Douglas, H., Kuhn, S., Carroll, E., O'Brien, G., Buckley, N., Dunne, N. J. & McCarthy, H. O., Oct 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 362, p. 536-547 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

52 Downloads (Pure)

Personalised pharmacy: embedding pharmacogenomics in the curriculum

Murray, C., Burden, R., Buckley, N. E. & Hanna, L.-A., 07 Nov 2023.

Research output: Contribution to conference › Poster › peer-review

File

55 Downloads (Pure)

PharmaCast: International Womens' Day 2023

Corbett, D. (Producer), Buckley, N. E. & Magee, E., 07 Mar 2023

Research output: Non-textual form › Digital or Visual Products

Open Access

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14 Downloads (Pure)

PharmaCast: The International Postgraduate Experience

Corbett, D. (Producer), Coulter, J., Buckley, N. E., Li, H. & Shambharkar, A., 03 May 2023

Research output: Non-textual form › Digital or Visual Products

Open Access

File

28 Downloads (Pure)

2022

Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

Parkes, E. E., Savage, K. I., Lioe, T., Boyd, C., Halliday, S., Walker, S. M., Lowry, K., Knight, L., Buckley, N. E., Grogan, A., Logan, G. E., Clayton, A., Hurwitz, J., Kirk, S. J., Xu, J., Sidi, F. A., Humphries, M. P., Bingham, V., Ang, M. & Askin, C. & 25 others, Bamford, L., Boyd, R., Buckley, M., Clarke, J., Darragh, L., Davis, E., Foreman, J., Gallagher, R., Gill, J., Hanna, M., Hill, N., Irwin, G., Mallon, P., McAleer, S., McAllister, J., Morris, M., Pierce, N., Refsum, S., Sloan, S., Treanor, S., James, J., James, C. R., Paul Harkin, D., Kennedy, R. D. & McIntosh, S. A., 01 Feb 2022, In: British Journal of Cancer. 126, 2, p. 247-258 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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20 Citations (Scopus)

130 Downloads (Pure)

Development of a DNA vaccine for ovarian cancer

Saha, C., Elkashif, A., Buckley, N. E., Dunne, N. J. & McCarthy, H., 07 Sept 2022.

Research output: Contribution to conference › Poster › peer-review

Nucleic acid vaccination strategies for ovarian cancer

Saha, C., Bojdo, J., Dunne, N. J., Duary, R. K., Buckley, N. E. & McCarthy, H. O., 07 Nov 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 953887.

Research output: Contribution to journal › Review article › peer-review

Open Access

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3 Citations (Scopus)

112 Downloads (Pure)

PDLIM2 is highly expressed in breast cancer tumour-associated macrophages and is required for M2 macrophage polarization

Cox, O. T., O’Sullivan, N., Tresse, E., Ward, S., Buckley, N. & O’Connor, R., 30 Nov 2022, (Early online date) In: Frontiers in Oncology. 12, 1028959.

Research output: Contribution to journal › Article › peer-review

Open Access

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44 Downloads (Pure)

Precision medicine and novel therapeutic strategies in detection and treatment of cancer: highlights from the 58th IACR Annual Conference

Kennedy, S. P., Treacy, O., Allott, E. H., Eustace, A. J., Lynam-Lennon, N., Buckley, N. & Robson, T., 16 Dec 2022, In: Cancers. 14, 24, 6213.

Research output: Contribution to journal › Article › peer-review

Open Access

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37 Downloads (Pure)

TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers

McIntyre, A. J., Angel, C. Z., Smith, J. S., Templeman, A., Beattie, K., Beattie, S., Ormrod, A., Devlin, E., McGreevy, C., Bothwell, C., Eddie, S. L., Buckley, N. E., Williams, R. & Mullan, P. B., 24 Jun 2022, In: Nucleic Acids Research. 50, 11, p. 6154–6173 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

100 Downloads (Pure)

2021

Characterisation of Cathepsin S as a novel therapeutic target in Triple Negative Breast Cancer.

McDowell, S., Burden, R., Buckley, N. E. & Scott, C., Mar 2021.

Research output: Contribution to conference › Poster

Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme

Jena, L. N., Bennie, L. A., McErlean, E. M., Pentlavalli, S., Glass, K., Burrows, J. F., Kett, V. L., Buckley, N. E., Coulter, J. A., Dunne, N. J. & McCarthy, H. O., 04 May 2021, In: Journal of Nanobiotechnology. 19, 1, p. 127

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

126 Downloads (Pure)

Investigating the role of Cathepsin S in Triple-Negative Breast Cancer.

McDowell, S., Glass, K., Coulter, P., Burden, R., Buckley, N. E. & Scott, C., Feb 2021.

Research output: Contribution to conference › Poster

Investigating the role of Cathepsin S in Triple-Negative Breast Cancer.

