• Room 03.059 - CEM

    United Kingdom

19952020

Research output per year

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Research Output

2020

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

Roberts, J. Z., Holohan, C., Sessler, T., Fox, J., Crawford, N., Riley, J. S., Khawaja, H., Majkut, J., Evergren, E., Humphreys, L. M., Ferris, J., Higgins, C., Espona-Fiedler, M., Moynagh, P., McDade, S. S. & Longley, D. B., 20 Apr 2020, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)
2019

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

Li, S., Wu, Y., Yang, D., Wu, C., Ma, C., Liu, X., Moynagh, P. N., Wang, B., Hu, G. & Yang, S., 29 Aug 2019, In : Journal of Experimental Medicine.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
123 Downloads (Pure)

IL-15 in autoimmunity and cancer O-tu-b or not O-tu-b?

Moynagh, P. N., 10 Jun 2019, In : Nature Immunology. 20, 7, p. 780-782 3 p.

Research output: Contribution to journalComment/debate

Obesity reduces mTORC1 activity in mucosal-associated invariant T cells, driving defective metabolic and functional responses

O'Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N. A. W., Foley, C., Mat, A., Tinley, F. C., Bannan, C., Sommerville, G., Veerapen, N., Besra, G. S., Sinclair, L. V., Moynagh, P. N., Lynch, L., Finlay, D. K., O'Shea, D. & Hogan, A. E., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3404-3411 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation

Li, J., Ma, C., Long, F., Yang, D., Liu, X., Hu, Y., Wu, C., Wang, B., Wang, M., Chen, Y., Liu, G., Moynagh, P. N., Zhou, J., Peng, T. & Yang, S., 28 Jun 2019, In : iScience. 16, p. 468-484 17 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
30 Downloads (Pure)

Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

Hombrebueno, J. R., Cairns, L., Dutton, L. R., Lyons, T. J., Brazil, D. P., Moynagh, P., Curtis, T. M. & Xu, H., 29 Oct 2019, In : JCI insight.

Research output: Contribution to journalArticle

Open Access
2018

Proteomic Analysis of Dental Pulp Cells Treated With Lipoteichoic Acid

Al-Natour, B., Holland, A., Moynagh, P., About, I., Lundy, F. & El Karim, I., 2018.

Research output: Contribution to conferencePoster

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

Humphries, F., Bergin, R., Jackson, R., Delagic, N., Wang, B., Yang, S., Dubois, A. V., Ingram, R. J. & Moynagh, P. N., 19 Apr 2018, In : Nature Communications. 9, 1, p. 1560 17 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
204 Downloads (Pure)
2017

Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins

Smith, S. M., Freeley, M., Moynagh, P. N. & Kelleher, D. P., 01 Feb 2017, In : Helicobacter. 22, 1, e12325.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Investigating CCN3 in Multiple Sclerosis - Selected for Postdoc Oral Presentation

Naughton, M., Moffat, J., Hawkins, K., Howell, O., De La Vega Gallardo, N., Hogan, A. E., Moynagh, P., Robertson, N., Gran, B. & Fitzgerald, D., 2017.

Research output: Contribution to conferencePoster

MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells

Sulaiman, G., Cooke, A., Ffrench, B., Gasch, C., Abdullai, O. A., O'Connor, K., Elbaruni, S., Blackshields, G., Spillane, C., Keegan, H., McEneaney, V., Knittel, R., Rogers, A., Jeffery, I. B., Doyle, B., Bates, M., d'Adhemar, C., Lee, M. Y., Campbell, E. L., Moynagh, P. N. & 5 others, Higgins, D. G., O'Toole, S., O'Neill, L., O'Leary, J. J. & Gallagher, M. F., 08 Sep 2017, In : Cell Death and Differentiation. 24, 11, p. 1975-1986 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

NF-κB signalling is involved in immune-modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock

O'Keeffe, S. M., Beynon, A. L., Davies, J. S., Moynagh, P. N. & Coogan, A. N., 01 Apr 2017, In : European Journal of Neuroscience. 45, 8, p. 1111-1123

Research output: Contribution to journalArticle

4 Citations (Scopus)

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., Hassan, R., Moffat, J., Falconer, J., Boyd, A., Hamilton, P., Allen, I. V., Kissenpfennig, A., Moynagh, P. N., Evergren, E., Perbal, B. & 5 others, Williams, A. C., Ingram, R. J., Chan, J. R., Franklin, R. J. M. & Fitzgerald, D. C., May 2017, In : Nature Neuroscience. 20, 5, p. 674–680 7 p.

