• Room 03.013 - CCRCB

    United Kingdom

20092020

Research output per year

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Research Output

2020

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
27 Downloads (Pure)
2019
Open Access
File
1 Citation (Scopus)
48 Downloads (Pure)
2018

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

McCann, C., Crawford, N., Majkut, J., Holohan, C., Armstrong, C., Maxwell, P., Ong, C. W., LaBonte Wilson, M., McDade, S., Waugh, D. & Longley, D., 22 Oct 2018, In : Cell, Death & Disease. 9, 1081, 13 p., 1081.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
174 Downloads (Pure)

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

Crawford, N., Salvucci, M., Hellwig, C. T., Lincoln, F. A., Mooney, R. E., O’Connor, C. L., Prehn, J. HM., Longley, D. B. & Rehm, M., 02 Mar 2018, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
119 Downloads (Pure)
2016

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
188 Downloads (Pure)

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

Armstrong, C. W. D., Maxwell, P. J., Ong, C. W., Redmond, K. M., McCann, C., Neisen, J., Ward, G. A., Chessari, G., Johnson, C., Crawford, N. T., LaBonte, M. J., Prise, K. M., Robson, T., Salto-Tellez, M., Longley, D. B. & Waugh, D. J. J., 20 Jan 2016, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
374 Downloads (Pure)
2015

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

Carson, R., Celtikci, B., Fenning, C., Javadi, A., Crawford, N., Perez Carbonell, L., Lawler, M., Longley, D. B., Johnston, P. G. & Van Schaeybroeck, S., 15 Jul 2015, In : Clinical Cancer Research. 21, 14, p. 3230-3240 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2014

Rational targeting of Inhibitor of Apoptosis Proteins (IAPs)for effective therapy of colorectal cancer

Crawford, N. T., Dunne, P. D., Johnston, P. G., Waugh, D. J. & Longley, D. B., 01 Oct 2014, In : Cancer Research. 74, Suppl 19, 2290.

Research output: Contribution to journalMeeting abstract

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
210 Downloads (Pure)
2013
Open Access
File
19 Citations (Scopus)
397 Downloads (Pure)
2012

Rational targeting of Inhibitor of Apoptosis Proteins for effective therapy of malignant pleural mesothelioma

Crawford, N., Holohan, C., Waugh, D. & Longley, D., Nov 2012, In : European Journal of Cancer. 48, p. 26

Research output: Contribution to journalMeeting abstract

2011

BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers

Tkocz, D., Crawford, N., Buckley, N. E., Berry, F. B., Kennedy, R., Miskelly, J., Harkin, P. & Mullan, P., 09 Dec 2011, In : Oncogene. 531, 32, p. 3667-3678 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis

Crawford, N., Chacko, A. D., Savage, K. I., McCoy, F., Redmond, K., Longley, D. B. & Fennell, D. A., Mar 2011, In : Apoptosis. 16, 3, p. 311-320 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The Delta Np63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer

Buckley, N., Conlon, S., Jirstrom, K., Kay, E. W., Crawford, N., O'Grady, A., Sheehan, K., McDade, S., Wang, C-W., McCance, D., Johnston, P., Kennedy, R., Harkin, P. & Mullan, P., 01 Mar 2011, In : Cancer Research. 71, 5, p. 1933-1944 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2010

BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription

Harte, M. T., O'Brien, G. J., Ryan, N. M., Gorski, J. J., Savage, K. I., Crawford, N. T., Mullan, P. B. & Harkin, D. P., 15 Mar 2010, In : Cancer Research. 70, 6, p. 2538-2547 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells

Redmond, K. L., Crawford, N., Farmer, H., D'Costa, Z. C., O'Brien, G. J., Buckley, N., Kennedy, R., Johnston, P., Harkin, P. & Mullan, P., 03 Jun 2010, In : Oncogene. 29, 22, p. 3252-3262 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2009

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing

Wilson, T., Redmond, K., McLaughlin, K., Crawford, N., Gately, K., O'Byrne, K., Le-Clorrenec, C., Holohan, C., Fennell, D., Johnston, P. & Longley, D., 2009, In : Cell Death and Differentiation. 16, 10, p. 1352-1361 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)