McDowell, S., Glass, K., Coulter, P., Burden, R., Buckley, N. E. & Scott, C., Mar 2021.

Research output: Contribution to conference › Poster

RALA Peptide: An Intelligent pH-Responsive Gene Delivery Vector

Shen, Y., McErlean, E., Buckley, N. E. & McCarthy, H., 09 Sept 2021.

Research output: Contribution to conference › Poster › peer-review

Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery

McErlean, E. M., Ziminska, M., McCrudden, C. M., McBride, J. W., Loughran, S. P., Cole, G., Mulholland, E. J., Kett, V., Buckley, N. E., Robson, T., Dunne, N. J. & McCarthy, H. O., 10 Feb 2021, In: Journal of Controlled Release. 330, p. 1288-1299 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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42 Citations (Scopus)

495 Downloads (Pure)

The clinical and molecular significance associated with STING signaling in breast cancer

Parkes, E. E., Humphries, M. P., Gilmore, E., Sidi, F. A., Bingham, V., Phyu, S. M., Craig, S., Graham, C., Miller, J., Griffin, D., Salto-Tellez, M., Madden, S., Kennedy, R. D., Bakhoum, S. F., McQuaid, S. & Buckley, N. E., 25 Jun 2021, In: npj Breast Cancer. 7, 1, 11 p., 81.

Research output: Contribution to journal › Article › peer-review

Open Access

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25 Citations (Scopus)

93 Downloads (Pure)

2020

Assessment of PDL-1 Expression by Digital Pathology demonstrates prognostic significance for overall survival in Triple Negative Breast Cancer and a novel association with overall survival in ER-/Her2+ breast cancer.

James, J., Humphries, M., Craig, S., Bingham, V., McQuaid, S. & Buckley, N. E., 2020.

Research output: Contribution to conference › Poster › peer-review

Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

Haughey, C. M., Mukherjee, D., Steele, R. E., Popple, A., Dura-Perez, L., Pickard, A., Jain, S., Mullan, P. B., Williams, R., Oliveira, P., Buckley, N. E., Honeychurch, J., Williams, R., McDade, S., Illidge, T., Mills, I. G. & Eddie, S. L., 2020

Research output: Other contribution

Open Access

Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer

Elkashif, A., Bingham, V., Haddock, P., Humphries, M., McQuaid, S., Mullan, P., McCarthy, H. & Buckley, N. E., 20 May 2020, In: Journal of Oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

103 Downloads (Pure)

Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

Haughey, C. M., Mukherjee, D., Steele, R. E., Popple, A., Dura-Perez, L., Pickard, A., Patel, M., Jain, S., Mullan, P. B., Williams, R., Oliveira, P., Buckley, N. E., Honeychurch, J., S McDade, S., Illidge, T., Mills, I. G. & Eddie, S. L., 29 Sept 2020, In: Cancers. 12, 10, 2804.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

120 Downloads (Pure)

Pin1 plays a key role in the response to treatment and clinical outcome in Triple Negative Breast Cancer

Knowlson, C., Coulter, P., Bingham, V., McQuaid, S., Mullan, P. & Buckley, N. E., 09 Mar 2020, (Early online date) In: Therapeutic Advances in Medical Oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Trastuzumab cardiotoxicity in HER2-positive breast cancer patients in tertiary health care center, sultanate of Oman

Abd Alghafar, D., Younos, I., Al Baimani, K., Al-Salhi, D., Al-Riyami, A., Rizvi, S. & Buckley, N. E., 27 Apr 2020, (Early online date) In: Journal of Oncology Pharmacy Practice.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

367 Downloads (Pure)

2019

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In: Journal of Oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

23 Citations (Scopus)

218 Downloads (Pure)

Cathepsin V modulates the GATA3-FOXA1-ER axis in ER+ breast cancer.

Sereesongsaeng, N., Buckley, N. E., Scott, C. & Burden, R., Feb 2019.

Research output: Contribution to conference › Poster

Characterisation of Cathepsin S in Triple Negative Breast Cancer.

McDowell, S., Burden, R., Buckley, N. E. & Scott, C., Mar 2019.

Research output: Contribution to conference › Poster

Defining the molecular evolution of extrauterine high grade serous carcinoma

Beirne, J. P., McArt, D. G., Roddy, A., McDermott, C., Ferris, J., Buckley, N. E., Coulter, P., McCabe, N., Eddie, S. L., Dunne, P. D., O'Reilly, P., Gilmore, A., Feeney, L., Ewing, D. L., Drapkin, R. I., Salto-Tellez, M., Kennedy, R. D., Harley, I. J. G., McCluggage, W. G. & Mullan, P. B., 04 Sept 2019, In: Gynecologic Oncology. 155, 2, p. 305-317 13 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Exploring the Potential of MicroRNA Let-7c as a Therapeutic for Prostate Cancer

Mulholland, E. J., Green, W. P., Buckley, N. E. & McCarthy, H. O., 22 Oct 2019, In: Molecular Therapy Nucleic Acids. 18, p. 927-937 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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20 Citations (Scopus)

125 Downloads (Pure)

Facilitating Professional Development and Networking Opportunities for Staff and Students in the School of Pharmacy

McGuckin, A., McCague, P., Lamprou, D., Hanna, L.-A., Al-Jamal, W., Coulter, J., Craig, R., Buckley, N. E. & Hall, M., 09 Sept 2019.