Research output: Contribution to journalArticle

Open Access
File
112 Citations (Scopus)
569 Downloads (Pure)
2016

Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse

Anderson, S. T., Commins, S., Moynagh, P. & Coogan, A. N., 15 Jan 2016, In : Behavioural Brain Research. 297, p. 112-115

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Functional conservation of an ancestral Pellino protein in helminth species

Cluxton, C. D., Caffrey, B. E., Kinsella, G. K., Moynagh, P. N., Fares, M. A. & Fallon, P. G., 29 Jun 2015, In : Scientific Reports. 5, 11 p., 11687.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
149 Downloads (Pure)

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Anderson, S. T., Commins, S., Moynagh, P. N. & Coogan, A. N., Jan 2015, In : Brain, Behavior and Immunity. 43, p. 98-109 12 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity

Humphries, F. & Moynagh, P. N., Jul 2015, In : Immunological Reviews. 266, 1, p. 93-108 16 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions

Mellett, M., Atzei, P., Bergin, R., Horgan, A., Floss, T., Wurst, W., Callanan, J. J. & Moynagh, P. N., 26 Mar 2015, In : Nature Communications. 6, 15 p., 6669.

Research output: Contribution to journalArticle

15 Citations (Scopus)

RIP kinases: key decision makers in cell death and innate immunity

Humphries, F., Yang, S., Wang, B. & Moynagh, P. N., Feb 2015, In : Cell Death and Differentiation. 22, 2, p. 225-36 12 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
2014

Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50

Canavan, M., McCarthy, C., Larbi, N. B., Dowling, J. K., Collins, L., O'Sullivan, F., Hurley, G., Murphy, C., Quinlan, A., Moloney, G., Darby, T., MacSharry, J., Kagechika, H., Moynagh, P., Melgar, S. & Loscher, C. E., 01 Oct 2014, In : Innate Immunity. 20, 7, p. 675-87

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
142 Downloads (Pure)

Epstein-Barr Virus Large Tegument Protein BPLF1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling

van Gent, M., Braem, S. G. E., de Jong, A., Delagic, N., Peeters, J. G. C., Boer, I. G. J., Moynagh, P. N., Kremmer, E., Wiertz, E. J., Ovaa, H., Griffin, B. D. & Ressing, M. E., Feb 2014, In : PLoS Pathogens. 10, 2, p. e1003960 17 p., e1003960.

Research output: Contribution to journalArticle

Open Access
File
60 Citations (Scopus)
207 Downloads (Pure)

Identification of the Flagellin Glycosylation System in Burkholderia cenocepacia and the Contribution of Glycosylated Flagellin to Evasion of Human Innate Immune Responses

Hanuszkiewicz, A., Pittock, P., Humphries, F., Moll, H., Rosales, A. R., Molinaro, A., Moynagh, P. N., Lajoie, G. A. & Valvano, M. A., 04 Jul 2014, In : Journal of Biological Chemistry. 289, p. 19231-19244 14 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
318 Downloads (Pure)

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance

Yang, S., Wang, B., Humphries, F., Hogan, A. E., O'Shea, D. & Moynagh, P. N., 18 Dec 2014, In : Immunity. 41, 6, p. 973-87 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The roles of Pellino E3 ubiquitin ligases in immunity

Moynagh, P. N., Feb 2014, In : Nature reviews. Immunology. 14, 2, p. 122-31 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2013

Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection

O'Shea, D., Corrigan, M., Dunne, M. R., Jackson, R., Woods, C., Gaoatswe, G., Moynagh, P. N., O'Connell, J. & Hogan, A. E., 01 Nov 2013, In : International Journal of Obesity. 37, 11, p. 1510-1513 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15

