Personal profile
Research Focus
My research focuses on the application of 'omic technologies to investigate pathology in complex tissues and biofluids, particularly in diabetes, and age-related degenerative conditions such as Alzheimer's disease, Down syndrome and Multiple Sclerosis. I have experience in the generation and bioinformatic analysis of single-cell RNA sequencing data, bulk transcriptomics, proteomics, and epigenetics. These projects give me the opportunity to collaborate with clinicians such as Professor Tunde Peto and practicioners from University of Ulster including Professor Julie-Anne Lyttle.
Keywords
- RE Ophthalmology
- Diabetic retinopathy
- Macular degeneration
- Down syndrome
- Alzheimer's disease
- Multiple sclerosis
- RZ Other systems of medicine
- Genomics
- Transcriptomics
- Proteomics
- Epigenetics
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Collaborations and top research areas from the last five years
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Deep phenotyping of a modified diabetic cardiomyopathy mouse model which reflects clinical disease progression
Karuna, N., Kerrigan, L., Edgar, K., Cappa, O., Simpson, D., Tonry, C., Grieve, D. J. & Watson, C. J., 14 Aug 2025, In: Diabetology and Metabolic Syndrome. 17, 16 p., 334.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)8 Downloads (Pure) -
Interferon mediated bronchial epithelium cellular senescence in chronic obstructive pulmonary disease
Guo-Parke, H., Cappa, O., Linden, D. A., Barksby, B. S., Burgoyne, R. A., Borthwick, L. A., Fisher, A. J., Weldon, S., Simpson, D. A., Taggart, C. C. & Kidney, J. C., 17 Jun 2025, (Early online date) In: American Journal of Respiratory Cell and Molecular Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)143 Downloads (Pure) -
ISG15 signalling promotes coronary microvascular endothelial dysfunction in experimental diabetes
Alsaggaf, M., Kerrigan, L., Edgar, K., Karuna, N., O'Neill, K. M., Pun, S. H., Cappa, O. & Watson, C., Jun 2024, In: Heart (British Cardiovascular Society). 110, Suppl 3, p. A249 1 p., BS08.Research output: Contribution to journal › Meeting abstract › peer-review
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Single-cell RNA sequencing reveals cardiac fibroblast-specific transcriptomic changes in dilated cardiomyopathy
Russell-Hallinan, A., Cappa, O., Kerrigan, L., Tonry, C., Edgar, K., Glezeva, N., Ledwidge, M., McDonald, K., Collier, P., Simpson, D. A. & Watson, C. J., May 2024, In: Cells. 13, 9, 14 p., 752.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Link opens in a new tab Citations (Scopus)99 Downloads (Pure) -
Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single-cell RNA sequencing study to understand age-related macular degeneration
Emri, E., Cappa, O., Kelly, C., Kortvely, E., SanGiovanni, J. P., McKay, B. S., Bergen, A. A., Simpson, D. A. & Lengyel, I., 01 Mar 2023, In: Cells. 12, 5, 25 p., 773.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)96 Downloads (Pure)
Activities
- 3 Publication peer-review
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Ophthalmology Science (Journal)
Cappa, O. (Peer reviewer)
06 Jan 2026Activity: Publication peer-review and editorial work types › Publication peer-review
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Ophthalmology Science (Journal)
Cappa, O. (Peer reviewer)
14 Nov 2025Activity: Publication peer-review and editorial work types › Publication peer-review
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Ophthalmology Science (Journal)
Cappa, O. (Peer reviewer)
12 Jun 2025Activity: Publication peer-review and editorial work types › Publication peer-review