• Room 02.007 - CCRCB

    United Kingdom

19962019

Research output per year

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Research Output

2019

High EMSY expression defines a BRCA-like subgroup of high-grade serous ovarian carcinoma with prolonged survival and hypersensitivity to platinum

Hollis, R. L., Churchman, M., Michie, C. O., Rye, T., Knight, L., McCavigan, A., Perren, T., Williams, A. R. W., McCluggage, W. G., Kaplan, R. S., Jayson, G. C., Oza, A., Harkin, D. P., Herrington, C. S., Kennedy, R. & Gourley, C., 15 Aug 2019, In : Cancer. 125, 16, p. 2772-2781 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
69 Downloads (Pure)

Immune Activation by DNA Damage Predicts Response to Chemotherapy and Survival in Oesophageal Adenocarcinoma

Turkington, R., Knight, L., Blayney, J., Secrier, M., Douglas, R., Parkes, E., Sutton, E., Stevenson, L., McManus, D., Halliday, S., McCavigan, A., Logan, G., Walker, S., Steele, C., Perner, J., Bornscein, J., MacRae, S., Miremadi, A., mccarron, E., McQuaid, S. & 10 others, Arthur, K., James, J., Eatock, M., O'Neill, R., Noble, F., Underwood, T., Harkin, D., Salto-Tellez, M., Fitzgerald, R. C. & Kennedy, R., 09 Mar 2019, In : Gut. 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
166 Downloads (Pure)
2018
Open Access
File
121 Downloads (Pure)

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

Bankhead, P., Fernández, J. A., McArt, D. G., Boyle, D. P., Li, G., Loughrey, M. B., Irwin, G. W., Harkin, D. P., James, J. A., McQuaid, S., Salto-Tellez, M. & Hamilton, P. W., Jan 2018, In : Laboratory investigation. 98, p. 15-26

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
524 Downloads (Pure)

The evolutionary landscape of colorectal tumorigenesis

The S:CORT Consortium, 31 Aug 2018, In : Nature Ecology and Evolution. 2, 10, p. 1661-1672 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2017

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Parkes, E. E., Walker, S. M., Taggart, L. E., McCabe, N., Knight, L. A., Wilkinson, R., McCloskey, K., Buckley, N. E., Savage, K. I., Salto-Tellez, M., McQuaid, S., Harte, M. T., Mullan, P. B., Harkin, D. P. & Kennedy, R. D., 01 Jan 2017, In : Journal of the National Cancer Institute. 109, 1

Research output: Contribution to journalArticle

Open Access
File
89 Citations (Scopus)
598 Downloads (Pure)

Association of a DNA damage response deficiency (DDRD) assay with prognosis in resected esophageal and gastric adenocarcinoma

Turkington, R., Knight, L., Douglas, R., Blayney, J., Stevenson, L., McManus, D., McCavigan, A., Walker, S., Bornschein, J., McRae, S., Noble, F., Underwood, T., O'Neill, R., McQuaid, S., Arthur, K., James, J., Eatock, M., Harkin, D., Fitzgerald, R. C. & Kennedy, R., 01 May 2017, In : Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. 35, 15_suppl, p. 4026-4026 1 p., 4026.

Research output: Contribution to journalMeeting abstract

Open Access
File
1 Citation (Scopus)
214 Downloads (Pure)

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

Walker, S. M., Knight, L. A., McCavigan, A. M., Logan, G. E., Berge, V., Sherif, A., Pandha, H., Warren, A. Y., Davidson, C., Uprichard, A., Blayney, J. K., Price, B., Jellema, G. L., Steele, C. J., Svindland, A., McDade, S. S., Eden, C. G., Foster, C., Mills, I. G., Neal, D. E. & 7 others, Mason, M. D., W Kay, E., Waugh, D. J., Harkin, D. P., Watson, R. W., Clarke, N. W. & Kennedy, R. D., 10 Apr 2017, In : European Urology.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
212 Downloads (Pure)