Doyle, S. L., Shirey, K. A., McGettrick, A. F., Kenny, E. F., Carpenter, S., Caffrey, B. E., Gargan, S., Quinn, S. R., Caamaño, J. H., Moynagh, P., Vogel, S. N. & O'Neill, L. A., 30 Aug 2013, In : The Journal of biological chemistry. 288, 35, p. 25066-75 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-∝

Yang, S., Wang, B., Tang, L. S., Siednienko, J., Callanan, J. J. & Moynagh, P., 11 Oct 2013, In : Nature Communications. 4, 2583, p. 1-19 19 p., 2583.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Yang, S., Wang, B., Humphries, F., Jackson, R., Healey, M. E., Bergin, R., Aviello, G., Hall, B., McNamara, D., Darby, T., Quinlan, A., Shanahan, F., Melgar, S., Fallon, P. G. & Moynagh, P. N., Sep 2013, In : Nature Immunology. 14, 9, p. 927-936iii 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes

Malynn, S., Campos-Torres, A., Moynagh, P. & Haase, J., Apr 2013, In : Neurochemical Research. 38, 4, p. 694-704 11 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2012

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia

Mellett, M., Atzei, P., Horgan, A., Hams, E., Floss, T., Wurst, W., Fallon, P. G. & Moynagh, P. N., Oct 2012, In : Nature Communications. 3, 1119, p. 1-10 10 p., 1119.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3-and viral-induced expression of type i interferons

Siednienko, J., Jackson, R., Mellett, M., Delagic, N., Yang, S., Wang, B., Tang, L. S., Callanan, J. J., Mahon, B. P. & Moynagh, P. N., Nov 2012, In : Nature Immunology. 13, 11, p. 1055-1062ii 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
1995

Royal academy of medicine in ireland section of biomedical sciences - Proceedings of winter meeting 1995

Galligan, E., Al-Assar, O., McIntyre, I. A., McKeown, S. R., Hollywood, M. A., Thornbury, K. D., McHale, N. G., Keenan, A. K., Gierschik, P., Nelson, A. A., McKenna, P. G., Barnett, Y. A., Curran, A. K., O'Halloran, K. D., Bradford, A., O'Haloran, K. D., Curran, A. K., Bradford, A., Kent, A., Keenan, A. K. & 70 others, Redrobe, J. P., Kelly, J. A., Leonard, B. E., Chambers, P. L., Ryan, P. M., Kelly, J. A., Leonard, B. E., Chambers, P. L., Redmond, A. M., Kelly, J. A., Leonard, B. E., McNamara, M. G., Kelly, J. A., Leonard, B. E., McShane, A. J., Tobin, E., Smith, T., Fox, G. B., Kennedy, N., Regan, C. M., O'Farrell, F. J., Hannigan, B. M., Barnett, Y. A., Walsh, I. K., Johnston, S. R., McKelvey-Martin, V. J., McKeown, S. R., McAleer, J. J. A., O'Halloran, K. D., Curran, A. K., Bradford, A., Curran, A. K., O'Halloran, K. D., Bradford, A., O'Regan, R. G., Kelly, J. A., Leonard, B. E., Mullen, A. M., Earley, B., Leonard, B. E., O'Neill, J., O'Connor, J. J., Moynagh, P., O'Neill, L. A. J., Kelly, J. A., Keenan, A. K., McHale, N. G., Gierschik, P., Browne, I., Gavin, K., Docherty, J. R., Gavin, K., Docherty, J. R., Cawley, T., Docherty, J. R., Geraghty, J., Osborne, H., Hyland, P. L., McKinney, M. W., McKenna, P. G., Barnett, Y. A., McKeown, S. R., Hejmadi, M. V., McAleer, J. J. A., Patterson, L. H., Sweeney, M., McLoughlin, P., O'Donnell, M. D., McGeeney, K. F. & Cottell, D. C., 01 Oct 1995, In : Irish journal of medical science. 164, 4, p. 311-319 9 p.

Research output: Contribution to journalArticle