Research output: Contribution to conference › Poster

Investigation of the pharmacological inhibition of HDAC6 with ricolinostat

Zhang, F., Maguire, A., Abdunnabi Ali, A., Tikhonova, I., Buckley, N. E. & Furlong, F., 09 Oct 2019.

Research output: Contribution to conference › Poster › peer-review

NUP98 – a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

Mullan, P. B., Bingham, V., Haddock, P., Irwin, G. W., Kay, E., McQuaid, S. & Buckley, N. E., 02 Apr 2019, In: BMC Cancer. 19, 13 p., 236.

Research output: Contribution to journal › Article › peer-review

Open Access

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14 Citations (Scopus)

232 Downloads (Pure)

PDLIM2 is a marker of adhesion and β-catenin activity in triple-negative breast cancer

Cox, O., Edmunds, S., Simon-Keller, K., Li, B., Moran, B., Buckley, N. E., Bustamante-Garrido, M., Healy, N., O'Flanagan, C. H., Gallagher, W. M., Kennedy, R., Bernards, R., Caldos, C., Chin, S.-F., Marx, A. & O'Connor, R., 18 Mar 2019, In: Cancer Research. 79, 10, p. 2619

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

156 Downloads (Pure)

TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells

Crawford, N. T., McIntyre, A. J., McCormick, A. J., D'Costa, Z. C., Buckley, N. E. & Mullan, P. B., 28 Jun 2019, In: Oncogene. 38, p. 5971

Research output: Contribution to journal › Article › peer-review

Open Access

File

40 Citations (Scopus)

187 Downloads (Pure)

The Evolution of Epigenetic Biomarkers: Methylation and similar DNA biomarkers, combined with liquid biopsy, may offer better testing options for difficult cancers

Buckley, N. E., Feeney, L., Beirne, J. & Mullan, P., 02 Jan 2019, The Pathologist.

Research output: Other contribution

Unravelling the Role of Cathepsin S in DNA Damage Repair Deficient Tumours

Gallaher, S., Wilkinson, R., Buckley, N. E., Burden, R., Williams, R. & Scott, C., Feb 2019.

Research output: Contribution to conference › Poster

2018

Assessment of PD-L1 Expression by Digital Pathology demonstrates prognostic significance for overall survival in Triple Negative Breast Cancer and a novel association with overall survival in ER-/HER+ breast cancer.

Humphries, M., Craig, S., Bingham, V., McQuaid, S., James, J., Buckley, N. E. & Salto-Tellez, M., 2018, (Unpublished).

Research output: Contribution to conference › Poster › peer-review

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

Humphries, M., Hynes, S., Bingham, V., Cougot, D., James, J., Patel-Socha, F., Parkes, E., Blayney, J., O'Rorke, M., Irwin, G., McArt, D., Kennedy, R., Mullan, P., McQuaid, S., Salto-Tellez, M. & Buckley, N. E., 17 Dec 2018, In: Journal of Oncology. 2018, 14 p., 2937012.

Research output: Contribution to journal › Article › peer-review

Open Access

File

44 Citations (Scopus)

393 Downloads (Pure)

Developing a Personalised Medicine Approach for Triple Negative Breast Cancer: The Role of the Glucocorticoid Receptor in response to Chemotherapy

Elkashif, A., Haddock, P., Donnelly, S., McQuaid, S., McCarthy, H. & Buckley, N. E., 2018, (Unpublished).

Research output: Contribution to conference › Poster

Dual mechanisms of LYN kinase dysregulation drive aggressive behaviour in breast cancer cells

Tornillo, G., Knowlson, C., Kendrick, H., Cooke, J., Mirza, H., Aurrekoetxea-Rodriguez, I., d.M Vivanco, M., Buckley, N. E., Grigoriadis, A. & Smalley, M. J., 26 Dec 2018, In: Cell Reports. 25, 13, p. 3674-3692.e10

Research output: Contribution to journal › Article › peer-review

Open Access

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38 Citations (Scopus)

275 Downloads (Pure)

Personalising the Fight against Triple Negative Breast Cancer

Elkashif, A., McCarthy, H. O. & Buckley, N. E., 12 Jul 2018, In: Journal of Breast Cancer Research and Advancements. 1, 1, 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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3790 Downloads (Pure)

Niamh Buckley

Research output

Search results