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

Vohhodina, J., Barros, E. M., Savage, A. L., Liberante, F. G., Manti, L., Bankhead, P., Cosgrove, N., Madden, A. F., Harkin, D. P. & Savage, K. I., 03 Nov 2017, In : Nucleic Acids Research. p. 1-18 18 p., gkx1046.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
180 Downloads (Pure)
2016

Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance)

Niedzwiecki, D., Frankel, W. L., Venook, A. P., Ye, X., Friedman, P. N., Goldberg, R. M., Mayer, R. J., Colacchio, T. A., Mulligan, J. M., Davison, T. S., O'Brien, E., Kerr, P., Johnston, P. G., Kennedy, R. D., Harkin, D. P., Schilsky, R. L., Bertagnolli, M. M., Warren, R. S. & Innocenti, F., 18 Jul 2016, In : Journal of Clinical Oncology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
155 Downloads (Pure)

Chemoprevention in BRCA1 Mutation Carriers—A Proof-of-Concept Study

Campbell, A., Savage, K., McIntosh, S. & Harkin, D., May 2016, In : Current Oncology. 23, 3, p. e290 1 p.

Research output: Contribution to journalMeeting abstract

Chemoprevention in BRCA1 Mutation Carriers—A Proof-of-Concept Study

Campbell, A., Savage, K., McIntosh, S. & Harkin, D., May 2016, p. e290. 1 p.

Research output: Contribution to conferencePoster

Delivering a Research-Enabled Multistakeholder Partnership for Enhanced Patient Care at a Population Level: The Northern Ireland Comprehensive Cancer Program

Lawler, M., Gavin, A., Salto-Tellez, M., Kennedy, R. D., Van Schaeybroeck, S., Wilson, R. H., Harkin, D. P., Grayson, M., Boyd, R. E., Hamilton, P. W., McArt, D. G., James, J., Robson, T., Ladner, R. D., Prise, K. M., O'Sullivan, J. M., Harrison, T., Murray, L., Johnston, P. G. & Waugh, D. J., 01 Mar 2016, In : Cancer. 122, 5, p. 664-673 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
298 Downloads (Pure)

Dual roles of DNA repair enzymes in RNA biology/post-transcriptional control

Vohhodina, J., Harkin, D. P. & Savage, K. I., Oct 2016, In : Wiley interdisciplinary reviews. RNA. 7, 5, p. 604-619

Research output: Contribution to journalReview article

12 Citations (Scopus)

Identification of potentially pathogenic variants in candidate breast and ovarian cancer susceptibility genes in BRCAX patients

Savage, A. L., Chenevix-Trench, G., Jun Li, J., McDade, S. S., Morrison, P. J., McIntosh, S. A., Harkin, D. P. & Savage, K. I., Jun 2016, In : Current Oncology. 23, 3, p. e308 1 p., P089.

Research output: Contribution to journalMeeting abstract

Prior knowledge transfer across transcriptional data sets and technologies using compositional statistics yields new mislabelled ovarian cell line

Blayney, J. K., Davison, T., McCabe, N., Walker, S., Keating, K., Delaney, T., Greenan, C., Williams, A. R., McCluggage, W. G., Capes-Davis, A., Harkin, D. P., Gourley, C. & Kennedy, R. D., 28 Jun 2016, In : Nucleic Acids Research. 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
225 Downloads (Pure)

The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription

Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In : Oncotarget. 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
282 Downloads (Pure)
2015

Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression

Stewart, J., James, J., McCluggage, G. W., McQuaid, S., Arthur, K., Boyle, D., Mullan, P., McArt, D., Yan, B., Irwin, G., Harkin, D. P., Zhengdeng, L., Ong, C. W., Yu, J., Virshup, D. M. & Salto-Tellez, M., 01 Mar 2015, In : Modern Pathology . 28, 3, p. 428-436 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

BRCA1, a 'complex' protein involved in the maintenance of genomic stability

Savage, K. I. & Harkin, D. P., Feb 2015, In : The FEBS Journal. 282, 4, p. 630-646 17 p.

Research output: Contribution to journalReview article

56 Citations (Scopus)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

McCabe, N., Hanna, C., Walker, S. M., Gonda, D., Li, J., Wikstrom, K., Savage, K. I., Butterworth, K. T., Chen, C., Harkin, D. P., Prise, K. M. & Kennedy, R. D., 01 Jun 2015, In : Cancer Research. 75, 11, p. 2159-2165 7 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
208 Downloads (Pure)

Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

Buckley, N., Boyle, D., McArt, D., Irwin, G., Harkin, D. P., Lioe, T., McQuaid, S., James, J. A., Maxwell, P., Hamilton, P., Mullan, P. B. & Salto-Tellez, M., 09 Dec 2015, In : Oncotarget. 6, 41, p. 43244-54 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
225 Downloads (Pure)

PICan: An integromics framework for dynamic cancer biomarker discovery

McArt, D. G., Blayney, J. K., Boyle, D. P., Irwin, G. W., Moran, M., Hutchinson, R. A., Bankhead, P., Kieran, D., Wang, Y., Dunne, P. D., Kennedy, R. D., Mullan, P. B., Harkin, D. P., Catherwood, M. A., James, J. A., Salto-Tellez, M. & Hamilton, P. W., 01 Jun 2015, In : Molecular oncology. 9, 6, p. 1234-1240 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

314: BCLAF1; a multi-faceted protein involved DNA repair, apoptosis and autophagy

Barros, E., Savage, K. S. & Harkin, D. P., Jul 2014, In : European Journal of Cancer. 50, Supp 5, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

314: BCLAF1; a multi-faceted protein involved DNA repair, apoptosis and autophagy

Barros, E., Savage, K. S. & Harkin, D. P., Jul 2014, p. S75. 1 p.

Research output: Contribution to conferencePoster

Abstract 1905: Defining a therapeutic classification of breast cancer by actionable targets

Salto-Tellez, M., Boyle, D. P., McArt, D., Irwin, G., Wilhelm-Benartzi, C. C., Lloe, T. G., Minter, M., McQuaid, S., Mullan, P., Kennedy, R. D., Hamilton, P. & Harkin, D. P., 01 Oct 2014, In : Cancer Research. 74, 19 (Suppl), 1905.

Research output: Contribution to journalMeeting abstract

Association between ColDx assay result and recurrence-free interval in stage II colon cancer patients on CALGB (Alliance) 9581

Niedzwiecki, D., Frankel, W., Venook, A. P., Ye, X., Friedman, P. N., Goldberg, R. M., Mayer, R. J., Colacchio, T. A., Kennedy, R., Davison, T., O'Brien, E. J., Mulligan, J., Johnston, P. G., Harkin, D. P., Schilsky, R. L., Bertagnolli, M. M. & Innocenti, F., 20 Jan 2014, In : Journal of Clinical Oncology. 32, 3 (suppl), 1 p.

Research output: Contribution to journalMeeting abstract

BRCA1 as a regulator of global cell metabolism - identifying functional targets through integromic analysis

Powell, A., Savage, K. I. & Harkin, D. P., Jul 2014, p. S77. 1 p.

Research output: Contribution to conferencePoster

BRCA1 as a regulator of global cell metabolism - identifying functional targets through integromic analysis

Powell, A., Savage, K. I. & Harkin, D. P., Jul 2014, In : European Journal of Cancer. 50, 5, p. S77 1 p.

Research output: Contribution to journalMeeting abstract

BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability

Savage, K. I., Matchett, K. B., Barros, E. M., Cooper, K. M., Irwin, G. W., Gorski, J. J., Orr, K. S., Vohhodina, J., Kavanagh, J. N., Madden, A. F., Powell, A., Manti, L., McDade, S. S., Park, B. H., Prise, K. M., McIntosh, S. A., Salto-Tellez, M., Richard, D. J., Elliott, C. T., Harkin, D. P. & 1 others, McDade, S., 15 May 2014, In : Cancer Research. 74, 10, p. 2773-2784 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Identification and Validation of an Anthracycline/Cyclophosphamide–Based Chemotherapy Response Assay in Breast Cancer

Mulligan, J. M., Hill, L. A., Deharo, S., Irwin, G., Boyle, D., Keating, K. E., Raji, O. Y., McDyer, F. A., O'Brien, E., Bylesjo, M., Quinn, J. E., Lindor, N. M., Mullan, P. B., James, C. R., Walker, S. M., Kerr, P., James, J., Davison, T. S., Proutski, V., Salto-Tellez, M. & 4 others, Johnston, P. G., Couch, F. J., Harkin, P. & Kennedy, R. D., 01 Jan 2014, In : Journal of the National Cancer Institute. 106, 1, 10 p., djt335.

Research output: Contribution to journalArticle

Open Access
File
54 Citations (Scopus)
236 Downloads (Pure)

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

Savage, K. I., Gorski, J. J., Barros, E. M., Irwin, G. W., Manti, L., Powell, A. J., Pellagatti, A., Lukashchuk, N., McCance, D. J., McCluggage, W. G., Schettino, G., Salto-Tellez, M., Boultwood, J., Richard, D. J., McDade, S. S. & Harkin, D. P., 08 May 2014, In : Molecular Cell. 54, 3, p. 445-459 15 p.

Research output: Contribution to journalArticle

Open Access
File
85 Citations (Scopus)
248 Downloads (Pure)

NF-κB is a critical mediator of BRCA1-induced chemoresistance

Harte, M. T., Gorski, J. J., Savage, K. I., Purcell, J. W., Barros, E. M., Burn, P. M., McFarlane, C., Mullan, P. B., Kennedy, R. D., Perkins, N. D. & Harkin, D. P., 06 Feb 2014, In : Oncogene. 33, 6, p. 713-723 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
222 Downloads (Pure)

The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer

Boyle, D. P., McArt, D. G., Irwin, G., Wilhelm-Benartzi, C. S., Lioe, T. F., Sebastian, E., McQuaid, S., Hamilton, P. W., James, J. A., Mullan, P. B., Catherwood, M. A., Harkin, D. P. & Salto-Tellez, M., Sep 2014, In : Histopathology. 65, 3, p. 340-352 13 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2013
Open Access
File
21 Citations (Scopus)
406 Downloads (Pure)

Model selection for prognostic time-to-event gene signature discovery with applications in early breast cancer data

Ahdesmaeki, M., Lancashire, L., Proutski, V., Wilson, C., Davison, T. S., Harkin, D. P. & Kennedy, R. D., Oct 2013, In : Statistical applications in genetics and molecular biology. 12, 5, p. 619-635 17 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
281 Downloads (Pure)
2012

Activation of and dependence on ataxia telangiectasia mutated kinase in PTEN-deficient tumor cells

McCabe, N., Walker, S. M., Goffard, N., Wikstrom, K., Greenan, C., McLean, E., McDyer, F. A., Keating, K. E., James, I., Harrison, T., Mullan, P. B., Harkin, D. P., Chen, C. & Kennedy, R. D., 20 May 2012, In : Journal of Clinical Oncology. 30, 15, S, 1 p.

Research output: Contribution to journalMeeting abstract

BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma

Busacca, S., Sheaff, M., Arthur, K., Gray, S. G., O'Byrne, K. J., Richard, D. J., Soltermann, A., Opitz, I., Pass, H., Harkin, D. P., Quinn-O'Brien, J. & Fennell, D. A., Jun 2012, In : Journal of Pathology. 227, 2, p. 200-208 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Deregulated estrogen metabolism in BRCA1 deficient cells induces chromosomal instability.

Matchett, K. B., Savage, K., Cooper, K., Gorski, J., Manti, L., Richard, D., Barros, E., Elliott, C. & Harkin, P., 2012, p. e95. 1 p.

Research output: Contribution to conferenceAbstract

Long-range Transcriptome Sequencing Reveals Cancer Cell Growth Regulatory Chimeric mRNA

Plebani, R., Oliver, G. R., Trerotola, M., Guerra, E., Cantanelli, P., Apicella, L., Emerson, A., Albiero, A., Harkin, P. D., Kennedy, R. D., Alberti, S. & Kennedy, R., Nov 2012, In : Neoplasia . 14, 11, p. 1087-96 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2011

BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers

Tkocz, D., Crawford, N., Buckley, N. E., Berry, F. B., Kennedy, R., Miskelly, J., Harkin, P. & Mullan, P., 09 Dec 2011, In : Oncogene. 531, 32, p. 3667-3678 12 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer.

Harkin, P., Carser, J., Quinn-O'Brien, J., Michie, C. O., O'Brien, E., McCluggage, W. G., Maxwell, P., Lamers-Schmidt, E., Loie, TF., Williams, AR. & Kennedy, R., Dec 2011, In : Gynecologic Oncology. 123(3), 3, p. 492-498 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Development and independent validation of a prognostic assay for stage ii colon cancer using formalin-fixed paraffin-embedded tissue

Kennedy, R., Bylesjo, M., Kerr, D., Davison, T., Black, J. M., Kay, E. W., Holt, R. J., Proutski, V., Ahdesmaki, M., Farztdinov, V., Goffard, N., Hey, P., McDyer, F., Mulligan, K., Mussen, J., O'Brien, E., Oliver, G., Walker, S. M., Mulligan, J., Wilson, C. & 22 others, Winter, A., O'Donoghue, D., Mulcahy, H., O'Sullivan, J., Sheahan, K., Hyland, J., Dhir, R., Bathe, O. F., Winqvist, O., Manne, U., Shanmugam, C., Ramaswamy, S., Leon, E. J., Smith, W. I., McDermott, U., Wilson, R., Longley, D., Marshall, J., Cummins, R., Sargent, D. J., Johnston, P. & Harkin, P., 10 Dec 2011, In : Journal of Clinical Oncology. 29, 35, p. 4620-4626 7 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Establishing a molecular taxonomy for epithelial ovarian cancer (EOC) from 363 formalin-fixed paraffin embedded (FFPE) specimens

Gourley, C., Michie, C. O., Keating, K. E., Deharo, S., O'Brien, E. J., Winter, A., McDyer, F. A., Mulligan, J. M., Hill, L. A., Davison, T. S., Halsey, T., McCoy, L., Wilson, C., Williams, A., Harrison, D. J., Harkin, D. P. & Kennedy, R. D., 20 May 2011, In : Journal of Clinical Oncology. 29, 15_suppl, p. 5000

Research output: Contribution to journalArticle

Identification of a novel breast cancer molecular subgroup associated with a deficiency in DNA-damage response

Mulligan, J. M., Hill, L. A., Deharo, S., McDyer, F. A., Davison, T. S., Bylesjo, M., Lindor, N. M., Galligan, L., Delaney, T., Halfpenny, I. A., Farztdinov, V., Goffard, N., Proutski, V., Keating, K. E., Mullan, P. B., Quinn, J. E., Johnston, P. G., Couch, F. J., Harkin, D. P. & Kennedy, R. D., 20 May 2011, In : Journal of Clinical Oncology. 29, 15_suppl, p. 10511

Research output: Contribution to journalArticle

PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer

Paul, I., Savage, K., Blayney, J., Lamers-Schmidt, E., Gately, K., Kerr, K., Sheaff, M., Arthur, K., Richard, D. J., Hamilton, P., James, J., O'Byrne, K. J., Harkin, P., Quinn, J. E. & Fennell, D., Aug 2011, In : Journal of Pathology. 224, 4, p. 564-574 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis

Gorski, J. J., Savage, K. I., Mulligan, J. M., McDade, S. S., Blayney, J. K., Ge, Z. & Harkin, P., 01 Dec 2011, In : Nucleic Acids Research. 39, 22, p. 9536-9548 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The Delta Np63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer

Buckley, N., Conlon, S., Jirstrom, K., Kay, E. W., Crawford, N., O'Grady, A., Sheehan, K., McDade, S., Wang, C-W., McCance, D., Johnston, P., Kennedy, R., Harkin, P. & Mullan, P., 01 Mar 2011, In : Cancer Research. 71, 5, p. 1933-1944 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2010

Activin B functions downstream of BRCA1 in stem cell maintenance

Murray, M. M., Buckley, N. & Harkin, P., May 2010, In : Breast Cancer Research. 12, 1, p. S3 1 p.

Research output: Contribution to journalMeeting abstract